Stefano Mangani

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 35

Top Venues

ACS infectious diseases

Journal of medicinal chemistry

Molecules (Basel, Switzerland)

Biomolecules

University of Siena

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Siena Nov 01 1983

Italy

Full Professor of Chemistry :: Biotechnology, Chemistry and Pharmacy

Publications

Giusy Tassone, Cecilia Pozzi, Stefano Mangani
Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective. International journal of molecular sciences 25 (15) (2024)
Giusy Tassone, Cecilia Pozzi, Stefano Mangani
Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective. International journal of molecular sciences 25 (15) (2024)
Valeria Francesconi, Marco Rizzo, Cecilia Pozzi, Lorenzo Tagliazucchi, Claude U Konchie Simo, Giulia Saporito, Giacomo Landi, Stefano Mangani, Anna Carbone, Silvia Schenone, Nuno Santarém, Joana Tavares, Anabela-Cordeiro da Silva, Maria Paola Costi, Michele Tonelli
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti- Trypanosoma brucei Agents. ACS infectious diseases 10 (8) (2024)
Valeria Francesconi, Marco Rizzo, Cecilia Pozzi, Lorenzo Tagliazucchi, Claude U Konchie Simo, Giulia Saporito, Giacomo Landi, Stefano Mangani, Anna Carbone, Silvia Schenone, Nuno Santarém, Joana Tavares, Anabela-Cordeiro da Silva, Maria Paola Costi, Michele Tonelli
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti- Trypanosoma brucei Agents. ACS infectious diseases (2024)
Chiara Bacchella, Francesca Camponeschi, Paulina Kolkowska, Arian Kola, Isabella Tessari, Maria Camilla Baratto, Marco Bisaglia, Enrico Monzani, Luigi Bubacco, Stefano Mangani, Luigi Casella, Simone Dell'Acqua, Daniela Valensin
Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment. Biomolecules 13 (2) (2023)
Chiara Bacchella, Francesca Camponeschi, Paulina Kolkowska, Arian Kola, Isabella Tessari, Maria Camilla Baratto, Marco Bisaglia, Enrico Monzani, Luigi Bubacco, Stefano Mangani, Luigi Casella, Simone Dell'Acqua, Daniela Valensin
Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment. Biomolecules 13 (2) (2023)
Chiara Bacchella, Francesca Camponeschi, Paulina Kolkowska, Arian Kola, Isabella Tessari, Maria Camilla Baratto, Marco Bisaglia, Enrico Monzani, Luigi Bubacco, Stefano Mangani, Luigi Casella, Simone Dell'Acqua, Daniela Valensin
Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment. Biomolecules 13 (2) (2023)
Chiara Bacchella, Francesca Camponeschi, Paulina Kolkowska, Arian Kola, Isabella Tessari, Maria Camilla Baratto, Marco Bisaglia, Enrico Monzani, Luigi Bubacco, Stefano Mangani, Luigi Casella, Simone Dell'Acqua, Daniela Valensin
Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment. Biomolecules 13 (2) (2023)
Giusy Tassone, Marco Mazzorana, Stefano Mangani, Elena Petricci, Elena Cini, Giuseppe Giannini, Cecilia Pozzi, Samuele Maramai
Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor. International journal of molecular sciences 23 (16) (2022)
Ina Poehner, Antonio Quotadamo, Joanna Panecka-Hofman, Rosaria Luciani, Matteo Santucci, Pasquale Linciano, Giacomo Landi, Flavio Di Pisa, Lucia Dello Iacono, Cecilia Pozzi, Stefano Mangani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Nuno Santarem, Anabela Cordeiro-da-Silva, Maria Paola Costi, Alberto Venturelli, Rebecca C Wade
Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1. Journal of medicinal chemistry 65 (13) (2022)
Lucia Dello Iacono, Flavio Di Pisa, Stefano Mangani
Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP + /NADPH and the substrate folic acid. Acta crystallographica. Section F, Structural biology communications 78 (Pt 4) (2022)
Alice Legru, Federica Verdirosa, Yen Vo-Hoang, Giusy Tassone, Filippo Vascon, Caitlyn A Thomas, Filomena Sannio, Giuseppina Corsica, Manuela Benvenuti, Georges Feller, Rémi Coulon, Francesca Marcoccia, Savannah Rowane Devente, Ezeddine Bouajila, Catherine Piveteau, Florence Leroux, Rebecca Deprez-Poulain, Benoît Deprez, Patricia Licznar-Fajardo, Michael W Crowder, Laura Cendron, Cecilia Pozzi, Stefano Mangani, Jean Denis Docquier, Jean-François Hernandez, Laurent Gavara
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates. Journal of medicinal chemistry (2022)
Giusy Tassone, Marco Paolino, Cecilia Pozzi, Annalisa Reale, Laura Salvini, Gianluca Giorgi, Maurizio Orlandini, Federico Galvagni, Stefano Mangani, Xuchun Yang, Benedetta Carlotti, Fausto Ortica, Loredana Latterini, Massimo Olivucci, Andrea Cappelli
Xanthopsin-Like Systems via Site-Specific Click-Functionalization of a Retinoic Acid Binding Protein. Chembiochem : a European journal of chemical biology (2021)
Silvia Ciambellotti, Alessandro Pratesi, Giusy Tassone, Paola Turano, Stefano Mangani, Cecilia Pozzi
Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin. Chemistry (Weinheim an der Bergstrasse, Germany) 27 (59) (2021)
Giusy Tassone, Giacomo Landi, Pasquale Linciano, Valeria Francesconi, Michele Tonelli, Lorenzo Tagliazucchi, Maria Paola Costi, Stefano Mangani, Cecilia Pozzi
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase. Pharmaceuticals (Basel, Switzerland) 14 (7) (2021)
Matteo Santucci, Rosaria Luciani, Eleonora Gianquinto, Cecilia Pozzi, Flavio di Pisa, Lucia Dello Iacono, Giacomo Landi, Lorenzo Tagliazucchi, Stefano Mangani, Francesca Spyrakis, Maria Paola Costi
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases. Pharmaceuticals (Basel, Switzerland) 14 (12) (2021)
Cecilia Pozzi, Matteo Santucci, Gaetano Marverti, Domenico D'Arca, Lorenzo Tagliazucchi, Stefania Ferrari, Gaia Gozzi, Lorena Losi, Giusy Tassone, Stefano Mangani, Glauco Ponterini, Maria Paola Costi
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations. Cancers 13 (9) (2021)
David T Davies, Simon Leiris, Nicolas Sprynski, Jérôme M Castandet, Clarisse Lozano, Justine Bousquet, Magdalena Zalacain, Srinivas Vasa, Praveen K Dasari, Ramesh Pattipati, Naresh Vempala, Swetha Gujjewar, SyamKumar Godi, Raju Jallala, Rajashekar Reddy Sathyap, Narasimha A Darshanoju, Vengala R Ravu, Ramakrishna R Juventhala, Narender Pottabathini, Somesh Sharma, Srinivasu Pothukanuri, Kirsty Holden, Peter Warn, Francesca Marcoccia, Manuela Benvenuti, Cecilia Pozzi, Stefano Mangani, Jean Denis Docquier, Marc Lemonnier, Martin J Everett
ANT2681: SAR Studies Leading to the Identification of a Metallo-β-lactamase Inhibitor with Potential for Clinical Use in Combination with Meropenem for the Treatment of Infections Caused by NDM-Producing Enterobacteriaceae. ACS infectious diseases 6 (9) (2020)
Silvia Ciambellotti, Cecilia Pozzi, Stefano Mangani, Paola Turano
Iron Biomineral Growth from the Initial Nucleation Seed in L-Ferritin. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (26) (2020)
David T Davies, Simon Leiris, Magdalena Zalacain, Nicolas Sprynski, Jérôme Castandet, Justine Bousquet, Clarisse Lozano, Agustina Llanos, Laethitia Alibaud, Srinivas Vasa, Ramesh Pattipati, Ravindar Valige, Bhaskar Kummari, Srinivasu Pothukanuri, Cyntia De Piano, Ian Morrissey, Kirsty Holden, Peter Warn, Francesca Marcoccia, Manuela Benvenuti, Cecilia Pozzi, Giusy Tassone, Stefano Mangani, Jean Denis Docquier, Thomas David Pallin, Richard Elliot, Marc Lemonnier, Martin J Everett
Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii. Journal of medicinal chemistry 63 (24) (2020)
Jodie C Hamrick, Jean Denis Docquier, Tsuyoshi Uehara, Cullen L Myers, David A Six, Cassandra L Chatwin, Kaitlyn J John, Salvador F Vernacchio, Susan M Cusick, Robert E L Trout, Cecilia Pozzi, Filomena De Luca, Manuela Benvenuti, Stefano Mangani, Bin Liu, Randy W Jackson, Greg Moeck, Luigi Xerri, Christopher J Burns, Daniel C Pevear, Denis M Daigle
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy 64 (3) (2020)
Leire Iralde-Lorente, Giusy Tassone, Letizia Clementi, Lorenzo Franci, Claire C Munier, Ylenia Cau, Mattia Mori, Mario Chiariello, Adriano Angelucci, Matthew W D Perry, Cecilia Pozzi, Stefano Mangani, Maurizio Botta
Identification of Phosphate-Containing Compounds as New Inhibitors of 14-3-3/c-Abl Protein-Protein Interaction. ACS chemical biology 15 (4) (2020)
Giacomo Landi, Pasquale Linciano, Giusy Tassone, Maria Paola Costi, Stefano Mangani, Cecilia Pozzi
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor. Acta crystallographica. Section D, Structural biology 76 (Pt 6) (2020)
Daniel N Bloch, Paulina Kolkowska, Isabella Tessari, Maria Camilla Baratto, Adalgisa Sinicropi, Luigi Bubacco, Stefano Mangani, Cecilia Pozzi, Daniela Valensin, Yifat Miller
Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini. Inorganic chemistry 58 (16) (2019)
Bin Liu, Robert E Lee Trout, Guo-Hua Chu, Daniel McGarry, Randy W Jackson, Jodie C Hamrick, Denis M Daigle, Susan M Cusick, Cecilia Pozzi, Filomena De Luca, Manuela Benvenuti, Stefano Mangani, Jean Denis Docquier, William J Weiss, Daniel C Pevear, Luigi Xerri, Christopher J Burns
Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. Journal of medicinal chemistry 63 (6) (2019)
Cecilia Pozzi, Stefania Ferrari, Rosaria Luciani, Maria Paola Costi, Stefano Mangani
Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors. Molecules (Basel, Switzerland) 24 (7) (2019)
Jean Jacques Vanden Eynde, Arduino Aleksander Mangoni, Jarkko Rautio, Jérôme Leprince, Yasu-Taka Azuma, Alfonso T García-Sosa, Christopher Hulme, Josef Jampilek, Rafik Karaman, Wei Li, Paula A C Gomes, Dimitra Hadjipavlou-Litina, Raffaele Capasso, Athina Geronikaki, Gennaro Chiappetta, Jean Marc Sabatier, Rino Ragno, Tiziano Tuccinardi, Andrea Trabocchi, Jean-Yves Winum, Francisco Javier Luque, Katalin Prokai-Tatrai, Mariana Spetea, Michael Gütschow, Ivan Kosalec, Catherine Guillou, Maria Helena Vasconcelos, George Kokotos, Giulio Rastelli, Maria Emília Sousa, Clementina Manera, Sandra Gemma, Stefano Mangani, Carlo Siciliano, Stefania Galdieroa, Hong Liu, Peter J H Scott, Cristóbal de Los Ríos, Luigi A Agrofoglio, Simona Collina, Rita C Guedes, Diego Muñoz-Torrero
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6. Molecules (Basel, Switzerland) 25 (1) (2019)
Giacomo Landi, Pasquale Linciano, Chiara Borsari, Claudia P Bertolacini, Carolina B Moraes, Anabela Cordeiro-da-Silva, Sheraz Gul, Gesa Witt, Maria Kuzikov, Maria Paola Costi, Cecilia Pozzi, Stefano Mangani
Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors. ACS infectious diseases 5 (7) (2019)
Cecilia Pozzi, Stefania Ferrari, Rosaria Luciani, Giusy Tassone, Maria Paola Costi, Stefano Mangani
Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities. Molecules (Basel, Switzerland) 24 (7) (2019)
Cecilia Pozzi, Ludovica Lopresti, Giusy Tassone, Stefano Mangani
Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS). Molecules (Basel, Switzerland) 24 (8) (2019)
Pasquale Linciano, Cecilia Pozzi, Lucia Dello Iacono, Flavio di Pisa, Giacomo Landi, Alessio Bonucci, Sheraz Gul, Maria Kuzikov, Bernhard Ellinger, Gesa Witt, Nuno Santarem, Catarina Baptista, Caio Franco, Carolina B Moraes, Wolfgang Müller, Ulrike Wittig, Rosaria Luciani, Antony Sesenna, Antonio Quotadamo, Stefania Ferrari, Ina Pöhner, Anabela Cordeiro-da-Silva, Stefano Mangani, Luca Costantino, Maria Paola Costi
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. Journal of medicinal chemistry 62 (8) (2019)
Simon Leiris, Alicia Coelho, Jérôme M Castandet, Maëlle Bayet, Clarisse Lozano, Juliette Bougnon, Justine Bousquet, Martin J Everett, Marc Lemonnier, Nicolas Sprynski, Magdalena Zalacain, Thomas David Pallin, Michael C Cramp, Neil Jennings, Gilles Raphy, Mark W Jones, Ramesh Pattipati, Battu Shankar, Relangi Sivasubrahmanyam, Ashok K Soodhagani, Ramakrishna R Juventhala, Narender Pottabathini, Srinivasu Pothukanuri, Manuela Benvenuti, Cecilia Pozzi, Stefano Mangani, Filomena De Luca, Giulia Cerboni, Jean Denis Docquier, David T Davies
SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model. ACS infectious diseases 5 (1) (2018)
Cecilia Pozzi, Flavio Di Pisa, Manuela Benvenuti, Stefano Mangani
The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 23 (8) (2018)
Cecilia Pozzi, Flavio Di Pisa, Filomena De Luca, Manuela Benvenuti, Jean Denis Docquier, Stefano Mangani
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam. ChemMedChem 13 (14) (2018)
Caterina Bernacchioni, Cecilia Pozzi, Flavio Di Pisa, Stefano Mangani, Paola Turano
Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity. Chemistry (Weinheim an der Bergstrasse, Germany) 22 (45) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Stefano Mangani