Peter Walter

ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 43

Top Venues

eLife

Proceedings of the National Academy of Sciences of the United States of America

Science (New York, N.Y.)

Nature communications

HHMI/UCSF

Rockefeller University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

HHMI/UCSF

United States

PI :: Biophysics and Biochemistry

Education History

Rockefeller University Sep 01 1978 - Jun 05 1981

United States

PHD :: Cell Biology

Vanderbilt University Sep 01 1976 - Jun 05 1977

United States

MSC :: Organic Chemistry

Publications

Advait Subramanian, Lan Wang, Tom Moss, Mark Voorhies, Smriti Sangwan, Erica Stevenson, Ernst H Pulido, Samentha Kwok, Robert J Chalkley, Kathy H Li, Nevan J Krogan, Danielle L Swaney, Alma L Burlingame, Stephen N Floor, Anita Sil, Peter Walter, Shaeri Mukherjee
A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response. Nature cell biology (2023)
Rosalie E Lawrence, Sophie R Shoemaker, Aniliese Deal, Smriti Sangwan, Aditya A Anand, Lan Wang, Susan Marqusee, Peter Walter
A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling. Nature chemical biology (2023)
Morgane Boone, Lan Wang, Rosalie E Lawrence, Adam Frost, Peter Walter, Michael Schoof
A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. eLife 11 (2022)
Lan Wang, Hannah Toutkoushian, Vladislav Belyy, Claire Y Kokontis, Peter Walter
Conserved structural elements specialize ATAD1 as a membrane protein extraction machine. eLife 11 (2022)
Friedrich Fauser, Josep Vilarrasa-Blasi, Masayuki Onishi, Silvia Ramundo, Weronika Patena, Matthew Millican, Jacqueline Osaki, Charlotte Philp, Matthew Nemeth, Patrice A Salomé, Xiaobo Li, Setsuko Wakao, Rick G Kim, Yuval Kaye, Arthur R Grossman, Krishna K Niyogi, Sabeeha S Merchant, Sean R Cutler, Peter Walter, José R Dinneny, Martin C Jonikas, Robert E Jinkerson
Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii. Nature genetics 54 (5) (2022)
Elma S Frias, Mahmood S Hoseini, Karen Krukowski, Maria Serena Paladini, Katherine Grue, Gonzalo Ureta, Kira D A Rienecker, Peter Walter, Michael P Stryker, Susanna Rosi
Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition. Proceedings of the National Academy of Sciences of the United States of America 119 (42) (2022)
Zehra Yildirim, Sabyasachi Baboo, Syed M Hamid, Asli E Atici, Ozlem Tufanli, Sabrina Robichaud, Christina Emerton, Jolene K Diedrich, Hasan Vatandaslar, Fotis Nikolos, Yanghong Gu, Takao Iwawaki, Elizabeth J Tarling, Mireille Ouimet, David L Nelson, John R Yates, Peter Walter, Ebru Erbay
Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression. EMBO molecular medicine 14 (4) (2022)
Vladislav Belyy, Iratxe Zuazo-Gaztelu, Andrew Alamban, Avi Ashkenazi, Peter Walter
Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers. eLife 11 (2022)
Michael Schoof, Morgane Boone, Lan Wang, Rosalie Lawrence, Adam Frost, Peter Walter
eIF2B conformation and assembly state regulate the integrated stress response. eLife 10 (2021)
Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M Harnoss, David A Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cécile Chalouni, Weihan Li, Hartmut Koeppen, Joachim Rudolph, Weiru Wang, Thomas D Wu, Peter Walter, Avi Ashkenazi
Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α. Nature communications 12 (1) (2021)
Michael Schoof, Lan Wang, J Zachery Cogan, Rosalie E Lawrence, Morgane Boone, Jennifer Deborah Wuerth, Adam Frost, Peter Walter
Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nature communications 12 (1) (2021)
Ngoc-Han T Tran, Stephen D Carter, Ann De Maziere, Avi Ashkenazi, Judith Klumperman, Peter Walter, George J Lu
The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes. Science (New York, N.Y.) 374 (6563) (2021)
Weihan Li, Kelly Crotty, Diego Garrido Ruiz, Mark Voorhies, Carlos Rivera, Anita Sil, R Dyche Mullins, Matthew P Jacobson, Jirka Peschek, Peter Walter
Protomer alignment modulates specificity of RNA substrate recognition by Ire1. eLife 10 (2021)
Christopher Jakubke, Rodaria Roussou, Andreas Maiser, Christina Schug, Felix Thoma, David Bunk, David Hörl, Heinrich Leonhardt, Peter Walter, Till Klecker, Christof Osman
Cristae-dependent quality control of the mitochondrial genome. Science advances 7 (36) (2021)
Lan Wang, Alexander Myasnikov, Xingjie Pan, Peter Walter
Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. eLife 9 (2020)
Mable Lam, Scot A Marsters, Avi Ashkenazi, Peter Walter
Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress. eLife 9 (2020)
Karen Krukowski, Amber Nolan, Elma S Frias, Morgane Boone, Gonzalo Ureta, Katherine Grue, Maria-Serena Paladini, Edward Elizarraras, Luz Delgado, Sebastian Bernales, Peter Walter, Susanna Rosi
Small molecule cognitive enhancer reverses age-related memory decline in mice. eLife 9 (2020)
Mauro Costa-Mattioli, Peter Walter
The integrated stress response: From mechanism to disease. Science (New York, N.Y.) 368 (6489) (2020)
Silvia Ramundo, Yukari Asakura, Patrice A Salomé, Daniela Strenkert, Morgane Boone, Luke C M Mackinder, Kazuaki Takafuji, Emine Dinc, Michèle Rahire, Michèle Crèvecoeur, Leonardo Magneschi, Olivier Schaad, Michael Hippler, Martin C Jonikas, Sabeeha Merchant, Masato Nakai, Jean-David Rochaix, Peter Walter
Coexpressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts. Proceedings of the National Academy of Sciences of the United States of America 117 (51) (2020)
Michael Schoof, Bryan Faust, Reuben A Saunders, Smriti Sangwan, Veronica V Rezelj, Nicholas Hoppe, Morgane Boone, Christian B Billesbølle, Cristina Puchades, Caleigh M Azumaya, Huong T Kratochvil, Marcell Zimanyi, Ishan Deshpande, Jiahao Liang, Miles Sasha Dickinson, Henry C Nguyen, Cynthia M Chio, Gregory E Merz, Michael C Thompson, Devan Diwanji, Kaitlin Schaefer, Aditya A Anand, Niv Dobzinski, Beth Shoshanna Zha, Camille R Simoneau, Kristoffer E Leon, Kris M White, Un Seng Chio, Meghna Gupta, Mingliang Jin, Fei Li, Yanxin Liu, Kaihua Zhang, David Bulkley, Ming Sun, Amber M Smith, Alexandrea N Rizo, Frank R Moss, Axel F Brilot, Sergei Pourmal, Raphael Trenker, Thomas H Pospiech, Sayan Gupta, Benjamin Barsi-Rhyne, Vladislav Belyy, Andrew W Barile-Hill, Silke Nock, Yuwei Liu, Nevan J Krogan, Corie Y Ralston, Danielle L Swaney, Adolfo García-Sastre, Melanie M Ott, Marco Vignuzzi, null null, Peter Walter, Aashish Manglik
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science (New York, N.Y.) 370 (6523) (2020)
Stephen D Carter, Cheri M Hampton, Robert Langlois, Roberto Melero, Zachary J Farino, Michael J Calderon, Wen Li, Callen T Wallace, Ngoc-Han T Tran, Robert A Grassucci, Stephanie E Siegmund, Joshua G Pemberton, Travis J Morgenstern, Leanna Eisenman, Jenny I Aguilar, Nili L Greenberg, Elana S Levy, Edward Yi, William G Mitchell, William J Rice, Christoph Wigge, Jyotsna Pilli, Emily W George, Despoina Aslanoglou, Maïté Courel, Robin J Freyberg, Jonathan A Javitch, Zachary P Wills, Estela Area-Gomez, Sruti Shiva, Francesca Bartolini, Allen Volchuk, Sandra A Murray, Meir Aridor, Kenneth N Fish, Peter Walter, Tamas Balla, Deborah Fass, Sharon Grayer Wolf, Simon C Watkins, José María Carazo, George J Lu, Joachim Frank, Zachary Z Freyberg
Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells. Science advances 6 (14) (2020)
Estefanie Dufey, José Manuel Bravo-San Pedro, Cristian Eggers, Matías González-Quiroz, Hery Urra, Alfredo I Sagredo, Denisse Sepulveda, Philippe Pihán, Amado Carreras-Sureda, Younis Hazari, Eduardo A Sagredo, Daniela Gutierrez, Cristian Valls, Alexandra Papaioannou, Diego Acosta-Alvear, Gisela Campos, Pedro M Domingos, Rémy Pedeux, Éric Chevet, Alejandra Alvarez, Patricio Godoy, Peter Walter, Alvaro Glavic, Guido Kroemer, Claudio Hetz
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response. Nature communications 11 (1) (2020)
Ping Jun Zhu, Sanjeev Khatiwada, Ya Cui, Lucas C Reineke, Sean W Dooling, Jean J Kim, Wei Li, Peter Walter, Mauro Costa-Mattioli
Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science (New York, N.Y.) 366 (6467) (2020)
Huib H Rabouw, Linda J Visser, Tim Casper Passchier, Martijn A Langereis, Fan Liu, Piero Giansanti, Arno L W van Vliet, José G Dekker, Susanne G van der Grein, Jesús G Saucedo, Aditya A Anand, Mikael E Trellet, Alexandre M J J Bonvin, Peter Walter, Albert J R Heck, Raoul J de Groot, Frank J M van Kuppeveld
Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association. Nature microbiology 5 (11) (2020)
Vladislav Belyy, Ngoc-Han T Tran, Peter Walter
Quantitative microscopy reveals dynamics and fate of clustered IRE1α. Proceedings of the National Academy of Sciences of the United States of America 117 (3) (2019)
Lillian R Kenner, Aditya A Anand, Henry C Nguyen, Alexander G Myasnikov, Carolin J Klose, Lea A McGeever, Jordan C Tsai, Lakshmi E Miller-Vedam, Peter Walter, Adam Frost
eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science (New York, N.Y.) 364 (6439) (2019)
Hao G Nguyen, Crystal S Conn, Yae Kye, Lingru Xue, Craig M Forester, Janet E Cowan, Andrew C Hsieh, John T Cunningham, Charles Truillet, Feven Tameire, Kenneth W Bayles, Christopher P Evans, Joy C Yang, Byron C Hann, Constantinos Koumenis, Peter Walter, Peter R Carroll, Davide Ruggero
Development of a stress response therapy targeting aggressive prostate cancer. Science translational medicine 10 (439) (2019)
Jonathan M Harnoss, Adrien Le Thomas, Anna Shemorry, Scot A Marsters, David A Lawrence, Min Lu, Yung-Chia Ariel Chen, Jing Qing, Klara Totpal, David Kan, Ehud Segal, Mark Merchant, Mike Reichelt, Heidi Ackerly Wallweber, Weiru Wang, Kevin Clark, Susan Kaufman, Maureen H Beresini, Steven T Laing, Wendy Sandoval, Maria Lorenzo, Jiansheng Wu, Justin Ly, Tom De Bruyn, Amy Heidersbach, Benjamin Haley, Alvin Gogineni, Robby M Weimer, Dong Lee, Marie-Gabrielle Braun, Joachim Rudolph, Michael J VanWyngarden, Daniel W Sherbenou, Patricia Gomez-Bougie, Martine Amiot, Diego Acosta-Alvear, Peter Walter, Avi Ashkenazi
Disruption of IRE1α through its kinase domain attenuates multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America 116 (33) (2019)
Jirka Peschek, Peter Walter
tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay. eLife 8 (2019)
Sandra Elizabeth Torres, Ciara M Gallagher, Lars Plate, Meghna Gupta, Christina R Liem, Xiaoyan Guo, Ruilin Tian, Robert M Stroud, Martin Edward Kampmann, Jonathan S Weissman, Peter Walter
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. eLife 8 (2019)
Huib H Rabouw, Martijn A Langereis, Aditya A Anand, Linda J Visser, Raoul J de Groot, Peter Walter, Frank J M van Kuppeveld
Small molecule ISRIB suppresses the integrated stress response within a defined window of activation. Proceedings of the National Academy of Sciences of the United States of America 116 (6) (2019)
Karina Perlaza, Hannah Toutkoushian, Morgane Boone, Mable Lam, Masakazu Iwai, Martin C Jonikas, Peter Walter, Silvia Ramundo
The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response. eLife 8 (2019)
Jordan C Tsai, Lakshmi E Miller-Vedam, Aditya A Anand, Priyadarshini Jaishankar, Henry C Nguyen, Adam R Renslo, Adam Frost, Peter Walter
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science (New York, N.Y.) 359 (6383) (2018)
Weihan Li, Voytek Okreglak, Jirka Peschek, Philipp Kimmig, Meghan Zubradt, Jonathan S Weissman, Peter Walter
Engineering ER-stress dependent non-conventional mRNA splicing. eLife 7 (2018)
Diego Acosta-Alvear, G Elif Karagöz, Florian Fröhlich, Han Li, Tobias C Walther, Peter Walter
The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1. eLife 7 (2018)
Austin Chou, Karen Krukowski, Timothy Jopson, Ping Jun Zhu, Mauro Costa-Mattioli, Peter Walter, Susanna Rosi
Inhibition of the integrated stress response reverses cognitive deficits after traumatic brain injury. Proceedings of the National Academy of Sciences of the United States of America 114 (31) (2017)
G Elif Karagöz, Diego Acosta-Alvear, Hieu T Nguyen, Crystal P Lee, Feixia Chu, Peter Walter
An unfolded protein-induced conformational switch activates mammalian IRE1. eLife 6 (2017)
Ozlem Tufanli, Pelin Telkoparan Akillilar, Diego Acosta-Alvear, Begum Kocaturk, Umut Inci Onat, Syed Muhammad Hamid, Ismail Çimen, Peter Walter, Christian Weber, Ebru Erbay
Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America 114 (8) (2017)
Nicholas R Guydosh, Philipp Kimmig, Peter Walter, Rachel Green
Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe. eLife 6 (2017)
Ciara M Gallagher, Carolina Garri, Erica L Cain, Kenny Kean-Hooi Ang, Christopher G Wilson, Steven Chen, Brian R Hearn, Priyadarshini Jaishankar, Andres Aranda-Diaz, Michelle R Arkin, Adam R Renslo, Peter Walter
Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. eLife 5 (2016)
Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher, Franck Madoux, Joseph C Genereux, Wesley Dobbs, Dan Garza, Timothy P Spicer, Louis Scampavia, Steven J Brown, Hugh Rosen, Evan T Powers, Peter Walter, Peter Hodder, R Luke Wiseman, Jeffery W Kelly
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation. eLife 5 (2016)
Ciara M Gallagher, Peter Walter
Ceapins inhibit ATF6α signaling by selectively preventing transport of ATF6α to the Golgi apparatus during ER stress. eLife 5 (2016)
Meera Rao, Voytek Okreglak, Un Seng Chio, Hyunju Cho, Peter Walter, Shu-Ou Shan
Multiple selection filters ensure accurate tail-anchored membrane protein targeting. eLife 5 (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Peter Walter