Karsten Melcher

ORCID

Publication Activity (10 Years)

Years Active: 2017-2022
Publications (10 Years): 21

Top Venues

The Journal of biological chemistry

Nature

Cell research

Nature communications

Van Andel Research Institute

Eberhard Karls Universität Tübingen (MSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Van Andel Research Institute Oct 06 2018

United States

Professor :: Center for Cancer and Cell Biology

Van Andel Research Institute

United States

Associate Professor :: Laboratory of Structural Biology and Biochemistry

Van Andel Research Institute

United States

Assistant Professor :: Laboratory of Structural Biology and Biochemistry

Van Andel Research Institute

United States

Research Scientist :: Laboratory of Structural Sciences

University of Ulster

United Kingdom

Lecturer in Yeast Genetics :: School of Biomedical Sciences

Goethe-Universitat Frankfurt

Germany

Group Leader (PI)/Privatdozent :: Department of Microbiology

Goethe-Universitat Frankfurt

Germany

Group Leader (PI)/ Hochschulassistent :: Department of Microbiology

Goethe-Universitat Frankfurt

Germany

Group Leader (PI)/ Habilitationsstipendiat of the German Research Council (DFG) :: Department of Microbiology

Education History

Eberhard Karls Universität Tübingen

Germany

MSC

Eberhard Karls Universität Tübingen

Germany

PHD

Publications

X Edward Zhou, Chad R Schultz, Kelly Suino Powell, Amy Henrickson, Jared Lamp, Joseph S Brunzelle, Borries Demeler, Irving E Vega, André S Bachmann, Karsten Melcher
Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R. ACS omega 7 (38) (2022)
Peiyu Xu, Sijie Huang, Huibing Zhang, Chunyou Mao, X Edward Zhou, Xi Cheng, Icaro A Simon, Dan-Dan Shen, Hsin-Yung Yen, Carol V Robinson, Kasper Harpsøe, Bo Svensson, Jia Guo, Hualiang Jiang, David E Gloriam, Karsten Melcher, Yi Jiang, Yan Zhang, H Eric Xu
Structural insights into the lipid and ligand regulation of serotonin receptors. Nature 592 (7854) (2021)
Yan Yan, Somnath Mukherjee, Kaleeckal G Harikumar, Timothy S Strutzenberg, X Edward Zhou, Kelly Suino-Powell, Ting-Hai Xu, Ryan D Sheldon, Jared Lamp, Joseph S Brunzelle, Katarzyna Radziwon, Abigail E Ellis, Scott J Novick, Irving E Vega, Russell G Jones, Laurence J Miller, H Eric Xu, Patrick R Griffin, Anthony A Kossiakoff, Karsten Melcher
Structure of an AMPK complex in an inactive, ATP-bound state. Science (New York, N.Y.) 373 (6553) (2021)
Yuxin Zhou, X Edward Zhou, Yuanping Gong, Yuanye Zhu, Xiaoman Cao, Joseph S Brunzelle, H Eric Xu, Mingguo Zhou, Karsten Melcher, Feng Zhang
Structural basis of Fusarium myosin I inhibition by phenamacril. PLoS pathogens 16 (3) (2020)
Parker W de Waal, Jingjing Shi, Erli You, Xiaoxi Wang, Karsten Melcher, Yi Jiang, H Eric Xu, Bradley M Dickson
Molecular mechanisms of fentanyl mediated β-arrestin biased signaling. PLoS computational biology 16 (4) (2020)
Stephen L Pinkosky, John W Scott, Eric M Desjardins, Brennan K Smith, Emily Anne Day, Rebecca J Ford, Christopher G Langendorf, Naomi X Y Ling, Tracy L Nero, Kim Loh, Sandra Galic, Ashfaqul Hoque, William J Smiles, Kevin R W Ngoei, Michael W Parker, Yan Yan, Karsten Melcher, Bruce E Kemp, Jonathan S Oakhill, Gregory R Steinberg
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms. Nature metabolism 2 (9) (2020)
Haowen Jiang, X Edward Zhou, Jingjing Shi, Zhi Zhou, Guanguan Zhao, Xinwen Zhang, Yili Sun, Kelly Suino-Powell, Lei Ma, Hui Gao, Xiyong Yu, Jia Li, Jingya Li, Karsten Melcher, H Eric Xu, Wei Yi
Identification and structural insight of an effective PPARγ modulator with improved therapeutic index for anti-diabetic drug discovery. Chemical science 11 (8) (2020)
Ting-Hai Xu, Minmin Liu, X Edward Zhou, Gangning Liang, Gongpu Zhao, H Eric Xu, Karsten Melcher, Peter A Jones
Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature 586 (7827) (2020)
Jia Duan, Dan-Dan Shen, X Edward Zhou, Peng Bi, Qiu-Feng Liu, Yang-Xia Tan, You-Wen Zhuang, Hui-Bing Zhang, Pei-Yu Xu, Si-Jie Huang, Shan-Shan Ma, Xin-Heng He, Karsten Melcher, Yan Zhang, H Eric Xu, Yi Jiang
Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy. Nature communications 11 (1) (2020)
Youwen Zhuang, Heng Liu, X Edward Zhou, Ravi Kumar Verma, Parker W de Waal, Wonjo Jang, Ting-Hai Xu, Lei Wang, Xing Meng, Gongpu Zhao, Yanyong Kang, Karsten Melcher, Hao Fan, Nevin A Lambert, H Eric Xu, Cheng Zhang
Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling. Nature communications 11 (1) (2020)
Wanchao Yin, Zhihai Li, Mingliang Jin, Yu-Ling Yin, Parker W de Waal, Kuntal Pal, Yanting Yin, Xiang Gao, Yuanzheng He, Jing Gao, Xiaoxi Wang, Yan Zhang, Hu Zhou, Karsten Melcher, Yi Jiang, Yao Cong, X Edward Zhou, Xuekui Yu, H Eric Xu
A complex structure of arrestin-2 bound to a G protein-coupled receptor. Cell research 29 (12) (2019)
Li-Hua Zhao, Shanshan Ma, Ieva Sutkeviciute, Dan-Dan Shen, X Edward Zhou, Parker W de Waal, Chen-Yao Li, Yanyong Kang, Lisa J Clark, Frédéric G Jean-Alphonse, Alex D White, Dehua Yang, Antao Dai, Xiaoqing Cai, Jian Chen, Cong Li, Yi Jiang, Tomoyuki Watanabe, Thomas J Gardella, Karsten Melcher, Ming-Wei Wang, Jean-Pierre Vilardaga, H Eric Xu, Yan Zhang
Structure and dynamics of the active human parathyroid hormone receptor-1. Science (New York, N.Y.) 364 (6436) (2019)
Yuanzheng He, Jingjing Shi, Quang Tam Nguyen, Erli You, Hongbo Liu, Xin Ren, Zhongshan Wu, Jianshuang Li, Wenli Qiu, Sok Kean Khoo, Tao Yang, Wei Yi, Feng Sun, Zhijian Xi, Xiaozhu Huang, Karsten Melcher, Booki Min, H Eric Xu
Development of highly potent glucocorticoids for steroid-resistant severe asthma. Proceedings of the National Academy of Sciences of the United States of America 116 (14) (2019)
Yang Lu, X Edward Zhou, Xiang Gao, Na Wang, Ruixue Xia, Zhenmei Xu, Yu Leng, Yuying Shi, Guangfu Wang, Karsten Melcher, H Eric Xu, Yuanzheng He
Crystal structure of heliorhodopsin 48C12. Cell research 30 (1) (2019)
Yan Yan, X Edward Zhou, H Eric Xu, Karsten Melcher
Structure and Physiological Regulation of AMPK. International journal of molecular sciences 19 (11) (2018)
Wanchao Yin, X Edward Zhou, Dehua Yang, Parker W de Waal, Meitian Wang, Antao Dai, Xiaoqing Cai, Chia-Ying Huang, Ping Liu, Xiaoxi Wang, Yanting Yin, Bo Liu, Yu Zhou, Jiang Wang, Hong Liu, Martin Caffrey, Karsten Melcher, Yechun Xu, Ming-Wei Wang, H Eric Xu, Yi Jiang
Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist. Cell discovery 4 (2018)
Xin Gu, Michael D Bridges, Yan Yan, Parker W de Waal, X Edward Zhou, Kelly M Suino-Powell, H Eric Xu, Wayne L Hubbell, Karsten Melcher
Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK). The Journal of biological chemistry 293 (44) (2018)
Yan Yan, X Edward Zhou, Scott J Novick, Simon J Shaw, Yingwu Li, Joseph S Brunzelle, Yasumichi Hitoshi, Patrick R Griffin, H Eric Xu, Karsten Melcher
Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. The Journal of biological chemistry 294 (3) (2018)
Honglei Ma, Jingbo Duan, Jiyuan Ke, Yuanzheng He, Xin Gu, Ting-Hai Xu, Hong Yu, Yonghong Wang, Joseph S Brunzelle, Yi Jiang, Scott B Rothbart, H Eric Xu, Jiayang Li, Karsten Melcher
A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Science advances 3 (6) (2017)
Feng Zhang, Jiyuan Ke, Li Zhang, Rongzhi Chen, Koichi Sugimoto, Gregg A Howe, H Eric Xu, Mingguo Zhou, Sheng Yang He, Karsten Melcher
Structural insights into alternative splicing-mediated desensitization of jasmonate signaling. Proceedings of the National Academy of Sciences of the United States of America 114 (7) (2017)
Zachary J DeBruine, Jiyuan Ke, Kaleeckal G Harikumar, Xin Gu, Peter Borowsky, Bart O Williams, Wenqing Xu, Laurence J Miller, H Eric Xu, Karsten Melcher
Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization. Genes & development 31 (9) (2017)

Karsten Melcher.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Karsten Melcher