Douglas R Higgs (D R Higgs, Doug R Higgs, Doug Higgs)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 32

Top Venues

Nature communications

Genome research

Blood

Nature genetics

MRC Weatherall Institute of Molecular Medicine

King's College London School of Medical Education (BSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

MRC Weatherall Institute of Molecular Medicine Oct 01 2012

United Kingdom

Director

MRC Weatherall Institute of Molecular Medicine Oct 01 2000

United Kingdom

Director :: MRC Molecular Haematology Unit

MRC Weatherall Institute of Molecular Medicine Oct 01 2005 - Sep 30 2012

United Kingdom

Deputy Director

John Radcliffe Hospital Apr 01 1996 - Sep 30 2000

United Kingdom

Professor of Haematology, Scientific Officer (Clinical) & Hon Consultant in Haematology :: MRC Molecular Haematology Unit & Department of Cellular Science

John Radcliffe Hospital Apr 01 1985 - Mar 31 1996

United Kingdom

Scientific Officer (Clinical) & Honorary Consultant in Haematology :: MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine

John Radcliffe Hospital Apr 01 1980 - Mar 31 1985

United Kingdom

Scientific Officer (Clinical) & Honorary Senior Registrar :: MRC Molecular Haematology Unit, Nuffield Department of Clinical Medicine

John Radcliffe Hospital Oct 01 1977 - Mar 31 1980

United Kingdom

MRC Training Fellowship & Honorary Registrar :: Nuffield Department of Clinical Medicine

Kings College School Apr 01 1976 - Sep 30 1977

United Kingdom

Registrar :: Department of Haematology

Kings College School Oct 01 1975 - Mar 31 1976

United Kingdom

Senior House Officer :: Department of Haematology

Kings College School Aug 01 1975 - Sep 30 1975

United Kingdom

Senior House Officer :: Department of Neurology

Kings College School May 01 1975 - Jul 31 1975

United Kingdom

House Surgeon :: Department of Surgery

Kings College School Jan 01 1975 - Apr 30 1975

United Kingdom

House Physician :: Department of Medicine

Education History

King's College London School of Medical Education Oct 01 1971 - Jul 31 1974

United Kingdom

BSC

Publications

Ali Amid, Siyu Liu, Christian Babbs, Douglas R Higgs
Hemoglobin Bart's hydrops fetalis: charting the past and envisioning the future. Blood 144 (8) (2024)
Guanjue Xiang, Xi He, Belinda M Giardine, Kathryn J Isaac, Dylan J Taylor, Rajiv C McCoy, Camden Jansen, Cheryl A Keller, Alexander Q Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, Elisabeth F Heuston, Stacie M Anderson, Jing Luan, Marit W Vermunt, Feng Yue, Michael E G Sauria, Michael C Schatz, James Taylor, Berthold Göttgens, Jim R Hughes, Douglas R Higgs, Mitchell J Weiss, Yong Cheng, Gerd A Blobel, David M Bodine, Yu Zhang, Qunhua Li, Shaun Mahony, Ross Cameron Hardison
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. Genome research 34 (7) (2024)
Ali Amid, Siyu Liu, Christian Babbs, Douglas R Higgs
Haemoglobin Bart's Hydrops Fetalis: Charting the Past and Envisioning the Future. Blood (2024)
Guanjue Xiang, Xi He, Belinda M Giardine, Kathryn J Isaac, Dylan J Taylor, Rajiv C McCoy, Camden Jansen, Cheryl A Keller, Alexander Q Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, Elisabeth F Heuston, Stacie M Anderson, Jing Luan, Marit W Vermunt, Feng Yue, Michael E G Sauria, Michael C Schatz, James Taylor, Berthold Göttgens, Jim R Hughes, Douglas R Higgs, Mitchell J Weiss, Yong Cheng, Gerd A Blobel, David M Bodine, Yu Zhang, Qunhua Li, Shaun Mahony, Ross Cameron Hardison
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. Genome research 34 (7) (2024)
Ali Amid, Siyu Liu, Christian Babbs, Douglas R Higgs
Haemoglobin Bart's Hydrops Fetalis: Charting the Past and Envisioning the Future. Blood (2024)
Guanjue Xiang, Xi He, Belinda M Giardine, Kathryn J Isaac, Dylan J Taylor, Rajiv C McCoy, Camden Jansen, Cheryl A Keller, Alexander Q Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, Elisabeth F Heuston, Stacie M Anderson, Jing Luan, Marit W Vermunt, Feng Yue, Michael E G Sauria, Michael C Schatz, James Taylor, Berthold Göttgens, Jim R Hughes, Douglas R Higgs, Mitchell J Weiss, Yong Cheng, Gerd A Blobel, David M Bodine, Yu Zhang, Qunhua Li, Shaun Mahony, Ross Cameron Hardison
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. Genome research (2024)
Guanjue Xiang, Xi He, Belinda M Giardine, Kathryn J Isaac, Dylan J Taylor, Rajiv C McCoy, Camden Jansen, Cheryl A Keller, Alexander Q Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, Elisabeth F Heuston, Stacie M Anderson, Jing Luan, Marit W Vermunt, Feng Yue, Michael E G Sauria, Michael C Schatz, James Taylor, Berthold Göttgens, Jim R Hughes, Douglas R Higgs, Mitchell J Weiss, Yong Cheng, Gerd A Blobel, David M Bodine, Yu Zhang, Qunhua Li, Shaun Mahony, Ross Cameron Hardison
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. Genome research (2024)
Ali Amid, Siyu Liu, Christian Babbs, Douglas R Higgs
Hemoglobin Bart's hydrops fetalis: charting the past and envisioning the future. Blood 144 (8) (2024)
Guanjue Xiang, Xi He, Belinda M Giardine, Kathryn J Isaac, Dylan J Taylor, Rajiv C McCoy, Camden Jansen, Cheryl A Keller, Alexander Q Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, Elisabeth F Heuston, Stacie M Anderson, Jing Luan, Marit W Vermunt, Feng Yue, Michael E G Sauria, Michael C Schatz, James Taylor, Berthold Göttgens, Jim R Hughes, Douglas R Higgs, Mitchell J Weiss, Yong Cheng, Gerd A Blobel, David M Bodine, Yu Zhang, Qunhua Li, Shaun Mahony, Ross Cameron Hardison
Interspecies regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. Genome research (2024)
Mohsin Badat, Ayesha Ejaz, Peng Hua, Siobhan Rice, Weijiao Zhang, Lance D Hentges, Christopher A Fisher, Nicholas D R Denny, Ron Schwessinger, Nirmani Yasara, Noemi B A Roy, Fadi Issa, Anindita Roy, Paul Telfer, Jim R Hughes, Sachith Mettananda, Douglas R Higgs, James O J Davies
Direct correction of haemoglobin E β-thalassaemia using base editors. Nature communications 14 (1) (2023)
Mira Kassouf, Seren Ford, Joseph Blayney, Douglas R Higgs
Understanding fundamental principles of enhancer biology at a model locus: Analysing the structure and function of an enhancer cluster at the α-globin locus. BioEssays : news and reviews in molecular, cellular and developmental biology (2023)
Danya J Martell, Hope E Merens, Claudia Fiorini, Alexis Caulier, Jacob C Ulirsch, Robert Ietswaart, Karine Choquet, Giovanna Graziadei, Valentina Brancaleoni, Maria Domenica Cappellini, Caroline Scott, Nigel Roberts, Melanie Proven, Noémi Ba Roy, Christian Babbs, Douglas R Higgs, Vijay G Sankaran, L Stirling Churchman
RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation. medRxiv : the preprint server for health sciences (2023)
Guanjue Xiang, Xi He, Belinda M Giardine, Kathryn J Weaver, Dylan J Taylor, Rajiv C McCoy, Camden Jansen, Cheryl A Keller, Alexander Q Wixom, April Cockburn, Amber Miller, Qian Qi, Yanghua He, Yichao Li, Jens Lichtenberg, Elisabeth F Heuston, Stacie M Anderson, Jing Luan, Marit W Vermunt, Feng Yue, Michael E G Sauria, Michael C Schatz, James Taylor, Berthold Göttgens, Jim R Hughes, Douglas R Higgs, Mitchell J Weiss, Yong Cheng, Gerd A Blobel, David Bodine, Yu Zhang, Qunhua Li, Shaun Mahony, Ross Cameron Hardison
Cross-species regulatory landscapes and elements revealed by novel joint systematic integration of human and mouse blood cell epigenomes. bioRxiv : the preprint server for biology (2023)
Julia Truch, Damien J Downes, Caroline Scott, E Ravza Gür, Jelena M Telenius, Emmanouela Repapi, Ron Schwessinger, Matthew E Gosden, Jill M Brown, Stephen Taylor, Pak Leng Cheong, Jim R Hughes, Douglas R Higgs, Richard J Gibbons
The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin. Nature communications 13 (1) (2022)
D M Jeziorska, E A J Tunnacliffe, Jill M Brown, H Ayyub, J Sloane-Stanley, J A Sharpe, B Christoffer Lagerholm, Christian Babbs, A J H Smith, Veronica J Buckle, Douglas R Higgs
On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation. Nature communications 13 (1) (2022)
Andrew J King, Duantida Songdej, Damien J Downes, Robert A Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C Suciu, A Marieke Oudelaar, Lars L P Hanssen, Danuta Jeziorska, Nigel A Roberts, Stephanie J Carpenter, Helena S Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T Kassouf, Stuart H Orkin, Len A Pennacchio, James O J Davies, Jim R Hughes, Douglas R Higgs, Christian Babbs
Reactivation of a developmentally silenced embryonic globin gene. Nature communications 12 (1) (2021)
Peng Hua, Mohsin Badat, Lars L P Hanssen, Lance D Hentges, Nicholas T Crump, Damien J Downes, Danuta M Jeziorska, A Marieke Oudelaar, Ron Schwessinger, Stephen Taylor, Thomas A Milne, Jim R Hughes, Douglas R Higgs, James O J Davies
Defining genome architecture at base-pair resolution. Nature 595 (7865) (2021)
Yavor K Bozhilov, Damien J Downes, Jelena Telenius, A Marieke Oudelaar, Emmanuel N Olivier, Joanne C Mountford, Jim R Hughes, Richard J Gibbons, Douglas R Higgs
A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker. Nature communications 12 (1) (2021)
Gerd A Blobel, Douglas R Higgs, Jennifer A Mitchell, Dimple Notani, Richard A Young
Testing the super-enhancer concept. Nature reviews. Genetics 22 (12) (2021)
Guanjue Xiang, Cheryl A Keller, Elisabeth F Heuston, Belinda M Giardine, Lin An, Alexander Q Wixom, Amber Miller, April Cockburn, Michael E G Sauria, Kathryn Weaver, Jens Lichtenberg, Berthold Göttgens, Qunhua Li, David Bodine, Shaun Mahony, James Taylor, Gerd A Blobel, Mitchell J Weiss, Yong Cheng, Feng Yue, Jim R Hughes, Douglas R Higgs, Yu Zhang, Ross Cameron Hardison
An integrative view of the regulatory and transcriptional landscapes in mouse hematopoiesis. Genome research 30 (3) (2020)
A Marieke Oudelaar, Douglas R Higgs
The relationship between genome structure and function. Nature reviews. Genetics 22 (3) (2020)
Douglas R Higgs
Enhancer-promoter interactions and transcription. Nature genetics 52 (5) (2020)
A Marieke Oudelaar, Robert A Beagrie, Matthew E Gosden, Sara De Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf Helmy El-Sagheer, Jelena M Telenius, Tom Brown, Veronica J Buckle, Merav Socolovsky, Douglas R Higgs, Jim R Hughes
Dynamics of the 4D genome during in vivo lineage specification and differentiation. Nature communications 11 (1) (2020)
Joke G van Bemmel, Rafael Galupa, Chris Gard, Nicolas Servant, Christel Picard, James O J Davies, Anthony James Szempruch, Yinxiu Zhan, Jan Jakub Żylicz, Elphѐge P Nora, Sonia Lameiras, Elzo de Wit, David Gentien, Sylvain Baulande, Luca Giorgetti, Mitchell Guttman, Jim R Hughes, Douglas R Higgs, Joost Gribnau, Edith Heard
The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist. Nature genetics 51 (6) (2019)
A Marieke Oudelaar, Caroline L Harrold, Lars L P Hanssen, Jelena M Telenius, Douglas R Higgs, Jim R Hughes
A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus. Nature communications 10 (1) (2019)
Jill M Brown, Nigel A Roberts, Bryony Graham, Dominic Waithe, Christoffer Lagerholm, Jelena M Telenius, Sara De Ornellas, A Marieke Oudelaar, Caroline Scott, Izabela Szczerbal, Christian Babbs, Mira T Kassouf, Jim R Hughes, Douglas R Higgs, Veronica J Buckle
A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions. Nature communications 9 (1) (2018)
A Marieke Oudelaar, James O J Davies, Lars L P Hanssen, Jelena M Telenius, Ron Schwessinger, Yu Liu, Jill M Brown, Damien J Downes, Andrea M Chiariello, Simona Bianco, Mario Nicodemi, Veronica J Buckle, Job Dekker, Douglas R Higgs, Jim R Hughes
Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains. Nature genetics 50 (12) (2018)
Duantida Songdej, Christian Babbs, Douglas R Higgs, null null
An international registry of survivors with Hb Bart's hydrops fetalis syndrome. Blood 129 (10) (2017)
Lars L P Hanssen, Mira T Kassouf, A Marieke Oudelaar, Daniel Biggs, Chris Preece, Damien J Downes, Matthew Gosden, Jacqueline A Sharpe, Jacqueline A Sloane-Stanley, Jim R Hughes, Benjamin Davies, Douglas R Higgs
Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo. Nature cell biology 19 (8) (2017)
Ron Schwessinger, Maria C Suciu, Simon J McGowan, Jelena Telenius, Stephen Taylor, Douglas R Higgs, Jim R Hughes
Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints. Genome research 27 (10) (2017)
Sachith Mettananda, Chris A Fisher, Deborah Hay, Mohsin Badat, Lynn Quek, Kevin Clark, Philip Hublitz, Damien Downes, Jon Kerry, Matthew Gosden, Jelena Telenius, Jackie A Sloane-Stanley, Paula Faustino, Andreia Coelho, Jessica Doondeea, Batchimeg Usukhbayar, Paul Sopp, Jacqueline A Sharpe, Jim R Hughes, Paresh Vyas, Richard J Gibbons, Douglas R Higgs
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia. Nature communications 8 (1) (2017)
Andrew Charles Perkins, Xiangmin Xu, Douglas R Higgs, George P Patrinos, Lionel Arnaud, James J Bieker, Sjaak Philipsen, null null
Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants. Blood 127 (15) (2016)

Douglas R Higgs.css-eqlu8i{font-size:small;padding-left:4px;} (D R Higgs, Doug R Higgs, Doug Higgs)

Publication Activity (10 Years)

Top Topics

Top Venues

Douglas R Higgs (D R Higgs, Doug R Higgs, Doug Higgs)