Daren Fearon

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 29

Top Topics

Protein Protein

Capillary Electrophoresis

Molecular Dynamics Simulations

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

bioRxiv : the preprint server for biology

Pathogens (Basel, Switzerland)

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Jasmin Cara Aschenbrenner, Andre Schutzer Godoy, Michael Fairhead, Charles W E Tomlinson, Max Winokan, Blake H Balcomb, Eda Capkin, Anu V Chandran, Mathew Golding, Lizbé Koekemoer, Peter J Harrison, Peter George Marples, Xiaomin Ni, Warren A Thompson, Conor Wild, Mary-Ann E Xavier, Daren Fearon, Frank von Delft
Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening. bioRxiv : the preprint server for biology (2024)
Peter J Harrison, Charles W E Tomlinson, Michael Fairhead, Max Winokan, Warren A Thompson, Conor Wild, Jasmin Cara Aschenbrenner, Blake H Balcomb, Peter George Marples, Anu V Chandran, Mathew Golding, Lizbé Koekemoer, Eleanor P Williams, SiYl Wang, Xiaomin Ni, Elizabeth MacLean, Charline Giroud, Andre Schutzer Godoy, Mary-Ann Elvina Xavier, Martin Austin Walsh, Daren Fearon, Frank von Delft
Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. bioRxiv : the preprint server for biology (2024)
Andre Schutzer Godoy, Nathalya C M R Mesquita, Gabriela Dias Noske, Victor Oliveira Gawriljuk, Peter J Harrison, Blake H Balcomb, Jasmin Cara Aschenbrenner, Charles W E Tomlinson, Max Winokan, Jenke Scheen, Peter George Marples, Anu V Chandran, Xiaomin Ni, Warren A Thompson, Michael Fairhead, Daren Fearon, Lizbé Koekemoer, Mary-Ann Elvina Xavier, Martin Austin Walsh, Glaucius Oliva, Frank von Delft
High-throughput crystallographic fragment screening of Zika virus NS3 Helicase. bioRxiv : the preprint server for biology (2024)
Andre Schutzer Godoy, Nathalya C M R Mesquita, Gabriela Dias Noske, Victor Oliveira Gawriljuk, Peter J Harrison, Blake H Balcomb, Jasmin Cara Aschenbrenner, Charles W E Tomlinson, Max Winokan, Jenke Scheen, Peter George Marples, Anu V Chandran, Xiaomin Ni, Warren A Thompson, Michael Fairhead, Daren Fearon, Lizbé Koekemoer, Mary-Ann Elvina Xavier, Martin Austin Walsh, Glaucius Oliva, Frank von Delft
High-throughput crystallographic fragment screening of Zika virus NS3 Helicase. bioRxiv : the preprint server for biology (2024)
Xiaomin Ni, Andre Schutzer Godoy, Peter George Marples, Michael Fairhead, Blake H Balcomb, Matteo P Ferla, Charles W E Tomlinson, Siyi Wang, Charline Giroud, Jasmin Cara Aschenbrenner, Peter J Harrison, Max Winokan, Anu V Chandran, Warren A Thompson, Mary-Ann Elvina Xavier, Eleanor P Williams, Martin Austin Walsh, Daren Fearon, Lizbé Koekemoer, Frank von Delft
Crystallographic fragment screening delivers diverse chemical scaffolds for Zika virus NS2B-NS3 protease inhibitor development. bioRxiv : the preprint server for biology (2024)
Marion Schuller, Tryfon Zarganes-Tzitzikas, James Bennett, Stephane De Cesco, Daren Fearon, Frank von Delft, Oleg Fedorov, Paul E Brennan, Ivan Ahel
Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors. Pathogens (Basel, Switzerland) 12 (2) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Vijil Chenthamarakshan, Samuel C Hoffman, C David Owen, Petra Lukacik, Claire Strain-Damerell, Daren Fearon, Tika R Malla, Anthony Tumber, Christopher J Schofield, Helen M E Duyvesteyn, Wanwisa Dejnirattisai, Loic Carrique, Thomas S Walter, Gavin R Screaton, Tetiana Matviiuk, Aleksandra Mojsilovic, Jason Crain, Martin Austin Walsh, David I Stuart, Payel Das
Accelerating drug target inhibitor discovery with a deep generative foundation model. Science advances 9 (25) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Marion Schuller, Tryfon Zarganes-Tzitzikas, James Bennett, Stephane De Cesco, Daren Fearon, Frank von Delft, Oleg Fedorov, Paul E Brennan, Ivan Ahel
Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors. Pathogens (Basel, Switzerland) 12 (2) (2023)
Marion Schuller, Tryfon Zarganes-Tzitzikas, James Bennett, Stephane De Cesco, Daren Fearon, Frank von Delft, Oleg Fedorov, Paul E Brennan, Ivan Ahel
Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors. Pathogens (Basel, Switzerland) 12 (2) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Kadi Liis Saar, William McCorkindale, Daren Fearon, Melissa Boby, Haim Barr, Amir Ben-Shmuel, null null, Nir London, Frank von Delft, John D Chodera, Alpha A Lee
Turning high-throughput structural biology into predictive inhibitor design. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Melissa L Boby, Daren Fearon, Matteo Ferla, Mihajlo Filep, Lizbé Koekemoer, Matthew C Robinson, null null, John D Chodera, Alpha A Lee, Nir London, Annette von Delft, Frank von Delft, Hagit Achdout, Anthony Aimon, Dominic S Alonzi, Robert Arbon, Jasmin C Aschenbrenner, Blake H Balcomb, Elad Bar-David, Haim Barr, Amir Ben-Shmuel, James Bennett, Vitaliy A Bilenko, Bruce Borden, Pascale Boulet, Gregory R Bowman, Lennart Brewitz, Juliane Brun, Sarma Bvnbs, Mark Calmiano, Anna Carbery, Daniel W Carney, Emma Cattermole, Edcon Chang, Eugene Chernyshenko, Austin Clyde, Joseph E Coffland, Galit Cohen, Jason C Cole, Alessandro Contini, Lisa Cox, Tristan Ian Croll, Milan Cvitkovic, Steven De Jonghe, Alex Dias, Kim Donckers, David L Dotson, Alice Douangamath, Shirly Duberstein, Tim Dudgeon, Louise E Dunnett, Peter Eastman, Noam Erez, Charles J Eyermann, Michael Fairhead, Gwen Fate, Oleg Fedorov, Rafaela S Fernandes, Lori Ferrins, Richard Foster, Holly Foster, Laurent Fraisse, Ronen Gabizon, Adolfo García-Sastre, Victor O Gawriljuk, Paul Gehrtz, Carina Gileadi, Charline Giroud, William G Glass, Robert C Glen, Itai Glinert, Andre S Godoy, Marian Gorichko, Tyler Gorrie-Stone, Ed J Griffen, Amna Haneef, Storm Hassell Hart, Jag Heer, Michael Henry, Michelle Hill, Sam Horrell, Qiu Yu Judy Huang, Victor D Huliak, Matthew F D Hurley, Tomer Israely, Andrew Jajack, Jitske Jansen, Eric Jnoff, Dirk Jochmans, Tobias John, Benjamin Kaminow, Lulu Kang, Anastassia L Kantsadi, Peter W Kenny, J L Kiappes, Serhii O Kinakh, Boris Kovar, Tobias Krojer, Van Ngoc Thuy La, Sophie Laghnimi-Hahn, Bruce A Lefker, Haim Levy, Ryan M Lithgo, Ivan G Logvinenko, Petra Lukacik, Hannah Bruce Macdonald, Elizabeth M MacLean, Laetitia L Makower, Tika R Malla, Peter G Marples, Tatiana Matviiuk, Willam McCorkindale, Briana L McGovern, Sharon Melamed, Kostiantyn P Melnykov, Oleg Michurin, Pascal Miesen, Halina Mikolajek, Bruce F Milne, David Minh, Aaron Morris, Garrett M Morris, Melody Jane Morwitzer, Demetri Moustakas, Charles E Mowbray, Aline M Nakamura, Jose Brandao Neto, Johan Neyts, Luong Nguyen, Gabriela D Noske, Vladas Oleinikovas, Glaucius Oliva, Gijs J Overheul, C David Owen, Ruby Pai, Jin Pan, Nir Paran, Alexander Matthew Payne, Benjamin Perry, Maneesh Pingle, Jakir Pinjari, Boaz Politi, Ailsa Powell, Vladimír Pšenák, Iván Pulido, Reut Puni, Victor L Rangel, Rambabu N Reddi, Paul Rees, St Patrick Reid, Lauren Reid, Efrat Resnick, Emily Grace Ripka, Ralph P Robinson, Jaime Rodriguez-Guerra, Romel Rosales, Dominic A Rufa, Kadi Saar, Kumar Singh Saikatendu, Eidarus Salah, David Schaller, Jenke Scheen, Celia A Schiffer, Christopher J Schofield, Mikhail Shafeev, Aarif Shaikh, Ala M Shaqra, Jiye Shi, Khriesto Shurrush, Sukrit Singh, Assa Sittner, Peter Sjö, Rachael Skyner, Adam Smalley, Bart Smeets, Mihaela D Smilova, Leonardo J Solmesky, John Spencer, Claire Strain-Damerell, Vishwanath Swamy, Hadas Tamir, Jenny C Taylor, Rachael E Tennant, Warren Thompson, Andrew Thompson, Susana Tomásio, Charles W E Tomlinson, Igor S Tsurupa, Anthony Tumber, Ioannis Vakonakis, Ronald P van Rij, Laura Vangeel, Finny S Varghese, Mariana Vaschetto, Einat B Vitner, Vincent Voelz, Andrea Volkamer, Martin A Walsh, Walter Ward, Charlie Weatherall, Shay Weiss, Kris M White, Conor Francis Wild, Karolina D Witt, Matthew Wittmann, Nathan Wright, Yfat Yahalom-Ronen, Nese Kurt Yilmaz, Daniel Zaidmann, Ivy Zhang, Hadeer Zidane, Nicole Zitzmann, Sarah N Zvornicanin
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors. Science (New York, N.Y.) 382 (6671) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Kadi Liis Saar, William McCorkindale, Daren Fearon, Melissa Boby, Haim Barr, Amir Ben-Shmuel, null null, Nir London, Frank von Delft, John D Chodera, Alpha A Lee
Turning high-throughput structural biology into predictive inhibitor design. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2. Proceedings of the National Academy of Sciences of the United States of America 120 (2) (2023)
Marion Schuller, Tryfon Zarganes-Tzitzikas, James Bennett, Stephane De Cesco, Daren Fearon, Frank von Delft, Oleg Fedorov, Paul E Brennan, Ivan Ahel
Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors. Pathogens (Basel, Switzerland) 12 (2) (2023)
Storm Hassell-Hart, Elisa Speranzini, Sirihathai Srikwanjai, Euan Hossack, S Mark Roe, Daren Fearon, Daniel Akinbosede, Stephen Hare, John Spencer
Synthesis of a Thiazole Library via an Iridium-Catalyzed Sulfur Ylide Insertion Reaction. Organic letters 24 (43) (2022)
Arathy Jose, Daniel Guest, Remi LeGay, Graham J Tizzard, Simon J Coles, Mariliza Derveni, Edward Wright, Lester Marrison, Alpha A Lee, Aaron Morris, Matt Robinson, Frank von Delft, Daren Fearon, Lizbé Koekemoer, Tetiana Matviuk, Anthony Aimon, Christopher J Schofield, Tika R Malla, Nir London, Barnaby W Greenland, Mark C Bagley, John Spencer, null The Covid Moonshot Consortium
Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds. ChemMedChem 17 (7) (2022)
Evgenii M Osipov, Ali H Munawar, Steven Beelen, Daren Fearon, Alice Douangamath, Conor Wild, Stephen D Weeks, Arthur Van Aerschot, Frank von Delft, Sergei V Strelkov
Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors. RSC chemical biology 3 (8) (2022)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2. bioRxiv : the preprint server for biology (2022)
Marion Schuller, Galen J Correy, Stefan Gahbauer, Daren Fearon, Taiasean Wu, Roberto Efraín Díaz, Iris D Young, Luan Carvalho Martins, Dominique H Smith, Ursula Schulze-Gahmen, Tristan W Owens, Ishan Deshpande, Gregory E Merz, Aye C Thwin, Justin T Biel, Jessica K Peters, Michelle Moritz, Nadia Herrera, Huong T Kratochvil, null null, Anthony Aimon, James M Bennett, José Brandão-Neto, Aina E Cohen, Alexandre Dias, Alice Douangamath, Louise Dunnett, Oleg Fedorov, Matteo P Ferla, Martin R Fuchs, Tyler J Gorrie-Stone, James M Holton, Michael G Johnson, Tobias Krojer, George Meigs, Ailsa J Powell, Johannes Gregor Matthias Rack, Victor L Rangel, Silvia Russi, Rachael E Skyner, Clyde A Smith, Alexei S Soares, Jennifer L Wierman, Kang Zhu, Peter O'Brien, Natalia Jura, Alan Ashworth, John J Irwin, Michael C Thompson, Jason E Gestwicki, Frank von Delft, Brian K Shoichet, Brian K Shoichet, Ivan Ahel
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking. Science advances 7 (16) (2021)
Dávid Bajusz, Warren S Wade, Grzegorz Satała, Andrzej J Bojarski, Janez Ilaš, Jessica Ebner, Florian Grebien, Henrietta Papp, Ferenc Jakab, Alice Douangamath, Daren Fearon, Frank von Delft, Marion Schuller, Ivan Ahel, Amanda Wakefield, Sándor Vajda, János Gerencsér, Péter Pallai, György Miklós Keserű
Exploring protein hotspots by optimized fragment pharmacophores. Nature communications 12 (1) (2021)
Joseph A Newman, Alice Douangamath, Setayesh Yadzani, Yuliana Yosaatmadja, Anthony Aimon, José Brandão-Neto, Louise Dunnett, Tyler Gorrie-Stone, Rachael E Skyner, Daren Fearon, Matthieu Schapira, Frank von Delft, Opher Gileadi
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase. Nature communications 12 (1) (2021)
Alice Douangamath, Daren Fearon, Paul Gehrtz, Tobias Krojer, Petra Lukacik, C David Owen, Efrat Resnick, Claire Strain-Damerell, Anthony Aimon, Péter Ábrányi-Balogh, José Brandão-Neto, Anna Carbery, Gemma Davison, Alexandre Dias, Thomas D Downes, Louise Dunnett, Michael Fairhead, James D Firth, S Paul Jones, Aaron Keeley, György M Keserü, Hanna F Klein, Mathew P Martin, Martin E M Noble, Peter O'Brien, Ailsa J Powell, Rambabu N Reddi, Rachael E Skyner, Matthew Snee, Michael J Waring, Conor Wild, Nir London, Frank von Delft, Martin Austin Walsh
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease. Nature communications 11 (1) (2020)