David M Sabatini (D M Sabatini, Jared Rutter)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 37

Top Topics

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Science (New York, N.Y.)

Nature communications

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Max L Valenstein, Pranav V Lalgudi, Xin Gu, Jibril F Kedir, Martin S Taylor, Raghu R Chivukula, David M Sabatini
Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
Max L Valenstein, Pranav V Lalgudi, Xin Gu, Jibril F Kedir, Martin S Taylor, Raghu R Chivukula, David M Sabatini
Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
Grace Y Liu, Patrick Jouandin, Raymond E Bahng, Norbert Perrimon, David M Sabatini
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Nature communications 15 (1) (2024)
Max L Valenstein, Pranav V Lalgudi, Xin Gu, Jibril F Kedir, Martin S Taylor, Raghu R Chivukula, David M Sabatini
Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway. Proceedings of the National Academy of Sciences of the United States of America 121 (35) (2024)
Grace Y Liu, Patrick Jouandin, Raymond E Bahng, Norbert Perrimon, David M Sabatini
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Nature communications 15 (1) (2024)
Grace Y Liu, Patrick Jouandin, Raymond E Bahng, Norbert Perrimon, David M Sabatini
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Nature communications 15 (1) (2024)
Grace Y Liu, Patrick Jouandin, Raymond E Bahng, Norbert Perrimon, David M Sabatini
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Nature communications 15 (1) (2024)
Grace Y Liu, Patrick Jouandin, Raymond E Bahng, Norbert Perrimon, David M Sabatini
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. Nature communications 15 (1) (2024)
Grace Y Liu, Patrick Jouandin, Raymond E Bahng, Norbert Perrimon, David M Sabatini
An evolutionary mechanism to assimilate new nutrient sensors into the mTORC1 pathway. bioRxiv : the preprint server for biology (2023)
Lydia W S Finley, Joshua M Gendron, Irene Miguel-Aliaga, David M Sabatini
Integrating the dynamic and energetic fields of metabolism and development. Development (Cambridge, England) 150 (20) (2023)
Andrew L Cangelosi, Anna M Puszynska, Justin M Roberts, Andrea Armani, Thao P Nguyen, Jessica Brooke Spinelli, Tenzin Kunchok, Brianna Wang, Sze Ham Chan, Caroline A Lewis, William C Comb, George W Bell, Aharon Helman, David M Sabatini
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine. Science (New York, N.Y.) 377 (6601) (2022)
Grzegorz Sienski, Priyanka Narayan, Julia Maeve Bonner, Nora Kory, Sebastian Boland, Aleksandra A Arczewska, William T Ralvenius, Leyla Anne Akay, Elana Lockshin, Liang He, Blerta Milo, Agnese Graziosi, Valeriya Baru, Caroline A Lewis, Manolis Kellis, David M Sabatini, Li-Huei Tsai, Susan Lindquist
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia. Science translational medicine 13 (583) (2021)
Kendall J Condon, Jose M Orozco, Charles H Adelmann, Jessica B Spinelli, Pim W van der Helm, Justin M Roberts, Tenzin Kunchok, David M Sabatini
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction. Proceedings of the National Academy of Sciences of the United States of America 118 (4) (2021)
Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando Garcίa, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Munoz, Mario Pende, Guadalupe Sabio, David M Sabatini, Alejo Efeyan
Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling. Nature communications 12 (1) (2021)
Jessica Brooke Spinelli, Paul C Rosen, Hans-Georg Sprenger, Anna M Puszynska, Jessica L Mann, Julian M Roessler, Andrew L Cangelosi, Antonia Henne, Kendall J Condon, Tong Zhang, Tenzin Kunchok, Caroline A Lewis, Navdeep S Chandel, David M Sabatini
Fumarate is a terminal electron acceptor in the mammalian electron transport chain. Science (New York, N.Y.) 374 (6572) (2021)
Lauren E Surface, Damon T Burrow, Jinmei Li, Jiwoong Park, Sandeep Kumar, Cheng Lyu, Niki Song, Zhou Yu, Abbhirami Rajagopal, Yangjin Bae, Brendan H Lee, Steven Mumm, Charles C Gu, Jonathan C Baker, Mahshid Mohseni, Melissa Sum, Margaret Huskey, Shenghui Duan, Vinieth N Bijanki, Roberto Civitelli, Michael J Gardner, Christopher M McAndrew, William M Ricci, Christina A Gurnett, Kathryn Diemer, Fei Wan, Christina L Costantino, Kristen M Shannon, Noopur Raje, Thomas B Dodson, Daniel A Haber, Jan E Carette, Malini Varadarajan, Thijn R Brummelkamp, Kivanç Birsoy, David M Sabatini, Gabe Haller, Timothy R Peterson
ATRAID regulates the action of nitrogen-containing bisphosphonates on bone. Science translational medicine 12 (544) (2021)
Anne Fassl, Christopher Brain, Monther Abu-Remaileh, Iga Stukan, Deborah Butter, Piotr Stepien, Avery S Feit, Johann Bergholz, Wojciech Michowski, Tobias Otto, Qing Sheng, Alice Loo, Walter Michael, Ralph Tiedt, Carmine DeAngelis, Rachel Schiff, Baishan Jiang, Bojana Jovanovic, Karolina Nowak, Maria Ericsson, Michael D Cameron, Nathanael S Gray, Deborah Dillon, Jean J Zhao, David M Sabatini, Rinath M Jeselsohn, Myles Brown, Kornelia Polyak, Piotr Sicinski
Increased lysosomal biomass is responsible for the resistance of triple-negative breast cancers to CDK4/6 inhibition. Science advances 6 (25) (2020)
Madhanagopal Anandapadamanaban, Glenn Robert Masson, Olga Perisic, Alex Berndt, Jonathan G G Kaufman, Christopher M Johnson, Santhanam Balaji, Kacper B Rogala, David M Sabatini, Roger L Williams
Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science (New York, N.Y.) 366 (6462) (2020)
Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J Liang, Alba Luengo, Shawn M Davidson, Ahmed Ali, Gino B Ferraro, Grant M Fischer, Roozbeh Eskandari, Diane S Kang, Jing Ni, Ariana Plasger, Vinagolu K Rajasekhar, Edward R Kastenhuber, Sarah Bacha, Roshan K Sriram, Benjamin D Stein, Samuel F Bakhoum, Matija Snuderl, Paolo Cotzia, John H Healey, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M Sabatini, Drew R Jones, Min Yu, Jean J Zhao, Rakesh K Jain, Kayvan R Keshari, Michael A Davies, Matthew G Vander Heiden, Eva Hernando, Matthias Mann, Lewis C Cantley, Michael E Pacold
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer discovery 10 (9) (2020)
Naama Kanarek, Boryana Petrova, David M Sabatini
Dietary modifications for enhanced cancer therapy. Nature 579 (7800) (2020)
Nora Kory, Jelmi Uit de Bos, Sanne van der Rijt, Nevena Jankovic, Miriam Güra, Nicholas L Arp, Izabella A Pena, Gyan Prakash, Sze Ham Chan, Tenzin Kunchok, Caroline A Lewis, David M Sabatini
MCART1/SLC25A51 is required for mitochondrial NAD transport. Science advances 6 (43) (2020)
Hyewon Kong, Colleen R Reczek, Gregory S McElroy, Elizabeth M Steinert, Tim Wang, David M Sabatini, Navdeep S Chandel
Metabolic determinants of cellular fitness dependent on mitochondrial reactive oxygen species. Science advances 6 (45) (2020)
Raghu R Chivukula, Daniel T Montoro, Hui Min Leung, Jason Yang, Hanan E Shamseldin, Martin S Taylor, Gerard W Dougherty, Maimoona A Zariwala, Johnny Carson, M Leigh Anne Daniels, Patrick R Sears, Katharine E Black, Lida P Hariri, Ibrahim Almogarri, Evgeni M Frenkel, Vladimir Vinarsky, Heymut Omran, Michael R Knowles, Guillermo J Tearney, Fowzan Sami Alkuraya, David M Sabatini
A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance. Nature medicine 26 (2) (2020)
Jose M Orozco, Patrycja A Krawczyk, Sonia M Scaria, Andrew L Cangelosi, Sze Ham Chan, Tenzin Kunchok, Caroline A Lewis, David M Sabatini
Dihydroxyacetone phosphate signals glucose availability to mTORC1. Nature metabolism 2 (9) (2020)
Charles H Adelmann, Anna K Traunbauer, Brandon Chen, Kendall J Condon, Sze Ham Chan, Tenzin Kunchok, Caroline A Lewis, David M Sabatini
MFSD12 mediates the import of cysteine into melanosomes and lysosomes. Nature 588 (7839) (2020)
Grace Y Liu, David M Sabatini
mTOR at the nexus of nutrition, growth, ageing and disease. Nature reviews. Molecular cell biology 21 (4) (2020)
Nora Kory, Gregory A Wyant, Gyan Prakash, Jelmi Uit de Bos, Francesca Bottanelli, Michael E Pacold, Sze Ham Chan, Caroline A Lewis, Tim Wang, Heather R Keys, Yang Eric Guo, David M Sabatini
SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Science (New York, N.Y.) 362 (6416) (2019)
Yun Li, Julien Muffat, Attya Omer Javed, Heather R Keys, Tenzin Lungjangwa, Irene Bosch, Mehreen Khan, Maria C Virgilio, Lee Gehrke, David M Sabatini, Rudolf Jaenisch
Genome-wide CRISPR screen for Zika virus resistance in human neural cells. Proceedings of the National Academy of Sciences of the United States of America 116 (19) (2019)
Kacper B Rogala, Xin Gu, Jibril F Kedir, Monther Abu-Remaileh, Laura F Bianchi, Alexia M S Bottino, Rikke Dueholm, Anna Niehaus, Daan Overwijn, Ange-Célia Priso Fils, Sherry X Zhou, Daniel D Leary, Nouf N Laqtom, Edward J Brignole, David M Sabatini
Structural basis for the docking of mTORC1 on the lysosomal surface. Science (New York, N.Y.) 366 (6464) (2019)
Chintan K Kikani, Xiaoying Wu, Sarah Fogarty, Seong Anthony Woo Kang, Noah Dephoure, Steven P Gygi, David M Sabatini, Jared Rutter
Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program. Proceedings of the National Academy of Sciences of the United States of America 116 (21) (2019)
Erol C Bayraktar, Lou Baudrier, Ceren Özerdem, Caroline A Lewis, Sze Ham Chan, Tenzin Kunchok, Monther Abu-Remaileh, Andrew L Cangelosi, David M Sabatini, Kıvanç Birsoy, Walter W Chen
MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. Proceedings of the National Academy of Sciences of the United States of America 116 (1) (2018)
Jin-Mi Heo, Alban Ordureau, S Swarup, Joao A Paulo, K Shen, David M Sabatini, J Wade Harper
RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway. Science advances 4 (11) (2018)
Gregory A Wyant, Monther Abu-Remaileh, Evgeni M Frenkel, Nouf N Laqtom, Vimisha Dharamdasani, Caroline A Lewis, Sze Ham Chan, Ivonne Heinze, Alessandro Ori, David M Sabatini
NUFIP1 is a ribosome receptor for starvation-induced ribophagy. Science (New York, N.Y.) 360 (6390) (2018)
Xin Gu, Jose M Orozco, Robert A Saxton, Kendall J Condon, Grace Y Liu, Patrycja A Krawczyk, Sonia M Scaria, J Wade Harper, Steven P Gygi, David M Sabatini
SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Science (New York, N.Y.) 358 (6364) (2018)
Kuang Shen, David M Sabatini
Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms. Proceedings of the National Academy of Sciences of the United States of America 115 (38) (2018)
Monther Abu-Remaileh, Gregory A Wyant, Choah Kim, Nouf N Laqtom, Maria Abbasi, Sze Ham Chan, Elizaveta Freinkman, David M Sabatini
Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes. Science (New York, N.Y.) 358 (6364) (2017)
David M Sabatini
Twenty-five years of mTOR: Uncovering the link from nutrients to growth. Proceedings of the National Academy of Sciences of the United States of America 114 (45) (2017)