Kilian V M Huber (Kilian Huber, K Huber, Kilian Vm Huber)

Scopus Author ID ResearcherID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 33

Top Venues

Journal of medicinal chemistry

Nature chemical biology

ACS chemical biology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Esra Balıkçı, Anne-Sophie M C Marques, Ludwig G Bauer, Raina Seupel, James M Bennett, Brigitt Raux, Karly Buchan, Klemensas Simelis, Usha Singh, Catherine Rogers, Jennifer Ward, Carol Cheng, Tamas Szommer, Kira Schützenhofer, Jonathan M Elkins, David L Sloman, Ivan Ahel, Oleg Fedorov, Paul E Brennan, Kilian V M Huber
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist. Journal of medicinal chemistry 67 (9) (2024)
Esra Balıkçı, Anne-Sophie M C Marques, Ludwig G Bauer, Raina Seupel, James M Bennett, Brigitt Raux, Karly Buchan, Klemensas Simelis, Usha Singh, Catherine Rogers, Jennifer Ward, Carol Cheng, Tamas Szommer, Kira Schützenhofer, Jonathan M Elkins, David L Sloman, Ivan Ahel, Oleg Fedorov, Paul E Brennan, Kilian V M Huber
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist. Journal of medicinal chemistry 67 (9) (2024)
Esra Balıkçı, Anne-Sophie M C Marques, Ludwig G Bauer, Raina Seupel, James M Bennett, Brigitt Raux, Karly Buchan, Klemensas Simelis, Usha Singh, Catherine Rogers, Jennifer Ward, Carol Cheng, Tamas Szommer, Kira Schützenhofer, Jonathan M Elkins, David L Sloman, Ivan Ahel, Oleg Fedorov, Paul E Brennan, Kilian V M Huber
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist. Journal of medicinal chemistry (2024)
Alpha A Lee, Isabelle Amick, Jasmin C Aschenbrenner, Haim M Barr, Jared Benjamin, Alexander Brandis, Galit Cohen, Randy Diaz-Tapia, Shirly Duberstein, Jessica Dixon, David Cousins, Michael Fairhead, Daren Fearon, James Frick, James Gayvert, Andre S Godoy, Ed J Griffin, Kilian V M Huber, Lizbé Koekemoer, Noa Lahav, Peter G Marples, Briana L McGovern, Tevie Mehlman, Matthew C Robinson, Usha Singh, Tamas Szommer, Charles W E Tomlinson, Thomas Vargo, Frank von Delft, SiYi Wang, Kris White, Eleanor Williams, Max Winokan
Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response. bioRxiv : the preprint server for biology (2024)
Xuemin Chen, McKenna C Crawford, Ying Xiong, Anver Basha Shaik, Kiall F Suazo, Ludwig G Bauer, Manini S Penikalapati, Joycelyn H Williams, Kilian V M Huber, Thorkell Andressen, Rolf E Swenson, Jordan L Meier
Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300. JACS Au 4 (8) (2024)
Esra Balıkçı, Anne-Sophie M C Marques, Ludwig G Bauer, Raina Seupel, James M Bennett, Brigitt Raux, Karly Buchan, Klemensas Simelis, Usha Singh, Catherine Rogers, Jennifer Ward, Carol Cheng, Tamas Szommer, Kira Schützenhofer, Jonathan M Elkins, David L Sloman, Ivan Ahel, Oleg Fedorov, Paul E Brennan, Kilian V M Huber
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist. Journal of medicinal chemistry 67 (9) (2024)
Esra Balıkçı, Anne-Sophie M C Marques, Jesper S Hansen, Kilian V M Huber
Open resources for chemical probes and their implications for future drug discovery. Expert opinion on drug discovery (2023)
Oliver D Coleman, Jessica Macdonald, Ben Thomson, Jennifer A Ward, Christopher J Stubbs, Tom E McAllister, Shane Clark, Siddique Amin, Yimang Cao, Martine I Abboud, Yijia Zhang, Hitesh Sanganee, Kilian V M Huber, Timothy D W Claridge, Akane Kawamura
Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function. Chemical science 14 (26) (2023)
Allyn T Londregan, Karlygash Aitmakhanova, James Bennett, Laura J Byrnes, Daniel P Canterbury, Xiayun Cheng, Thomas Christott, Jennifer Clemens, Steven B Coffey, João M Dias, Matthew S Dowling, Gillian Farnie, Oleg Fedorov, Kimberly F Fennell, Vicki Gamble, Carina Gileadi, Charline Giroud, Michael R Harris, Brett D Hollingshead, Kilian V M Huber, Magdalena Korczynska, Kimberly Lapham, Paula M Loria, Arjun Narayanan, Dafydd R Owen, Brigitt Raux, Parag V Sahasrabudhe, Roger B Ruggeri, Laura Díaz Sáez, Ingrid A Stock, Benjamin A Thuma, Andy Tsai, Alison E Varghese
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. Journal of medicinal chemistry (2022)
Allyn T Londregan, Karlygash Aitmakhanova, James Bennett, Laura J Byrnes, Daniel P Canterbury, Xiayun Cheng, Thomas Christott, Jennifer Clemens, Steven B Coffey, João M Dias, Matthew S Dowling, Gillian Farnie, Oleg Fedorov, Kimberly F Fennell, Vicki Gamble, Carina Gileadi, Charline Giroud, Michael R Harris, Brett D Hollingshead, Kilian V M Huber, Magdalena Korczynska, Kimberly Lapham, Paula M Loria, Arjun Narayanan, Dafydd R Owen, Brigitt Raux, Parag V Sahasrabudhe, Roger B Ruggeri, Laura Díaz Sáez, Ingrid A Stock, Benjamin A Thuma, Andy Tsai, Alison E Varghese
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. Journal of medicinal chemistry 66 (1) (2022)
Elisabeth M Rothweiler, Paul E Brennan, Kilian V M Huber
Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators. Biological chemistry 403 (4) (2022)
Allyn T Londregan, Karlygash Aitmakhanova, James Bennett, Laura J Byrnes, Daniel P Canterbury, Xiayun Cheng, Thomas Christott, Jennifer Clemens, Steven B Coffey, João M Dias, Matthew S Dowling, Gillian Farnie, Oleg Fedorov, Kimberly F Fennell, Vicki Gamble, Carina Gileadi, Charline Giroud, Michael R Harris, Brett D Hollingshead, Kilian V M Huber, Magdalena Korczynska, Kimberly Lapham, Paula M Loria, Arjun Narayanan, Dafydd R Owen, Brigitt Raux, Parag V Sahasrabudhe, Roger B Ruggeri, Laura Díaz Sáez, Ingrid A Stock, Benjamin A Thuma, Andy Tsai, Alison E Varghese
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. Journal of medicinal chemistry 66 (1) (2022)
Allyn T Londregan, Karlygash Aitmakhanova, James Bennett, Laura J Byrnes, Daniel P Canterbury, Xiayun Cheng, Thomas Christott, Jennifer Clemens, Steven B Coffey, João M Dias, Matthew S Dowling, Gillian Farnie, Oleg Fedorov, Kimberly F Fennell, Vicki Gamble, Carina Gileadi, Charline Giroud, Michael R Harris, Brett D Hollingshead, Kilian V M Huber, Magdalena Korczynska, Kimberly Lapham, Paula M Loria, Arjun Narayanan, Dafydd R Owen, Brigitt Raux, Parag V Sahasrabudhe, Roger B Ruggeri, Laura Díaz Sáez, Ingrid A Stock, Benjamin A Thuma, Andy Tsai, Alison E Varghese
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. Journal of medicinal chemistry 66 (1) (2022)
Sabrina R Mackinnon, Tobias Krojer, William R Foster, Laura Diaz-Saez, Manshu Tang, Kilian V M Huber, Frank von Delft, Kent Lai, Paul E Brennan, Gustavo Arruda Bezerra, Wyatt W Yue
Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia. ACS chemical biology 16 (4) (2021)
Jeffrey G Martin, Jennifer A Ward, Felix Feyertag, Lu Zhang, Shalise Couvertier, Kevin Guckian, Kilian V M Huber, Douglas S Johnson
Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity. Chembiochem : a European journal of chemical biology 22 (12) (2021)
Raysa Khan Tareque, Storm Hassell-Hart, Tobias Krojer, Anthony Bradley, Srikannathasan Velupillai, Romain Talon, Michael Fairhead, Iain J Day, Kamlesh Bala, Robert Felix, Paul D Kemmitt, Paul E Brennan, Frank von Delft, Laura Díaz Sáez, Kilian V M Huber, John Spencer
Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism. ChemMedChem 15 (24) (2020)
Carrow I Wells, James D Vasta, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich, Morgan R Ingold, Julie E Pickett, David Harold Drewry, Kathryn M Pugh, Marie K Schwinn, Byounghoon Brian Hwang, Hicham Zegzouti, Kilian V M Huber, Mei Cong, Poncho L Meisenheimer, Timothy M Willson, Matthew B Robers
Quantifying CDK inhibitor selectivity in live cells. Nature communications 11 (1) (2020)
Jennifer A Ward, Adan Pinto-Fernandez, Loïc Cornelissen, Sarah Bonham, Laura Díaz-Sáez, Olivier Riant, Kilian V M Huber, Benedikt M Kessler, Olivier Feron, Edward William Tate
Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs. Journal of medicinal chemistry 63 (7) (2020)
Sarah L Kidd, Elaine Fowler, Till Reinhardt, Thomas Compton, Natalia Mateu, Hector Newman, Dom Bellini, Romain Talon, Joseph McLoughlin, Tobias Krojer, Anthony Aimon, Anthony Bradley, Michael Fairhead, Paul D Brear, Laura Díaz-Sáez, Katherine McAuley, Hannah F Sore, Andrew Madin, Daniel H O' Donovan, Kilian V M Huber, Marko Hyvönen, Frank von Delft, Christopher G Dowson, David R Spring
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Chemical science 11 (39) (2020)
Sebastian Scheer, Suzanne Ackloo, Tiago S Medina, Matthieu Schapira, Fengling Li, Jennifer A Ward, Andrew M Lewis, Jeffrey P Northrop, Paul L Richardson, Husnu Ümit Kaniskan, Yudao Shen, Jing Liu, David Smil, David A McLeod, Carlos A Zepeda-Velazquez, Minkui Luo, Jian Jin, Dalia Barsyte-Lovejoy, Kilian V M Huber, Daniel D De Carvalho, Masoud Vedadi, Colby Zaph, Peter J Brown, Cheryl H Arrowsmith
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nature communications 10 (1) (2019)
Jark Böttcher, David Dilworth, Ulrich Reiser, Ralph A Neumüller, Michael Schleicher, Mark Petronczki, Markus Zeeb, Nikolai Mischerikow, Abdellah Allali-Hassani, Magdalena M Szewczyk, Fengling Li, Steven Kennedy, Masoud Vedadi, Dalia Barsyte-Lovejoy, Peter J Brown, Kilian V M Huber, Catherine M Rogers, Carrow I Wells, Oleg Fedorov, Klaus Rumpel, Andreas Zoephel, Moriz Mayer, Tobias Wunberg, Dietrich Böse, Stephan Zahn, Heribert Arnhof, Helmut Berger, Christoph Reiser, Alexandra Hörmann, Teresa Krammer, Maja Corcokovic, Bernadette Sharps, Sandra Winkler, Daniela Häring, Xiao-Ling Cockcroft, Julian E Fuchs, Barbara Müllauer, Alexander Weiss-Puxbaum, Thomas Gerstberger, Guido Boehmelt, Christopher R Vakoc, Cheryl H Arrowsmith, Mark Pearson, Darryl B McConnell
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature chemical biology 15 (8) (2019)
Efrat Resnick, Anthony Bradley, Jinrui Gan, Alice Douangamath, Tobias Krojer, Ritika Sethi, Paul P Geurink, Anthony Aimon, Gabriel Amitai, Dom Bellini, James Bennett, Michael Fairhead, Oleg Fedorov, Ronen Gabizon, Jin Gan, Jingxu Guo, Alexander Plotnikov, Nava Reznik, Gian Filippo Ruda, Laura Díaz-Sáez, Verena M Straub, Tamas Szommer, Srikannathasan Velupillai, Daniel Zaidman, Yanling Zhang, Alun R Coker, Christopher G Dowson, Haim M Barr, Chu Wang, Kilian V M Huber, Paul E Brennan, Huib Ovaa, Frank von Delft, Nir London
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. Journal of the American Chemical Society 141 (22) (2019)
Vincent Fagan, Catrine Johansson, Carina Gileadi, Octovia Monteiro, James E Dunford, Reshma Nibhani, Martin Philpott, Jessica Malzahn, Graham Wells, Ruth Faram, Adam P Cribbs, Nadia Halidi, Fengling Li, Irene Chau, Holger Greschik, Srikannathasan Velupillai, Abdellah Allali-Hassani, James Bennett, Thomas Christott, Charline Giroud, Andrew M Lewis, Kilian V M Huber, Nick Athanasou, Chas Bountra, Manfred Jung, Roland Schüle, Masoud Vedadi, Cheryl H Arrowsmith, Yan Xiong, Jian Jin, Oleg Fedorov, Gillian Farnie, Paul E Brennan, Udo Oppermann
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function. Journal of medicinal chemistry 62 (20) (2019)
Kilian V M Huber
Target engagement: Shining a light. Nature chemical biology 13 (2) (2018)
Matous Hrdinka, Lisa Schlicher, Bing Dai, Daniel M Pinkas, Joshua C Bufton, Sarah Picaud, Jennifer A Ward, Catherine Rogers, Chalada Suebsuwong, Sameer Nikhar, Gregory D Cuny, Kilian V M Huber, Panagis Filippakopoulos, Alex N Bullock, Alexei Degterev, Mads Gyrd-Hansen
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. The EMBO journal 37 (17) (2018)
Jakub Stefaniak, Andrew M Lewis, Daniel Conole, Sébastien R G Galan, Carole J R Bataille, Graham M Wynne, M Paola Castaldi, Thomas Lundbäck, Angela J Russell, Kilian V M Huber
Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors. ACS chemical biology 13 (10) (2018)
Fredrik Rahm, Jenny Viklund, Lionel Trésaugues, Manuel Ellermann, Anja Giese, Ulrika Ericsson, Rickard Forsblom, Tobias Ginman, Judith Günther, Kenth Hallberg, Johan Lindström, Lars Boukharta Persson, Camilla Silvander, Antoine Talagas, Laura Díaz-Sáez, Oleg Fedorov, Kilian V M Huber, Ioanna Panagakou, Paulina Siejka, Mátyás Gorjánácz, Marcus Bauser, Martin Andersson
Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design. Journal of medicinal chemistry 61 (6) (2018)
Léa Bouché, Clara D Christ, Stephan Siegel, Amaury E Fernández-Montalván, Simon J Holton, Oleg Fedorov, Antonius Ter Laak, Tatsuo Sugawara, Detlef Stöckigt, Cynthia Tallant, James Bennett, Octovia Monteiro, Laura Díaz-Sáez, Paulina Siejka, Julia Meier, Vera Pütter, Jörg Weiske, Susanne Müller, Kilian V M Huber, Ingo V Hartung, Bernard Haendler
Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. Journal of medicinal chemistry 60 (9) (2017)
Gregory I Vladimer, Berend Snijder, Nikolaus Krall, Johannes W Bigenzahn, Kilian V M Huber, Charles-Hugues Lardeau, Kumar Sanjiv, Anna Ringler, Ulrika Warpman Berglund, Monika Sabler, Oscar Lopez de la Fuente, Paul Knöbl, Stefan Kubicek, Thomas Helleday, Ulrich Jäger, Giulio Superti-Furga
Global survey of the immunomodulatory potential of common drugs. Nature chemical biology 13 (6) (2017)
Branka Radic-Sarikas, Melinda Halasz, Kilian V M Huber, Georg E Winter, Kalliopi P Tsafou, Theodore Papamarkou, Søren Brunak, Walter Kolch, Giulio Superti-Furga
Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter. Scientific reports 7 (1) (2017)
Emir Hadzijusufovic, K Albrecht-Schgoer, Kilian V M Huber, G Hoermann, Florian Grebien, G Eisenwort, W Schgoer, S Herndlhofer, C Kaun, M Theurl, W R Sperr, Uwe Rix, I Sadovnik, B Jilma, G H Schernthaner, J Wojta, D Wolf, Giulio Superti-Furga, R Kirchmair, P Valent
Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site. Leukemia 31 (11) (2017)
Rui Martins, Julia Maier, Anna-Dorothea Gorki, Kilian V M Huber, Omar Sharif, Philipp Starkl, Simona Saluzzo, Federica Quattrone, Riem Gawish, Karin Lakovits, Michael C Aichinger, Branka Radic-Sarikas, Charles-Hugues Lardeau, Anastasiya Hladik, Ana Korosec, Markus Brown, Kari Vaahtomeri, Michelle Duggan, Dontscho Kerjaschki, Harald Esterbauer, Jacques Colinge, Stephanie C Eisenbarth, Thomas Decker, Keiryn L Bennett, Stefan Kubicek, Michael Sixt, Giulio Superti-Furga, Sylvia Knapp
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions. Nature immunology 17 (12) (2016)
Sara Sdelci, Charles-Hugues Lardeau, Cynthia Tallant, Freya Klepsch, Björn Klaiber, James Bennett, Philipp Rathert, Michael Schuster, Thomas Penz, Oleg Fedorov, Giulio Superti-Furga, Christoph Bock, Johannes Zuber, Kilian V M Huber, Stefan Knapp, Susanne Müller, Stefan Kubicek
Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk. Nature chemical biology 12 (7) (2016)
Kilian V M Huber, Karin M Olek, André C Müller, Chris Soon Heng Tan, Keiryn L Bennett, Jacques Colinge, Giulio Superti-Furga
Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling. Nature methods 12 (11) (2015)

Kilian V M Huber.css-eqlu8i{font-size:small;padding-left:4px;} (Kilian Huber, K Huber, Kilian Vm Huber)

Publication Activity (10 Years)

Top Topics

Top Venues

Kilian V M Huber (Kilian Huber, K Huber, Kilian Vm Huber)