Hualiang Jiang

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 38

Top Topics

Structural Basis

Respiratory Syncytial Virus

Top Venues

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Xin-Heng He, Lifen Zhao, Yinping Tian, Rui Li, Qinyu Chu, Zhiyong Gu, Mingyue Zheng, Yusong Wang, Shaoning Li, Hualiang Jiang, Yi Jiang, Liuqing Wen, Dingyan Wang, Xi Cheng
Highly accurate carbohydrate-binding site prediction with DeepGlycanSite. Nature communications 15 (1) (2024)
Xin-Heng He, Lifen Zhao, Yinping Tian, Rui Li, Qinyu Chu, Zhiyong Gu, Mingyue Zheng, Yusong Wang, Shaoning Li, Hualiang Jiang, Yi Jiang, Liuqing Wen, Dingyan Wang, Xi Cheng
Highly accurate carbohydrate-binding site prediction with DeepGlycanSite. Nature communications 15 (1) (2024)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Yujie Ji, Jia Duan, Qingning Yuan, Xin-Heng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Structural basis of peptide recognition and activation of endothelin receptors. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Xiangrui Jiang, Haixia Su, Weijuan Shang, Feng Zhou, Yan Zhang, Wenfeng Zhao, Qiumeng Zhang, Hang Xie, Lei Jiang, Tianqing Nie, Feipu Yang, Muya Xiong, Xiaoxing Huang, Minjun Li, Ping Chen, Shaoping Peng, Geng-Fu Xiao, Hualiang Jiang, Renhong Tang, Lei-Ke Zhang, Jingshan Shen, Yechun Xu
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Lifan Chen, Zisheng Fan, Jie Chang, Ruirui Yang, Hui Hou, Hao Guo, Yinghui Zhang, Tianbiao Yang, Chenmao Zhou, Qibang Sui, Zhengyang Chen, Chen Zheng, Xinyue Hao, Keke Zhang, Rongrong Cui, Zehong Zhang, Hudson Ma, Yiluan Ding, Naixia Zhang, Xiaojie Lu, Xiaomin Luo, Hualiang Jiang, Sulin Zhang, Mingyue Zheng
Sequence-based drug design as a concept in computational drug design. Nature communications 14 (1) (2023)
Yujie Ji, Jia Duan, Qingning Yuan, Xin-Heng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Structural basis of peptide recognition and activation of endothelin receptors. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xin-Heng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor. Nature communications 14 (1) (2023)
Yujie Ji, Jia Duan, Qingning Yuan, Xin-Heng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Structural basis of peptide recognition and activation of endothelin receptors. Nature communications 14 (1) (2023)
Yumin Zhang, Yuan Sun, Yuanchao Xie, Weijuan Shang, Zhen Wang, Hualiang Jiang, Jingshan Shen, Geng-Fu Xiao, Lei-Ke Zhang
A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir. Signal transduction and targeted therapy 8 (1) (2023)
Hongmin Cai, Youwei Xu, Shimeng Guo, Xin-Heng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H Eric Xu, Xin Xie, Yi Jiang
Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell discovery 8 (1) (2022)
Na Wang, Xin-Heng He, Jing Zhao, Hualiang Jiang, Xi Cheng, Yu Xia, H Eric Xu, Yuanzheng He
Structural basis of leukotriene B4 receptor 1 activation. Nature communications 13 (1) (2022)
Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xin-Heng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell discovery 8 (1) (2022)
Youwei Xu, Hongmin Cai, Chongzhao You, Xin-Heng He, Qingning Yuan, Hualiang Jiang, Xi Cheng, Yi Jiang, H Eric Xu
Structural insights into ligand binding and activation of the human thyrotropin-releasing hormone receptor. Cell research 32 (9) (2022)
Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xin-Heng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell discovery 8 (1) (2022)
Peiyu Xu, Sijie Huang, Shimeng Guo, Ying Yun, Xi Cheng, Xin-Heng He, Pengjun Cai, Yuan Lan, Hu Zhou, Hualiang Jiang, Yi Jiang, Xin Xie, H Eric Xu
Structural identification of lysophosphatidylcholines as activating ligands for orphan receptor GPR119. Nature structural & molecular biology 29 (9) (2022)
Jia Duan, Dan-Dan Shen, Tingting Zhao, Shimeng Guo, Xin-Heng He, Wanchao Yin, Peiyu Xu, Yujie Ji, Li-Nan Chen, Jinyu Liu, Huibing Zhang, Qiufeng Liu, Yi Shi, Xi Cheng, Hualiang Jiang, H Eric Xu, Yan Zhang, Xin Xie, Yi Jiang
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors. Nature communications 13 (1) (2022)
Ruxue Zhang, Yumin Zhang, Wei Zheng, Weijuan Shang, Yan Wu, Ning Li, Jun Xiong, Hualiang Jiang, Jingshan Shen, Gengfu Xiao, Yuanchao Xie, Lei-Ke Zhang
Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model. Signal transduction and targeted therapy 7 (1) (2022)
Wanchao Yin, Youwei Xu, Peiyu Xu, Xiaodan Cao, Canrong Wu, Chunyin Gu, Xin-Heng He, Xiaoxi Wang, Sijie Huang, Qingning Yuan, Kai Wu, Wen Hu, Zifu Huang, Jia Liu, Zongda Wang, Fangfang Jia, Kaiwen Xia, Peipei Liu, Xueping Wang, Bin Song, Jie Zheng, Hualiang Jiang, Xi Cheng, Yi Jiang, Su-Jun Deng, H Eric Xu
Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody. Science (New York, N.Y.) 375 (6584) (2022)
Hongmin Cai, Youwei Xu, Shimeng Guo, Xin-Heng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H Eric Xu, Xin Xie, Yi Jiang
Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell discovery 8 (1) (2022)
Jia Duan, Peiyu Xu, Xiaodong Luan, Yujie Ji, Xin-Heng He, Ning Song, Qingning Yuan, Ye Jin, Xi Cheng, Hualiang Jiang, Jie Zheng, Shu-Yang Zhang, Yi Jiang, H Eric Xu
Hormone- and antibody-mediated activation of the thyrotropin receptor. Nature 609 (7928) (2022)
Hongmin Cai, Youwei Xu, Shimeng Guo, Xin-Heng He, Jun Sun, Xin Li, Changyao Li, Wanchao Yin, Xi Cheng, Hualiang Jiang, H Eric Xu, Xin Xie, Yi Jiang
Structures of adenosine receptor A 2B R bound to endogenous and synthetic agonists. Cell discovery 8 (1) (2022)
Jia Duan, Qiufeng Liu, Qingning Yuan, Yujie Ji, Shengnan Zhu, Yangxia Tan, Xin-Heng He, Youwei Xu, Jingjing Shi, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang
Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell discovery 8 (1) (2022)
Yuanchao Xie, Wanchao Yin, Yumin Zhang, Weijuan Shang, Zhen Wang, Xiaodong Luan, Guanghui Tian, Haji A Aisa, Yechun Xu, Gengfu Xiao, Jia Li, Hualiang Jiang, Shu-Yang Zhang, Lei-Ke Zhang, H Eric Xu, Jingshan Shen
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2. Cell research 31 (11) (2021)
Feisheng Zhong, Xiaolong Wu, Ruirui Yang, Xutong Li, Dingyan Wang, Zunyun Fu, Xiaohong Liu, XiaoZhe Wan, Tianbiao Yang, Zisheng Fan, Yinghui Zhang, Xiaomin Luo, Kaixian Chen, Sulin Zhang, Hualiang Jiang, Mingyue Zheng
Drug target inference by mining transcriptional data using a novel graph convolutional network framework. Protein & cell (2021)
Jia Duan, Peiyu Xu, Xi Cheng, Chunyou Mao, Tristan Croll, Xin-Heng He, Jingjing Shi, Xiaodong Luan, Wanchao Yin, Erli You, Qiufeng Liu, Shu-Yang Zhang, Hualiang Jiang, Yan Zhang, Yi Jiang, H Eric Xu
Structures of full-length glycoprotein hormone receptor signalling complexes. Nature 598 (7882) (2021)
Wanchao Yin, Xiaodong Luan, Zhihai Li, Ziwei Zhou, Qingxing Wang, Minqi Gao, Xiaoxi Wang, Fulai Zhou, Jingjing Shi, Erli You, Mingliang Liu, Qingxia Wang, Yi Jiang, Hualiang Jiang, Gengfu Xiao, Lei-Ke Zhang, Xuekui Yu, Shu-Yang Zhang, H Eric Xu
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nature structural & molecular biology 28 (3) (2021)
Youwen Zhuang, Brian E Krumm, Huibing Zhang, X Edward Zhou, Yue Wang, Xi-Ping Huang, Yongfeng Liu, Xi Cheng, Yi Jiang, Hualiang Jiang, Cheng Zhang, Wei Yi, Bryan L Roth, Yan Zhang, H Eric Xu
Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell research 31 (5) (2021)
Bingqing Xia, Xurui Shen, Yang He, Xiaoyan Pan, Feng-Liang Liu, Yi Wang, Feipu Yang, Sui Fang, Yan Wu, Zilei Duan, Xiaoli Zuo, Zhuqing Xie, Xiangrui Jiang, Ling Xu, Hao Chi, Shuangqu Li, Qian Meng, Hu Zhou, Yubo Zhou, Xi Cheng, Xiaoming Xin, Lin Jin, Hai-Lin Zhang, Dan-Dan Yu, Ming-Hua Li, Xiao-Li Feng, Jie-Kai Chen, Hualiang Jiang, Gengfu Xiao, Yong-Tang Zheng, Lei-Ke Zhang, Jingshan Shen, Jia Li, Zhaobing Gao
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target. Cell research 31 (8) (2021)
Haixia Su, Sheng Yao, Wenfeng Zhao, Yumin Zhang, Jia Liu, Qiang Shao, Qingxing Wang, Minjun Li, Hang Xie, Weijuan Shang, Changqiang Ke, Lu Feng, Xiangrui Jiang, Jingshan Shen, Gengfu Xiao, Hualiang Jiang, Lei-Ke Zhang, Yang Ye, Yechun Xu
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. Nature communications 12 (1) (2021)
Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X Edward Zhou, Xi Cheng, Icaro A Simon, Dan-Dan Shen, Hsin-Yung Yen, Carol V Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H Eric Xu
Structural insights into the lipid and ligand regulation of serotonin receptors. Nature 592 (7854) (2021)
Wenhao Dai, Bing Zhang, Xia-Ming Jiang, Haixia Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jingjing Peng, Fengjiang Liu, Chunpu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Gengfu Xiao, Hualiang Jiang, Zihe Rao, Lei-Ke Zhang, Yechun Xu, Haitao Yang, Hong Liu
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. Science (New York, N.Y.) 368 (6497) (2020)
Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Rendi Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, Luke W Guddat, Wenqing Xu, Gengfu Xiao, Chengfeng Qin, Zheng-Li Shi, Hualiang Jiang, Zihe Rao, Haitao Yang
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature 582 (7811) (2020)
Fulai Zhou, Huibing Zhang, Zhaotong Cong, Li-Hua Zhao, Qingtong Zhou, Chunyou Mao, Xi Cheng, Dan-Dan Shen, Xiaoqing Cai, Cheng Ma, Yuzhe Wang, Antao Dai, Yan Zhou, Wen Sun, Fenghui Zhao, Suwen Zhao, Hualiang Jiang, Yi Jiang, Dehua Yang, H Eric Xu, Yan Zhang, Ming-Wei Wang
Structural basis for activation of the growth hormone-releasing hormone receptor. Nature communications 11 (1) (2020)
Wanchao Yin, Chunyou Mao, Xiaodong Luan, Dan-Dan Shen, Qingya Shen, Haixia Su, Xiaoxi Wang, Fulai Zhou, Wenfeng Zhao, Minqi Gao, Shenghai Chang, Yuan-Chao Xie, Guanghui Tian, He-Wei Jiang, Sheng-Ce Tao, Jingshan Shen, Yi Jiang, Hualiang Jiang, Yechun Xu, Shu-Yang Zhang, Yan Zhang, H Eric Xu
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir. Science (New York, N.Y.) 368 (6498) (2020)