Caroline A Lewis

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 19

Top Venues

Nature metabolism

Science (New York, N.Y.)

Nature

Nature cell biology

Univserity of Manchester (BSC)

This page only lists publications with an associated author ORCID identifier.

Education History

Univserity of Manchester Oct 01 2002 - Jun 01 2006

United Kingdom

BSC :: Faculty of Life Sciences

Publications

Sharanya Sivanand, Yetis Gultekin, Peter S Winter, Sidney Y Vermeulen, Konstantine M Tchourine, Keene L Abbott, Laura V Danai, Florian Gourgue, Brian T Do, Kayla Crowder, Tenzin Kunchok, Allison N Lau, Alicia M Darnell, Alexandria Jefferson, Satoru Morita, Dan G Duda, Andrew J Aguirre, Brian M Wolpin, Nicole Henning, Virginia Spanoudaki, Laura Maiorino, Darrell J Irvine, Ömer H Yilmaz, Caroline A Lewis, Dennis Vitkup, Alex K Shalek, Matthew G Vander Heiden
Cancer tissue of origin constrains the growth and metabolism of metastases. Nature metabolism (2024)
Samantha J Linder, Tiziano Bernasocchi, Bárbara Martínez-Pastor, Kelly D Sullivan, Matthew D Galbraith, Caroline A Lewis, Christina M Ferrer, Ruben Boon, Giorgia G Silveira, Hyo Min Cho, Charles Vidoudez, Stuti G Shroff, Joao P Oliveira-Costa, Kenneth N Ross, Rami Massri, Yusuke Matoba, Eugene Kim, Bo R Rueda, Shannon L Stott, Eyal Gottlieb, Joaquín Maximiliano Espinosa, Raul Mostoslavsky
Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells. Nature metabolism (2023)
Rodrigo Romero, Francisco J Sánchez Rivera, Peter M K Westcott, Kim L Mercer, Arjun Bhutkar, Alexander Muir, Tania J González Robles, Swanny Lamboy Rodríguez, Laura Z Liao, Sheng Rong Ng, Leanne Li, Caterina I Colón, Santiago Naranjo, Mary Clare Beytagh, Caroline A Lewis, Peggy P Hsu, Roderick T Bronson, Matthew G Vander Heiden, Tyler Jacks
Publisher Correction: Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1. Nature cancer 1 (9) (2023)
Andrew L Cangelosi, Anna M Puszynska, Justin M Roberts, Andrea Armani, Thao P Nguyen, Jessica Brooke Spinelli, Tenzin Kunchok, Brianna Wang, Sze Ham Chan, Caroline A Lewis, William C Comb, George W Bell, Aharon Helman, David M Sabatini
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. Science (New York, N.Y.) 377 (6601) (2022)
Bradley E Reinfeld, Matthew Z Madden, Melissa M Wolf, Anna Chytil, Jackie E Bader, Andrew R Patterson, Ayaka Sugiura, Allison S Cohen, Ahmed Ali, Brian T Do, Alexander Muir, Caroline A Lewis, Rachel A Hongo, Kirsten L Young, Rachel E Brown, Vera M Todd, Tessa Huffstater, Abin Abraham, Richard T O'Neil, Matthew H Wilson, Fuxue Xin, M Noor Tantawy, W David Merryman, Rachelle W Johnson, Christopher S Williams, Emily F Mason, Frank M Mason, Katherine E Beckermann, Matthew G Vander Heiden, H Charles Manning, Jeffrey C Rathmell, W Kimryn Rathmell
Cell-programmed nutrient partitioning in the tumour microenvironment. Nature 593 (7858) (2021)
Grzegorz Sienski, Priyanka Narayan, Julia Maeve Bonner, Nora Kory, Sebastian Boland, Aleksandra A Arczewska, William T Ralvenius, Leyla Anne Akay, Elana Lockshin, Liang He, Blerta Milo, Agnese Graziosi, Valeriya Baru, Caroline A Lewis, Manolis Kellis, David M Sabatini, Li-Huei Tsai, Susan Lindquist
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia. Science translational medicine 13 (583) (2021)
Jessica Brooke Spinelli, Paul C Rosen, Hans-Georg Sprenger, Anna M Puszynska, Jessica L Mann, Julian M Roessler, Andrew L Cangelosi, Antonia Henne, Kendall J Condon, Tong Zhang, Tenzin Kunchok, Caroline A Lewis, Navdeep S Chandel, David M Sabatini
Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science (New York, N.Y.) 374 (6572) (2021)
Jee-Eun Choi, Carlos Sebastian, Christina M Ferrer, Caroline A Lewis, Moshe Sade-Feldman, Thomas J LaSalle, Anna L K Gonye, Begona G C Lopez, Walid M Abdelmoula, Michael S Regan, Murat Cetinbas, Gloria Pascual, Gregory R Wojtkiewicz, Giorgia G Silveira, Ruben Boon, Kenneth N Ross, Michael Mints, Srinivas V Saladi, Leif W Ellisen, Ruslan I Sadreyev, Salvador Aznar Benitah, Nathalie Y R Agar, Nir Hacohen, Raul Mostoslavsky
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma. Nature metabolism 3 (2) (2021)
Mark R Sullivan, Alicia M Darnell, Montana F Reilly, Tenzin Kunchok, Lena Joesch-Cohen, Daniel Rosenberg, Ahmed Ali, Matthew G Rees, Jennifer A Roth, Caroline A Lewis, Matthew G Vander Heiden
Methionine synthase is essential for cancer cell proliferation in physiological folate environments. Nature metabolism 3 (11) (2021)
Leanne Li, Sheng Rong Ng, Caterina I Colón, Benjamin J Drapkin, Peggy P Hsu, Zhaoqi Li, Christopher S Nabel, Caroline A Lewis, Rodrigo Romero, Kim L Mercer, Arjun Bhutkar, Sarah Phat, David T Myers, Mandar Deepak Muzumdar, Peter M K Westcott, Mary Clare Beytagh, Anna F Farago, Matthew G Vander Heiden, Nicholas J Dyson, Tyler Jacks
Identification of DHODH as a therapeutic target in small cell lung cancer. Science translational medicine 11 (517) (2020)
Nora Kory, Jelmi Uit de Bos, Sanne van der Rijt, Nevena Jankovic, Miriam Güra, Nicholas L Arp, Izabella A Pena, Gyan Prakash, Sze Ham Chan, Tenzin Kunchok, Caroline A Lewis, David M Sabatini
MCART1/SLC25A51 is required for mitochondrial NAD transport. Science advances 6 (43) (2020)
Jose M Orozco, Patrycja A Krawczyk, Sonia M Scaria, Andrew L Cangelosi, Sze Ham Chan, Tenzin Kunchok, Caroline A Lewis, David M Sabatini
Dihydroxyacetone phosphate signals glucose availability to mTORC1. Nature metabolism 2 (9) (2020)
Charles H Adelmann, Anna K Traunbauer, Brandon Chen, Kendall J Condon, Sze Ham Chan, Tenzin Kunchok, Caroline A Lewis, David M Sabatini
MFSD12 mediates the import of cysteine into melanosomes and lysosomes. Nature 588 (7839) (2020)
Nora Kory, Gregory A Wyant, Gyan Prakash, Jelmi Uit de Bos, Francesca Bottanelli, Michael E Pacold, Sze Ham Chan, Caroline A Lewis, Tim Wang, Heather R Keys, Yang Eric Guo, David M Sabatini
SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science (New York, N.Y.) 362 (6416) (2019)
Frances F Diehl, Caroline A Lewis, Brian P Fiske, Matthew G Vander Heiden
Cellular redox state constrains serine synthesis and nucleotide production to impact cell proliferation. Nature metabolism 1 (9) (2019)
Alba Luengo, Keene L Abbott, Shawn M Davidson, Aaron M Hosios, Brandon Faubert, Sze Ham Chan, Elizaveta Freinkman, Lauren G Zacharias, Thomas P Mathews, Andrew T Chan, Ralph J DeBerardinis, Caroline A Lewis, Matthew G Vander Heiden
Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer. Nature communications 10 (1) (2019)
Mark R Sullivan, Laura V Danai, Caroline A Lewis, Sze Ham Chan, Dan Y Gui, Tenzin Kunchok, Emily A Dennstedt, Matthew G Vander Heiden, Alexander Muir
Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability. eLife 8 (2019)
Javier Garcia-Bermudez, Lou Baudrier, Konnor La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O Sviderskiy, Thales Papagiannakopoulos, Henrik Molina, Matija Snuderl, Caroline A Lewis, Richard L Possemato, Kivanç Birsoy
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nature cell biology 20 (7) (2018)
Lucas B Sullivan, Alba Luengo, Laura V Danai, Lauren N Bush, Frances F Diehl, Aaron M Hosios, Allison N Lau, Sarah Elmiligy, Scott Malstrom, Caroline A Lewis, Matthew G Vander Heiden
Aspartate is an endogenous metabolic limitation for tumour growth. Nature cell biology 20 (7) (2018)

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Publication Activity (10 Years)

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Caroline A Lewis