Nir Hacohen

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 99

Top Topics

Small Cell Lung Cancer

Immune Response

Dendritic Cells

Top Venues

Nature medicine

Nature communications

Science (New York, N.Y.)

This page only lists publications with an associated author ORCID identifier.

Publications

Meghan J Mooradian, Florian J Fintelmann, Thomas J LaSalle, Judit Simon, Alexander Graur, Alona Muzikansky, Mari Mino-Kenudson, Sophia Z Shalhout, Howard L Kaufman, Russell William Jenkins, Donald Lawrence, Aleigha Lawless, Tatyana Sharova, Raul N Uppot, Jacy Fang, Emily M Blaum, Anna L K Gonye, Irena Gushterova, Genevieve Marie Boland, Christopher Azzoli, Nir Hacohen, Moshe Sade-Feldman, Ryan J Sullivan
Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial. Nature communications 15 (1) (2024)
Matteo Gentili, Rebecca J Carlson, Bingxu Liu, Quentin Hellier, Jocelyn Andrews, Yue Qin, Paul C Blainey, Nir Hacohen
Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening. bioRxiv : the preprint server for biology (2024)
Molly Fisher Thomas, Kamil Slowikowski, Kasidet Manakongtreecheep, Pritha Sen, Nandini Samanta, Jessica Tantivit, Mazen Nasrallah, Leyre Zubiri, Neal P Smith, Alice Tirard, Swetha Ramesh, Benjamin Y Arnold, Linda T Nieman, Jonathan H Chen, Thomas Eisenhaure, Karin Pelka, Yuhui Song, Katherine H Xu, Vjola Jorgji, Christopher J Pinto, Tatyana Sharova, Rachel Glasser, PuiYee Chan, Ryan J Sullivan, Hamed Khalili, Dejan Juric, Genevieve Marie Boland, Michael Dougan, Nir Hacohen, Bo Li, Kerry L Reynolds, Alexandra-Chloé Villani
Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis. Nature medicine 30 (5) (2024)
Meghan J Mooradian, Florian J Fintelmann, Thomas J LaSalle, Judit Simon, Alexander Graur, Alona Muzikansky, Mari Mino-Kenudson, Sophia Z Shalhout, Howard L Kaufman, Russell William Jenkins, Donald Lawrence, Aleigha Lawless, Tatyana Sharova, Raul N Uppot, Jacy Fang, Emily M Blaum, Anna L K Gonye, Irena Gushterova, Genevieve Marie Boland, Christopher Azzoli, Nir Hacohen, Moshe Sade-Feldman, Ryan J Sullivan
Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial. Nature communications 15 (1) (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Meghan J Mooradian, Florian J Fintelmann, Thomas J LaSalle, Judit Simon, Alexander Graur, Alona Muzikansky, Mari Mino-Kenudson, Sophia Z Shalhout, Howard L Kaufman, Russell William Jenkins, Donald Lawrence, Aleigha Lawless, Tatyana Sharova, Raul N Uppot, Jacy Fang, Emily M Blaum, Anna L K Gonye, Irena Gushterova, Genevieve Marie Boland, Christopher Azzoli, Nir Hacohen, Moshe Sade-Feldman, Ryan J Sullivan
Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial. Nature communications 15 (1) (2024)
Molly Fisher Thomas, Kamil Slowikowski, Kasidet Manakongtreecheep, Pritha Sen, Nandini Samanta, Jessica Tantivit, Mazen Nasrallah, Leyre Zubiri, Neal P Smith, Alice Tirard, Swetha Ramesh, Benjamin Y Arnold, Linda T Nieman, Jonathan H Chen, Thomas Eisenhaure, Karin Pelka, Yuhui Song, Katherine H Xu, Vjola Jorgji, Christopher J Pinto, Tatyana Sharova, Rachel Glasser, PuiYee Chan, Ryan J Sullivan, Hamed Khalili, Dejan Juric, Genevieve Marie Boland, Michael Dougan, Nir Hacohen, Bo Li, Kerry L Reynolds, Alexandra-Chloé Villani
Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis. Nature medicine (2024)
Jonathan H Chen, Linda T Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine H Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta, Christopher S Nabel, Samuel S Freeman, Joshua D Pirl, Chenyue Lu, Catherine B Meador, Jaimie L Barth, Mustafa Sakhi, Alexander L Tang, Siranush Sarkizova, Colles Price, Nicolas F Fernandez, George Emanuel, Jiang He, Katrina Van Raay, Jason W Reeves, Keren Yizhak, Matan Hofree, Angela R Shih, Moshe Sade-Feldman, Genevieve Marie Boland, Karin Pelka, Martin J Aryee, Mari A Mino-Kenudson, Justin F Gainor, Ilya Korsunsky, Nir Hacohen
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy. Nature immunology (2024)
Jonathan H Chen, Linda T Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine H Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta, Christopher S Nabel, Samuel S Freeman, Joshua D Pirl, Chenyue Lu, Catherine B Meador, Jaimie L Barth, Mustafa Sakhi, Alexander L Tang, Siranush Sarkizova, Colles Price, Nicolas F Fernandez, George Emanuel, Jiang He, Katrina Van Raay, Jason W Reeves, Keren Yizhak, Matan Hofree, Angela R Shih, Moshe Sade-Feldman, Genevieve Marie Boland, Karin Pelka, Martin J Aryee, Mari A Mino-Kenudson, Justin F Gainor, Ilya Korsunsky, Nir Hacohen
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy. Nature immunology 25 (4) (2024)
Rebecca J Carlson, J J Patten, George Stefanakis, Brian Y Soong, Adityanarayanan Radhakrishnan, Avtar Singh, Naveen Thakur, Gaya K Amarasinghe, Nir Hacohen, Christopher F Basler, Daisy W Leung, Caroline Uhler, Robert A Davey, Paul C Blainey
Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics. bioRxiv : the preprint server for biology (2024)
Matteo Gentili, Rebecca J Carlson, Bingxu Liu, Quentin Hellier, Jocelyn Andrews, Yue Qin, Paul C Blainey, Nir Hacohen
Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening. bioRxiv : the preprint server for biology (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Jonathan H Chen, Linda T Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine H Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta, Christopher S Nabel, Samuel S Freeman, Joshua D Pirl, Chenyue Lu, Catherine B Meador, Jaimie L Barth, Mustafa Sakhi, Alexander L Tang, Siranush Sarkizova, Colles Price, Nicolas F Fernandez, George Emanuel, Jiang He, Katrina Van Raay, Jason W Reeves, Keren Yizhak, Matan Hofree, Angela R Shih, Moshe Sade-Feldman, Genevieve Marie Boland, Karin Pelka, Martin J Aryee, Mari A Mino-Kenudson, Justin F Gainor, Ilya Korsunsky, Nir Hacohen
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy. Nature immunology 25 (4) (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Lauren E Milling, Samuel C Markson, Qin Tjokrosurjo, Nicole M Derosia, Ivy S L Streeter, Grant H Hickok, Ashlyn M Lemmen, Thao H Nguyen, Priyamvada Prathima, William Fithian, Marc Andre Schwartz, Nir Hacohen, John G Doench, Martin W LaFleur, Arlene H Sharpe
Framework for in vivo T cell screens. The Journal of experimental medicine 221 (4) (2024)
Rebecca J Carlson, J J Patten, George Stefanakis, Brian Y Soong, Adityanarayanan Radhakrishnan, Avtar Singh, Naveen Thakur, Gaya K Amarasinghe, Nir Hacohen, Christopher F Basler, Daisy W Leung, Caroline Uhler, Robert A Davey, Paul C Blainey
Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics. bioRxiv : the preprint server for biology (2024)
Rebecca J Carlson, J J Patten, George Stefanakis, Brian Y Soong, Adityanarayanan Radhakrishnan, Avtar Singh, Naveen Thakur, Gaya K Amarasinghe, Nir Hacohen, Christopher F Basler, Daisy W Leung, Caroline Uhler, Robert A Davey, Paul C Blainey
Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics. bioRxiv : the preprint server for biology (2024)
Jonathan H Chen, Linda T Nieman, Maxwell Spurrell, Vjola Jorgji, Liad Elmelech, Peter Richieri, Katherine H Xu, Roopa Madhu, Milan Parikh, Izabella Zamora, Arnav Mehta, Christopher S Nabel, Samuel S Freeman, Joshua D Pirl, Chenyue Lu, Catherine B Meador, Jaimie L Barth, Mustafa Sakhi, Alexander L Tang, Siranush Sarkizova, Colles Price, Nicolas F Fernandez, George Emanuel, Jiang He, Katrina Van Raay, Jason W Reeves, Keren Yizhak, Matan Hofree, Angela R Shih, Moshe Sade-Feldman, Genevieve Marie Boland, Karin Pelka, Martin J Aryee, Mari A Mino-Kenudson, Justin F Gainor, Ilya Korsunsky, Nir Hacohen
Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy. Nature immunology 25 (4) (2024)
Meghan J Mooradian, Florian J Fintelmann, Thomas J LaSalle, Judit Simon, Alexander Graur, Alona Muzikansky, Mari Mino-Kenudson, Sophia Z Shalhout, Howard L Kaufman, Russell William Jenkins, Donald Lawrence, Aleigha Lawless, Tatyana Sharova, Raul N Uppot, Jacy Fang, Emily M Blaum, Anna L K Gonye, Irena Gushterova, Genevieve Marie Boland, Christopher Azzoli, Nir Hacohen, Moshe Sade-Feldman, Ryan J Sullivan
Cryoablation and post-progression immune checkpoint inhibition in metastatic melanoma: a phase II trial. Nature communications 15 (1) (2024)
Molly Fisher Thomas, Kamil Slowikowski, Kasidet Manakongtreecheep, Pritha Sen, Nandini Samanta, Jessica Tantivit, Mazen Nasrallah, Leyre Zubiri, Neal P Smith, Alice Tirard, Swetha Ramesh, Benjamin Y Arnold, Linda T Nieman, Jonathan H Chen, Thomas Eisenhaure, Karin Pelka, Yuhui Song, Katherine H Xu, Vjola Jorgji, Christopher J Pinto, Tatyana Sharova, Rachel Glasser, PuiYee Chan, Ryan J Sullivan, Hamed Khalili, Dejan Juric, Genevieve Marie Boland, Michael Dougan, Nir Hacohen, Bo Li, Kerry L Reynolds, Alexandra-Chloé Villani
Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis. Nature medicine 30 (5) (2024)
Rebecca J Carlson, J J Patten, George Stefanakis, Brian Y Soong, Adityanarayanan Radhakrishnan, Avtar Singh, Naveen Thakur, Gaya K Amarasinghe, Nir Hacohen, Christopher F Basler, Daisy W Leung, Caroline Uhler, Robert A Davey, Paul C Blainey
Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics. bioRxiv : the preprint server for biology (2024)
Aereas Aung, Ang Cui, Laura Maiorino, Ava P Soleimany, Justin R Gregory, Maurice Bukenya, Yiming J Zhang, Heya Lee, Christopher A Cottrell, Duncan M Morgan, Murillo Silva, Heikyung Suh, Jesse D Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Leah M Froehle, Shuhao Xiao, Wuhbet Abraham, Josetta Adams, John Christopher Love, Phillip Huyett, Douglas S Kwon, Nir Hacohen, William R Schief, Sangeeta N Bhatia, Darrell J Irvine
Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science (New York, N.Y.) 379 (6630) (2023)
Miguel Reyes, Samantha M Leff, Matteo Gentili, Nir Hacohen, Paul C Blainey
Microscale combinatorial stimulation of human myeloid cells reveals inflammatory priming by viral ligands. Science advances 9 (8) (2023)
Aereas Aung, Ang Cui, Laura Maiorino, Ava P Soleimany, Justin R Gregory, Maurice Bukenya, Yiming J Zhang, Heya Lee, Christopher A Cottrell, Duncan M Morgan, Murillo Silva, Heikyung Suh, Jesse D Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Leah M Froehle, Shuhao Xiao, Wuhbet Abraham, Josetta Adams, John Christopher Love, Phillip Huyett, Douglas S Kwon, Nir Hacohen, William R Schief, Sangeeta N Bhatia, Darrell J Irvine
Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science (New York, N.Y.) 379 (6630) (2023)
Aereas Aung, Ang Cui, Laura Maiorino, Ava P Soleimany, Justin R Gregory, Maurice Bukenya, Yiming J Zhang, Heya Lee, Christopher A Cottrell, Duncan M Morgan, Murillo Silva, Heikyung Suh, Jesse D Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Leah M Froehle, Shuhao Xiao, Wuhbet Abraham, Josetta Adams, John Christopher Love, Phillip Huyett, Douglas S Kwon, Nir Hacohen, William R Schief, Sangeeta N Bhatia, Darrell J Irvine
Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science (New York, N.Y.) 379 (6630) (2023)
Yi Sun, Or-Yam Revach, Seth Anderson, Emily A Kessler, Clara H Wolfe, Anne Jenney, Caitlin E Mills, Emily J Robitschek, Thomas G R Davis, Sarah Kim, Amina Fu, Xiang Ma, Jia Gwee, Payal Tiwari, Peter P Du, Princy Sindurakar, Jun Tian, Arnav Mehta, Alexis M Schneider, Keren Yizhak, Moshe Sade-Feldman, Thomas LaSalle, Tatyana Sharova, Hongyan Xie, Shuming Liu, William A Michaud, Rodrigo Saad-Beretta, Kathleen B Yates, Arvin Iracheta-Vellve, Johan K E Spetz, Xingping Qin, Kristopher A Sarosiek, Gao Zhang, Jong Wook Kim, Mack Y Su, Angelina M Cicerchia, Martin Q Rasmussen, Samuel J Klempner, Dejan Juric, Sara I Pai, David M Miller, Anita Giobbie-Hurder, Jonathan H Chen, Karin Pelka, Dennie T Frederick, Susanna Stinson, Elena Ivanova, Amir R Aref, Cloud P Paweletz, David A Barbie, Debattama R Sen, David E Fisher, Ryan B Corcoran, Nir Hacohen, Peter Karl Sorger, Keith T Flaherty, Genevieve M Boland, Robert T Manguso, Russell William Jenkins
Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature (2023)
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah O Dele-Oni, Marc A Schwartz, Rebecca J Carlson, Aziz M Al'Khafaji, Karsten Krug, Adam Brown, John G Doench, Steven A Carr, Nir Hacohen
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature communications 14 (1) (2023)
Aereas Aung, Ang Cui, Laura Maiorino, Ava P Soleimany, Justin R Gregory, Maurice Bukenya, Yiming J Zhang, Heya Lee, Christopher A Cottrell, Duncan M Morgan, Murillo Silva, Heikyung Suh, Jesse D Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Leah M Froehle, Shuhao Xiao, Wuhbet Abraham, Josetta Adams, John Christopher Love, Phillip Huyett, Douglas S Kwon, Nir Hacohen, William R Schief, Sangeeta N Bhatia, Darrell J Irvine
Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science (New York, N.Y.) 379 (6630) (2023)
Jun Tian, Jonathan H Chen, Sherry X Chao, Karin Pelka, Marios Giannakis, Julian M Hess, Kelly P Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N Allen, Thomas A Abrams, Jeffrey W Clark, Andrea C Enzinger, Peter C Enzinger, Samuel J Klempner, Nadine Jackson McCleary, Jeffrey A Meyerhardt, David P Ryan, Matthew B Yurgelun, Katie N Kanter, Emily E Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B Bradford, Edmond Wong, Alexa G Michel, Isobel J Fetter, Giulia Siravegna, Angelo J Gemma, Arlene H Sharpe, Shadhmer Demehri, Rebecca Leary, Catarina D Campbell, Omer Yilmaz, Gad A Getz, Aparna Raj Parikh, Nir Hacohen, Ryan B Corcoran
Combined PD-1, BRAF and MEK inhibition in BRAF V600E colorectal cancer: a phase 2 trial. Nature medicine (2023)
Douglas B Fox, Richard Y Ebright, Xin Hong, Hunter C Russell, Hongshan Guo, Thomas J LaSalle, Ben S Wittner, Nicolas Poux, Joanna A Vuille, Mehmet Toner, Nir Hacohen, Genevieve Marie Boland, Debattama R Sen, Ryan J Sullivan, Shyamala Maheswaran, Daniel A Haber
Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade. NPJ precision oncology 7 (1) (2023)
Aereas Aung, Ang Cui, Laura Maiorino, Ava P Soleimany, Justin R Gregory, Maurice Bukenya, Yiming J Zhang, Heya Lee, Christopher A Cottrell, Duncan M Morgan, Murillo Silva, Heikyung Suh, Jesse D Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Leah M Froehle, Shuhao Xiao, Wuhbet Abraham, Josetta Adams, John Christopher Love, Phillip Huyett, Douglas S Kwon, Nir Hacohen, William R Schief, Sangeeta N Bhatia, Darrell J Irvine
Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science (New York, N.Y.) 379 (6630) (2023)
Jun Tian, Jonathan H Chen, Sherry X Chao, Karin Pelka, Marios Giannakis, Julian M Hess, Kelly P Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N Allen, Thomas A Abrams, Jeffrey W Clark, Andrea C Enzinger, Peter C Enzinger, Samuel J Klempner, Nadine Jackson McCleary, Jeffrey A Meyerhardt, David P Ryan, Matthew B Yurgelun, Katie N Kanter, Emily E Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B Bradford, Edmond Wong, Alexa G Michel, Isobel J Fetter, Giulia Siravegna, Angelo J Gemma, Arlene H Sharpe, Shadhmer Demehri, Rebecca Leary, Catarina D Campbell, Omer Yilmaz, Gad A Getz, Aparna Raj Parikh, Nir Hacohen, Ryan B Corcoran
Combined PD-1, BRAF and MEK inhibition in BRAF V600E colorectal cancer: a phase 2 trial. Nature medicine 29 (2) (2023)
Jun Tian, Jonathan H Chen, Sherry X Chao, Karin Pelka, Marios Giannakis, Julian M Hess, Kelly P Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N Allen, Thomas A Abrams, Jeffrey W Clark, Andrea C Enzinger, Peter C Enzinger, Samuel J Klempner, Nadine Jackson McCleary, Jeffrey A Meyerhardt, David P Ryan, Matthew B Yurgelun, Katie N Kanter, Emily E Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B Bradford, Edmond Wong, Alexa G Michel, Isobel J Fetter, Giulia Siravegna, Angelo J Gemma, Arlene H Sharpe, Shadhmer Demehri, Rebecca Leary, Catarina D Campbell, Omer Yilmaz, Gad A Getz, Aparna Raj Parikh, Nir Hacohen, Ryan B Corcoran
Combined PD-1, BRAF and MEK inhibition in BRAF V600E colorectal cancer: a phase 2 trial. Nature medicine 29 (2) (2023)
Aereas Aung, Ang Cui, Laura Maiorino, Ava P Soleimany, Justin R Gregory, Maurice Bukenya, Yiming J Zhang, Heya Lee, Christopher A Cottrell, Duncan M Morgan, Murillo Silva, Heikyung Suh, Jesse D Kirkpatrick, Parastoo Amlashi, Tanaka Remba, Leah M Froehle, Shuhao Xiao, Wuhbet Abraham, Josetta Adams, John Christopher Love, Phillip Huyett, Douglas S Kwon, Nir Hacohen, William R Schief, Sangeeta N Bhatia, Darrell J Irvine
Low protease activity in B cell follicles promotes retention of intact antigens after immunization. Science (New York, N.Y.) 379 (6630) (2023)
Douglas B Fox, Richard Y Ebright, Xin Hong, Hunter C Russell, Hongshan Guo, Thomas J LaSalle, Ben S Wittner, Nicolas Poux, Joanna A Vuille, Mehmet Toner, Nir Hacohen, Genevieve Marie Boland, Debattama R Sen, Ryan J Sullivan, Shyamala Maheswaran, Daniel A Haber
Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade. NPJ precision oncology 7 (1) (2023)
Jun Tian, Jonathan H Chen, Sherry X Chao, Karin Pelka, Marios Giannakis, Julian M Hess, Kelly P Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N Allen, Thomas A Abrams, Jeffrey W Clark, Andrea C Enzinger, Peter C Enzinger, Samuel J Klempner, Nadine Jackson McCleary, Jeffrey A Meyerhardt, David P Ryan, Matthew B Yurgelun, Katie N Kanter, Emily E Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B Bradford, Edmond Wong, Alexa G Michel, Isobel J Fetter, Giulia Siravegna, Angelo J Gemma, Arlene H Sharpe, Shadhmer Demehri, Rebecca Leary, Catarina D Campbell, Omer Yilmaz, Gad A Getz, Aparna Raj Parikh, Nir Hacohen, Ryan B Corcoran
Combined PD-1, BRAF and MEK inhibition in BRAF V600E colorectal cancer: a phase 2 trial. Nature medicine (2023)
Ruben Bill, Pratyaksha Wirapati, Marius Messemaker, Whijae Roh, Beatrice Zitti, Florent Duval, Máté Kiss, Jong Chul Park, Talia M Saal, Jan Hoelzl, David Tarussio, Fabrizio Benedetti, Stéphanie R Tissot, Lana Elias Kandalaft, Marco Varrone, Giovanni Ciriello, Thomas A McKee, Yan Monnier, Maxime Mermod, Emily M Blaum, Irena Gushterova, Anna L K Gonye, Nir Hacohen, Gad A Getz, Thorsten R Mempel, Allon M Klein, Ralph Weissleder, William C Faquin Md PhD, Peter M Sadow, Derrick Lin, Sara I Pai, Moshe Sade-Feldman, Mikaël J Pittet
CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers. Science (New York, N.Y.) 381 (6657) (2023)
Jun Tian, Jonathan H Chen, Sherry X Chao, Karin Pelka, Marios Giannakis, Julian M Hess, Kelly P Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N Allen, Thomas A Abrams, Jeffrey W Clark, Andrea C Enzinger, Peter C Enzinger, Samuel J Klempner, Nadine Jackson McCleary, Jeffrey A Meyerhardt, David P Ryan, Matthew B Yurgelun, Katie N Kanter, Emily E Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B Bradford, Edmond Wong, Alexa G Michel, Isobel J Fetter, Giulia Siravegna, Angelo J Gemma, Arlene H Sharpe, Shadhmer Demehri, Rebecca Leary, Catarina D Campbell, Omer Yilmaz, Gad A Getz, Aparna Raj Parikh, Nir Hacohen, Ryan B Corcoran
Combined PD-1, BRAF and MEK inhibition in BRAF V600E colorectal cancer: a phase 2 trial. Nature medicine (2023)
Matteo Gentili, Bingxu Liu, Malvina Papanastasiou, Deborah O Dele-Oni, Marc A Schwartz, Rebecca J Carlson, Aziz M Al'Khafaji, Karsten Krug, Adam Brown, John G Doench, Steven A Carr, Nir Hacohen
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling. Nature communications 14 (1) (2023)
Jun Tian, Jonathan H Chen, Sherry X Chao, Karin Pelka, Marios Giannakis, Julian M Hess, Kelly P Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N Allen, Thomas A Abrams, Jeffrey W Clark, Andrea C Enzinger, Peter C Enzinger, Samuel J Klempner, Nadine Jackson McCleary, Jeffrey A Meyerhardt, David P Ryan, Matthew B Yurgelun, Katie N Kanter, Emily E Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B Bradford, Edmond Wong, Alexa G Michel, Isobel J Fetter, Giulia Siravegna, Angelo J Gemma, Arlene H Sharpe, Shadhmer Demehri, Rebecca Leary, Catarina D Campbell, Omer Yilmaz, Gad A Getz, Aparna Raj Parikh, Nir Hacohen, Ryan B Corcoran
Combined PD-1, BRAF and MEK inhibition in BRAF V600E colorectal cancer: a phase 2 trial. Nature medicine 29 (2) (2023)
Jun Tian, Jonathan H Chen, Sherry X Chao, Karin Pelka, Marios Giannakis, Julian M Hess, Kelly P Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N Allen, Thomas A Abrams, Jeffrey W Clark, Andrea C Enzinger, Peter C Enzinger, Samuel J Klempner, Nadine Jackson McCleary, Jeffrey A Meyerhardt, David P Ryan, Matthew B Yurgelun, Katie N Kanter, Emily E Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B Bradford, Edmond Wong, Alexa G Michel, Isobel J Fetter, Giulia Siravegna, Angelo J Gemma, Arlene H Sharpe, Shadhmer Demehri, Rebecca Leary, Catarina D Campbell, Omer Yilmaz, Gad A Getz, Aparna Raj Parikh, Nir Hacohen, Ryan B Corcoran
Combined PD-1, BRAF and MEK inhibition in BRAF V600E colorectal cancer: a phase 2 trial. Nature medicine 29 (2) (2023)
Douglas B Fox, Richard Y Ebright, Xin Hong, Hunter C Russell, Hongshan Guo, Thomas J LaSalle, Ben S Wittner, Nicolas Poux, Joanna A Vuille, Mehmet Toner, Nir Hacohen, Genevieve Marie Boland, Debattama R Sen, Ryan J Sullivan, Shyamala Maheswaran, Daniel A Haber
Downregulation of KEAP1 in melanoma promotes resistance to immune checkpoint blockade. NPJ precision oncology 7 (1) (2023)
Rebecca J Carlson, Michael D Leiken, Alina Guna, Nir Hacohen, Paul C Blainey
A genome-wide optical pooled screen reveals regulators of cellular antiviral responses. Proceedings of the National Academy of Sciences of the United States of America 120 (16) (2023)
Michael-John Dolan, Martine Therrien, Saša Jereb, Tushar Kamath, Vahid Gazestani, Trevor Atkeson, Samuel E Marsh, Aleksandrina Goeva, Neal M Lojek, Sarah Murphy, Cassandra M White, Julia Joung, Bingxu Liu, Francesco Limone, Kevin Eggan, Nir Hacohen, Bradley E Bernstein, Christopher K Glass, Ville Leinonen, Mathew Blurton Jones, Feng Zhang, Charles B Epstein, Evan Z Macosko, Beth Stevens
Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro. Nature immunology (2023)
Miguel Reyes, Samantha M Leff, Matteo Gentili, Nir Hacohen, Paul C Blainey
Microscale combinatorial stimulation of human myeloid cells reveals inflammatory priming by viral ligands. Science advances 9 (8) (2023)
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An immune-cell signature of bacterial sepsis. Nature medicine 26 (3) (2020)
Niyati Desai, Azfar Neyaz, Annamaria Szabolcs, Angela R Shih, Jonathan H Chen, Vishal Thapar, Linda T Nieman, Alexander Solovyov, Arnav Mehta, David J Lieb, Anupriya S Kulkarni, Christopher Jaicks, Katherine H Xu, Michael J Raabe, Christopher J Pinto, Dejan Juric, Ivan Chebib, Robert B Colvin, Arthur Y Kim, Robert Monroe, Sarah E Warren, Patrick Danaher, Jason W Reeves, Jingjing Gong, Erroll H Rueckert, Benjamin D Greenbaum, Nir Hacohen, Stephen M Lagana, Miguel N Rivera, Lynette M Sholl, James R Stone, David Tsai Ting, Vikram Deshpande
Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection. Nature communications 11 (1) (2020)
Caleb A Lareau, Leif S Ludwig, Christoph Muus, Satyen H Gohil, Tongtong Zhao, Zachary Chiang, Karin Pelka, Jeffrey M Verboon, Wendy Luo, Elena Christian, Daniel Rosebrock, Gad A Getz, Genevieve M Boland, Fei Chen, Jason D Buenrostro, Nir Hacohen, Catherine J Wu, Martin J Aryee, Aviv Regev, Vijay G Sankaran
Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling. Nature biotechnology 39 (4) (2020)
Ellen L Shrock, Eric Fujimura, Tomasz Kula, Richard T Timms, I-Hsiu Lee, Yumei Leng, Matthew L Robinson, Brandon M Sie, Mamie Z Li, Yuezhou Chen, Jennifer Logue, Adam Zuiani, Denise J McCulloch, Felipe J N Lelis, Stephanie Henson, Daniel R Monaco, Meghan Travers, Shaghayegh Habibi, William A Clarke, Patrizio Caturegli, Oliver Laeyendecker, Alicja Piechocka-Trocha, Jonathan Z Li, Ashok Khatri, Helen Y Chu, null null, Alexandra-Chloé Villani, Kyle Kays, Marcia B Goldberg, Nir Hacohen, Michael R Filbin, Xu G Yu, Bruce D Walker, Duane R Wesemann, H Benjamin Larman, James A Lederer, Stephen J Elledge
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science (New York, N.Y.) 370 (6520) (2020)
Vivek Verma, Rajeev K Shrimali, Shamim Ahmad, Winjie Dai, Hua Wang, Sumin Lu, Rahul Nandre, Pankaj Gaur, Jose Lopez, Moshe Sade-Feldman, Keren Yizhak, Stacey L Bjorgaard, Keith T Flaherty, Jennifer A Wargo, Genevieve M Boland, Ryan J Sullivan, Gad A Getz, Scott A Hammond, Ming Tan, Jingjing Qi, Phillip Wong, Taha Merghoub, Jedd D Wolchok, Nir Hacohen, John E Janik, Mikayel Mkrtichyan, Seema Gupta, Samir N Khleif
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance. Nature immunology 20 (9) (2019)
Arnon Arazi, Deepak A Rao, Celine C Berthier, Anne Davidson, Yanyan Liu, Paul J Hoover, Adam Chicoine, Thomas M Eisenhaure, A Helena Jonsson, Shuqiang Li, David J Lieb, Fan Zhang, Kamil Slowikowski, Edward P Browne, Akiko Noma, Danielle Sutherby, Scott Steelman, Dawn E Smilek, Patti Tosta, William Apruzzese, Elena Massarotti, Maria Dall'Era, Meyeon Park, Diane L Kamen, Richard A Furie, Fernanda Payan-Schober, William F Pendergraft, Elizabeth A McInnis, Jill P Buyon, Michelle A Petri, Chaim Putterman, Kenneth C Kalunian, E Steve Woodle, James A Lederer, David A Hildeman, Chad Nusbaum, Soumya Raychaudhuri, Matthias Kretzler, Jennifer H Anolik, Michael B Brenner, David Wofsy, Nir Hacohen, Betty Diamond, null null
The immune cell landscape in kidneys of patients with lupus nephritis. Nature immunology 20 (7) (2019)
Miguel Reyes, Dwayne Vickers, Kianna Billman, Thomas Eisenhaure, Paul Hoover, Edward P Browne, Deepak A Rao, Nir Hacohen, Paul C Blainey
Multiplexed enrichment and genomic profiling of peripheral blood cells reveal subset-specific immune signatures. Science advances 5 (1) (2019)
Siranush Sarkizova, Susan Klaeger, Phuong M Le, Letitia W Li, Giacomo Oliveira, Hasmik Keshishian, Christina R Hartigan, Wandi Zhang, David A Braun, Keith L Ligon, Pavan Bachireddy, Ioannis K Zervantonakis, Jennifer M Rosenbluth, Tamara Ouspenskaia, Travis Law, Sune Justesen, Jonathan Stevens, William J Lane, Thomas Eisenhaure, Guang Lan Zhang, Karl R Clauser, Nir Hacohen, Steven A Carr, Catherine J Wu, Derin B Keskin
A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Nature biotechnology 38 (2) (2019)
Kathleen M Mahoney, Sachet A Shukla, Nikolaos Patsoukis, Apoorvi Chaudhri, Edward P Browne, Arnon Arazi, Thomas M Eisenhaure, William F Pendergraft, Ping Hua, Hung C Pham, Xia Bu, Baogong Zhu, Nir Hacohen, Edward F Fritsch, Vassiliki A Boussiotis, Catherine J Wu, Gordon J Freeman
A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression. Cancer immunology, immunotherapy : CII 68 (3) (2018)
Sharon R Grossman, Jesse Engreitz, John P Ray, Tung H Nguyen, Nir Hacohen, Eric S Lander
Positional specificity of different transcription factor classes within enhancers. Proceedings of the National Academy of Sciences of the United States of America 115 (30) (2018)
Alexandra-Chloé Villani, Rahul Satija, Gary Reynolds, Siranush Sarkizova, Karthik Shekhar, James Fletcher, Morgane Griesbeck, Andrew W Butler, Shiwei Zheng, Suzan Lazo, Laura Jardine, David Dixon, Emily Stephenson, Emil Nilsson, Ida Grundberg, David McDonald, Andrew Filby, Weibo Li, Philip L De Jager, Orit Rozenblatt-Rosen, Andrew A Lane, Muzlifah A Haniffa, Aviv Regev, Nir Hacohen
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science (New York, N.Y.) 356 (6335) (2017)