Yan Zhang

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 44

Top Venues

Nature communications

Cell research

Nature

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhejiang University

Shanghai Institute of Organic Chemistry (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Zhejiang University

China

Principle Investigator :: School of Medicine

Stanford University

United States

Postdoctoral Research Fellow :: Department of Molecular and Cellular Physiology

University of Michigan

United States

Postdoctoral Research Fellow :: Life Sciences Institute

Shanghai Institute of Organic Chemistry

China

Research Fellow

Education History

Shanghai Institute of Organic Chemistry

China

PHD

Publications

Qingya Shen, Xinyan Tang, Xin Wen, Shizhuo Cheng, Peng Xiao, Shao-Kun Zang, Dan-Dan Shen, Lei Jiang, Yanrong Zheng, Huibing Zhang, Haomang Xu, Chunyou Mao, Min Zhang, Weiwei Hu, Jin-Peng Sun, Yan Zhang, Zhong Chen
Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (23) (2024)
Qingya Shen, Xinyan Tang, Xin Wen, Shizhuo Cheng, Peng Xiao, Shao-Kun Zang, Dan-Dan Shen, Lei Jiang, Yanrong Zheng, Huibing Zhang, Haomang Xu, Chunyou Mao, Min Zhang, Weiwei Hu, Jin-Peng Sun, Yan Zhang, Zhong Chen
Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (23) (2024)
Qingya Shen, Xinyan Tang, Xin Wen, Shizhuo Cheng, Peng Xiao, Shao-Kun Zang, Dan-Dan Shen, Lei Jiang, Yanrong Zheng, Huibing Zhang, Haomang Xu, Chunyou Mao, Min Zhang, Weiwei Hu, Jin-Peng Sun, Yan Zhang, Zhong Chen
Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (23) (2024)
Jia Guo, Yun-Li Zhou, Yixin Yang, Shimeng Guo, Erli You, Xin Xie, Yi Jiang, Chunyou Mao, H Eric Xu, Yan Zhang
Structural basis of tethered agonism and G protein coupling of protease-activated receptors. Cell research (2024)
Qingya Shen, Xinyan Tang, Xin Wen, Shizhuo Cheng, Peng Xiao, Shao-Kun Zang, Dan-Dan Shen, Lei Jiang, Yanrong Zheng, Huibing Zhang, Haomang Xu, Chunyou Mao, Min Zhang, Weiwei Hu, Jin-Peng Sun, Yan Zhang, Zhong Chen
Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Peiyu Xu, Sijie Huang, Brian E Krumm, Youwen Zhuang, Chunyou Mao, Yumu Zhang, Yue Wang, Xi-Ping Huang, Yong-Feng Liu, Xin-Heng He, Huadong Li, Wanchao Yin, Yi Jiang, Yan Zhang, Bryan L Roth, H Eric Xu
Structural genomics of the human dopamine receptor system. Cell research (2023)
Shuangshuang Ma, Min Chen, Yihao Jiang, Xinkuan Xiang, Shiqi Wang, Zuohang Wu, Shuo Li, Yihui Cui, Junying Wang, Yanqing Zhu, Yan Zhang, Huan Ma, Shu-Min Duan, Haohong Li, Yan Yang, Christopher J Lingle, Hai-Lan Hu
Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb. Nature (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Chunyou Mao, Peng Xiao, Xiao-Na Tao, Jiao Qin, Qing-Tao He, Chao Zhang, Sheng-Chao Guo, Ya-Qin Du, Li-Nan Chen, Dan-Dan Shen, Zhi-Shuai Yang, Han-Qiong Zhang, Shen-Ming Huang, Yong-Hao He, Jie Cheng, Ya-Ni Zhong, Pan Shang, Jun Chen, Dao-Lai Zhang, Qian-Lang Wang, Mei-Xia Liu, Guo-Yu Li, Yongyuan Guo, H Eric Xu, Chuanxin Wang, Cheng Zhang, Shiqing Feng, Xiao Yu, Yan Zhang, Jin-Peng Sun
Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science (New York, N.Y.) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Shuangshuang Ma, Min Chen, Yihao Jiang, Xinkuan Xiang, Shiqi Wang, Zuohang Wu, Shuo Li, Yihui Cui, Junying Wang, Yanqing Zhu, Yan Zhang, Huan Ma, Shu-Min Duan, Haohong Li, Yan Yang, Christopher J Lingle, Hai-Lan Hu
Author Correction: Sustained antidepressant effect of ketamine through NMDAR trapping in the LHb. Nature (2023)
Chunyou Mao, Mengru Gao, Shao-Kun Zang, Yanqing Zhu, Dan-Dan Shen, Li-Nan Chen, Liu Yang, Zhiwei Wang, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Yanhui Lu, Xin Ma, Yan Zhang
Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nature communications 14 (1) (2023)
Xiuwen Zhai, Chunyou Mao, Qingya Shen, Shaokun Zang, Dan-Dan Shen, Huibing Zhang, Zhaohong Chen, Gang Wang, Changming Zhang, Yan Zhang, Zhi-Hong Liu
Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation. Nature communications 13 (1) (2022)
Fenghui Zhao, Qingtong Zhou, Zhaotong Cong, Kaini Hang, Xinyu Zou, Chao Zhang, Yan Chen, Antao Dai, Anyi Liang, Qianqian Ming, Mu Wang, Li-Nan Chen, Peiyu Xu, Rulve Chang, Wenbo Feng, Tian Xia, Yan Zhang, Beili Wu, Dehua Yang, Li-Hua Zhao, H Eric Xu, Ming-Wei Wang
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nature communications 13 (1) (2022)
Zhehua Shao, Yangxia Tan, Qingya Shen, Li Hou, Bingpeng Yao, Jiao Qin, Peiyu Xu, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhi-Hua Chen, Yi Jiang, H Eric Xu, Songmin Ying, Honglei Ma, Yan Zhang, Huahao Shen
Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell discovery 8 (1) (2022)
Li-Hua Zhao, Jing-Yu Lin, Su-Yu Ji, X Edward Zhou, Chunyou Mao, Dan-Dan Shen, Xinheng He, Peng Xiao, Jin-Peng Sun, Karsten Melcher, Yan Zhang, Xiao Yu, H Eric Xu
Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor. Nature communications 13 (1) (2022)
Jia Duan, Dan-Dan Shen, Tingting Zhao, Shimeng Guo, Xin-Heng He, Wanchao Yin, Peiyu Xu, Yujie Ji, Li-Nan Chen, Jinyu Liu, Huibing Zhang, Qiufeng Liu, Yi Shi, Xi Cheng, Hualiang Jiang, H Eric Xu, Yan Zhang, Xin Xie, Yi Jiang
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. Nature communications 13 (1) (2022)
Li-Nan Chen, Wei-Wei Wang, Ying-Jun Dong, Dan-Dan Shen, Jia Guo, Xuefei Yu, Jiao Qin, Su-Yu Ji, Huibing Zhang, Qingya Shen, Qiaojun He, Bo Yang, Yan Zhang, Qinglin Li, Chunyou Mao
Structures of the endogenous peptide- and selective non-peptide agonist-bound SSTR2 signaling complexes. Cell research 32 (8) (2022)
Yu Ding, Huibing Zhang, Yu-Ying Liao, Li-Nan Chen, Su-Yu Ji, Jiao Qin, Chunyou Mao, Dan-Dan Shen, Lin Lin, Hao Wang, Yan Zhang, Xiao-Ming Li
Structural insights into human brain-gut peptide cholecystokinin receptors. Cell discovery 8 (1) (2022)
Su-Yu Ji, Ying-Jun Dong, Li-Nan Chen, Shao-Kun Zang, Jiawei Wang, Dan-Dan Shen, Jia Guo, Jiao Qin, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Yan Zhang, Zhangfa Song, Chunyou Mao
Molecular basis for the activation of thyrotropin-releasing hormone receptor. Cell discovery 8 (1) (2022)
Lijuan Ma, Fan Yang, Xiang Wu, Chunyou Mao, Lulu Guo, Tianshu Miao, Shao-Kun Zang, Xiaoyu Jiang, Dan-Dan Shen, Tianhui Wei, Hengxing Zhou, Qin Wei, Shiyang Li, Qiang Shu, Shiqing Feng, Changtao Jiang, Bo Chu, Lutao Du, Jin-Peng Sun, Xiao Yu, Yan Zhang, Pengju Zhang
Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proceedings of the National Academy of Sciences of the United States of America 119 (29) (2022)
Jiao Qin, Ye Cai, Zheng Xu, Qianqian Ming, Su-Yu Ji, Chao Wu, Huibing Zhang, Chunyou Mao, Dan-Dan Shen, Kunio Hirata, Yanbin Ma, Wei Yan, Yan Zhang, Zhenhua Shao
Molecular mechanism of agonism and inverse agonism in ghrelin receptor. Nature communications 13 (1) (2022)
Zhaotong Cong, Qingtong Zhou, Yang Li, Li-Nan Chen, Zi-Chen Zhang, Anyi Liang, Qing Liu, Xiaoyan Wu, Antao Dai, Tian Xia, Wei Wu, Yan Zhang, Dehua Yang, Ming-Wei Wang
Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24. Proceedings of the National Academy of Sciences of the United States of America 119 (20) (2022)
Huibing Zhang, Li-Nan Chen, Dehua Yang, Chunyou Mao, Qingya Shen, Wenbo Feng, Dan-Dan Shen, Antao Dai, Shanshan Xie, Yan Zhou, Jiao Qin, Jin-Peng Sun, Daniel H Scharf, Tingjun Hou, Tianhua Zhou, Ming-Wei Wang, Yan Zhang
Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell research 31 (11) (2021)
Cangsong Shen, Chunyou Mao, Chanjuan Xu, Nan Jin, Huibing Zhang, Dan-Dan Shen, Qingya Shen, Xiaomei Wang, Tingjun Hou, Zhong Chen, Philippe Rondard, Jean-Philippe Pin, Yan Zhang, Jianfeng Liu
Structural basis of GABAB receptor-Gi protein coupling. Nature 594 (7864) (2021)
Jia Duan, Peiyu Xu, Xi Cheng, Chunyou Mao, Tristan Croll, Xin-Heng He, Jingjing Shi, Xiaodong Luan, Wanchao Yin, Erli You, Qiufeng Liu, Shu-Yang Zhang, Hualiang Jiang, Yan Zhang, Yi Jiang, H Eric Xu
Structures of full-length glycoprotein hormone receptor signalling complexes. Nature 598 (7882) (2021)
Chang-Xiu Qu, Chunyou Mao, Peng Xiao, Qingya Shen, Ya-Ni Zhong, Fan Yang, Dan-Dan Shen, Xiaona Tao, Huibing Zhang, Xu Yan, Ru-Jia Zhao, Junyan He, Ying Guan, Chao Zhang, Guihua Hou, Peng-Ju Zhang, Gui-Ge Hou, Zijian Li, Xiao Yu, Ren-Jie Chai, You-Fei Guan, Jin-Peng Sun, Yan Zhang
Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype. Science advances 7 (14) (2021)
Yu-Qi Ping, Chunyou Mao, Peng Xiao, Ru-Jia Zhao, Yi Jiang, Zhao Yang, Wen-Tao An, Dan-Dan Shen, Fan Yang, Huibing Zhang, Changxiu Qu, Qingya Shen, Caiping Tian, Zi-Jian Li, Shaolong Li, Guang-Yu Wang, Xiaona Tao, Xin Wen, Ya-Ni Zhong, Jing Yang, Fan Yi, Xiao Yu, H Eric Xu, Yan Zhang, Jin-Peng Sun
Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex. Nature 589 (7843) (2021)
Youwen Zhuang, Brian E Krumm, Huibing Zhang, X Edward Zhou, Yue Wang, Xi-Ping Huang, Yongfeng Liu, Xi Cheng, Yi Jiang, Hualiang Jiang, Cheng Zhang, Wei Yi, Bryan L Roth, Yan Zhang, H Eric Xu
Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell research 31 (5) (2021)
Liang Shi, Boqiang Liu, Dan-Dan Shen, Peijian Yan, Yanan Zhang, Yuanshi Tian, Lidan Hou, Guangyi Jiang, Yinxin Zhu, Yuelong Liang, Xiao Liang, Bo Shen, Hong Yu, Yan Zhang, Yifan Wang, Xing Guo, Xiujun Cai
A tumor-suppressive circular RNA mediates uncanonical integrin degradation by the proteasome in liver cancer. Science advances 7 (13) (2021)
Zhaotong Cong, Li-Nan Chen, Honglei Ma, Qingtong Zhou, Xinyu Zou, Chenyu Ye, Antao Dai, Qing Liu, Wei Huang, Xianqiang Sun, Xi Wang, Peiyu Xu, Lihua Zhao, Tian Xia, Wenge Zhong, Dehua Yang, H Eric Xu, Yan Zhang, Ming-Wei Wang
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nature communications 12 (1) (2021)
Zhehua Shao, Qingya Shen, Bingpeng Yao, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Honglei Ma, Zhi-Hua Chen, H Eric Xu, Songmin Ying, Yan Zhang, Huahao Shen
Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1. Nature chemical biology 18 (3) (2021)
Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X Edward Zhou, Xi Cheng, Icaro A Simon, Dan-Dan Shen, Hsin-Yung Yen, Carol V Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H Eric Xu
Structural insights into the lipid and ligand regulation of serotonin receptors. Nature 592 (7854) (2021)
Wen Sun, Li-Nan Chen, Qingtong Zhou, Li-Hua Zhao, Dehua Yang, Huibing Zhang, Zhaotong Cong, Dan-Dan Shen, Fenghui Zhao, Fulai Zhou, Xiaoqing Cai, Yan Chen, Yan Zhou, Sarina Gadgaard, Wijnand J C van der Velden, Suwen Zhao, Yi Jiang, Mette M Rosenkilde, H Eric Xu, Yan Zhang, Ming-Wei Wang
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell research 30 (12) (2020)
Chunyou Mao, Cangsong Shen, Chuntao Li, Dan-Dan Shen, Chanjuan Xu, Shenglan Zhang, Rui Zhou, Qingya Shen, Li-Nan Chen, Zhinong Jiang, Jianfeng Liu, Yan Zhang
Cryo-EM structures of inactive and active GABAB receptor. Cell research 30 (7) (2020)
Fulai Zhou, Huibing Zhang, Zhaotong Cong, Li-Hua Zhao, Qingtong Zhou, Chunyou Mao, Xi Cheng, Dan-Dan Shen, Xiaoqing Cai, Cheng Ma, Yuzhe Wang, Antao Dai, Yan Zhou, Wen Sun, Fenghui Zhao, Suwen Zhao, Hualiang Jiang, Yi Jiang, Dehua Yang, H Eric Xu, Yan Zhang, Ming-Wei Wang
Structural basis for activation of the growth hormone-releasing hormone receptor. Nature communications 11 (1) (2020)
Wanchao Yin, Chunyou Mao, Xiaodong Luan, Dan-Dan Shen, Qingya Shen, Haixia Su, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao, Shenghai Chang, Yuan-Chao Xie, Guanghui Tian, He-Wei Jiang, Sheng-Ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science (New York, N.Y.) 368 (6498) (2020)
Fan Yang, Chunyou Mao, Lulu Guo, Jingyu Lin, Qianqian Ming, Peng Xiao, Xiang Wu, Qingya Shen, Shimeng Guo, Dan-Dan Shen, Ruirui Lu, Linqi Zhang, Shenming Huang, Yuqi Ping, Chenlu Zhang, Cheng Ma, Kai Zhang, Xiaoying Liang, Yuemao Shen, Fajun Nan, Fan Yi, Vincent C Luca, Jiuyao Zhou, Chang-Tao Jiang, Jin-Peng Sun, Xin Xie, Xiao Yu, Yan Zhang
Structural basis of GPBAR activation and bile acid recognition. Nature 587 (7834) (2020)
Jia Duan, Dan-Dan Shen, X Edward Zhou, Peng Bi, Qiu-Feng Liu, Yang-Xia Tan, You-Wen Zhuang, Hui-Bing Zhang, Pei-Yu Xu, Si-Jie Huang, Shan-Shan Ma, Xin-Heng He, Karsten Melcher, Yan Zhang, H Eric Xu, Yi Jiang
Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nature communications 11 (1) (2020)
Wanchao Yin, Zhihai Li, Mingliang Jin, Yu-Ling Yin, Parker W de Waal, Kuntal Pal, Yanting Yin, Xiang Gao, Yuanzheng He, Jing Gao, Xiaoxi Wang, Yan Zhang, Hu Zhou, Karsten Melcher, Yi Jiang, Yao Cong, X Edward Zhou, Xuekui Yu, H Eric Xu
A complex structure of arrestin-2 bound to a G protein-coupled receptor. Cell research 29 (12) (2019)
Li-Hua Zhao, Shanshan Ma, Ieva Sutkeviciute, Dan-Dan Shen, X Edward Zhou, Parker W de Waal, Chen-Yao Li, Yanyong Kang, Lisa J Clark, Frédéric G Jean-Alphonse, Alex D White, Dehua Yang, Antao Dai, Xiaoqing Cai, Jian Chen, Cong Li, Yi Jiang, Tomoyuki Watanabe, Thomas J Gardella, Karsten Melcher, Ming-Wei Wang, Jean-Pierre Vilardaga, H Eric Xu, Yan Zhang
Structure and dynamics of the active human parathyroid hormone receptor-1. Science (New York, N.Y.) 364 (6436) (2019)

Yan Zhang.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Yan Zhang