Heinrich Leonhardt (H Leonhardt)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 44

Top Topics

Acute Myeloid Leukemia

Dna Methylation

Gene Expression

Top Venues

Nature communications

Nucleus (Austin, Tex.)

Nucleic acids research

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, Fumihito Miura, Pavel Bashtrykov, Frédéric Bonhomme, Catalina Salinas-Luypaert, Deis Haxholli, Nicole Gutekunst, Bihter Özdemir Aygenli, Laure Ferry, Olivier Kirsh, Marthe Laisné, Andrea Scelfo, Enes Ugur, Paola B Arimondo, Heinrich Leonhardt, Masato T Kanemaki, Till Bartke, Daniele Fachinetti, Albert Jeltsch, Takashi Ito, Pierre-Antoine Defossez
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells. Nature communications 15 (1) (2024)
Dieter Weichenhan, Anna Riedel, Etienne Sollier, Umut H Toprak, Joschka Hey, Kersten Henrik Breuer, Justyna Anna Wierzbinska, Aurore Touzart, Pavlo Lutsik, Marion Bähr, Anders Östlund, Tina Nilsson, Susanna Jacobsson, Ahmed Waraky, Yvonne Lisa Behrens, Gudrun Göhring, Brigitte Schlegelberger, Clemens Steinek, Hartmann Harz, Heinrich Leonhardt, Anna Dolnik, Dirk Reinhardt, Lars Bullinger, Lars Palmqvist, Daniel B Lipka, Christoph Plass
Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13). Blood advances (2024)
Katharina Bachem, Xinyi Li, Stefano Ceolin, Bettina Mühling, David Hörl, Hartmann Harz, Heinrich Leonhardt, Laurent Arnoult, Sabrina Weber, Blair Matarlo, Benjamin Prud'homme, Nicolas Gompel
Regulatory evolution tuning pigmentation intensity quantitatively in Drosophila . Science advances 10 (4) (2024)
Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, Fumihito Miura, Pavel Bashtrykov, Frédéric Bonhomme, Catalina Salinas-Luypaert, Deis Haxholli, Nicole Gutekunst, Bihter Özdemir Aygenli, Laure Ferry, Olivier Kirsh, Marthe Laisné, Andrea Scelfo, Enes Ugur, Paola B Arimondo, Heinrich Leonhardt, Masato T Kanemaki, Till Bartke, Daniele Fachinetti, Albert Jeltsch, Takashi Ito, Pierre-Antoine Defossez
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells. Nature communications 15 (1) (2024)
Katharina Bachem, Xinyi Li, Stefano Ceolin, Bettina Mühling, David Hörl, Hartmann Harz, Heinrich Leonhardt, Laurent Arnoult, Sabrina Weber, Blair Matarlo, Benjamin Prud'homme, Nicolas Gompel
Regulatory evolution tuning pigmentation intensity quantitatively in Drosophila . Science advances 10 (4) (2024)
Katharina Bachem, Xinyi Li, Stefano Ceolin, Bettina Mühling, David Hörl, Hartmann Harz, Heinrich Leonhardt, Laurent Arnoult, Sabrina Weber, Blair Matarlo, Benjamin Prud'homme, Nicolas Gompel
Regulatory evolution tuning pigmentation intensity quantitatively in Drosophila . Science advances 10 (4) (2024)
Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, Fumihito Miura, Pavel Bashtrykov, Frédéric Bonhomme, Catalina Salinas-Luypaert, Deis Haxholli, Nicole Gutekunst, Bihter Özdemir Aygenli, Laure Ferry, Olivier Kirsh, Marthe Laisné, Andrea Scelfo, Enes Ugur, Paola B Arimondo, Heinrich Leonhardt, Masato T Kanemaki, Till Bartke, Daniele Fachinetti, Albert Jeltsch, Takashi Ito, Pierre-Antoine Defossez
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells. Nature communications 15 (1) (2024)
Kosuke Yamaguchi, Xiaoying Chen, Brianna Rodgers, Fumihito Miura, Pavel Bashtrykov, Frédéric Bonhomme, Catalina Salinas-Luypaert, Deis Haxholli, Nicole Gutekunst, Bihter Özdemir Aygenli, Laure Ferry, Olivier Kirsh, Marthe Laisné, Andrea Scelfo, Enes Ugur, Paola B Arimondo, Heinrich Leonhardt, Masato T Kanemaki, Till Bartke, Daniele Fachinetti, Albert Jeltsch, Takashi Ito, Pierre-Antoine Defossez
Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells. Nature communications 15 (1) (2024)
Hui Zhang, Weihua Qin, Hector Romero, Heinrich Leonhardt, Maria Cristina Cardoso
Heterochromatin organization and phase separation. Nucleus (Austin, Tex.) 14 (1) (2023)
Daniel Nixdorf, M Sponheimer, D Berghammer, Fabian Engert, U Bader, Nora Philipp, Maryam Kazerani, T Straub, L Rohrbacher, Lucas Esteban Wange, S Dapa, D Atar, C M Seitz, K Brandstetter, A Linder, M von Bergwelt, Heinrich Leonhardt, J Mittelstaet, A Kaiser, Veit L Bücklein, Marion Subklewe
Adapter CAR T cells to counteract T-cell exhaustion and enable flexible targeting in AML. Leukemia (2023)
Hui Zhang, Weihua Qin, Hector Romero, Heinrich Leonhardt, Maria Cristina Cardoso
Heterochromatin organization and phase separation. Nucleus (Austin, Tex.) 14 (1) (2023)
Karin A Ziegler, Andrea Ahles, Anne Dueck, Dena Esfandyari, Pauline Pichler, Karolin Weber, Stefan Kotschi, Alexander Bartelt, Inga Sinicina, Matthias Graw, Heinrich Leonhardt, Ludwig T Weckbach, Steffen Massberg, Martina Schifferer, Mikael Simons, Luciano Hoeher, Jie Luo, Ali Ertürk, Gabriele G Schiattarella, Yassine Sassi, Thomas Misgeld, Stefan Engelhardt
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease. Science (New York, N.Y.) 381 (6655) (2023)
Hui Zhang, Weihua Qin, Hector Romero, Heinrich Leonhardt, Maria Cristina Cardoso
Heterochromatin organization and phase separation. Nucleus (Austin, Tex.) 14 (1) (2023)
Enes Ugur, Alexandra de la Porte, Weihua Qin, Sebastian Bultmann, Alina Ivanova, Micha Drukker, Matthias Mann, Michael Wierer, Heinrich Leonhardt
Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components. Nucleic acids research (2023)
Hui Zhang, Weihua Qin, Hector Romero, Heinrich Leonhardt, Maria Cristina Cardoso
Heterochromatin organization and phase separation. Nucleus (Austin, Tex.) 14 (1) (2023)
Keiichi Hata, Naohiro Kobayashi, Keita Sugimura, Weihua Qin, Deis Haxholli, Yoshie Chiba, Sae Yoshimi, Gosuke Hayashi, Hiroki Onoda, Takahisa Ikegami, Christopher B Mulholland, Atsuya Nishiyama, Makoto Nakanishi, Heinrich Leonhardt, Tsuyoshi Konuma, Kyohei Arita
Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger. Nucleic acids research (2022)
Hui Zhang, Hector Romero, Annika Schmidt, Katalina Gagova, Weihua Qin, Bianca Bertulat, Anne Lehmkuhl, Manuela Milden, Malte Eck, Tobias Meckel, Heinrich Leonhardt, Maria Cristina Cardoso
MeCP2-induced heterochromatin organization is driven by oligomerization-based liquid-liquid phase separation and restricted by DNA methylation. Nucleus (Austin, Tex.) 13 (1) (2022)
Susanne Leidescher, Johannes Ribisel, Simon Ullrich, Yana Feodorova, Erica Hildebrand, Aleksandra A Galitsyna, Sebastian Bultmann, Stephanie Link, Katharina Thanisch, Christopher B Mulholland, Job Dekker, Heinrich Leonhardt, Leonid A Mirny, Irina Solovei
Spatial organization of transcribed eukaryotic genes. Nature cell biology 24 (3) (2022)
Weihua Qin, Andreas Stengl, Enes Ugur, Susanne Leidescher, Joel Ryan, Maria Cristina Cardoso, Heinrich Leonhardt
HP1β carries an acidic linker domain and requires H3K9me3 for phase separation. Nucleus (Austin, Tex.) 12 (1) (2022)
Zeyang Wang, Rui Fan, Angela Russo, Filippo M Cernilogar, Alexander Nuber, Silvia Schirge, Irina Shcherbakova, Iva Dzhilyanova, Enes Ugur, Tobias Anton, Lisa Richter, Heinrich Leonhardt, Heiko Lickert, Gunnar Schotta
Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm. Nature communications 13 (1) (2022)
Maike Roas, Binje Vick, Marc-André Kasper, Marina Able, Harald Polzer, Marcus Gerlach, Elisabeth Kremmer, Judith S Hecker, Saskia Schmitt, Andreas Stengl, Verena Waller, Natascha Hohmann, Moreno Festini, Alexander Edmund Ludwig, Lisa Rohrbacher, Tobias Herold, Marion Subklewe, Katharina S Götze, Christian P R Hackenberger, Dominik Schumacher, Jonas Helma-Smets, Irmela Jeremias, Heinrich Leonhardt, Karsten Spiekermann
TARGETING FLT3 BY NEW-GENERATION ANTIBODY-DRUG-CONJUGATE IN COMBINATION WITH KINASE INHIBITORS FOR TREATMENT OF AML. Blood (2022)
Paul Stolz, Angelo Salazar Mantero, Andrey Tvardovskiy, Enes Ugur, Lucas E Wange, Christopher B Mulholland, Yuying Cheng, Michael Wierer, Wolfgang Enard, Robert Schneider, Till Bartke, Heinrich Leonhardt, Simon J Elsässer, Sebastian Bultmann
TET1 regulates gene expression and repression of endogenous retroviruses independent of DNA demethylation. Nucleic acids research 50 (15) (2022)
Weihua Qin, Clemens Steinek, Ksenia Kolobynina, Ignasi Forné, Axel Imhof, Maria Cristina Cardoso, Heinrich Leonhardt
Probing protein ubiquitination in live cells. Nucleic acids research (2022)
Ningjun Duan, Maria Arroyo, Wen Deng, Maria Cristina Cardoso, Heinrich Leonhardt
Visualization and characterization of RNA-protein interactions in living cells. Nucleic acids research 49 (18) (2021)
Theresa Landspersky, Mehmet Saçma, Jennifer Rivière, Judith S Hecker, Franziska Hettler, Erik Hameister, Katharina Brandstetter, Rouzanna Istvanffy, Sandra Romero Marquez, Romina Ludwig, Marilena Götz, Michèle Constanze Buck, Martin Wolf, Matthias Schiemann, Juergen Ruland, Dirk Strunk, Akiko Shimamura, Kasiani C Myers, Terry P Yamaguchi, Matthias Kieslinger, Heinrich Leonhardt, Florian Bassermann, Katharina S Götze, Hartmut Geiger, Christina Schreck, Robert A J Oostendorp
Autophagy In Mesenchymal Progenitors Protects Mice Against Bone Marrow Failure After Severe Intermittent Stress. Blood (2021)
Weihua Qin, Enes Ugur, Christopher B Mulholland, Sebastian Bultmann, Irina Solovei, Miha Modic, Martha Smets, Michael Wierer, Ignasi Forné, Axel Imhof, Maria Cristina Cardoso, Heinrich Leonhardt
Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency. Nucleic acids research 49 (13) (2021)
Jian Lei, Yue Ma-Lauer, Yinze Han, Matthias Thoms, Robert Buschauer, Joerg Jores, Volker Thiel, Roland Beckmann, Wen Deng, Heinrich Leonhardt, Rolf Hilgenfeld, Albrecht von Brunn
The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation. The EMBO journal 40 (11) (2021)
Christopher Jakubke, Rodaria Roussou, Andreas Maiser, Christina Schug, Felix Thoma, David Bunk, David Hörl, Heinrich Leonhardt, Peter Walter, Till Klecker, Christof Osman
Cristae-dependent quality control of the mitochondrial genome. Science advances 7 (36) (2021)
Marc-André Kasper, Marcus Gerlach, Anselm F L Schneider, Christiane Groneberg, Philipp Ochtrop, Stefanie Boldt, Dominik Schumacher, Jonas Helma, Heinrich Leonhardt, Mathias Christmann, Christian P R Hackenberger
N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates. Chembiochem : a European journal of chemical biology 21 (1-2) (2020)
Atsuya Nishiyama, Christopher B Mulholland, Sebastian Bultmann, Satomi Kori, Akinori Endo, Yasushi Saeki, Weihua Qin, Carina Trummer, Yoshie Chiba, Haruka Yokoyama, Soichiro Kumamoto, Toru Kawakami, Hironobu Hojo, Genta Nagae, Hiroyuki Aburatani, Keiji Tanaka, Kyohei Arita, Heinrich Leonhardt, Makoto Nakanishi
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nature communications 11 (1) (2020)
Yann Le Poul, Yaqun Xin, Liucong Ling, Bettina Mühling, Rita Jaenichen, David Hörl, David Bunk, Hartmann Harz, Heinrich Leonhardt, Yingfei Wang, Elena Osipova, Mariam Museridze, Deepak Dharmadhikari, Eamonn Murphy, Remo Rohs, Stephan Preibisch, Benjamin Prud'homme, Nicolas Gompel
Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer. Science advances 6 (49) (2020)
Christopher B Mulholland, Atsuya Nishiyama, Joel Ryan, Ryohei Nakamura, Merve Yiğit, Ivo M Glück, Carina Trummer, Weihua Qin, Michael David Bartoschek, Franziska R Traube, Edris Parsa, Enes Ugur, Miha Modic, Aishwarya Acharya, Paul Stolz, Christoph Ziegenhain, Michael Wierer, Wolfgang Enard, Thomas Carell, Don C Lamb, Hiroyuki Takeda, Makoto Nakanishi, Sebastian Bultmann, Heinrich Leonhardt
Author Correction: Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nature communications 11 (1) (2020)
Andreas Maiser, Stefan Dillinger, Gernot Längst, Lothar Schermelleh, Heinrich Leonhardt, Attila Németh
Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus. Scientific reports 10 (1) (2020)
Wen Deng, Jack A Bates, Hai Wei, Michael David Bartoschek, Barbara Conradt, Heinrich Leonhardt
Tunable light and drug induced depletion of target proteins. Nature communications 11 (1) (2020)
Marion Cremer, Katharina Brandstetter, Andreas Maiser, Suhas S P Rao, Volker J Schmid, Miguel Guirao-Ortiz, Namita Mitra, Stefania Mamberti, Kyle N Klein, David M Gilbert, Heinrich Leonhardt, Maria Cristina Cardoso, Erez Lieberman Aiden, Hartmann Harz, Thomas Cremer
Cohesin depleted cells rebuild functional nuclear compartments after endomitosis. Nature communications 11 (1) (2020)
Vadim O Chagin, Britta Reinhart, Annette Becker, Oliver Mortusewicz, K Laurence Jost, Alexander Rapp, Heinrich Leonhardt, M Cristina Cardoso
Processive DNA synthesis is associated with localized decompaction of constitutive heterochromatin at the sites of DNA replication and repair. Nucleus (Austin, Tex.) 10 (1) (2020)
Amy Pandya-Jones, Yolanda Markaki, Jacques Serizay, Tsotne Chitiashvili, Walter R Mancia Leon, Andrey Damianov, Constantinos Chronis, Bernadett Papp, Chun-Kan Chen, Robin McKee, Xiao-Jun Wang, Anthony Chau, Shan Sabri, Heinrich Leonhardt, Sika Zheng, Mitchell Guttman, Douglas L Black, Kathrin Plath
A protein assembly mediates Xist localization and gene silencing. Nature 587 (7832) (2020)
Christopher B Mulholland, Atsuya Nishiyama, Joel Ryan, Ryohei Nakamura, Merve Yiğit, Ivo M Glück, Carina Trummer, Weihua Qin, Michael David Bartoschek, Franziska R Traube, Edris Parsa, Enes Ugur, Miha Modic, Aishwarya Acharya, Paul Stolz, Christoph Ziegenhain, Michael Wierer, Wolfgang Enard, Thomas Carell, Don C Lamb, Hiroyuki Takeda, Makoto Nakanishi, Sebastian Bultmann, Heinrich Leonhardt
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals. Nature communications 11 (1) (2020)
Hsin-Yi Chiu, Jack A Bates, Jonas Helma, Hanna Engelke, Hartmann Harz, Thomas Bein, Heinrich Leonhardt
Nanoparticle mediated delivery and small molecule triggered activation of proteins in the nucleus. Nucleus (Austin, Tex.) 9 (1) (2019)
Manuel Effenberger, Andreas Stengl, Kilian Schober, Maria Gerget, Maximilian Kampick, Thomas R Müller, Dominik Schumacher, Jonas Helma, Heinrich Leonhardt, Dirk H Busch
FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers. Journal of immunology (Baltimore, Md. : 1950) 202 (7) (2019)
Sophie M Stief, Anna-Li Hanneforth, Sabrina Weser, Raphael Mattes, Michela Carlet, Wen-Hsin Liu, Michael D Bartoschek, Helena Domínguez Moreno, Matthias Oettle, Julia Kempf, Binje Vick, Bianka Ksienzyk, Belay Tizazu, Maja Rothenberg-Thurley, Hilmar Quentmeier, Wolfgang Hiddemann, Sebastian Vosberg, Philipp A Greif, Klaus H Metzeler, Gunnar Schotta, Sebastian Bultmann, Irmela Jeremias, Heinrich Leonhardt, Karsten Spiekermann
Loss of KDM6A confers drug resistance in acute myeloid leukemia. Leukemia 34 (1) (2019)
David Hörl, Fabio Rojas Rusak, Friedrich Preusser, Paul W Tillberg, Nadine Randel, Raghav K Chhetri, Albert Cardona, Philipp J Keller, Hartmann Harz, Heinrich Leonhardt, Mathias Treier, Stephan Preibisch
BigStitcher: reconstructing high-resolution image datasets of cleared and expanded samples. Nature methods 16 (9) (2019)
David M Chiasson, Victor Giménez-Oya, Martin Bircheneder, Sabine Bachmaier, Tanja Studtrucker, Joel Ryan, Katharina Sollweck, Heinrich Leonhardt, Michael Boshart, Petra Dietrich, Martin Parniske
A unified multi-kingdom Golden Gate cloning platform. Scientific reports 9 (1) (2019)
Peng Zhang, Anne K Ludwig, Florian D Hastert, Cathia Rausch, Anne Lehmkuhl, Ines Hellmann, Martha Smets, Heinrich Leonhardt, M Cristina Cardoso
L1 retrotransposition is activated by Ten-eleven-translocation protein 1 and repressed by methyl-CpG binding proteins. Nucleus (Austin, Tex.) 8 (5) (2017)