Susan M Lea (S M Lea, Susan Lea)

Scopus Author ID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 60

Top Topics

Escherichia Coli

Structural Basis

Helicobacter Pylori

Top Venues

Nature microbiology

Nature communications

Science advances

Research square

This page only lists publications with an associated author ORCID identifier.

Publications

Frédéric Lauber, Justin C Deme, Xiaolong Liu, Andreas Kjær, Helen L Miller, Felicity Alcock, Susan M Lea, Ben C Berks
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon. Nature microbiology 9 (4) (2024)
Simon Newstead, Joanne L Parker, Justin C Deme, Simon M Lichtinger, Gabriel Kuteyi, Philip Charles Biggin, Susan M Lea
Structural basis for antibiotic transport and inhibition in PepT2, the mammalian proton-coupled peptide transporter. Research square (2024)
Steven Johnson, Justin C Deme, Emily J Furlong, Joseph J E Caesar, Fabienne F V Chevance, Kelly T Hughes, Susan M Lea
Structural basis of directional switching by the bacterial flagellum. Nature microbiology (2024)
Steven Johnson, Justin C Deme, Emily J Furlong, Joseph J E Caesar, Fabienne F V Chevance, Kelly T Hughes, Susan M Lea
Structural basis of directional switching by the bacterial flagellum. Nature microbiology 9 (5) (2024)
Steven Johnson, Justin C Deme, Emily J Furlong, Joseph J E Caesar, Fabienne F V Chevance, Kelly T Hughes, Susan M Lea
Structural basis of directional switching by the bacterial flagellum. Nature microbiology (2024)
Frédéric Lauber, Justin C Deme, Xiaolong Liu, Andreas Kjær, Helen L Miller, Felicity Alcock, Susan M Lea, Ben C Berks
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon. Nature microbiology 9 (4) (2024)
Frédéric Lauber, Justin C Deme, Xiaolong Liu, Andreas Kjær, Helen L Miller, Felicity Alcock, Susan M Lea, Ben C Berks
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon. Nature microbiology 9 (4) (2024)
Frédéric Lauber, Justin C Deme, Xiaolong Liu, Andreas Kjær, Helen L Miller, Felicity Alcock, Susan M Lea, Ben C Berks
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon. Nature microbiology 9 (4) (2024)
Frédéric Lauber, Justin C Deme, Xiaolong Liu, Andreas Kjær, Helen L Miller, Felicity Alcock, Susan M Lea, Ben C Berks
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon. Nature microbiology 9 (4) (2024)
Simon Newstead, Joanne L Parker, Justin C Deme, Simon M Lichtinger, Gabriel Kuteyi, Philip Charles Biggin, Susan M Lea
Structural basis for antibiotic transport and inhibition in PepT2, the mammalian proton-coupled peptide transporter. Research square (2024)
Steven Johnson, Justin C Deme, Emily J Furlong, Joseph J E Caesar, Fabienne F V Chevance, Kelly T Hughes, Susan M Lea
Structural basis of directional switching by the bacterial flagellum. Nature microbiology 9 (5) (2024)
Simon Newstead, Joanne L Parker, Justin C Deme, Simon M Lichtinger, Gabriel Kuteyi, Philip Charles Biggin, Susan M Lea
Structural basis for antibiotic transport and inhibition in PepT2, the mammalian proton-coupled peptide transporter. Research square (2024)
Frédéric Lauber, Justin C Deme, Xiaolong Liu, Andreas Kjær, Helen L Miller, Felicity Alcock, Susan M Lea, Ben C Berks
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon. Nature microbiology 9 (4) (2024)
Frédéric Lauber, Justin C Deme, Xiaolong Liu, Andreas Kjær, Helen L Miller, Felicity Alcock, Susan M Lea, Ben C Berks
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon. Nature microbiology (2024)
Steven Johnson, Justin C Deme, Emily J Furlong, Joseph J E Caesar, Fabienne F V Chevance, Kelly T Hughes, Susan M Lea
Structural basis of directional switching by the bacterial flagellum. Nature microbiology 9 (5) (2024)
Frédéric Lauber, Justin C Deme, Xiaolong Liu, Andreas Kjær, Helen L Miller, Felicity Alcock, Susan M Lea, Ben C Berks
Structural insights into the mechanism of protein transport by the Type 9 Secretion System translocon. Nature microbiology 9 (4) (2024)
Stephen R Garrett, Nicole Mietrach, Justin C Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement. Nature communications 14 (1) (2023)
Yap Shing Nim, Ivan Yu Hang Fong, Justin C Deme, Ka Lung Tsang, Joseph Caesar, Steven Johnson, Longson Tsz Hin Pang, Nicholas Man Hon Yuen, Tin Long Chris Ng, Tung Choi, Yakie Yat Hei Wong, Susan M Lea, Kam-Bo Wong
Delivering a toxic metal to the active site of urease. Science advances 9 (16) (2023)
Susan M Lea, Steven Johnson, Justin C Deme, Emily J Furlong, Fabienne Chevance, Kelly T Hughes, Joseph Caesar
Structural Basis of Directional Switching by the Bacterial Flagellum. Research square (2023)
Steven Johnson, Justin C Deme, Emily J Furlong, Joseph J E Caesar, Fabienne F V Chevance, Kelly T Hughes, Susan M Lea
Structural Basis of Directional Switching by the Bacterial Flagellum. Research square (2023)
Steven Johnson, Justin C Deme, Emily J Furlong, Joseph J E Caesar, Fabienne F V Chevance, Kelly T Hughes, Susan M Lea
Structural Basis of Directional Switching by the Bacterial Flagellum. Research square (2023)
Yap Shing Nim, Ivan Yu Hang Fong, Justin C Deme, Ka Lung Tsang, Joseph Caesar, Steven Johnson, Longson Tsz Hin Pang, Nicholas Man Hon Yuen, Tin Long Chris Ng, Tung Choi, Yakie Yat Hei Wong, Susan M Lea, Kam-Bo Wong
Delivering a toxic metal to the active site of urease. Science advances 9 (16) (2023)
Yap Shing Nim, Ivan Yu Hang Fong, Justin C Deme, Ka Lung Tsang, Joseph Caesar, Steven Johnson, Longson Tsz Hin Pang, Nicholas Man Hon Yuen, Tin Long Chris Ng, Tung Choi, Yakie Yat Hei Wong, Susan M Lea, Kam-Bo Wong
Delivering a toxic metal to the active site of urease. Science advances 9 (16) (2023)
Yap Shing Nim, Ivan Yu Hang Fong, Justin C Deme, Ka Lung Tsang, Joseph Caesar, Steven Johnson, Longson Tsz Hin Pang, Nicholas Man Hon Yuen, Tin Long Chris Ng, Tung Choi, Yakie Yat Hei Wong, Susan M Lea, Kam-Bo Wong
Delivering a toxic metal to the active site of urease. Science advances 9 (16) (2023)
Susan M Lea, Steven Johnson, Justin C Deme, Emily J Furlong, Fabienne Chevance, Kelly T Hughes, Joseph Caesar
Structural Basis of Directional Switching by the Bacterial Flagellum. Research square (2023)
Yevgen Levdansky, Tobias Raisch, Justin C Deme, Filip Pekovic, Hans Elmlund, Susan M Lea, Eugene Valkov
Structure and assembly of the NOT10:11 module of the CCR4-NOT complex. Communications biology 6 (1) (2023)
Yap Shing Nim, Ivan Yu Hang Fong, Justin C Deme, Ka Lung Tsang, Joseph Caesar, Steven Johnson, Longson Tsz Hin Pang, Nicholas Man Hon Yuen, Tin Long Chris Ng, Tung Choi, Yakie Yat Hei Wong, Susan M Lea, Kam-Bo Wong
Delivering a toxic metal to the active site of urease. Science advances 9 (16) (2023)
Yap Shing Nim, Ivan Yu Hang Fong, Justin C Deme, Ka Lung Tsang, Joseph Caesar, Steven Johnson, Longson Tsz Hin Pang, Nicholas Man Hon Yuen, Tin Long Chris Ng, Tung Choi, Yakie Yat Hei Wong, Susan M Lea, Kam-Bo Wong
Delivering a toxic metal to the active site of urease. Science advances 9 (16) (2023)
Stephen R Garrett, Nicole Mietrach, Justin C Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement. Nature communications 14 (1) (2023)
Stephen R Garrett, Nicole Mietrach, Justin C Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement. Nature communications 14 (1) (2023)
Jienyu Ding, Justin C Deme, Jason R Stagno, Ping Yu, Susan M Lea, Yun-Xing Wang
Capturing heterogeneous conformers of cobalamin riboswitch by cryo-EM. Nucleic acids research (2023)
Stephen R Garrett, Nicole Mietrach, Justin C Deme, Alina Bitzer, Yaping Yang, Fatima R Ulhuq, Dorothee Kretschmer, Simon Heilbronner, Terry K Smith, Susan M Lea, Tracy Palmer
A type VII-secreted lipase toxin with reverse domain arrangement. Nature communications 14 (1) (2023)
Yaping Yang, Eleanor Boardman, Justin Deme, Felicity Alcock, Susan M Lea, Tracy Palmer
Three small partner proteins facilitate the type VII-dependent secretion of an antibacterial nuclease. mBio (2023)
Yap Shing Nim, Ivan Yu Hang Fong, Justin C Deme, Ka Lung Tsang, Joseph Caesar, Steven Johnson, Longson Tsz Hin Pang, Nicholas Man Hon Yuen, Tin Long Chris Ng, Tung Choi, Yakie Yat Hei Wong, Susan M Lea, Kam-Bo Wong
Delivering a toxic metal to the active site of urease. Science advances 9 (16) (2023)
Katharina Braunger, Jiyoon Ahn, Matthijs M Jore, Steven Johnson, Terence T L Tang, Dennis V Pedersen, Gregers Rom Andersen, Susan M Lea
Structure and function of a family of tick-derived complement inhibitors targeting properdin. Nature communications 13 (1) (2022)
Jessica E Martyn, Giulia Pilla, Sarah Hollingshead, Kristoffer Skovbo Winther, Susan M Lea, Gareth McVicker, Christoph M Tang
Maintenance of the Shigella sonnei Virulence Plasmid Is Dependent on Its Repertoire and Amino Acid Sequence of Toxin-Antitoxin Systems. Journal of bacteriology 204 (3) (2022)
Rory Hennell James, Justin C Deme, Alicia Hunter, Ben C Berks, Susan M Lea
Structures of the Type IX Secretion/Gliding Motility Motor from across the Phylum Bacteroidetes . mBio 13 (3) (2022)
Augustinas Silale, Susan M Lea, Ben C Berks
The DNA transporter ComEC has metal-dependent nuclease activity that is important for natural transformation. Molecular microbiology 116 (2) (2021)
Steven Johnson, Emily J Furlong, Justin C Deme, Ashley L Nord, Joseph J E Caesar, Fabienne F V Chevance, Richard M Berry, Kelly T Hughes, Susan M Lea
Molecular structure of the intact bacterial flagellar basal body. Nature microbiology 6 (6) (2021)
Arun Dhillon, Justin C Deme, Emily Furlong, Dorina Roem, Ilse Jongerius, Steven Johnson, Susan M Lea
Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex. mBio 12 (2) (2021)
Torcato Martins, Yao Meng, Boguslawa Korona, Richard Suckling, Steven Johnson, Penny A Handford, Susan M Lea, Sarah J Bray
The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling. EMBO reports 22 (10) (2021)
Yoel A Klug, Justin C Deme, Robin A Corey, Mike F Renne, Phillip J Stansfeld, Susan M Lea, Pedro Carvalho
Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex. Nature communications 12 (1) (2021)
Lucas Kuhlen, Steven Johnson, Jerry Cao, Justin C Deme, Susan M Lea
Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein. PloS one 16 (6) (2021)
Joanne L Parker, Justin C Deme, Gabriel Kuteyi, Zhiyi Wu, Jiandong Huo, I David Goldman, Raymond J Owens, Philip Charles Biggin, Susan M Lea, Simon Newstead
Structural basis of antifolate recognition and transport by PCFT. Nature 595 (7865) (2021)
Rory Hennell James, Justin C Deme, Andreas Kjaer, Felicity Alcock, Augustinas Silale, Frédéric Lauber, Steven Johnson, Ben C Berks, Susan M Lea
Structure and mechanism of the proton-driven motor that powers type 9 secretion and gliding motility. Nature microbiology 6 (2) (2021)
Joanne L Parker, Justin C Deme, Dimitrios Kolokouris, Gabriel Kuteyi, Philip Charles Biggin, Susan M Lea, Simon Newstead
Molecular basis for redox control by the human cystine/glutamate antiporter system xc. Nature communications 12 (1) (2021)
Rachel J Harding, Justin C Deme, Johannes F Hevler, Sem Tamara, Alexander Lemak, Jeffrey P Cantle, Magdalena M Szewczyk, Nola Begeja, Siobhan Goss, Xiao-Bing Zuo, Peter Loppnau, Alma Seitova, Ashley Hutchinson, Lixin Fan, Ray Truant, Matthieu Schapira, Jeffrey B Carroll, Albert J R Heck, Susan M Lea, Cheryl H Arrowsmith
Huntingtin structure is orchestrated by HAP40 and shows a polyglutamine expansion-specific interaction with exon 1. Communications biology 4 (1) (2021)
Joanne L Parker, Justin C Deme, Zhiyi Wu, Gabriel Kuteyi, Jiandong Huo, Raymond J Owens, Philip Charles Biggin, Susan M Lea, Simon Newstead
Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals. Science advances 7 (35) (2021)
Steven Johnson, Yu Hang Fong, Justin C Deme, Emily J Furlong, Lucas Kuhlen, Susan M Lea
Symmetry mismatch in the MS-ring of the bacterial flagellar rotor explains the structural coordination of secretion and rotation. Nature microbiology 5 (7) (2020)
Justin C Deme, Steven Johnson, Owen Vickery, Amy Aron, Holly Monkhouse, Thomas Griffiths, Rory Hennell James, Ben C Berks, James W Coulton, Phillip J Stansfeld, Susan M Lea
Structures of the stator complex that drives rotation of the bacterial flagellum. Nature microbiology 5 (12) (2020)
Lucas Kuhlen, Steven Johnson, Andreas Zeitler, Sandra Bäurle, Justin C Deme, Joseph J E Caesar, Rebecca Debo, Joseph Fisher, Samuel Wagner, Susan M Lea
The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion. Nature communications 11 (1) (2020)
Martin Parnov Reichhardt, Vuokko Loimaranta, Susan M Lea, Steven Johnson
Structures of SALSA/DMBT1 SRCR domains reveal the conserved ligand-binding mechanism of the ancient SRCR fold. Life science alliance 3 (4) (2020)
Martin Parnov Reichhardt, Steven Johnson, Terence Tang, Thomas Morgan, Nchimunya Tebeka, Niko Popitsch, Justin C Deme, Matthijs M Jore, Susan M Lea
An inhibitor of complement C5 provides structural insights into activation. Proceedings of the National Academy of Sciences of the United States of America 117 (1) (2019)
Lucas Kuhlen, Patrizia Abrusci, Steven Johnson, Joseph Gault, Justin Deme, Joseph Caesar, Tobias Dietsche, Mehari Tesfazgi Mebrhatu, Tariq Ganief, Boris Macek, Samuel Wagner, Carol V Robinson, Susan M Lea
Structure of the core of the type III secretion system export apparatus. Nature structural & molecular biology 25 (7) (2018)
S Hollingshead, I Jongerius, R M Exley, S Johnson, Susan M Lea, C M Tang
Structure-based design of chimeric antigens for multivalent protein vaccines. Nature communications 9 (1) (2018)
Qi Huang, Felicity Alcock, Holger Kneuper, Justin C Deme, Sarah E Rollauer, Susan M Lea, Ben C Berks, Tracy Palmer
A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase. Proceedings of the National Academy of Sciences of the United States of America 114 (10) (2017)
Richard J Suckling, Boguslawa Korona, Pat Whiteman, Chandramouli Chillakuri, Laurie Holt, Penny A Handford, Susan M Lea
Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands. The EMBO journal 36 (15) (2017)
Pietro Roversi, Steven Johnson, Stephen G Preston, Miles A Nunn, Guido C Paesen, Jonathan M Austyn, Patricia A Nuttall, Susan M Lea
Structural basis of cholesterol binding by a novel clade of dendritic cell modulators from ticks. Scientific reports 7 (1) (2017)
Matthijs M Jore, Steven Johnson, Devon Sheppard, Natalie M Barber, Yang I Li, Miles A Nunn, Hans Elmlund, Susan M Lea
Structural basis for therapeutic inhibition of complement C5. Nature structural & molecular biology 23 (5) (2016)
Tobias Dietsche, Mehari Tesfazgi Mebrhatu, Matthias J Brunner, Patrizia Abrusci, Jun Yan, Mirita Franz-Wachtel, Charlotta Schärfe, Susann Zilkenat, Iwan Grin, Jorge E Galán, Oliver Kohlbacher, Susan M Lea, Boris Macek, Thomas C Marlovits, Carol V Robinson, Samuel Wagner
Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus. PLoS pathogens 12 (12) (2016)
Daniel B Grabarczyk, Paul E Chappell, Steven Johnson, Lukas S Stelzl, Susan M Lea, Ben C Berks
Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle. Proceedings of the National Academy of Sciences of the United States of America 112 (52) (2015)