Thomas A Milne (Thomas Milne)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 28

Top Venues

Nature communications

Nature cardiovascular research

Blood

Nature protocols

University of British Columbia (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

University of British Columbia Sep 01 2001 - Nov 01 2004

Canada

PHD :: Genetics

Publications

Belén Lopez-Millan, Alba Rubio-Gayarre, Meritxell Vinyoles, Juan L Trincado, Mario F Fraga, Narcís Fernandez-Fuentes, Mercedes Guerrero Murillo, Alba Martinez-Moreno, Talía Velasco-Hernandez, Aïda Falgas, Carla Panisello, Gemma Valcarcel, Jose Luis Sardina, Paula López-Martí, Biola M Javierre, Beatriz Del Valle-Pérez, Antonio García de Herreros, Franco Locatelli, Rob Pieters, Michela Bardini, Giovanni Cazzaniga, Juan Carlos Rodríguez-Manzaneque, Thomas Hanewald, Rolf Marschalek, Thomas A Milne, Ronald W Stam, Juan Ramón Ramón Tejedor, Pablo Menendez, Clara Bueno
NG2 is a target gene of MLL-AF4 and underlies glucocorticoid resistance in MLL-r B-ALL by regulating NR3C1 expression. Blood (2024)
Kyung Chan Park, Nicholas T Crump, Niamh Louwman, Steve Krywawych, Yuen Jian Cheong, Iolanda Vendrell, Eleanor K Gill, Mala Gunadasa-Rohling, Kerrie L Ford, David Hauton, Marjorie Fournier, Elisabete Pires, Lydia Watson, Gerald Roseman, James Holder, Andreas Koschinski, Ricardo Carnicer, M Kate Curtis, Manuela Zaccolo, Alzbeta Hulikova, Roman Fischer, Holger B Kramer, James S O McCullagh, Sophie Trefely, Thomas A Milne, Pawel Swietach
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation. Nature cardiovascular research 2 (2023)
Kyung Chan Park, Nicholas T Crump, Niamh Louwman, Steve Krywawych, Yuen Jian Cheong, Iolanda Vendrell, Eleanor K Gill, Mala Gunadasa-Rohling, Kerrie L Ford, David Hauton, Marjorie Fournier, Elisabete Pires, Lydia Watson, Gerald Roseman, James Holder, Andreas Koschinski, Ricardo Carnicer, M Kate Curtis, Manuela Zaccolo, Alzbeta Hulikova, Roman Fischer, Holger B Kramer, James S O McCullagh, Sophie Trefely, Thomas A Milne, Pawel Swietach
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation. Nature cardiovascular research 2 (2023)
Kyung Chan Park, Nicholas T Crump, Niamh Louwman, Steve Krywawych, Yuen Jian Cheong, Iolanda Vendrell, Eleanor K Gill, Mala Gunadasa-Rohling, Kerrie L Ford, David Hauton, Marjorie Fournier, Elisabete Pires, Lydia Watson, Gerald Roseman, James Holder, Andreas Koschinski, Ricardo Carnicer, M Kate Curtis, Manuela Zaccolo, Alzbeta Hulikova, Roman Fischer, Holger B Kramer, James S O McCullagh, Sophie Trefely, Thomas A Milne, Pawel Swietach
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation. Nature cardiovascular research 2 (2023)
Nicholas T Crump, Alastair L Smith, Laura Godfrey, Ana M Dopico-Fernandez, Nicholas Denny, Joe R Harman, Joseph C Hamley, Nicole E Jackson, Catherine Chahrour, Simone Riva, Siobhan Rice, Jaehoon Kim, Venkatesha Basrur, Damian Fermin, Kojo Elenitoba-Johnson, Robert G Roeder, C David Allis, Irene Roberts, Anindita Roy, Huimin Geng, James O J Davies, Thomas A Milne
MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia. Nature communications 14 (1) (2023)
Damien J Downes, Alastair L Smith, Magdalena A Karpińska, Taras Velychko, Kevin Christophe Rue-Albrecht, David Sims, Thomas A Milne, James O J Davies, A Marieke Oudelaar, Jim R Hughes
Author Correction: Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture. Nature protocols (2023)
Kyung Chan Park, Nicholas T Crump, Niamh Louwman, Steve Krywawych, Yuen Jian Cheong, Iolanda Vendrell, Eleanor K Gill, Mala Gunadasa-Rohling, Kerrie L Ford, David Hauton, Marjorie Fournier, Elisabete Pires, Lydia Watson, Gerald Roseman, James Holder, Andreas Koschinski, Ricardo Carnicer, M Kate Curtis, Manuela Zaccolo, Alzbeta Hulikova, Roman Fischer, Holger B Kramer, James S O McCullagh, Sophie Trefely, Thomas A Milne, Pawel Swietach
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation. Nature cardiovascular research 2 (2023)
Kyung Chan Park, Nicholas T Crump, Niamh Louwman, Steve Krywawych, Yuen Jian Cheong, Iolanda Vendrell, Eleanor K Gill, Mala Gunadasa-Rohling, Kerrie L Ford, David Hauton, Marjorie Fournier, Elisabete Pires, Lydia Watson, Gerald Roseman, James Holder, Andreas Koschinski, Ricardo Carnicer, M Kate Curtis, Manuela Zaccolo, Alzbeta Hulikova, Roman Fischer, Holger B Kramer, James S O McCullagh, Sophie Trefely, Thomas A Milne, Pawel Swietach
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation. Nature cardiovascular research 2 (2023)
Clara Bueno, Raul Torres-Ruíz, Talía Velasco-Hernandez, William C Earnshaw, Paolo Petazzi, Alba Martinez-Moreno, Virginia Carolina Rodríguez-Cortez, Meritxell Vinyoles, Sandra Cantilena, Owen Williams, Nerea Vega-García, Sandra Rodríguez-Perales, José Carlos Segovia, Oscar Quintana-Bustamante, Anindita Roy, Claus Meyer, Rolf Marschalek, Alastair L Smith, Thomas A Milne, Mario F Fraga, Juan Ramón Ramón Tejedor, Pablo Menendez
A human genome editing-based MLL::AF4 B-cell ALL model recapitulates key cellular and molecular leukemogenic features. Blood (2023)
Damien J Downes, Alastair L Smith, Magdalena A Karpińska, Taras Velychko, Kevin Christophe Rue-Albrecht, David Sims, Thomas A Milne, James O J Davies, A Marieke Oudelaar, Jim R Hughes
Capture-C: a modular and flexible approach for high-resolution chromosome conformation capture. Nature protocols 17 (2) (2022)
Klaudyna Fidyt, Agata Pastorczak, Julia Cyran, Nicholas T Crump, Agnieszka Goral, Joanna Madzio, Angelika Muchowicz, Martyna Poprzeczko, Krzysztof Domka, Lukasz Komorowski, Magdalena Winiarska, Joe R Harman, Karolina Siudakowska, Agnieszka Graczyk-Jarzynka, Elżbieta Patkowska, Ewa Lech-Maranda, Wojciech Mlynarski, Jakub Golab, Thomas A Milne, Malgorzata Firczuk
Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax. Oncogene 41 (11) (2022)
Siobhan Rice, Thomas Jackson, Nicholas T Crump, Nicholas Fordham, Natalina Elliott, Sorcha O'Byrne, Maria Del Mar Lara Fanego, Dilys Addy, Trisevgeni Crabb, Carryl Dryden, Sarah Inglott, Dariusz Ladon, Gary Wright, Jack Bartram, Philip Ancliff, Adam J Mead, Christina Halsey, Irene Roberts, Thomas A Milne, Anindita Roy
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program. Nature communications 12 (1) (2021)
Peng Hua, Mohsin Badat, Lars L P Hanssen, Lance D Hentges, Nicholas T Crump, Damien J Downes, Danuta M Jeziorska, A Marieke Oudelaar, Ron Schwessinger, Stephen Taylor, Thomas A Milne, Jim R Hughes, Douglas R Higgs, James O J Davies
Defining genome architecture at base-pair resolution. Nature 595 (7865) (2021)
Nicholas T Crump, Erica Ballabio, Laura Godfrey, Ross Thorne, Emmanouela Repapi, Jon Kerry, Marta Tapia, Peng Hua, Christoffer Lagerholm, Panagis Filippakopoulos, James O J Davies, Thomas A Milne
BET inhibition disrupts transcription but retains enhancer-promoter contact. Nature communications 12 (1) (2021)
Joe R Harman, Ross Thorne, Max Jamilly, Marta Tapia, Nicholas T Crump, Siobhan Rice, Ryan Beveridge, Edward Morrissey, Marella F T R de Bruijn, Irene Roberts, Anindita Roy, Tudor A Fulga, Thomas A Milne
A KMT2A-AFF1 gene regulatory network highlights the role of core transcription factors and reveals the regulatory logic of key downstream target genes. Genome research (2021)
Laura Godfrey, Nicholas T Crump, Sorcha O'Byrne, I-Jun Lau, Siobhan Rice, Joe R Harman, Thomas Jackson, Natalina Elliott, Gemma Buck, Christopher Connor, Ross Thorne, David J H F Knapp, Olaf Heidenreich, Paresh Vyas, Pablo Menendez, Sarah Inglott, Philip Ancliff, Huimin Geng, Irene Roberts, Anindita Roy, Thomas A Milne
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells. Leukemia 35 (1) (2020)
Laura C Godfrey, Nicholas T Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L Smith, Joe R Harman, Jelena M Telenius, A Marieke Oudelaar, Damien J Downes, Paresh Vyas, Jim R Hughes, Thomas A Milne
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation. Nature communications 10 (1) (2019)
David J H F Knapp, Yale S Michaels, Max Jamilly, Quentin R V Ferry, Hector Barbosa, Thomas A Milne, Tudor A Fulga
Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression. Nature communications 10 (1) (2019)
Nicholas T Crump, Thomas A Milne
Why are so many MLL lysine methyltransferases required for normal mammalian development? Cellular and molecular life sciences : CMLS 76 (15) (2019)
Yale S Michaels, Mike Bogetofte Barnkob, Hector Barbosa, Toni A Baeumler, Mary Kay Thompson, Violaine Andre, Huw Colin-York, Marco Fritzsche, Uzi Gileadi, Hilary M Sheppard, David J H F Knapp, Thomas A Milne, Vincenzo Cerundolo, Tudor A Fulga
Addendum: Precise tuning of gene expression levels in mammalian cells. Nature communications 10 (1) (2019)
Sorcha O'Byrne, Natalina Elliott, Siobhan Rice, Gemma Buck, Nicholas Fordham, Catherine Garnett, Laura Godfrey, Nicholas T Crump, Gary Wright, Sarah Inglott, Peng Hua, Bethan Psaila, Benjamin Povinelli, David J H F Knapp, Antonio Agraz-Doblas, Clara Bueno, Ignacio Varela, Phillip Bennett, Hashem Koohy, Suzanne M Watt, Anastasios Karadimitris, Adam J Mead, Phillip Ancliff, Paresh Vyas, Pablo Menendez, Thomas A Milne, Irene Roberts, Anindita Roy
Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs. Blood 134 (13) (2019)
Yale S Michaels, Mike Bogetofte Barnkob, Hector Barbosa, Toni A Baeumler, Mary Kay Thompson, Violaine Andre, Huw Colin-York, Marco Fritzsche, Uzi Gileadi, Hilary M Sheppard, David J H F Knapp, Thomas A Milne, Vincenzo Cerundolo, Tudor A Fulga
Precise tuning of gene expression levels in mammalian cells. Nature communications 10 (1) (2019)
Christian Hurtz, Lai N Chan, Huimin Geng, Erica Ballabio, Gang Xiao, Gauri Deb, Haytham Khoury, Chun-Wei Chen, Scott A Armstrong, Jianjun Chen, Patricia Ernst, Ari Melnick, Thomas A Milne, Markus Müschen
Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia. Genes & development 33 (17-18) (2019)
Akihiko Numata, Hui Si Kwok, Akira Kawasaki, Jia Li, Qi-Ling Zhou, Jon Kerry, Touati Benoukraf, Deepak Bararia, Feng Li, Erica Ballabio, Marta Tapia, Aniruddha J Deshpande, Robert S Welner, Ruud Delwel, Henry Yang, Thomas A Milne, Reshma Taneja, Daniel Geoffrey Tenen
The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia. Nature communications 9 (1) (2018)
Thomas A Milne
LEDGF: a leukemia-specific target. Blood 131 (1) (2018)
Qianxin Wu, Quentin R V Ferry, Toni A Baeumler, Yale S Michaels, Dimitrios Michael Vitsios, Omer Habib, Roland Arnold, Xiaowei Jiang, Stefano Maio, Bruno R Steinkraus, Marta Tapia, Paolo Piazza, Ni Xu, Georg A Holländer, Thomas A Milne, Jin-Soo Kim, Anton J Enright, Andrew R Bassett, Tudor A Fulga
In situ functional dissection of RNA cis-regulatory elements by multiplex CRISPR-Cas9 genome engineering. Nature communications 8 (1) (2017)
Thomas A Milne
Mouse models of MLL leukemia: recapitulating the human disease. Blood 129 (16) (2017)
Sant-Rayn Pasricha, Pei Jin Lim, Tiago L Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U Muckenthaler, Jim R Hughes, Stefano Rivella, Thomas A Milne, Andrew E Armitage, Hal Drakesmith
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nature communications 8 (1) (2017)

Thomas A Milne.css-eqlu8i{font-size:small;padding-left:4px;} (Thomas Milne)

Publication Activity (10 Years)

Top Topics

Top Venues

Thomas A Milne (Thomas Milne)