Bryan L Roth

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 94

Top Topics

Mass Spectrometry

Top Venues

Science (New York, N.Y.)

Nature communications

Science signaling

This page only lists publications with an associated author ORCID identifier.

Publications

Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Daphne Chun-Che Chien, Nathachit Limjunyawong, Can Cao, James Meixiong, Qi Peng, Cheng-Ying Ho, Jonathan F Fay, Bryan L Roth, Xinzhong Dong
MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model. Science translational medicine 16 (746) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika Vartak, Jiewei Xu, Jeffrey F DiBerto, Bryan L Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J Krogan, Ruth Hüttenhain
A proximity proteomics pipeline with improved reproducibility and throughput. Molecular systems biology (2024)
Shuai Wang, Chelsea DeLeon, Wenfei Sun, Stephen R Quake, Bryan L Roth, Thomas C Südhof
Alternative splicing of latrophilin-3 controls synapse formation. Nature 626 (7997) (2024)
Kevin M Knight, Brian E Krumm, Nicholas J Kapolka, W Grant Ludlam, Meng Cui, Sepehr Mani, Iya Prytkova, Elizabeth G Obarow, Tyler J Lefevre, Wenyuan Wei, Ning Ma, Xi Ping Huang, Jonathan F Fay, Nagarajan Vaidehi, Alan V Smrcka, Paul A Slesinger, Diomedes E Logothetis, Kirill A Martemyanov, Bryan L Roth, Henrik G Dohlman
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nature communications 15 (1) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature (2024)
Kevin M Knight, Brian E Krumm, Nicholas J Kapolka, W Grant Ludlam, Meng Cui, Sepehr Mani, Iya Prytkova, Elizabeth G Obarow, Tyler J Lefevre, Wenyuan Wei, Ning Ma, Xi Ping Huang, Jonathan F Fay, Nagarajan Vaidehi, Alan V Smrcka, Paul A Slesinger, Diomedes E Logothetis, Kirill A Martemyanov, Bryan L Roth, Henrik G Dohlman
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nature communications 15 (1) (2024)
Shuai Wang, Chelsea DeLeon, Wenfei Sun, Stephen R Quake, Bryan L Roth, Thomas C Südhof
Alternative splicing of latrophilin-3 controls synapse formation. Nature (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Shuai Wang, Chelsea DeLeon, Wenfei Sun, Stephen R Quake, Bryan L Roth, Thomas C Südhof
Alternative splicing of latrophilin-3 controls synapse formation. Nature 626 (7997) (2024)
Daphne Chun-Che Chien, Nathachit Limjunyawong, Can Cao, James Meixiong, Qi Peng, Cheng-Ying Ho, Jonathan F Fay, Bryan L Roth, Xinzhong Dong
MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model. Science translational medicine 16 (746) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology 19 (4) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) (2024)
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika Vartak, Jiewei Xu, Jeffrey F DiBerto, Bryan L Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J Krogan, Ruth Hüttenhain
A proximity proteomics pipeline with improved reproducibility and throughput. Molecular systems biology (2024)
Shuai Wang, Chelsea DeLeon, Wenfei Sun, Stephen R Quake, Bryan L Roth, Thomas C Südhof
Alternative splicing of latrophilin-3 controls synapse formation. Nature 626 (7997) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology 19 (4) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Author Correction: Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature (2024)
Daphne Chun-Che Chien, Nathachit Limjunyawong, Can Cao, James Meixiong, Qi Peng, Cheng-Ying Ho, Jonathan F Fay, Bryan L Roth, Xinzhong Dong
MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model. Science translational medicine 16 (746) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology 19 (4) (2024)
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika Vartak, Jiewei Xu, Jeffrey F DiBerto, Bryan L Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J Krogan, Ruth Hüttenhain
A proximity proteomics pipeline with improved reproducibility and throughput. Molecular systems biology 20 (8) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) 384 (6702) (2024)
Blake A Fordyce, Bryan L Roth
Piecing together aminergic polypharmacology. Cell research (2024)
Jiankun Lyu, Nicholas J Kapolka, Ryan Gumpper, Assaf Alon, Liang Wang, Manish Kumar Jain, Ximena Barros-Álvarez, Kensuke Sakamoto, Yoojoong Kim, Jeffrey F DiBerto, Kuglae Kim, Isabella S Glenn, Tia A Tummino, Sijie Huang, John J Irwin, Olga O Tarkhanova, Yurii S Moroz, Georgios Skiniotis, Andrew C Kruse, Brian K Shoichet, Bryan L Roth
AlphaFold2 structures guide prospective ligand discovery. Science (New York, N.Y.) (2024)
Yoojoong Kim, Ryan H Gumpper, Yong-Feng Liu, D Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E Krumm, Manish Kumar Jain, Shicheng Zhang, Jian Jin, Bryan L Roth
Bitter taste receptor activation by cholesterol and an intracellular tastant. Nature 628 (8008) (2024)
Blake A Fordyce, Bryan L Roth
Piecing together aminergic polypharmacology. Cell research 34 (9) (2024)
Kevin M Knight, Brian E Krumm, Nicholas J Kapolka, W Grant Ludlam, Meng Cui, Sepehr Mani, Iya Prytkova, Elizabeth G Obarow, Tyler J Lefevre, Wenyuan Wei, Ning Ma, Xi Ping Huang, Jonathan F Fay, Nagarajan Vaidehi, Alan V Smrcka, Paul A Slesinger, Diomedes E Logothetis, Kirill A Martemyanov, Bryan L Roth, Henrik G Dohlman
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nature communications 15 (1) (2024)
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika Vartak, Jiewei Xu, Jeffrey F DiBerto, Bryan L Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J Krogan, Ruth Hüttenhain
A proximity proteomics pipeline with improved reproducibility and throughput. Molecular systems biology 20 (8) (2024)
Shuai Wang, Chelsea DeLeon, Wenfei Sun, Stephen R Quake, Bryan L Roth, Thomas C Südhof
Alternative splicing of latrophilin-3 controls synapse formation. Nature 626 (7997) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology 19 (4) (2024)
Katharina Grotsch, Anastasiia V Sadybekov, Sydney Hiller, Saheem Zaidi, Dmitry B Eremin, Austen Le, Yong-Feng Liu, Evan Carlton Smith, Christos Illiopoulis-Tsoutsouvas, Joice Thomas, Shubhangi Aggarwal, Julie E Pickett, Cesar Reyes, Elias Picazo, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch, Valery V Fokin
Virtual Screening of a Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target. ACS chemical biology (2024)
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Aaron Marley, Helene Foussard, Prachi Khare, Rasika Vartak, Jiewei Xu, Jeffrey F DiBerto, Bryan L Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J Krogan, Ruth Hüttenhain
A proximity proteomics pipeline with improved reproducibility and throughput. Molecular systems biology 20 (8) (2024)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Jeffrey F DiBerto, Rasika Vartak, Jiewei Xu, Aaron Marley, Helene Foussard, Bryan L Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J Krogan, Ruth Hüttenhain
An automated proximity proteomics pipeline for subcellular proteome and protein interaction mapping. bioRxiv : the preprint server for biology (2023)
Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C Stevens, Wei Peng, Bryan L Roth, Zihe Rao, Zhi-Jie Liu
Structural insights into the human niacin receptor HCA2-G i signalling complex. Nature communications 14 (1) (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Ryan H Gumpper, Bryan L Roth
Psychedelics: preclinical insights provide directions for future research. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology (2023)
Peiyu Xu, Sijie Huang, Brian E Krumm, Youwen Zhuang, Chunyou Mao, Yumu Zhang, Yue Wang, Xi-Ping Huang, Yong-Feng Liu, Xin-Heng He, Huadong Li, Wanchao Yin, Yi Jiang, Yan Zhang, Bryan L Roth, H Eric Xu
Structural genomics of the human dopamine receptor system. Cell research (2023)
Shicheng Zhang, Bryan L Roth
Sensing unsaturated fatty acids: insights from GPR120 signaling. Cell research (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Jeffrey F DiBerto, Rasika Vartak, Jiewei Xu, Aaron Marley, Helene Foussard, Bryan L Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J Krogan, Ruth Hüttenhain
An automated proximity proteomics pipeline for subcellular proteome and protein interaction mapping. bioRxiv : the preprint server for biology (2023)
Richard T Eastman, Radda Rusinova, Karl F Herold, Xi Ping Huang, Patricia K Dranchak, Ty C Voss, Sandeep Rana, Jonathan H Shrimp, Alex D White, Hugh Carroll Hemmings, Bryan L Roth, James Inglese, Olaf S Andersen, Jayme L Dahlin
Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity. bioRxiv : the preprint server for biology (2023)
Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C Stevens, Wei Peng, Bryan L Roth, Zihe Rao, Zhi-Jie Liu
Structural insights into the human niacin receptor HCA2-G i signalling complex. Nature communications 14 (1) (2023)
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Jeffrey F DiBerto, Rasika Vartak, Jiewei Xu, Aaron Marley, Helene Foussard, Bryan L Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J Krogan, Ruth Hüttenhain
An automated proximity proteomics pipeline for subcellular proteome and protein interaction mapping. bioRxiv : the preprint server for biology (2023)
Leslie Salas-Estrada, Davide Provasi, Xing Qiu, Husnu Ümit Kaniskan, Xi-Ping Huang, Jeffrey F DiBerto, João Marcelo Lamim Ribeiro, Jian Jin, Bryan L Roth, Marta Filizola
De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework. Journal of chemical information and modeling (2023)
Yang Yang, Hye Jin Kang, Ruogu Gao, Jingjing Wang, Gye Won Han, Jeffrey F DiBerto, Lijie Wu, Jiahui Tong, Lu Qu, Yiran Wu, Ryan Pileski, Xuemei Li, Xuejun Cai Zhang, Suwen Zhao, Terry Kenakin, Quan Wang, Raymond C Stevens, Wei Peng, Bryan L Roth, Zihe Rao, Zhi-Jie Liu
Structural insights into the human niacin receptor HCA2-G i signalling complex. Nature communications 14 (1) (2023)
Xiaofang Zhong, Qiongyu Li, Benjamin J Polacco, Trupti Patil, Jeffrey F DiBerto, Rasika Vartak, Jiewei Xu, Aaron Marley, Helene Foussard, Bryan L Roth, Manon Eckhardt, Mark Von Zastrow, Nevan J Krogan, Ruth Hüttenhain
An automated proximity proteomics pipeline for subcellular proteome and protein interaction mapping. bioRxiv : the preprint server for biology (2023)
Dongqi Zhang, Yong-Feng Liu, Saheem A Zaidi, Lingyi Xu, Yuting Zhan, Anqi Chen, Jiang Tao Guo, Xi-Ping Huang, Bryan L Roth, Vsevolod Katritch, Vadim Cherezov, Haitao Zhang
Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists. The EMBO journal (2023)
Brian E Krumm, Jeffrey F DiBerto, Reid H J Olsen, Hye Jin Kang, Samuel T Slocum, Shicheng Zhang, Ryan T Strachan, Xi-Ping Huang, Lauren M Slosky, Anthony B Pinkerton, Lawrence S Barak, Marc G Caron, Terry Kenakin, Jonathan F Fay, Bryan L Roth
Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator. Biochemistry (2023)
Natalie Hewitt, Ning Ma, Nadia Arang, Sarah A Martin, Ajit Prakash, Jeffrey F DiBerto, Kevin M Knight, Soumadwip Ghosh, Reid H J Olsen, Bryan L Roth, Jorge Silvio Gutkind, Nagarajan Vaidehi, Sharon L Campbell, Henrik G Dohlman
Catalytic site mutations confer multiple states of G protein activation. Science signaling 16 (772) (2023)
Yi-Yuan Lee, Mustafa Guler, Desnor N Chigumba, Shen Wang, Neel Mittal, Cameron Miller, Benjamin Krummenacher, Haodong Liu, Liu Cao, Aditya Kannan, Keshav Narayan, Samuel T Slocum, Bryan L Roth, Alexey Gurevich, Bahar Behsaz, Roland D Kersten, Hosein Mohimani
HypoRiPPAtlas as an Atlas of hypothetical natural products for mass spectrometry database search. Nature communications 14 (1) (2023)
Stefan Gahbauer, Chelsea DeLeon, João M Braz, Veronica Craik, Hye Jin Kang, Xiaobo Wan, Xi-Ping Huang, Christian B Billesbølle, Yong-Feng Liu, Tao Che, Ishan Deshpande, Madison Jewell, Elissa A Fink, Ivan S Kondratov, Yurii S Moroz, John J Irwin, Allan I Basbaum, Bryan L Roth, Brian K Shoichet
Docking for EP4R antagonists active against inflammatory pain. Nature communications 14 (1) (2023)
Qianhui Qu, Weijiao Huang, Deniz Aydin, Joseph M Paggi, Alpay B Seven, Haoqing Wang, Soumen Chakraborty, Tao Che, Jeffrey F DiBerto, Michael J Robertson, Asuka Inoue, Carl-Mikael Suomivuori, Bryan L Roth, Susruta Majumdar, Ron O Dror, Brian K Kobilka, Georgios Skiniotis
Insights into distinct signaling profiles of the µOR activated by diverse agonists. Nature chemical biology (2022)
Shicheng Zhang, He Chen, Chengwei Zhang, Ying Yang, Petr Popov, Jing Liu, Brian E Krumm, Can Cao, Kuglae Kim, Yan Xiong, Vsevolod Katritch, Brian K Shoichet, Jian Jin, Jonathan F Fay, Bryan L Roth
Inactive and active state structures template selective tools for the human 5-HT 5A receptor. Nature structural & molecular biology 29 (7) (2022)
Abdelfattah Faouzi, Haoqing Wang, Saheem A Zaidi, Jeffrey F DiBerto, Tao Che, Qianhui Qu, Michael J Robertson, Manish K Madasu, Amal El Daibani, Balazs R Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T Slocum, Shainnel O Eans, Michael D Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L Roth, Jay P McLaughlin, Georgios Skiniotis, Vsevolod Katritch, Brian K Kobilka, Susruta Majumdar
Structure-based design of bitopic ligands for the µ-opioid receptor. Nature (2022)
Alex C Kwan, David E Olson, Katrin H Preller, Bryan L Roth
The neural basis of psychedelic action. Nature neuroscience 25 (11) (2022)
Tristan D McClure-Begley, Bryan L Roth
The promises and perils of psychedelic pharmacology for psychiatry. Nature reviews. Drug discovery 21 (6) (2022)
Gavin P Schmitz, Manish Kumar Jain, Samuel T Slocum, Bryan L Roth
5-HT 2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics. ACS chemical neuroscience 13 (16) (2022)
Yong-Feng Liu, Can Cao, Xi-Ping Huang, Ryan H Gumpper, Moira M Rachman, Sheng-Luen Shih, Brian E Krumm, Shicheng Zhang, Brian K Shoichet, Jonathan F Fay, Bryan L Roth
Ligand recognition and allosteric modulation of the human MRGPRX1 receptor. Nature chemical biology (2022)
Anat Levit Kaplan, Danielle N Confair, Kuglae Kim, Ximena Barros-Álvarez, Ramona M Rodriguiz, Ying Yang, Oh Sang Kweon, Tao Che, John D McCorvy, David N Kamber, James P Phelan, Luan Carvalho Martins, Vladimir M Pogorelov, Jeffrey F DiBerto, Samuel T Slocum, Xi-Ping Huang, Manish Kumar Jain, Michael J Robertson, Ouliana Panova, Alpay B Seven, Autumn Q Wetsel, William C Wetsel, John J Irwin, Georgios Skiniotis, Brian K Shoichet, Bryan L Roth, Jonathan A Ellman
Bespoke library docking for 5-HT 2A receptor agonists with antidepressant activity. Nature 610 (7932) (2022)
Anat Levit Kaplan, Ryan T Strachan, Joao M Braz, Veronica Craik, Samuel Slocum, Thomas Mangano, Vanessa Amabo, Henry O'Donnell, Parnian Lak, Allan I Basbaum, Bryan L Roth, Brian K Shoichet
Structure-Based Design of a Chemical Probe Set for the 5-HT 5A Serotonin Receptor. Journal of medicinal chemistry 65 (5) (2022)
Shicheng Zhang, Ryan H Gumpper, Xi-Ping Huang, Yong-Feng Liu, Brian E Krumm, Can Cao, Jonathan F Fay, Bryan L Roth
Molecular basis for selective activation of DREADD-based chemogenetics. Nature 612 (7939) (2022)
Tao Che, Hemlata Dwivedi-Agnihotri, Arun K Shukla, Bryan L Roth
Biased ligands at opioid receptors: Current status and future directions. Science signaling 14 (677) (2021)
Arman A Sadybekov, Anastasiia V Sadybekov, Yong-Feng Liu, Christos Iliopoulos-Tsoutsouvas, Xi-Ping Huang, Julie E Pickett, Blake Houser, Nilkanth Patel, Ngan K Tran, Fei Tong, Nikolai Zvonok, Manish Kumar Jain, Olena Savych, Dmytro S Radchenko, Spyros P Nikas, Nicos A Petasis, Yurii S Moroz, Bryan L Roth, Alexandros Makriyannis, Vsevolod Katritch
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds. Nature 601 (7893) (2021)
Youwen Zhuang, Brian E Krumm, Huibing Zhang, X Edward Zhou, Yue Wang, Xi-Ping Huang, Yongfeng Liu, Xi Cheng, Yi Jiang, Hualiang Jiang, Cheng Zhang, Wei Yi, Bryan L Roth, Yan Zhang, H Eric Xu
Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor. Cell research 31 (5) (2021)
Soumen Chakraborty, Jeffrey F DiBerto, Abdelfattah Faouzi, Sarah M Bernhard, Anna M Gutridge, Steven Ramsey, Yuchen Zhou, Davide Provasi, Nitin Nuthikattu, Rahul Jilakara, Melissa N F Nelson, Wesley B Asher, Shainnel O Eans, Lisa L Wilson, Satyanarayana M Chintala, Marta Filizola, Richard M Van Rijn, Elyssa B Margolis, Bryan L Roth, Jay P McLaughlin, Tao Che, Dalibor Sames, Jonathan A Javitch, Susruta Majumdar
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of medicinal chemistry 64 (18) (2021)
Assaf Alon, Jiankun Lyu, Joao M Braz, Tia A Tummino, Veronica Craik, Matthew J O'Meara, Chase M Webb, Dmytro S Radchenko, Yurii S Moroz, Xi-Ping Huang, Yong-Feng Liu, Bryan L Roth, John J Irwin, Allan I Basbaum, Brian K Shoichet, Andrew C Kruse
Structures of the σ2 receptor enable docking for bioactive ligand discovery. Nature (2021)
Bryan L Roth
Introduction to the Biochemistry of Pain Special Issue. Biochemistry 60 (18) (2021)
Samuel T Slocum, Jeffrey F DiBerto, Bryan L Roth
Molecular insights into psychedelic drug action. Journal of neurochemistry (2021)
Can Cao, Hye Jin Kang, Isha Singh, He Chen, Chengwei Zhang, Wenlei Ye, Byron W Hayes, Jing Liu, Ryan H Gumpper, Brian J Bender, Samuel T Slocum, Brian E Krumm, Katherine Lansu, John D McCorvy, Wesley K Kroeze, Justin G English, Jeffrey F DiBerto, Reid H J Olsen, Xi-Ping Huang, Shicheng Zhang, Yong-Feng Liu, Kuglae Kim, Joel Karpiak, Lily Yeh Jan, Soman N Abraham, Jian Jin, Brian K Shoichet, Jonathan F Fay, Bryan L Roth
Structure, function and pharmacology of human itch GPCRs. Nature 600 (7887) (2021)
Xi Ping Huang, Terrence P Kenakin, Shuo Gu, Brian K Shoichet, Bryan L Roth
Differential Roles of Extracellular Histidine Residues of GPR68 for Proton-Sensing and Allosteric Modulation by Divalent Metal Ions. Biochemistry 59 (38) (2020)
Yuji Nagai, Naohisa Miyakawa, Hiroyuki Takuwa, Yukiko Hori, Kei Oyama, Bin Ji, Manami Takahashi, Xi-Ping Huang, Samuel T Slocum, Jeffrey F DiBerto, Yan Xiong, Takuya Urushihata, Toshiyuki Hirabayashi, Atsushi Fujimoto, Koki Mimura, Justin G English, Jing Liu, Ken-Ichi Inoue, Katsushi Kumata, Chie Seki, Maiko Ono, Masafumi Shimojo, Ming-Rong Zhang, Yutaka Tomita, Jin Nakahara, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Jian Jin, Bryan L Roth, Takafumi Minanimoto
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nature neuroscience 23 (9) (2020)
Tao Che, Justin G English, Brian E Krumm, Kuglae Kim, Els Pardon, Reid H J Olsen, Sheng Wang, Shicheng Zhang, Jeffrey F Diberto, Noah Sciaky, F Ivy Carroll, Jan Steyaert, Daniel Wacker, Bryan L Roth
Nanobody-enabled monitoring of kappa opioid receptor states. Nature communications 11 (1) (2020)
David E Gordon, Gwendolyn M Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M White, Matthew J O'Meara, Veronica V Rezelj, Jeffrey Z Guo, Danielle L Swaney, Tia A Tummino, Ruth Hüttenhain, Robyn M Kaake, Alicia L Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J Polacco, Hannes Braberg, Jacqueline M Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J Bennett, Merve Cakir, Michael J McGregor, Qiongyu Li, Bjoern Meyer, Ferdinand Roesch, Thomas Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ying Shi, Ziyang Zhang, Wenqi Shen, Ilsa T Kirby, James E Melnyk, John S Chorba, Kevin Lou, Shizhong A Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J P Mathy, Tina Perica, Kala Bharath Pilla, Sai J Ganesan, Daniel J Saltzberg, Ramachandran Rakesh, Xi Liu, Sara Brin Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, José M Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, YongFeng Liu, Stephanie A Wankowicz, Markus Bohn, Maliheh Safari, Fatima S Ugur, Cassandra Koh, Nastaran Sadat Savar, Quang Dinh Tran, Djoshkun Shengjuler, Sabrina J Fletcher, Michael C O'Neal, Yiming Cai, Jason C J Chang, David J Broadhurst, Saker Klippsten, Phillip P Sharp, Nicole A Wenzell, Duygu Kuzuoglu-Ozturk, Hao-Yuan Wang, Raphael Trenker, Janet M Young, Devin A Cavero, Joseph Hiatt, Theodore L Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Robert M Stroud, Alan D Frankel, Oren S Rosenberg, Kliment A Verba, David A Agard, Melanie Ott, Michael Emerman, Natalia Jura, Mark Von Zastrow, Eric Verdin, Alan Ashworth, Olivier Schwartz, Christophe D'Enfert, Shaeri Mukherjee, Matthew P Jacobson, Harmit Singh Malik, Danica G Fujimori, Trey Ideker, Charles S Craik, Stephen N Floor, Brian K Shoichet, John D Gross, Andrej Sali, Bryan L Roth, Davide Ruggero, Jack Taunton, Tanja Kortemme, Pedro Beltrao, Marco Vignuzzi, Adolfo García-Sastre, Kevan M Shokat, Brian K Shoichet, Nevan J Krogan
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 583 (7816) (2020)
Reid H J Olsen, Jeffrey F DiBerto, Justin G English, Alexis M Glaudin, Brian E Krumm, Samuel T Slocum, Tao Che, Ariana C Gavin, John D McCorvy, Bryan L Roth, Ryan T Strachan
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome. Nature chemical biology 16 (8) (2020)
Joshua Pottel, Duncan Armstrong, Ling Zou, Alexander Fekete, Xi Ping Huang, Hayarpi Torosyan, Dallas Bednarczyk, Steven Whitebread, Barun Bhhatarai, Guiqing Liang, Hong Jin, Seyyed Nassir Ghaemi, Samuel T Slocum, Katalin V Lukacs, John J Irwin, Ellen L Berg, Kathleen M Giacomini, Bryan L Roth, Brian K Shoichet, Laszlo Urban
The activities of drug inactive ingredients on biological targets. Science (New York, N.Y.) 369 (6502) (2020)
Michael L Martini, Jing Liu, Caroline Ray, Xufen Yu, Xi-Ping Huang, Aarti Urs, Nikhil Urs, John D McCorvy, Marc G Caron, Bryan L Roth, Jian Jin
Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. Journal of medicinal chemistry 62 (7) (2019)
Bryan L Roth
Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs. Nature structural & molecular biology 26 (7) (2019)
Yudao Shen, John D McCorvy, Michael L Martini, Ramona M Rodriguiz, Vladimir M Pogorelov, Karen M Ward, William C Wetsel, Jing Liu, Bryan L Roth, Jian Jin
D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine. Journal of medicinal chemistry 62 (9) (2019)
Sheng Wang, Daniel Wacker, Anat Levit Kaplan, Tao Che, Robin M Betz, John D McCorvy, A J Venkatakrishnan, Xi-Ping Huang, Ron O Dror, Brian K Shoichet, Bryan L Roth
D4 dopamine receptor high-resolution structures enable the discovery of selective agonists. Science (New York, N.Y.) 358 (6361) (2018)
Michael S Placzek, Frederick A Schroeder, Tao Che, Hsiao-Ying Wey, Ramesh Neelamegam, Changning Wang, Bryan L Roth, Jacob M Hooker
Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging. ACS chemical neuroscience 10 (1) (2018)
Tao Che, Bryan L Roth
Phosphoproteomics Illuminates Opioid Actions. Biochemistry 57 (38) (2018)
John D McCorvy, Daniel Wacker, Sheng Wang, Bemnat Agegnehu, Jing Liu, Katherine Lansu, Alexandra R Tribo, Reid H J Olsen, Tao Che, Jian Jin, Bryan L Roth
Structural determinants of 5-HT2B receptor activation and biased agonism. Nature structural & molecular biology 25 (9) (2018)