A Thomas Look

ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 22

Top Venues

Clinical cancer research : an official journal of the American Association for Cancer Research

Science advances

Oncogene

Cancer research

Dana Farber Cancer Institute

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Dana Farber Cancer Institute

United States

Associate Physician :: Pediatric Oncology

Children’s Hospital Boston

United States

Senior Associate :: Hematology-Oncology

Dana Farber Cancer Institute

United States

Vice Chair for Research :: Pediatric Oncology

St. Jude Children's Hospital

United States

Chairman :: Experimental Oncology

07/92 - 05/99 St. Jude Children's Hospital

United States

Endowed Chair Leukemia Research :: Leukemia Research

St. Jude Children's Hospital

United States

Member :: Hematology-Oncology

St. Jude Children's Hospital

United States

Vice Chairman, Research :: Hematology-Oncology

St. Jude Children's Hospital

United States

Appointment :: Tumor Cell Biology

University of Tennessee Medical Center

United States

Associate Member :: Hematology Oncology

University of Tennessee Medical Center

United States

Assistant Member :: Hematology Oncology

Publications

Evan C Chen, Helen Gandler, Isidora Tošić, Geoffrey G Fell, Ashlee Fiore, Olga Pozdnyakova, Daniel J DeAngelo, Ilene Galinsky, Marlise R Luskin, Martha S Wadleigh, Eric S Winer, Rebecca Leonard, Kelsey O'Day, Adrienne de Jonge, Donna S Neuberg, A Thomas Look, Richard M Stone, David A Frank, Jacqueline S Garcia
Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (5) (2023)
Evan C Chen, Helen Gandler, Isidora Tošić, Geoffrey G Fell, Ashlee Fiore, Olga Pozdnyakova, Daniel J DeAngelo, Ilene Galinsky, Marlise R Luskin, Martha S Wadleigh, Eric S Winer, Rebecca Leonard, Kelsey O'Day, Adrienne de Jonge, Donna S Neuberg, A Thomas Look, Richard M Stone, David A Frank, Jacqueline S Garcia
Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (5) (2023)
Evan C Chen, Helen Gandler, Isidora Tošić, Geoffrey G Fell, Ashlee Fiore, Olga Pozdnyakova, Daniel J DeAngelo, Ilene Galinsky, Marlise R Luskin, Martha S Wadleigh, Eric S Winer, Rebecca Leonard, Kelsey O'Day, Adrienne de Jonge, Donna S Neuberg, A Thomas Look, Richard M Stone, David A Frank, Jacqueline S Garcia
Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (5) (2023)
Chang-Bin Jing, Nicole Prutsch, Shuning He, Mark W Zimmerman, Yosef Landesman, A Thomas Look
Synthetic lethal targeting of TET2-mutant haematopoietic stem and progenitor cells by XPO1 inhibitors. British journal of haematology (2023)
Evan C Chen, Helen Gandler, Isidora Tošić, Geoffrey G Fell, Ashlee Fiore, Olga Pozdnyakova, Daniel J DeAngelo, Ilene Galinsky, Marlise R Luskin, Martha S Wadleigh, Eric S Winer, Rebecca Leonard, Kelsey O'Day, Adrienne de Jonge, Donna S Neuberg, A Thomas Look, Richard M Stone, David A Frank, Jacqueline S Garcia
Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates. Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Felix Oppel, Senyao Shao, Sarah Gendreizig, Mark W Zimmerman, Matthias Schürmann, Viyof Ful Flavian, Peter Kin Cho Goon, Susan N Chi, Jon C Aster, Holger Sudhoff, A Thomas Look
p53 Pathway Inactivation Drives SMARCB1-deficient p53-wildtype Epithelioid Sarcoma Onset Indicating Therapeutic Vulnerability Through MDM2 Inhibition. Molecular cancer therapeutics 21 (11) (2022)
Koshi Akahane, Shunsuke Kimura, Kunio Miyake, Atsushi Watanabe, Keiko Kagami, Kentaro Yoshimura, Tamao Shinohara, Daisuke Harama, Shin Kasai, Kumiko Goi, Tomoko Kawai, Kenichiro Hata, Nobutaka Kiyokawa, Katsuyoshi Koh, Toshihiko Imamura, Keizo Horibe, A Thomas Look, Masayoshi Minegishi, Kanji Sugita, Junko Takita, Takeshi Inukai
Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL. Blood advances (2021)
Zhiwei Dong, Kok-Siong Yeo, Gonzalo Lopez, Cheng Zhang, Erin N Dankert Eggum, Jo Lynne Rokita, Choong Yong Ung, Taylor M Levee, Zuag Paj Her, Cassie J Howe, Xiaonan Hou, Janine H van Ree, Shuai Li, Shuning He, Ting Tao, Karen Fritchie, Jorge Torres-Mora, Julia S Lehman, Alexander Meves, Gina L Razidlo, Komal S Rathi, S John Weroha, A Thomas Look, Jan M van Deursen, Hu Li, Jennifer J Westendorf, John M Maris, Shizhen Zhu
GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma. Cancer research 81 (11) (2021)
Shuning He, Mark W Zimmerman, Hillary M Layden, Alla Berezovskaya, Julia Etchin, Megan W Martel, Grace Thurston, Chang-Bin Jing, Ellen van Rooijen, Charles K Kaufman, Scott J Rodig, Leonard I Zon, E Elizabeth Patton, Marc R Mansour, A Thomas Look
Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene 40 (38) (2021)
Mark W Zimmerman, Adam D Durbin, Shuning He, Felix Oppel, Hui Shi, Ting Tao, Zhaodong Li, Alla Berezovskaya, Yu Liu, Jinghui Zhang, Richard A Young, Brian J Abraham, A Thomas Look
Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma. Science advances 7 (43) (2021)
Adam D Durbin, Tingjian Wang, Virangika K Wimalasena, Mark W Zimmerman, Deyao Li, Neekesh V Dharia, Luca Mariani, Noha A M Shendy, Stephanie Nance, Anand G Patel, Ying Shao, Maya Mundada, Lily Maxham, Paul M C Park, Logan H Sigua, Ken Morita, Amy Saur Conway, Amanda L Robichaud, Antonio R Perez-Atayde, Melissa J Bikowitz, Taylor R Quinn, Olaf G Wiest, John Easton, Ernst Schonbrunn, Martha L Bulyk, Brian J Abraham, Kimberly Stegmaier, A Thomas Look, Jun Qi
EP300 selectively controls the enhancer landscape of MYCN-amplified neuroblastoma. Cancer discovery (2021)
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne-Aidee Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel Adriano Silva, K Christopher Garcia, Julien S Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence L de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma. Nature communications 12 (1) (2021)
Nicole M Anderson, Xiaodan Qin, Jennifer M Finan, Andrew Lam, Jacob Athoe, Rindert Missiaen, Nicolas Skuli, Annie Kennedy, Amandeep S Saini, Ting Tao, Shizhen Zhu, Itzhak Nissim, A Thomas Look, Guoliang Qing, M Celeste Simon, Hui Feng
Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer research 81 (17) (2021)
Chang-Bin Jing, Cong Fu, Nicole Prutsch, Meng Wang, Shuning He, A Thomas Look
Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors. Leukemia 34 (11) (2020)
Felix Oppel, Dong H Ki, Mark W Zimmerman, Kenneth N Ross, Ting Tao, Hui Shi, Shuning He, Jon C Aster, A Thomas Look
suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types. Disease models & mechanisms 13 (8) (2020)
Hui Shi, Ting Tao, Brian J Abraham, Adam D Durbin, Mark W Zimmerman, Cigall Kadoch, A Thomas Look
ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression. Science advances 6 (29) (2020)
Yu Liu, Chunliang Li, Shuhong Shen, Xiaolong Chen, Karol Szlachta, Michael N Edmonson, Ying Shao, Xiaotu Ma, Judith Hyle, Shaela Wright, Bensheng Ju, Michael C Rusch, Yanling Liu, Benshang Li, Michael Macias, Liqing Tian, John Easton, Maoxiang Qian, Jun J Yang, Shaoyan Hu, A Thomas Look, Jinghui Zhang
Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X. Nature genetics 52 (8) (2020)
Dong Hyuk Ki, Felix Oppel, Adam D Durbin, A Thomas Look
Mechanisms underlying synergy between DNA topoisomerase I-targeted drugs and mTOR kinase inhibitors in NF1-associated malignant peripheral nerve sheath tumors. Oncogene 38 (39) (2019)
Evisa Gjini, Chang-Bin Jing, Ashley T Nguyen, Deepak Reyon, Emma Gans, Michiel Kesarsing, Joshua Peterson, Olga Pozdnyakova, Scott J Rodig, Marc R Mansour, Keith Joung, A Thomas Look
Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish. Disease models & mechanisms 12 (5) (2019)
Felix Oppel, Ting Tao, Hui Shi, Kenneth N Ross, Mark W Zimmerman, Shuning He, Guangxiang Tong, Jon C Aster, A Thomas Look
Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies. PLoS genetics 15 (4) (2019)
Marc R Mansour, Shuning He, Zhaodong Li, Riadh Lobbardi, Brian J Abraham, Clemens Hug, Sunniyat Rahman, Theresa E León, You-Yi Kuang, Mark W Zimmerman, Traci M Blonquist, Evisa Gjini, Alejandro Gutierrez, Qin Tang, Laura Garcia-Perez, Karin Pike-Overzet, Lars Anders, Alla Berezovskaya, Yi Zhou, Leonard I Zon, Donna S Neuberg, Adele K Fielding, Frank J T Staal, David M Langenau, Takaomi Sanda, Richard A Young, A Thomas Look
JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. The Journal of experimental medicine 215 (7) (2018)
Shuning He, Marc R Mansour, Mark W Zimmerman, Dong Hyuk Ki, Hillary M Layden, Koshi Akahane, Evisa Gjini, Eric D de Groh, Antonio R Perez-Atayde, Shizhen Zhu, Jonathan A Epstein, A Thomas Look
Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. eLife 5 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

A Thomas Look