Philip Charles Biggin (Philip Biggin, Philip C Biggin)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 58

Top Topics

Molecular Dynamics Simulations

Structural Basis

Top Venues

Nature communications

ACS chemical neuroscience

Proceedings of the National Academy of Sciences of the United States of America

Journal of chemical information and modeling

This page only lists publications with an associated author ORCID identifier.

Publications

Daniel Crusius, Flaviu Cipcigan, Philip Charles Biggin
Are we fitting data or noise? Analysing the predictive power of commonly used datasets in drug-, materials-, and molecular-discovery. Faraday discussions (2024)
Simon Newstead, Joanne L Parker, Justin C Deme, Simon M Lichtinger, Gabriel Kuteyi, Philip Charles Biggin, Susan M Lea
Structural basis for antibiotic transport and inhibition in PepT2, the mammalian proton-coupled peptide transporter. Research square (2024)
Rebecca Appiani, Franco Viscarra, Philip Charles Biggin, Isabel Bermudez, Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi
Selective Potentiation of the (α4) 3 (β2) 2 Nicotinic Acetylcholine Receptor Response by NS9283 Analogues. ACS chemical neuroscience 15 (7) (2024)
Rebecca Appiani, Franco Viscarra, Philip Charles Biggin, Isabel Bermudez, Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi
Selective Potentiation of the (α4) 3 (β2) 2 Nicotinic Acetylcholine Receptor Response by NS9283 Analogues. ACS chemical neuroscience 15 (7) (2024)
Simon Newstead, Joanne L Parker, Justin C Deme, Simon M Lichtinger, Gabriel Kuteyi, Philip Charles Biggin, Susan M Lea
Structural basis for antibiotic transport and inhibition in PepT2, the mammalian proton-coupled peptide transporter. Research square (2024)
Yasmin Bay, Raminta Venskutonytė, Stine M Frantsen, Thor S Thorsen, Maria Musgaard, Karla A Frydenvang, Pierre Francotte, Bernard Pirotte, Philip Charles Biggin, Anders S Kristensen, Thomas Boesen, Darryl S Pickering, Michael Gajhede, Jette Sandholm Kastrup
Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. The FEBS journal 291 (7) (2024)
Nikhil Bharambe, Zhuowen Li, David Seiferth, Asha Manikkoth Balakrishna, Philip Charles Biggin, Sandip Basak
Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment. Nature communications 15 (1) (2024)
Rebecca Appiani, Franco Viscarra, Philip Charles Biggin, Isabel Bermudez, Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi
Selective Potentiation of the (α4) 3 (β2) 2 Nicotinic Acetylcholine Receptor Response by NS9283 Analogues. ACS chemical neuroscience (2024)
Nikhil Bharambe, Zhuowen Li, David Seiferth, Asha Manikkoth Balakrishna, Philip Charles Biggin, Sandip Basak
Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment. Nature communications 15 (1) (2024)
Benjamin Ries, Irfan Alibay, Nithishwer Mouroug Anand, Philip Charles Biggin, Aniket Magarkar
Automated Absolute Binding Free Energy Calculation Workflow for Drug Discovery. Journal of chemical information and modeling 64 (14) (2024)
Afroditi-Maria Zaki, Süleyman Selim Çınaroğlu, Taufiq Rahman, Sandip Patel, Philip Charles Biggin
Plasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Simon Newstead, Joanne L Parker, Justin C Deme, Simon M Lichtinger, Gabriel Kuteyi, Philip Charles Biggin, Susan M Lea
Structural basis for antibiotic transport and inhibition in PepT2, the mammalian proton-coupled peptide transporter. Research square (2024)
Rebecca Appiani, Franco Viscarra, Philip Charles Biggin, Isabel Bermudez, Alessandro Giraudo, Marco Pallavicini, Cristiano Bolchi
Selective Potentiation of the (α4) 3 (β2) 2 Nicotinic Acetylcholine Receptor Response by NS9283 Analogues. ACS chemical neuroscience 15 (7) (2024)
Benjamin Ries, Irfan Alibay, Nithishwer Mouroug Anand, Philip Charles Biggin, Aniket Magarkar
Automated Absolute Binding Free Energy Calculation Workflow for Drug Discovery. Journal of chemical information and modeling (2024)
Simon M Lichtinger, Joanne L Parker, Simon Newstead, Philip Charles Biggin
The mechanism of mammalian proton-coupled peptide transporters. eLife 13 (2024)
Simon M Lichtinger, Joanne L Parker, Simon Newstead, Philip Charles Biggin
The mechanism of mammalian proton-coupled peptide transporters. eLife 13 (2024)
Afroditi-Maria Zaki, Süleyman Selim Çınaroğlu, Taufiq Rahman, Sandip Patel, Philip Charles Biggin
Plasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Nikhil Bharambe, Zhuowen Li, David Seiferth, Asha Manikkoth Balakrishna, Philip Charles Biggin, Sandip Basak
Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment. Nature communications 15 (1) (2024)
Afroditi-Maria Zaki, Süleyman Selim Çınaroğlu, Taufiq Rahman, Sandip Patel, Philip Charles Biggin
Plasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Yasmin Bay, Raminta Venskutonytė, Stine M Frantsen, Thor S Thorsen, Maria Musgaard, Karla A Frydenvang, Pierre Francotte, Bernard Pirotte, Philip Charles Biggin, Anders S Kristensen, Thomas Boesen, Darryl S Pickering, Michael Gajhede, Jette Sandholm Kastrup
Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. The FEBS journal 291 (7) (2024)
David Seiferth, Stephen J Tucker, Philip Charles Biggin
Limitations of non-polarizable force fields in describing anion binding poses in non-polar synthetic hosts. Physical chemistry chemical physics : PCCP (2023)
Eric Gibbs, Emily Klemm, David Seiferth, Arvind Kumar, Serban L Ilca, Philip Charles Biggin, Sudha Chakrapani
Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nature communications 14 (1) (2023)
Eric Gibbs, Emily Klemm, David Seiferth, Arvind Kumar, Serban L Ilca, Philip Charles Biggin, Sudha Chakrapani
Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nature communications 14 (1) (2023)
Simon M Lichtinger, Philip Charles Biggin
Tackling Hysteresis in Conformational Sampling: How to Be Forgetful with MEMENTO. Journal of chemical theory and computation (2023)
Süleyman Selim Çınaroğlu, Philip Charles Biggin
Computed Protein-Protein Enthalpy Signatures as a Tool for Identifying Conformation Sampling Problems. Journal of chemical information and modeling (2023)
David Seiferth, Stephen J Tucker, Philip Charles Biggin
Limitations of non-polarizable force fields in describing anion binding poses in non-polar synthetic hosts. Physical chemistry chemical physics : PCCP (2023)
Yasmin Bay, Raminta Venskutonytė, Stine M Frantsen, Thor S Thorsen, Maria Musgaard, Karla A Frydenvang, Pierre Francotte, Bernard Pirotte, Philip Charles Biggin, Anders S Kristensen, Thomas Boesen, Darryl S Pickering, Michael Gajhede, Jette Sandholm Kastrup
Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. The FEBS journal (2023)
Adam M Thomas, Marta Serafini, Emma K Grant, Edward A J Coombs, Joseph P Bluck, Matthias Schiedel, Michael A McDonough, Jessica K Reynolds, Bernadette Lee, Michael Platt, Vassilena Sharlandjieva, Philip Charles Biggin, Fernanda Duarte, Thomas A Milne, Jacob T Bush, Stuart J Conway
Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation. ACS chemical biology (2023)
Süleyman Selim Çınaroğlu, Philip Charles Biggin
The role of loop dynamics in the prediction of ligand-protein binding enthalpy. Chemical science 14 (24) (2023)
Eric Gibbs, Emily Klemm, David Seiferth, Arvind Kumar, Serban L Ilca, Philip Charles Biggin, Sudha Chakrapani
Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nature communications 14 (1) (2023)
Franco Viscarra, Juan Facundo Chrestia, Yaima Sanchez, Edwin G Pérez, Philip Charles Biggin, Cecilia Bouzat, Isabel Bermudez, Jhon J López
Side Groups Convert the α7 Nicotinic Receptor Agonist Ether Quinuclidine into a Type I Positive Allosteric Modulator. ACS chemical neuroscience (2023)
Harold Grosjean, Mehtap Işık, Anthony Aimon, David L Mobley, John D Chodera, Frank von Delft, Philip Charles Biggin
SAMPL7 protein-ligand challenge: A community-wide evaluation of computational methods against fragment screening and pose-prediction. Journal of computer-aided molecular design 36 (4) (2022)
David Seiferth, Philip Charles Biggin, Stephen J Tucker
When is a hydrophobic gate not a hydrophobic gate? The Journal of general physiology 154 (11) (2022)
Angelina R Sekirnik, Jessica K Reynolds, Larissa See, Joseph P Bluck, Amy R Scorah, Cynthia Tallant, Bernadette Lee, Katarzyna B Leszczynska, Rachel L Grimley, R Ian Storer, Marta Malattia, Sara Crespillo, Sofia Caria, Stephanie Duclos, Eva-Leonne Göttgens, Stefan Knapp, Garrett M Morris, Fernanda Duarte, Philip Charles Biggin, Stuart J Conway
Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains. ACS chemical biology 17 (10) (2022)
Arvind Kumar, Kayla Kindig, Shanlin Rao, Afroditi-Maria Zaki, Sandip Basak, Mark S P Sansom, Philip Charles Biggin, Sudha Chakrapani
Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nature communications 13 (1) (2022)
Lucy Kate Ladefoged, Rebekka Koch, Philip Charles Biggin, Birgit Schiøtt
Binding and Activation of Serotonergic G-Protein Coupled Receptors by the Multimodal Antidepressant Vortioxetine. ACS chemical neuroscience 13 (8) (2022)
Tsung-Han Chou, Max Epstein, Kevin Michalski, Eve Fine, Philip Charles Biggin, Hiro Furukawa
Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nature structural & molecular biology 29 (6) (2022)
Adamo S Mancino, William G Glass, Yuhao Yan, Philip Charles Biggin, Derek Bowie
Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms. The Journal of general physiology 154 (5) (2022)
Irfan Alibay, Aniket Magarkar, Daniel Seeliger, Philip Charles Biggin
Evaluating the use of absolute binding free energy in the fragment optimisation process. Communications chemistry 5 (1) (2022)
Zhiyi Wu, Philip Charles Biggin
Correction Schemes for Absolute Binding Free Energies Involving Lipid Bilayers. Journal of chemical theory and computation 18 (4) (2022)
Irfan Alibay, Aniket Magarkar, Daniel Seeliger, Philip Charles Biggin
Evaluating the use of absolute binding free energy in the fragment optimisation process. Communications chemistry 5 (1) (2022)
Marc André Dämgen, Philip Charles Biggin
State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane. PLoS computational biology 17 (2) (2021)
Petra Lukacik, C David Owen, Gemma Harris, Jani Reddy Bolla, Sarah Picaud, Irfan Alibay, Joanne E Nettleship, Louise E Bird, Raymond J Owens, Philip Charles Biggin, Panagis Filippakopoulos, Carol V Robinson, Martin A Walsh
The structure of nontypeable Haemophilus influenzae SapA in a closed conformation reveals a constricted ligand-binding cavity and a novel RNA binding motif. PloS one 16 (10) (2021)
Joanne L Parker, Justin C Deme, Gabriel Kuteyi, Zhiyi Wu, Jiandong Huo, I David Goldman, Raymond J Owens, Philip Charles Biggin, Susan M Lea, Simon Newstead
Structural basis of antifolate recognition and transport by PCFT. Nature 595 (7865) (2021)
Andreas Gerondopoulos, Philipp Bräuer, Tomoaki Sobajima, Zhiyi Wu, Joanne L Parker, Philip Charles Biggin, Francis A Barr, Simon Newstead
A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval. eLife 10 (2021)
Michael Brand, James Clayton, Mustafa Moroglu, Matthias Schiedel, Sarah Picaud, Joseph P Bluck, Anna Skwarska, Hannah Bolland, Anthony K C Chan, Corentine M C Laurin, Amy R Scorah, Larissa See, Timothy P C Rooney, Katrina H Andrews, Oleg Fedorov, Gabriella Perell, Prakriti Kalra, Kayla B Vinh, Wilian A Cortopassi, Pascal Heitel, Kirsten E Christensen, Richard I Cooper, Robert S Paton, William C K Pomerantz, Philip Charles Biggin, Eva-Leonne Göttgens, Panagis Filippakopoulos, Stuart J Conway
Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain. Journal of medicinal chemistry 64 (14) (2021)
Joanne L Parker, Justin C Deme, Dimitrios Kolokouris, Gabriel Kuteyi, Philip Charles Biggin, Susan M Lea, Simon Newstead
Molecular basis for redox control by the human cystine/glutamate antiporter system xc. Nature communications 12 (1) (2021)
Süleyman Selim Çınaroğlu, Philip Charles Biggin
Evaluating the Performance of Water Models with Host-Guest Force Fields in Binding Enthalpy Calculations for Cucurbit[7]uril-Guest Systems. The journal of physical chemistry. B 125 (6) (2021)
Rocco Meli, Andrew Anighoro, Mike J Bodkin, Garrett M Morris, Philip Charles Biggin
Learning protein-ligand binding affinity with atomic environment vectors. Journal of cheminformatics 13 (1) (2021)
Joanne L Parker, Justin C Deme, Zhiyi Wu, Gabriel Kuteyi, Jiandong Huo, Raymond J Owens, Philip Charles Biggin, Susan M Lea, Simon Newstead
Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals. Science advances 7 (35) (2021)
Corentine M C Laurin, Joseph P Bluck, Anthony K C Chan, Michelle Keller, Andrew Boczek, Amy R Scorah, K F Larissa See, Laura E Jennings, David S Hewings, Fern Woodhouse, Jessica K Reynolds, Matthias Schiedel, Philip G Humphreys, Philip Charles Biggin, Stuart J Conway
Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi. ACS infectious diseases 7 (8) (2020)
Rocco Meli, Philip Charles Biggin
spyrmsd: symmetry-corrected RMSD calculations in Python. Journal of cheminformatics 12 (1) (2020)
Hakan Cetin, Max Epstein, Wei W Liu, Susan Maxwell, Pedro M Rodriguez Cruz, Judith Cossins, Angela Vincent, Richard Webster, Philip Charles Biggin, Hakan Cetin
Muscle acetylcholine receptor conversion into chloride conductance at positive potentials by a single mutation. Proceedings of the National Academy of Sciences of the United States of America 116 (42) (2019)
Julia M C Busch, Michèle C Erat, Iris D Blank, Maria Musgaard, Philip Charles Biggin, Ioannis Vakonakis
A dynamically interacting flexible loop assists oligomerisation of the Caenorhabditis elegans centriolar protein SAS-6. Scientific reports 9 (1) (2019)
Fatemah Safar, Elliot Hurdiss, Marios Erotocritou, Timo Greiner, Remigijus Lape, Mark W Irvine, Guangyu Fang, David Jane, Rilei Yu, Marc A Dämgen, Philip Charles Biggin, Lucia G Sivilotti
The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site. The Journal of biological chemistry 292 (12) (2017)
Matteo Aldeghi, Michael J Bodkin, Stefan Knapp, Philip Charles Biggin
Statistical Analysis on the Performance of Molecular Mechanics Poisson-Boltzmann Surface Area versus Absolute Binding Free Energy Calculations: Bromodomains as a Case Study. Journal of chemical information and modeling 57 (9) (2017)
Akshay Sridhar, Gregory A Ross, Philip Charles Biggin
Waterdock 2.0: Water placement prediction for Holo-structures with a pymol plugin. PloS one 12 (2) (2017)
Matteo Aldeghi, Alexander Heifetz, Michael J Bodkin, Stefan Knapp, Philip Charles Biggin
Predictions of Ligand Selectivity from Absolute Binding Free Energy Calculations. Journal of the American Chemical Society 139 (2) (2017)