John Spencer

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 39

Top Venues

International journal of molecular sciences

Chemistry (Weinheim an der Bergstrasse, Germany)

RSC chemical biology

ChemMedChem

University of Sussex School of Life Sciences

Universite de Strasbourg (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Sussex School of Life Sciences

United Kingdom

Professor :: Chemistry

University of Greenwich at Medway

United Kingdom

Reader :: Science

James Black Foundation

United Kingdom

Group Leader :: Chemistry

Thrombosis Research Institute

United Kingdom

Group leader :: Chemistry

Vernalis Group plc

United Kingdom

Medicinal Chemist :: Chemistry

Xenova Group Plc

United Kingdom

Medicinal Chemist :: Chemistry

Konjunkturforschungsstelle der ETH Zürich

Switzerland

Postdoc :: Chemistry

Education History

Universite de Strasbourg

France

PHD :: Chimie

University of Sussex

United Kingdom

BSC :: Chemistry

Publications

Joshua Nicks, Greig C Shearer, Joseph Paul-Taylor, James Lai-Morrice, Chris Dadswell, Daniel Guest, William O H Hughes, John Spencer, Tina Düren, Andrew D Burrows
Controlling the Uptake and Release of Semiochemicals in Channel-Type Metal-Organic Frameworks Through Pore Expansion. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Joshua Nicks, Greig C Shearer, Joseph Paul-Taylor, James Lai-Morrice, Chris Dadswell, Daniel Guest, William O H Hughes, John Spencer, Tina Düren, Andrew D Burrows
Controlling the Uptake and Release of Semiochemicals in Channel-Type Metal-Organic Frameworks Through Pore Expansion. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (39) (2024)
Gemma L Nixon, Khondaker Miraz Rahman, John Spencer
Introduction to 'Medicinal Chemistry Small Molecule Probes'. RSC chemical biology 5 (5) (2024)
Alessandro Agnarelli, Andrea Lauer Betrán, Athanasios Papakyriakou, Viviana Vella, Mark Samuels, Panagiotis Papanastasopoulos, Christina Giamas, Erika J Mancini, Justin Stebbing, John Spencer, Chiara Cilibrasi, Angeliki Ditsiou, Georgios Giamas
The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. International journal of molecular sciences 24 (1) (2023)
Alessandro Agnarelli, Andrea Lauer Betrán, Athanasios Papakyriakou, Viviana Vella, Mark Samuels, Panagiotis Papanastasopoulos, Christina Giamas, Erika J Mancini, Justin Stebbing, John Spencer, Chiara Cilibrasi, Angeliki Ditsiou, Georgios Giamas
The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. International journal of molecular sciences 24 (1) (2023)
Thibaud Reyser, Lucie Paloque, Michel Nguyen, Jean-Michel Augereau, Matthew John Fuchter, Marie Lopez, Paola Barbara Arimondo, Storm Hassell-Hart, John Spencer, Luisa Di Stefano, Françoise Benoit-Vical
Epidrugs as Promising Tools to Eliminate Plasmodium falciparum Artemisinin-Resistant and Quiescent Parasites. Pharmaceutics 15 (10) (2023)
Alessandro Agnarelli, Andrea Lauer Betrán, Athanasios Papakyriakou, Viviana Vella, Mark Samuels, Panagiotis Papanastasopoulos, Christina Giamas, Erika J Mancini, Justin Stebbing, John Spencer, Chiara Cilibrasi, Angeliki Ditsiou, Georgios Giamas
The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. International journal of molecular sciences 24 (1) (2023)
Andrew McGown, Jordan Nafie, Mohammed Otayfah, Storm Hassell-Hart, Graham J Tizzard, Simon J Coles, Rebecca Banks, Graham P Marsh, Hannah J Maple, George E Kostakis, Ilaria Proietti Silvestri, Paul Colbon, John Spencer
Chirality: a key parameter in chemical probes. RSC chemical biology 4 (10) (2023)
Alessandro Agnarelli, Andrea Lauer Betrán, Athanasios Papakyriakou, Viviana Vella, Mark Samuels, Panagiotis Papanastasopoulos, Christina Giamas, Erika J Mancini, Justin Stebbing, John Spencer, Chiara Cilibrasi, Angeliki Ditsiou, Georgios Giamas
The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. International journal of molecular sciences 24 (1) (2023)
S Mark Roe, Zsolt Török, Andrew McGown, Ibolya Horváth, John Spencer, Tamás Pázmány, László Vigh, Chrisostomos Prodromou
The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease. Biomolecules 13 (7) (2023)
Storm Hassell-Hart, Elisa Speranzini, Sirihathai Srikwanjai, Euan Hossack, S Mark Roe, Daren Fearon, Daniel Akinbosede, Stephen Hare, John Spencer
Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction. Organic letters 24 (43) (2022)
Arathy Jose, Daniel Guest, Remi LeGay, Graham J Tizzard, Simon J Coles, Mariliza Derveni, Edward Wright, Lester Marrison, Alpha A Lee, Aaron Morris, Matt Robinson, Frank von Delft, Daren Fearon, Lizbé Koekemoer, Tetiana Matviuk, Anthony Aimon, Christopher J Schofield, Tika R Malla, Nir London, Barnaby W Greenland, Mark C Bagley, John Spencer, null The Covid Moonshot Consortium
Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds. ChemMedChem 17 (7) (2022)
Anthony K Edmonds, Catherine S Oakes, Storm Hassell-Hart, Didier Bruyère, Graham J Tizzard, Simon J Coles, Robert Felix, Hannah J Maple, Graham P Marsh, John Spencer
Scale-up and optimization of the synthesis of dual CBP/BRD4 inhibitor ISOX-DUAL. Organic & biomolecular chemistry 20 (19) (2022)
Lydia A Panther, Daniel P Guest, Andrew McGown, Hugo Emerit, Raysa Khan Tareque, Arathy Jose, Chris M Dadswell, Simon J Coles, Graham J Tizzard, Ramón González-Méndez, Charles A I Goodall, Mark C Bagley, John Spencer, Barnaby W Greenland
Solvent-Free Synthesis of Core-Functionalised Naphthalene Diimides by Using a Vibratory Ball Mill: Suzuki, Sonogashira and Buchwald-Hartwig Reactions. Chemistry (Weinheim an der Bergstrasse, Germany) 28 (49) (2022)
Wing T Lam, Tahkur S Babra, Julian H D Smith, Mark C Bagley, John Spencer, Edward Wright, Barnaby W Greenland
Synthesis and Evaluation of a Silver Nanoparticle/Polyurethane Composite That Exhibits Antiviral Activity against SARS-CoV-2. Polymers 14 (19) (2022)
Andrew McGown, Anthony K Edmonds, Daniel Guest, Verity L Holmes, Chris Dadswell, Ramón González-Méndez, Charles A I Goodall, Mark C Bagley, Barnaby W Greenland, John Spencer
A Convenient, Rapid, Conventional Heating Route to MIDA Boronates. Molecules (Basel, Switzerland) 27 (16) (2022)
Maria Gil-Moles, Sebastian Türck, Uttara Basu, Andrea Pettenuzzo, Saurav Bhattacharya, Ananthu Rajan, Xiang Ma, Rolf Büssing, Jessica Wölker, Hilke Burmeister, Henrik Hoffmeister, Pia Schneeberg, Andre Prause, Petra Lippmann, Josephine Kusi-Nimarko, Storm Hassell-Hart, Andrew McGown, Daniel Guest, Yan Lin, Anna Notaro, Robin Vinck, Johannes Karges, Kevin Cariou, Kun Peng, Xue Qin, Xing Wang, Joanna Skiba, Łukasz Szczupak, Konrad Kowalski, Ulrich Schatzschneider, Catherine Hemmert, Heinz Gornitzka, Elena R Milaeva, Alexey A Nazarov, Gilles Gasser, John Spencer, Luca Ronconi, Ulrich Kortz, Jindrich Cinatl, Denisa Bojkova, Ingo Ott
Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PLpro. Chemistry (Weinheim an der Bergstrasse, Germany) (2021)
Brenno A D Neto, José Raimundo Corrêa, John Spencer
Fluorescent Benzothiadiazole Derivatives as Fluorescence Imaging Dyes: A Decade of New Generation Probes. Chemistry (Weinheim an der Bergstrasse, Germany) (2021)
Claudio Luparello, Claudio Luparello, Andreas C Joerger, Cory A Ocasio, Rhiannon Jones, Raysa Khan Tareque, Mark C Bagley, John Spencer, Martin Walker, Carol Austin, Tiziana Ferrara, Pietro D Oca, Rossella Bellina, Rossella Branni, Fabio Caradonna
Genotoxicity and Epigenotoxicity of Carbazole-Derived Molecules on MCF-7 Breast Cancer Cells. International journal of molecular sciences 22 (7) (2021)
Adam T Watson, Storm Hassell-Hart, John Spencer, Antony M Carr
Rice (Oryza sativa) TIR1 and 5'adamantyl-IAA Significantly Improve the Auxin-Inducible Degron System in Schizosaccharomyces pombe. Genes 12 (6) (2021)
Melvyn B Ansell, George E Kostakis, Oscar Navarro, John Spencer
Synthesis of trans-Mono(silyl)palladium(II) Bromide Complexes. Molecules (Basel, Switzerland) 26 (9) (2021)
Harina Amer Hamzah, Daniel Rixson, Joseph Paul-Taylor, Huan V Doan, Christopher Dadswell, Gavin W Roffe, Arun Srikanth Sridhar, Claire L Hobday, Charlie Wedd, Tina Düren, William O H Hughes, John Spencer, Andrew D Burrows
Inclusion and release of ant alarm pheromones from metal-organic frameworks. Dalton transactions (Cambridge, England : 2003) 49 (30) (2021)
Riccardo Rubbiani, Tobias Weil, Noemi Tocci, Luciano Mastrobuoni, Severin Jeger, Marco Moretto, James Ng, Yan Lin, Jeannine Hess, Stefano Ferrari, Andres Kaech, Luke Young, John Spencer, Anthony L Moore, Kevin Cariou, Giorgia Renga, Marilena Pariano, Luigina Romani, Gilles Gasser
In vivo active organometallic-containing antimycotic agents. RSC chemical biology 2 (4) (2021)
Jack Devonport, Nikolett Bodnár, Andrew McGown, Mahmoud Bukar Maina, Louise C Serpell, Csilla Kállay, John Spencer, George E Kostakis
Salpyran: A Cu(II) Selective Chelator with Therapeutic Potential. Inorganic chemistry 60 (20) (2021)
Jack Devonport, John Spencer, George E Kostakis
Breaking the symmetry: C1-salans with (N-H) backbones. Dalton transactions (Cambridge, England : 2003) 50 (35) (2021)
Jack Devonport, Lauren Sully, Athanassios K Boudalis, Storm Hassell-Hart, Matthew C Leech, Kevin Lam, Alaa Abdul-Sada, Graham J Tizzard, Simon J Coles, John Spencer, Alfredo Vargas, George E Kostakis
Room-Temperature Cu(II) Radical-Triggered Alkyne C-H Activation. JACS Au 1 (11) (2021)
Raysa Khan Tareque, Storm Hassell-Hart, Tobias Krojer, Anthony Bradley, Srikannathasan Velupillai, Romain Talon, Michael Fairhead, Iain J Day, Kamlesh Bala, Robert Felix, Paul D Kemmitt, Paul E Brennan, Frank von Delft, Laura Díaz Sáez, Kilian V M Huber, John Spencer
Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism. ChemMedChem 15 (24) (2020)
Angeliki Ditsiou, Chiara Cilibrasi, Nikiana Simigdala, Athanasios Papakyriakou, Leanne Milton-Harris, Viviana Vella, Joanne E Nettleship, Jae Ho Lo, Shivani Soni, Goar Smbatyan, Panagiota Ntavelou, Teresa Gagliano, Maria Chiara Iachini, Sahir Khurshid, Thomas Simon, Lihong Zhou, Storm Hassell-Hart, Philip Carter, Laurence H Pearl, Robin L Owen, Raymond J Owens, S Mark Roe, Naomi E Chayen, Heinz-Josef Lenz, John Spencer, Chrisostomos Prodromou, Apostolos Klinakis, Justin Stebbing, Georgios Giamas
The structure-function relationship of oncogenic LMTK3. Science advances 6 (46) (2020)
Matthias R Bauer, Andreas Krämer, Giovanni Settanni, Rhiannon N Jones, Xiaomin Ni, Raysa Khan Tareque, Alan R Fersht, John Spencer, Andreas C Joerger
Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. ACS chemical biology 15 (3) (2020)
Matthias R Bauer, Rhiannon N Jones, Raysa K Tareque, Bradley Springett, Felix A Dingler, Lorena Verduci, Ketan J Patel, Alan R Fersht, Andreas C Joerger, John Spencer
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. Future medicinal chemistry 11 (19) (2020)
Julia Baguña Torres, Zilin Yu, Jayanta Bordoloi, Kavitha Sunassee, David Smith, Claire Smith, Oscar Chen, Rupert Purchase, Karin Tuschl, John Spencer, Frances Mary Platt, Philip J Blower
Imaging of changes in copper trafficking and redistribution in a mouse model of Niemann-Pick C disease using positron emission tomography. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 32 (2) (2019)
Stavroula I Sampani, Andrew McGown, Alfredo Vargas, Alaa Abdul-Sada, Graham J Tizzard, Simon J Coles, John Spencer, George E Kostakis
Solvent-Free Synthesis and Key Intermediate Isolation in Ni2Dy2 Catalyst Development in the Domino Ring-Opening Electrocyclization Reaction of Furfural and Amines. The Journal of organic chemistry 84 (11) (2019)
Claudio Luparello, Dalia Maria Lucia Asaro, Ilenia Cruciata, Fabio Caradonna, Supojjanee Sansook, John Spencer
Cytotoxic Activity of the Histone Deacetylase 3-Selective Inhibitor Pojamide on MDA-MB-231 Triple-Negative Breast Cancer Cells. International journal of molecular sciences 20 (4) (2019)
Jose Miguel Gascon, Valentina Oliveri, Andrew McGown, Ecem Kaya, Yu-Lin Chen, Carol Austin, Martin Walker, Frances Mary Platt, Graziella Vecchio, John Spencer
Synthesis and Study of Multifunctional Cyclodextrin-Deferasirox Hybrids. ChemMedChem 14 (16) (2019)
Supojjanee Sansook, Cory A Ocasio, Iain J Day, Graham J Tizzard, Simon J Coles, Oleg Fedorov, James M Bennett, Jonathan M Elkins, John Spencer
Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety. Organic & biomolecular chemistry 15 (40) (2018)
Cory A Ocasio, Alexander A Warkentin, Patrick J McIntyre, Krister J Barkovich, Clare Vesely, John Spencer, Kevan M Shokat, Richard Bayliss
Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases. ACS chemical biology 13 (10) (2018)
Supojjanee Sansook, Ella Lineham, Storm Hassell-Hart, Graham J Tizzard, Simon J Coles, John Spencer, Simon J Morley
Probing the Anticancer Action of Novel Ferrocene Analogues of MNK Inhibitors. Molecules (Basel, Switzerland) 23 (9) (2018)
Mariangela Librizzi, Fabio Caradonna, Ilenia Cruciata, Janusz Dębski, Supojjanee Sansook, Michał Dadlez, John Spencer, Claudio Luparello
Molecular Signatures Associated with Treatment of Triple-Negative MDA-MB231 Breast Cancer Cells with Histone Deacetylase Inhibitors JAHA and SAHA. Chemical research in toxicology 30 (12) (2017)
Gavin W Roffe, Sarote Boonseng, Christine B Baltus, Simon J Coles, Iain J Day, Rhiannon N Jones, Neil J Press, Mario Ruiz, Graham J Tizzard, Hazel Cox, John Spencer
A synthetic, catalytic and theoretical investigation of an unsymmetrical SCN pincer palladacycle. Royal Society open science 3 (4) (2016)
Oakley B Cox, Tobias Krojer, Patrick Collins, Octovia Monteiro, Romain Talon, Anthony Bradley, Oleg Fedorov, Jahangir Amin, Brian D Marsden, John Spencer, Frank von Delft, Paul E Brennan
A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chemical science 7 (3) (2015)

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Publication Activity (10 Years)

Top Topics

Top Venues

John Spencer