Kelvin C Luk (Kelvin Luk)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 37

Top Venues

Research square

Science advances

NPJ Parkinson's disease

Journal of neuroinflammation

McGill University (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

McGill University

Canada

PHD

Publications

Joseph R Patterson, Joseph Kochmanski, Anna C Stoll, Michael Kubik, Christopher J Kemp, Megan F Duffy, Kajene Thompson, Jacob W Howe, Allyson Cole-Strauss, Nathan C Kuhn, Kathryn M Miller, Seth Nelson, Christopher U Onyekpe, John S Beck, Scott E Counts, Alison I Bernstein, Kathy Steece-Collier, Kelvin C Luk, Caryl E Sortwell
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils. NPJ Parkinson's disease 10 (1) (2024)
Saranya Santhosh Kumar, Nima N Naseri, Sarshan R Pather, Erinc Hallacli, Alain Ndayisaba, Chris Buenaventura, Karen Acosta, Jennifer Roof, Hossein Fazelinia, Lynn A Spruce, Kelvin C Luk, Vikram Khurana, Elizabeth Rhoades, Ophir Shalem
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Science advances 10 (6) (2024)
Saranya Santhosh Kumar, Nima N Naseri, Sarshan R Pather, Erinc Hallacli, Alain Ndayisaba, Chris Buenaventura, Karen Acosta, Jennifer Roof, Hossein Fazelinia, Lynn A Spruce, Kelvin C Luk, Vikram Khurana, Elizabeth Rhoades, Ophir Shalem
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Science advances 10 (6) (2024)
Saranya Santhosh Kumar, Nima N Naseri, Sarshan R Pather, Erinc Hallacli, Alain Ndayisaba, Chris Buenaventura, Karen Acosta, Jennifer Roof, Hossein Fazelinia, Lynn A Spruce, Kelvin C Luk, Vikram Khurana, Elizabeth Rhoades, Ophir Shalem
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Science advances 10 (6) (2024)
Saranya Santhosh Kumar, Nima N Naseri, Sarshan R Pather, Erinc Hallacli, Alain Ndayisaba, Chris Buenaventura, Karen Acosta, Jennifer Roof, Hossein Fazelinia, Lynn A Spruce, Kelvin C Luk, Vikram Khurana, Elizabeth Rhoades, Ophir Shalem
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Science advances 10 (6) (2024)
Joseph R Patterson, Joseph Kochmanski, Anna C Stoll, Michael Kubik, Christopher J Kemp, Megan F Duffy, Kajene Thompson, Jacob W Howe, Allyson Cole-Strauss, Nathan C Kuhn, Kathryn M Miller, Seth Nelson, Christopher U Onyekpe, John S Beck, Scott E Counts, Alison I Bernstein, Kathy Steece-Collier, Kelvin C Luk, Caryl E Sortwell
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils. NPJ Parkinson's disease 10 (1) (2024)
George T Kannarkat, Rebecca Zack, R Tyler Skrinak, James F Morley, Roseanne Davila-Rivera, Sanaz Arezoumandan, Katherine Dorfmann, Kelvin C Luk, David A Wolk, Daniel Weintraub, Thomas F Tropea, Edward B Lee, Sharon X Xie, Ganesh Chandrasekaran, Virginia M-Y Lee, David Irwin, Rizwan S Akhtar, Alice S Chen-Plotkin
α-Synuclein Conformations in Plasma Distinguish Parkinson's Disease from Dementia with Lewy Bodies. bioRxiv : the preprint server for biology (2024)
Saranya Santhosh Kumar, Nima N Naseri, Sarshan R Pather, Erinc Hallacli, Alain Ndayisaba, Chris Buenaventura, Karen Acosta, Jennifer Roof, Hossein Fazelinia, Lynn A Spruce, Kelvin C Luk, Vikram Khurana, Elizabeth Rhoades, Ophir Shalem
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Science advances 10 (6) (2024)
Saranya Santhosh Kumar, Nima N Naseri, Sarshan R Pather, Erinc Hallacli, Alain Ndayisaba, Chris Buenaventura, Karen Acosta, Jennifer Roof, Hossein Fazelinia, Lynn A Spruce, Kelvin C Luk, Vikram Khurana, Elizabeth Rhoades, Ophir Shalem
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Science advances 10 (6) (2024)
Jeffrey H Kordower, David Butler, Diptaman Chatterjee, Lianna D'Brant, Benjamin Hiller, David Marmion, Ivette Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer
Engineered Nanobodies With Programmable Target Antigen Proteolysis (Ptap) Fusions Regulate Intracellular Alpha-synuclein in Vitro and in Vivo. Research square (2024)
Diptaman Chatterjee, Lianna Y D'Brant, Benjamin M Hiller, David J Marmion, Ivette M Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer, Jeffrey H Kordower, David C Butler
ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO. Research square (2024)
Saranya Santhosh Kumar, Nima N Naseri, Sarshan R Pather, Erinc Hallacli, Alain Ndayisaba, Chris Buenaventura, Karen Acosta, Jennifer Roof, Hossein Fazelinia, Lynn A Spruce, Kelvin C Luk, Vikram Khurana, Elizabeth Rhoades, Ophir Shalem
Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons. Science advances 10 (6) (2024)
Joseph R Patterson, Joseph Kochmanski, Anna C Stoll, Michael Kubik, Christopher J Kemp, Megan F Duffy, Kajene Thompson, Jacob W Howe, Allyson Cole-Strauss, Nathan C Kuhn, Kathryn M Miller, Seth Nelson, Christopher U Onyekpe, John S Beck, Scott E Counts, Alison I Bernstein, Kathy Steece-Collier, Kelvin C Luk, Caryl E Sortwell
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils. NPJ Parkinson's disease 10 (1) (2024)
Jeffrey H Kordower, David Butler, Diptaman Chatterjee, Lianna D'Brant, Benjamin Hiller, David Marmion, Ivette Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer
Engineered Nanobodies With Programmable Target Antigen Proteolysis (Ptap) Fusions Regulate Intracellular Alpha-synuclein in Vitro and in Vivo. Research square (2024)
Diptaman Chatterjee, Lianna Y D'Brant, Benjamin M Hiller, David J Marmion, Ivette M Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer, Jeffrey H Kordower, David C Butler
ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO. Research square (2024)
Joseph R Patterson, Joseph Kochmanski, Anna C Stoll, Michael Kubik, Christopher J Kemp, Megan F Duffy, Kajene Thompson, Jacob W Howe, Allyson Cole-Strauss, Nathan C Kuhn, Kathryn M Miller, Seth Nelson, Christopher U Onyekpe, John S Beck, Scott E Counts, Alison I Bernstein, Kathy Steece-Collier, Kelvin C Luk, Caryl E Sortwell
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils. NPJ Parkinson's disease 10 (1) (2024)
Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Trojanowski, Virginia M Y Lee
Distinct biological activity of Lewy body α-Synuclein strain in mice. Research square (2023)
Sierra L Boyd, Nathan C Kuhn, Joseph R Patterson, Anna C Stoll, Sydney A Zimmerman, Mason R Kolanowski, Joseph J Neubecker, Kelvin C Luk, Eric S Ramsson, Caryl E Sortwell, Alison I Bernstein
Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice. Toxicological sciences : an official journal of the Society of Toxicology (2023)
Norihito Uemura, Nicholas P Marotta, Jahan Ara, Emily S Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Q Trojanowski, Virginia M Y Lee
α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice. Nature communications 14 (1) (2023)
Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Trojanowski, Virginia M Y Lee
Distinct biological activity of Lewy body α-Synuclein strain in mice. Research square (2023)
Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Trojanowski, Virginia M Y Lee
Distinct biological activity of Lewy body α-Synuclein strain in mice. Research square (2023)
Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Trojanowski, Virginia M Y Lee
Distinct biological activity of Lewy body α-Synuclein strain in mice. Research square (2023)
Thomas Steinkellner, William S Conrad, Imre Kovacs, Robert A Rissman, Edward B Lee, John Q Trojanowski, Zachary Freyberg, Subhojit Roy, Kelvin C Luk, Virginia M Lee, Thomas S Hnasko
Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain : a journal of neurology 145 (3) (2022)
Maria E Diaz-Ortiz, Yunji Seo, Marijan Posavi, Marc Carceles Cordon, Elisia Clark, Nimansha Jain, Rakshita Charan, Michael D Gallagher, Travis L Unger, Noor Amari, R Tyler Skrinak, Roseanne Davila-Rivera, Eliza M Brody, Noah Han, Rebecca Zack, Vivanna M Van Deerlin, Thomas Francis Tropea, Kelvin C Luk, Edward B Lee, Daniel Weintraub, Alice S Chen-Plotkin
GPNMB confers risk for Parkinson's disease through interaction with α-synuclein. Science (New York, N.Y.) 377 (6608) (2022)
Shady Rahayel, Bratislav Mišić, Ying-Qiu Zheng, Zhen-Qi Liu, Alaa Abdelgawad, Nooshin Abbasi, Anna Caputo, Bin Zhang, Angela Lo, Victoria Kehm, Michael Kozak, Han Soo Yoo, Alain Dagher, Kelvin C Luk
Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns. Brain : a journal of neurology 145 (5) (2022)
Jinhong Wie, Zhenjiang Liu, Haikun Song, Thomas F Tropea, Lu Yang, Huanhuan Wang, Yuling Liang, Chunlei Cang, Kimberly Aranda, Joey Lohmann, Jing Yang, Boxun Lu, Alice S Chen-Plotkin, Kelvin C Luk, Dejian Ren
A growth-factor-activated lysosomal K+ channel regulates Parkinson's pathology. Nature 591 (7850) (2021)
Anthony R Braun, Elly E Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D Evans, William C K Pomerantz, Elizabeth Rhoades, Kelvin C Luk, Razvan L Cornea, David D Thomas, Jonathan N Sachs
Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors. NPJ Parkinson's disease 7 (1) (2021)
Marc Emmenegger, Elena De Cecco, Marian Hruska-Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa-Vergniory, Andrès Gonzalez-Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin C Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies. EMBO molecular medicine 13 (9) (2021)
Kathryn M Miller, Joseph R Patterson, Joseph Kochmanski, Christopher J Kemp, Anna C Stoll, Christopher U Onyekpe, Allyson Cole-Strauss, Kathy Steece-Collier, Jacob W Howe, Kelvin C Luk, Caryl E Sortwell
Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS. The Journal of neuroscience : the official journal of the Society for Neuroscience 41 (9) (2021)
Anna Caputo, Yuling Liang, Tobias D Raabe, Angela Lo, Mian Horvath, Bin Zhang, Hannah J Brown, Anna Stieber, Kelvin C Luk
Snca-GFP Knock-In Mice Reflect Patterns of Endogenous Expression and Pathological Seeding. eNeuro 7 (4) (2020)
Nabil F Darwich, Jessica M Phan, Boram Kim, EunRan Suh, John D Papatriantafyllou, Lakshmi Changolkar, Aivi T Nguyen, Caroline M O'Rourke, Zhuohao He, Sílvia Porta, Garrett S Gibbons, Kelvin C Luk, Sokratis G Papageorgiou, Murray Grossman, Lauren Massimo, David John Irwin, Corey T McMillan, Ilya M Nasrallah, Camilo Toro, Geoffrey K Aguirre, Vivianna M Van Deerlin, Edward B Lee
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science (New York, N.Y.) 370 (6519) (2020)
Allison J Schaser, Valerie R Osterberg, Sydney E Dent, Teresa L Stackhouse, Colin M Wakeham, Sydney W Boutros, Leah J Weston, Nichole Owen, Tamily A Weissman, Esteban Luna, Jacob Raber, Kelvin C Luk, Amanda K McCullough, Randall L Woltjer, Vivek K Unni
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders. Scientific reports 9 (1) (2019)
Megan F Duffy, Timothy J Collier, Joseph R Patterson, Christopher J Kemp, Kelvin C Luk, Malú G Tansey, Katrina L Paumier, Nicholas M Kanaan, David Luke Fischer, Nicole K Polinski, Olivia L Barth, Jacob W Howe, Nishant N Vaikath, Nour K Majbour, Omar M A El-Agnaf, Caryl E Sortwell
Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of neuroinflammation 15 (1) (2018)
Rizwan S Akhtar, Joseph P Licata, Kelvin C Luk, Leslie M Shaw, John Q Trojanowski, Virginia M Y Lee
Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease. Journal of neurochemistry 145 (6) (2018)
Megan F Duffy, Timothy J Collier, Joseph R Patterson, Christopher J Kemp, Kelvin C Luk, Malú G Tansey, Katrina L Paumier, Nicholas M Kanaan, David Luke Fischer, Nicole K Polinski, Olivia L Barth, Jacob W Howe, Nishant N Vaikath, Nour K Majbour, Omar M A El-Agnaf, Caryl E Sortwell
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration. Journal of neuroinflammation 15 (1) (2018)
Walther Haenseler, Federico Zambon, Heyne Lee, Jane Vowles, Federica Rinaldi, Galbha Duggal, Henry Houlden, Katrina Gwinn, Selina Wray, Kelvin C Luk, Richard Wade-Martins, William S James, Sally A Cowley
Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages. Scientific reports 7 (1) (2017)
Nolwen L Rey, Jennifer A Steiner, Nazia Maroof, Kelvin C Luk, Zachary B Madaj, John Q Trojanowski, Virginia M-Y Lee, Patrik Brundin
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease. The Journal of experimental medicine 213 (9) (2016)

Kelvin C Luk.css-eqlu8i{font-size:small;padding-left:4px;} (Kelvin Luk)

Publication Activity (10 Years)

Top Topics

Top Venues

Kelvin C Luk (Kelvin Luk)