Xin-Heng He (Xinheng He)

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 56

Top Topics

Molecular Dynamics Simulations

Structural Basis

Top Venues

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Jia Duan, Xin-Heng He, Shu-Jie Li, H Eric Xu
Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism. Nature reviews. Endocrinology (2024)
Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xin-Heng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H Eric Xu
Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell research 34 (7) (2024)
Jia Duan, Xin-Heng He, Shu-Jie Li, H Eric Xu
Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism. Nature reviews. Endocrinology 20 (6) (2024)
Xin-Heng He, Lifen Zhao, Yinping Tian, Rui Li, Qinyu Chu, Zhiyong Gu, Mingyue Zheng, Yusong Wang, Shaoning Li, Hualiang Jiang, Yi Jiang, Liuqing Wen, Dingyan Wang, Xi Cheng
Highly accurate carbohydrate-binding site prediction with DeepGlycanSite. Nature communications 15 (1) (2024)
Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xin-Heng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H Eric Xu
Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell research 34 (7) (2024)
Changyao Li, Heng Liu, Jingru Li, Xin-Heng He, Haoran Zhu, Wei Fu, H Eric Xu
Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1. Cell research 34 (8) (2024)
Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xin-Heng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H Eric Xu
Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell research 34 (7) (2024)
Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xin-Heng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H Eric Xu
Author Correction: Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell research (2024)
Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xin-Heng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H Eric Xu
Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell research 34 (7) (2024)
Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xin-Heng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H Eric Xu
Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell research 34 (7) (2024)
Sanshan Jin, Shimeng Guo, Youwei Xu, Xin Li, Canrong Wu, Xin-Heng He, Benxun Pan, Wenwen Xin, Heng Zhang, Wen Hu, Yuling Yin, Tianwei Zhang, Kai Wu, Qingning Yuan, H Eric Xu, Xin Xie, Yi Jiang
Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor. Cell discovery 10 (1) (2024)
Changyao Li, Heng Liu, Jingru Li, Xin-Heng He, Haoran Zhu, Wei Fu, H Eric Xu
Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1. Cell research 34 (8) (2024)
Jia Duan, Xin-Heng He, Shu-Jie Li, H Eric Xu
Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism. Nature reviews. Endocrinology 20 (6) (2024)
Changyao Li, Heng Liu, Jingru Li, Xin-Heng He, Haoran Zhu, Wei Fu, H Eric Xu
Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1. Cell research 34 (8) (2024)
Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xin-Heng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H Eric Xu
Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell research (2024)
Heng Liu, Shimeng Guo, Antao Dai, Peiyu Xu, Xin Li, Sijie Huang, Xin-Heng He, Kai Wu, Xinyue Zhang, Dehua Yang, Xin Xie, H Eric Xu
Structural and functional evidence that GPR30 is not a direct estrogen receptor. Cell research 34 (7) (2024)
Sanshan Jin, Shimeng Guo, Youwei Xu, Xin Li, Canrong Wu, Xin-Heng He, Benxun Pan, Wenwen Xin, Heng Zhang, Wen Hu, Yuling Yin, Tianwei Zhang, Kai Wu, Qingning Yuan, H Eric Xu, Xin Xie, Yi Jiang
Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor. Cell discovery 10 (1) (2024)
Xin-Heng He, Lifen Zhao, Yinping Tian, Rui Li, Qinyu Chu, Zhiyong Gu, Mingyue Zheng, Yusong Wang, Shaoning Li, Hualiang Jiang, Yi Jiang, Liuqing Wen, Dingyan Wang, Xi Cheng
Highly accurate carbohydrate-binding site prediction with DeepGlycanSite. Nature communications 15 (1) (2024)
Jia Duan, Xin-Heng He, Shu-Jie Li, H Eric Xu
Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism. Nature reviews. Endocrinology 20 (6) (2024)
Sanshan Jin, Shimeng Guo, Youwei Xu, Xin Li, Canrong Wu, Xin-Heng He, Benxun Pan, Wenwen Xin, Heng Zhang, Wen Hu, Yuling Yin, Tianwei Zhang, Kai Wu, Qingning Yuan, H Eric Xu, Xin Xie, Yi Jiang
Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor. Cell discovery 10 (1) (2024)
Changyao Li, Heng Liu, Jingru Li, Xin-Heng He, Haoran Zhu, Wei Fu, H Eric Xu
Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1. Cell research (2024)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Zun Wang, Hongfei Wu, Lixin Sun, Xin-Heng He, Zhirong Liu, Bin Shao, Tong Wang, Tie-Yan Liu
Improving machine learning force fields for molecular dynamics simulations with fine-grained force metrics. The Journal of chemical physics 159 (3) (2023)
Heng Liu, Qing Zhang, Xin-Heng He, Mengting Jiang, Siwei Wang, Xiaoci Yan, Xi Cheng, Yang Liu, Fa-Jun Nan, H Eric Xu, Xin Xie, Wanchao Yin
Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nature communications 14 (1) (2023)
Yujie Ji, Jia Duan, Qingning Yuan, Xin-Heng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Structural basis of peptide recognition and activation of endothelin receptors. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Peiyu Xu, Sijie Huang, Brian E Krumm, Youwen Zhuang, Chunyou Mao, Yumu Zhang, Yue Wang, Xi-Ping Huang, Yong-Feng Liu, Xin-Heng He, Huadong Li, Wanchao Yin, Yi Jiang, Yan Zhang, Bryan L Roth, H Eric Xu
Structural genomics of the human dopamine receptor system. Cell research (2023)
Yujie Ji, Jia Duan, Qingning Yuan, Xin-Heng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Structural basis of peptide recognition and activation of endothelin receptors. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Heng Liu, Qing Zhang, Xin-Heng He, Mengting Jiang, Siwei Wang, Xiaoci Yan, Xi Cheng, Yang Liu, Fa-Jun Nan, H Eric Xu, Xin Xie, Wanchao Yin
Author Correction: Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nature communications 14 (1) (2023)
Yujie Ji, Jia Duan, Qingning Yuan, Xin-Heng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Structural basis of peptide recognition and activation of endothelin receptors. Nature communications 14 (1) (2023)
Jia Duan, Heng Liu, Fenghui Zhao, Qingning Yuan, Yujie Ji, Xiaoqing Cai, Xin-Heng He, Xinzhu Li, Junrui Li, Kai Wu, Tianyu Gao, Shengnan Zhu, Shi Lin, Ming-Wei Wang, Xi Cheng, Wanchao Yin, Yi Jiang, Dehua Yang, H Eric Xu
GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature (2023)
Yue Wang, Weiyi Liu, Youwei Xu, Xin-Heng He, Qingning Yuan, Ping Luo, Wenjia Fan, Jingpeng Zhu, Xinyue Zhang, Xi Cheng, Yi Jiang, H Eric Xu, Youwen Zhuang
Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nature chemical biology (2023)
Heng Liu, You Zheng, Yue Wang, Yumeng Wang, Xin-Heng He, Peiyu Xu, Sijie Huang, Qingning Yuan, Xinyue Zhang, Ling Wang, Kexin Jiang, Hong Chen, Zhen Li, Wenbin Liu, Sheng Wang, H Eric Xu, Tingting Wu
Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature (2023)
Hongmin Cai, Youwei Xu, Shimeng Guo, Xin-Heng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H Eric Xu, Xin Xie, Yi Jiang
Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell discovery 8 (1) (2022)
Na Wang, Xin-Heng He, Jing Zhao, Hualiang Jiang, Xi Cheng, Yu Xia, H Eric Xu, Yuanzheng He
Structural basis of leukotriene B4 receptor 1 activation. Nature communications 13 (1) (2022)
Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xin-Heng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell discovery 8 (1) (2022)
Youwei Xu, Hongmin Cai, Chongzhao You, Xin-Heng He, Qingning Yuan, Hualiang Jiang, Xi Cheng, Yi Jiang, H Eric Xu
Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor. Cell research 32 (9) (2022)
Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xin-Heng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell discovery 8 (1) (2022)
Peiyu Xu, Sijie Huang, Shimeng Guo, Ying Yun, Xi Cheng, Xin-Heng He, Pengjun Cai, Yuan Lan, Hu Zhou, Hualiang Jiang, Yi Jiang, Xin Xie, H Eric Xu
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nature structural & molecular biology 29 (9) (2022)
Jia Duan, Dan-Dan Shen, Tingting Zhao, Shimeng Guo, Xin-Heng He, Wanchao Yin, Peiyu Xu, Yujie Ji, Li-Nan Chen, Jinyu Liu, Huibing Zhang, Qiufeng Liu, Yi Shi, Xi Cheng, Hualiang Jiang, H Eric Xu, Yan Zhang, Xin Xie, Yi Jiang
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. Nature communications 13 (1) (2022)
Wanchao Yin, Youwei Xu, Peiyu Xu, Xiaodan Cao, Canrong Wu, Chunyin Gu, Xin-Heng He, Xiaoxi Wang, Sijie Huang, Qingning Yuan, Kai Wu, Wen Hu, Zifu Huang, Jia Liu, Zongda Wang, Fangfang Jia, Kaiwen Xia, Peipei Liu, Xueping Wang, Bin Song, Jie Zheng, Hualiang Jiang, Xi Cheng, Yi Jiang, Su-Jun Deng, H Eric Xu
Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody. Science (New York, N.Y.) 375 (6584) (2022)
Shuyuan Zhang, Qingtai Liang, Xin-Heng He, Chongchong Zhao, Wenlin Ren, Ziqing Yang, Ziyi Wang, Qiang Ding, Haiteng Deng, Tong Wang, Linqi Zhang, Xinquan Wang
Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2. Cell research 32 (3) (2022)
Hongmin Cai, Youwei Xu, Shimeng Guo, Xin-Heng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H Eric Xu, Xin Xie, Yi Jiang
Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell discovery 8 (1) (2022)
Jia Duan, Peiyu Xu, Xiaodong Luan, Yujie Ji, Xin-Heng He, Ning Song, Qingning Yuan, Ye Jin, Xi Cheng, Hualiang Jiang, Jie Zheng, Shu-Yang Zhang, Yi Jiang, H Eric Xu
Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature 609 (7928) (2022)
Hongmin Cai, Youwei Xu, Shimeng Guo, Xin-Heng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H Eric Xu, Xin Xie, Yi Jiang
Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell discovery 8 (1) (2022)
Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xin-Heng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell discovery 8 (1) (2022)
Jun Lan, Xin-Heng He, Yifei Ren, Ziyi Wang, Huan Zhou, Shilong Fan, Chenyou Zhu, Dongsheng Liu, Bin Shao, Tie-Yan Liu, Qisheng Wang, Linqi Zhang, Jiwan Ge, Tong Wang, Xinquan Wang
Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction. Cell research 32 (6) (2022)
Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu, Xin-Heng He, Jia Guo, Wanchao Yin, H Eric Xu, Xin Xie, Yi Jiang
Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor. Nature communications 12 (1) (2021)
Jia Duan, Peiyu Xu, Xi Cheng, Chunyou Mao, Tristan Croll, Xin-Heng He, Jingjing Shi, Xiaodong Luan, Wanchao Yin, Erli You, Qiufeng Liu, Shu-Yang Zhang, Hualiang Jiang, Yan Zhang, Yi Jiang, H Eric Xu
Structures of full-length glycoprotein hormone receptor signalling complexes. Nature 598 (7882) (2021)
Shaoyong Lu, Xin-Heng He, Zhao Yang, Zongtao Chai, Shuhua Zhou, Junyan Wang, Ashfaq Ur Rehman, Duan Ni, Jun Pu, Jin-Peng Sun, Jian Zhang
Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design. Nature communications 12 (1) (2021)
Qiufeng Liu, Dehua Yang, Youwen Zhuang, Tristan I Croll, Xiaoqing Cai, Antao Dai, Xin-Heng He, Jia Duan, Wanchao Yin, Chenyu Ye, Fulai Zhou, Beili Wu, Qiang Zhao, H Eric Xu, Ming-Wei Wang, Yi Jiang
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor. Nature chemical biology 17 (12) (2021)
Duan Ni, Jiacheng Wei, Xin-Heng He, Ashfaq Ur Rehman, Xinyi Li, Yuran Qiu, Jun Pu, Shaoyong Lu, Jian Zhang
Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy. Chemical science 12 (1) (2020)
Jia Duan, Dan-Dan Shen, X Edward Zhou, Peng Bi, Qiu-Feng Liu, Yang-Xia Tan, You-Wen Zhuang, Hui-Bing Zhang, Pei-Yu Xu, Si-Jie Huang, Shan-Shan Ma, Xin-Heng He, Karsten Melcher, Yan Zhang, H Eric Xu, Yi Jiang
Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nature communications 11 (1) (2020)