Adriano Aguzzi

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 93

Top Venues

Nature communications

Science (New York, N.Y.)

Nature microbiology

Nature

University of Zurich

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Zurich Jul 01 1992

Switzerland

Director :: Neuropathology

Publications

Yingjun Liu, Jingjing Guo, Maja Matoga, Marina Korotkova, Per-Johan Jakobsson, Adriano Aguzzi
NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. Nature neuroscience 27 (8) (2024)
Carlo Cervia-Hasler, Sarah Catharina Brüningk, Tobias Hoch, Bowen Fan, Giulia Muzio, Ryan C Thompson, Laura Ceglarek, Roman Meledin, Patrick Westermann, Marc Emmenegger, Patrick Taeschler, Yves Zurbuchen, Michele Pons, Dominik Menges, Tala Ballouz, Sara Hasler, Sarah Adamo, Miriam Merad, Alexander W Charney, Milo Puhan, Petter Brodin, Jakob Nilsson, Adriano Aguzzi, Miro E Raeber, Christoph B Messner, Noam D Beckmann, Karsten M Borgwardt, Onur Boyman
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. Science (New York, N.Y.) 383 (6680) (2024)
Yingjun Liu, Jingjing Guo, Maja Matoga, Marina Korotkova, Per-Johan Jakobsson, Adriano Aguzzi
NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. Nature neuroscience 27 (8) (2024)
Nikita Vladimirov, Fabian F Voigt, Thomas Naert, Gabriela R Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther T Stoeckli, Laura Baudis, Soeren Sten Lienkamp, Fritjof Helmchen
Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples. Nature communications 15 (1) (2024)
Shahar Bracha, Hannah J Johnson, Nicole A Pranckevicius, Francesca Catto, Athena E Economides, Sergey Litvinov, Karoliina Hassi, Marco Tullio Rigoli, Cristina Cheroni, Matteo Bonfanti, Alessia Valenti, Sarah Stucchi, Shruti Attreya, Paul D Ross, Daniel Walsh, Nati Malachi, Hagay Livne, Reut Eshel, Vladislav Krupalnik, Doron Levin, Stuart Cobb, Petros Koumoutsakos, Nicolò Caporale, Giuseppe Testa, Adriano Aguzzi, Anita A Koshy, Lilach Sheiner, Oded Rechavi
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nature microbiology 9 (8) (2024)
Carlos Company, Matthias Jürgen Schmitt, Yuliia Dramaretska, Michela Serresi, Sonia Kertalli, Ben Jiang, Jiang-An Yin, Adriano Aguzzi, Iros Barozzi, Ciro Gargiulo Isacco
Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes. Nature communications 15 (1) (2024)
Yingjun Liu, Jingjing Guo, Maja Matoga, Marina Korotkova, Per-Johan Jakobsson, Adriano Aguzzi
NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. Nature neuroscience (2024)
Nikita Vladimirov, Fabian F Voigt, Thomas Naert, Gabriela R Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther T Stoeckli, Laura Baudis, Soeren Sten Lienkamp, Fritjof Helmchen
Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples. Nature communications 15 (1) (2024)
Carlo Cervia-Hasler, Sarah Catharina Brüningk, Tobias Hoch, Bowen Fan, Giulia Muzio, Ryan C Thompson, Laura Ceglarek, Roman Meledin, Patrick Westermann, Marc Emmenegger, Patrick Taeschler, Yves Zurbuchen, Michele Pons, Dominik Menges, Tala Ballouz, Sara Hasler, Sarah Adamo, Miriam Merad, Alexander W Charney, Milo Puhan, Petter Brodin, Jakob Nilsson, Adriano Aguzzi, Miro E Raeber, Christoph B Messner, Noam D Beckmann, Karsten M Borgwardt, Onur Boyman
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. Science (New York, N.Y.) 383 (6680) (2024)
Francesca Catto, Ehsan Dadgar-Kiani, Daniel Kirschenbaum, Athena E Economides, Anna Maria Reuss, Chiara Trevisan, Davide Caredio, Delic Mirzet, Lukas Frick, Ulrike Weber-Stadlbauer, Sergey Litvinov, Petros Koumoutsakos, Jin Hyung Lee, Adriano Aguzzi
Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone. bioRxiv : the preprint server for biology (2024)
Marian Hruska-Plochan, Vera I Wiersma, Katharina M Hembach, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl J Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D Robinson, Theofanis Karayannis, Martin Müller, Andreas Hierlemann, Magdalini Polymenidou
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. Nature 626 (8001) (2024)
Francesca Catto, Ehsan Dadgar-Kiani, Daniel Kirschenbaum, Athena E Economides, Anna Maria Reuss, Chiara Trevisan, Davide Caredio, Delic Mirzet, Lukas Frick, Ulrike Weber-Stadlbauer, Sergey Litvinov, Petros Koumoutsakos, Jin Hyung Lee, Adriano Aguzzi
Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone. bioRxiv : the preprint server for biology (2024)
Carlo Cervia-Hasler, Sarah Catharina Brüningk, Tobias Hoch, Bowen Fan, Giulia Muzio, Ryan C Thompson, Laura Ceglarek, Roman Meledin, Patrick Westermann, Marc Emmenegger, Patrick Taeschler, Yves Zurbuchen, Michele Pons, Dominik Menges, Tala Ballouz, Sara Hasler, Sarah Adamo, Miriam Merad, Alexander W Charney, Milo Puhan, Petter Brodin, Jakob Nilsson, Adriano Aguzzi, Miro E Raeber, Christoph B Messner, Noam D Beckmann, Karsten M Borgwardt, Onur Boyman
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. Science (New York, N.Y.) 383 (6680) (2024)
Adriano Aguzzi
Prion science and its unsung heroes. Science (New York, N.Y.) 383 (6680) (2024)
Shahar Bracha, Hannah J Johnson, Nicole A Pranckevicius, Francesca Catto, Athena E Economides, Sergey Litvinov, Karoliina Hassi, Marco Tullio Rigoli, Cristina Cheroni, Matteo Bonfanti, Alessia Valenti, Sarah Stucchi, Shruti Attreya, Paul D Ross, Daniel Walsh, Nati Malachi, Hagay Livne, Reut Eshel, Vladislav Krupalnik, Doron Levin, Stuart Cobb, Petros Koumoutsakos, Nicolò Caporale, Giuseppe Testa, Adriano Aguzzi, Anita A Koshy, Lilach Sheiner, Oded Rechavi
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nature microbiology 9 (8) (2024)
Marian Hruska-Plochan, Vera I Wiersma, Katharina M Hembach, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl J Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D Robinson, Theofanis Karayannis, Martin Müller, Andreas Hierlemann, Magdalini Polymenidou
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. Nature (2024)
Carlos Company, Matthias Jürgen Schmitt, Yuliia Dramaretska, Michela Serresi, Sonia Kertalli, Ben Jiang, Jiang-An Yin, Adriano Aguzzi, Iros Barozzi, Ciro Gargiulo Isacco
Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes. Nature communications 15 (1) (2024)
Marian Hruska-Plochan, Vera I Wiersma, Katharina M Hembach, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl J Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D Robinson, Theofanis Karayannis, Martin Müller, Andreas Hierlemann, Magdalini Polymenidou
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. Nature 626 (8001) (2024)
Marian Hruska-Plochan, Vera I Wiersma, Katharina M Hembach, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl J Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D Robinson, Theofanis Karayannis, Martin Müller, Andreas Hierlemann, Magdalini Polymenidou
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. Nature (2024)
Yingjun Liu, Jingjing Guo, Maja Matoga, Marina Korotkova, Per-Johan Jakobsson, Adriano Aguzzi
NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. Nature neuroscience 27 (8) (2024)
Davide Caredio, Maruša Koderman, Karl J Frontzek, Silvia Sorce, Mario Nuvolone, Juliane Bremer, Giovanni Mariutti, Petra Schwarz, Lidia Madrigal, Marija Mitrovic, Stefano Sellitto, Nathalie Streichenberger, Claudia Scheckel, Adriano Aguzzi
Prion diseases disrupt glutamate/glutamine metabolism in skeletal muscle. PLoS pathogens 20 (9) (2024)
Adriano Aguzzi
Prion science and its unsung heroes. Science (New York, N.Y.) 383 (6680) (2024)
Adriano Aguzzi
Prion science and its unsung heroes. Science (New York, N.Y.) 383 (6680) (2024)
Francesca Catto, Ehsan Dadgar-Kiani, Daniel Kirschenbaum, Athena E Economides, Anna Maria Reuss, Chiara Trevisan, Davide Caredio, Delic Mirzet, Lukas Frick, Ulrike Weber-Stadlbauer, Sergey Litvinov, Petros Koumoutsakos, Jin Hyung Lee, Adriano Aguzzi
Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone. bioRxiv : the preprint server for biology (2024)
Shahar Bracha, Hannah J Johnson, Nicole A Pranckevicius, Francesca Catto, Athena E Economides, Sergey Litvinov, Karoliina Hassi, Marco Tullio Rigoli, Cristina Cheroni, Matteo Bonfanti, Alessia Valenti, Sarah Stucchi, Shruti Attreya, Paul D Ross, Daniel Walsh, Nati Malachi, Hagay Livne, Reut Eshel, Vladislav Krupalnik, Doron Levin, Stuart Cobb, Petros Koumoutsakos, Nicolò Caporale, Giuseppe Testa, Adriano Aguzzi, Anita A Koshy, Lilach Sheiner, Oded Rechavi
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nature microbiology 9 (8) (2024)
Shahar Bracha, Hannah J Johnson, Nicole A Pranckevicius, Francesca Catto, Athena E Economides, Sergey Litvinov, Karoliina Hassi, Marco Tullio Rigoli, Cristina Cheroni, Matteo Bonfanti, Alessia Valenti, Sarah Stucchi, Shruti Attreya, Paul D Ross, Daniel Walsh, Nati Malachi, Hagay Livne, Reut Eshel, Vladislav Krupalnik, Doron Levin, Stuart Cobb, Petros Koumoutsakos, Nicolò Caporale, Giuseppe Testa, Adriano Aguzzi, Anita A Koshy, Lilach Sheiner, Oded Rechavi
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nature microbiology 9 (8) (2024)
Shahar Bracha, Hannah J Johnson, Nicole A Pranckevicius, Francesca Catto, Athena E Economides, Sergey Litvinov, Karoliina Hassi, Marco Tullio Rigoli, Cristina Cheroni, Matteo Bonfanti, Alessia Valenti, Sarah Stucchi, Shruti Attreya, Paul D Ross, Daniel Walsh, Nati Malachi, Hagay Livne, Reut Eshel, Vladislav Krupalnik, Doron Levin, Stuart Cobb, Petros Koumoutsakos, Nicolò Caporale, Giuseppe Testa, Adriano Aguzzi, Anita A Koshy, Lilach Sheiner, Oded Rechavi
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nature microbiology 9 (8) (2024)
Marian Hruska-Plochan, Vera I Wiersma, Katharina M Hembach, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl J Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D Robinson, Theofanis Karayannis, Martin Müller, Andreas Hierlemann, Magdalini Polymenidou
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. Nature 626 (8001) (2024)
Yingjun Liu, Jingjing Guo, Maja Matoga, Marina Korotkova, Per-Johan Jakobsson, Adriano Aguzzi
NG2 glia protect against prion neurotoxicity by inhibiting microglia-to-neuron prostaglandin E2 signaling. Nature neuroscience 27 (8) (2024)
Nikita Vladimirov, Fabian F Voigt, Thomas Naert, Gabriela R Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther T Stoeckli, Laura Baudis, Soeren Sten Lienkamp, Fritjof Helmchen
Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples. Nature communications 15 (1) (2024)
Shahar Bracha, Hannah J Johnson, Nicole A Pranckevicius, Francesca Catto, Athena E Economides, Sergey Litvinov, Karoliina Hassi, Marco Tullio Rigoli, Cristina Cheroni, Matteo Bonfanti, Alessia Valenti, Sarah Stucchi, Shruti Attreya, Paul D Ross, Daniel Walsh, Nati Malachi, Hagay Livne, Reut Eshel, Vladislav Krupalnik, Doron Levin, Stuart Cobb, Petros Koumoutsakos, Nicolò Caporale, Giuseppe Testa, Adriano Aguzzi, Anita A Koshy, Lilach Sheiner, Oded Rechavi
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nature microbiology (2024)
Marian Hruska-Plochan, Vera I Wiersma, Katharina M Hembach, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl J Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D Robinson, Theofanis Karayannis, Martin Müller, Andreas Hierlemann, Magdalini Polymenidou
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. Nature (2024)
Shahar Bracha, Hannah J Johnson, Nicole A Pranckevicius, Francesca Catto, Athena E Economides, Sergey Litvinov, Karoliina Hassi, Marco Tullio Rigoli, Cristina Cheroni, Matteo Bonfanti, Alessia Valenti, Sarah Stucchi, Shruti Attreya, Paul D Ross, Daniel Walsh, Nati Malachi, Hagay Livne, Reut Eshel, Vladislav Krupalnik, Doron Levin, Stuart Cobb, Petros Koumoutsakos, Nicolò Caporale, Giuseppe Testa, Adriano Aguzzi, Anita A Koshy, Lilach Sheiner, Oded Rechavi
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nature microbiology 9 (8) (2024)
Nikita Vladimirov, Fabian F Voigt, Thomas Naert, Gabriela R Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther T Stoeckli, Laura Baudis, Soeren Sten Lienkamp, Fritjof Helmchen
Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples. Nature communications 15 (1) (2024)
Shahar Bracha, Hannah J Johnson, Nicole A Pranckevicius, Francesca Catto, Athena E Economides, Sergey Litvinov, Karoliina Hassi, Marco Tullio Rigoli, Cristina Cheroni, Matteo Bonfanti, Alessia Valenti, Sarah Stucchi, Shruti Attreya, Paul D Ross, Daniel Walsh, Nati Malachi, Hagay Livne, Reut Eshel, Vladislav Krupalnik, Doron Levin, Stuart Cobb, Petros Koumoutsakos, Nicolò Caporale, Giuseppe Testa, Adriano Aguzzi, Anita A Koshy, Lilach Sheiner, Oded Rechavi
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons. Nature microbiology 9 (8) (2024)
Nikita Vladimirov, Fabian F Voigt, Thomas Naert, Gabriela R Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Ertürk, Adriano Aguzzi, Urs Ziegler, Esther T Stoeckli, Laura Baudis, Soeren Sten Lienkamp, Fritjof Helmchen
Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for cleared samples. Nature communications 15 (1) (2024)
Carlos Company, Matthias Jürgen Schmitt, Yuliia Dramaretska, Michela Serresi, Sonia Kertalli, Ben Jiang, Jiang-An Yin, Adriano Aguzzi, Iros Barozzi, Ciro Gargiulo Isacco
Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes. Nature communications 15 (1) (2024)
Marian Hruska-Plochan, Vera I Wiersma, Katharina M Hembach, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma, Laura De Vos, Karl J Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D Robinson, Theofanis Karayannis, Martin Müller, Andreas Hierlemann, Magdalini Polymenidou
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. Nature 626 (8001) (2024)
Carlo Cervia-Hasler, Sarah Catharina Brüningk, Tobias Hoch, Bowen Fan, Giulia Muzio, Ryan C Thompson, Laura Ceglarek, Roman Meledin, Patrick Westermann, Marc Emmenegger, Patrick Taeschler, Yves Zurbuchen, Michele Pons, Dominik Menges, Tala Ballouz, Sara Hasler, Sarah Adamo, Miriam Merad, Alexander W Charney, Milo Puhan, Petter Brodin, Jakob Nilsson, Adriano Aguzzi, Miro E Raeber, Christoph B Messner, Noam D Beckmann, Karsten M Borgwardt, Onur Boyman
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. Science (New York, N.Y.) 383 (6680) (2024)
Adriano Aguzzi
Prion science and its unsung heroes. Science (New York, N.Y.) 383 (6680) (2024)
Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niklas Bargenda, Niels J Rupp, Manfredi C Carta, Karl J Frontzek, Veronika Lysenko, Regina R Reimann, Petra Schwarz, Mario Nuvolone, Gunilla T Westermark, K Peter R Nilsson, Magdalini Polymenidou, Alexandre Pa Theocharides, Simone Hornemann, Paola Picotti, Adriano Aguzzi
The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis. EMBO molecular medicine (2024)
Carlo Cervia-Hasler, Sarah Catharina Brüningk, Tobias Hoch, Bowen Fan, Giulia Muzio, Ryan C Thompson, Laura Ceglarek, Roman Meledin, Patrick Westermann, Marc Emmenegger, Patrick Taeschler, Yves Zurbuchen, Michele Pons, Dominik Menges, Tala Ballouz, Sara Hasler, Sarah Adamo, Miriam Merad, Alexander W Charney, Milo Puhan, Petter Brodin, Jakob Nilsson, Adriano Aguzzi, Miro E Raeber, Christoph B Messner, Noam D Beckmann, Karsten M Borgwardt, Onur Boyman
Persistent complement dysregulation with signs of thromboinflammation in active Long Covid. Science (New York, N.Y.) 383 (6680) (2024)
Nikita Vladimirov, Fabian F Voigt, Thomas Naert, Gabriela R Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Erturk, Adriano Aguzzi, Urs Ziegler, Esther T Stoeckli, Laura Baudis, Soeren Sten Lienkamp, Fritjof Helmchen
The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples. bioRxiv : the preprint server for biology (2023)
Nikita Vladimirov, Fabian F Voigt, Thomas Naert, Gabriela R Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Erturk, Adriano Aguzzi, Urs Ziegler, Esther T Stoeckli, Laura Baudis, Soeren Sten Lienkamp, Fritjof Helmchen
The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples. bioRxiv : the preprint server for biology (2023)
Nikita Vladimirov, Fabian F Voigt, Thomas Naert, Gabriela R Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Erturk, Adriano Aguzzi, Urs Ziegler, Esther T Stoeckli, Laura Baudis, Soeren Sten Lienkamp, Fritjof Helmchen
The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples. bioRxiv : the preprint server for biology (2023)
Fabian F Voigt, Anna Maria Reuss, Thomas Naert, Sven Hildebrand, Martina Schaettin, Adriana L Hotz, Lachlan W Whitehead, Armin Bahl, Stephan C F Neuhauss, Alard Roebroeck, Esther T Stoeckli, Soeren Sten Lienkamp, Adriano Aguzzi, Fritjof Helmchen
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope. Nature biotechnology (2023)
Fabian F Voigt, Anna Maria Reuss, Thomas Naert, Sven Hildebrand, Martina Schaettin, Adriana L Hotz, Lachlan W Whitehead, Armin Bahl, Stephan C F Neuhauss, Alard Roebroeck, Esther T Stoeckli, Soeren Sten Lienkamp, Adriano Aguzzi, Fritjof Helmchen
Reflective multi-immersion microscope objectives inspired by the Schmidt telescope. Nature biotechnology (2023)
Nikita Vladimirov, Fabian F Voigt, Thomas Naert, Gabriela R Araujo, Ruiyao Cai, Anna Maria Reuss, Shan Zhao, Patricia Schmid, Sven Hildebrand, Martina Schaettin, Dominik Groos, José María Mateos Melero, Philipp Bethge, Taiyo Yamamoto, Valentino Aerne, Alard Roebroeck, Ali Erturk, Adriano Aguzzi, Urs Ziegler, Esther T Stoeckli, Laura Baudis, Soeren Sten Lienkamp, Fritjof Helmchen
The Benchtop mesoSPIM: a next-generation open-source light-sheet microscope for large cleared samples. bioRxiv : the preprint server for biology (2023)
Adriano Aguzzi, Martin Edward Kampmann
Neurodegeneration enters the era of functional genomics. Science (New York, N.Y.) 381 (6662) (2023)
Ruiqing Ni, Zhenyue Chen, Xosé Luís Deán-Ben, Fabian F Voigt, Daniel Kirschenbaum, Gloria Shi, Alessia Villois, Quanyu Zhou, Alessandro Crimi, Paolo Arosio, Roger M Nitsch, K Peter R Nilsson, Adriano Aguzzi, Fritjof Helmchen, Jan Klohs, Daniel Razansky
Multiscale optical and optoacoustic imaging of amyloid-β deposits in mice. Nature biomedical engineering 6 (9) (2022)
Daniel Kirschenbaum, Ehsan Dadgar-Kiani, Francesca Catto, Fabian F Voigt, Chiara Trevisan, Oliver Bichsel, Hamid Shirani, K Peter R Nilsson, Karl J Frontzek, Paolo Paganetti, Fritjof Helmchen, Jin Hyung Lee, Adriano Aguzzi
Whole-brain microscopy reveals distinct temporal and spatial efficacy of anti-Aβ therapies. EMBO molecular medicine (2022)
Yingjun Liu, Assunta Senatore, Silvia Sorce, Mario Nuvolone, Jingjing Guo, Zeynep Hülya Gümüş, Adriano Aguzzi
Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions. Communications biology 5 (1) (2022)
Regina Rose Reimann, Martina Puzio, Antonella Rosati, Marc Emmenegger, Bernard L Schneider, Pamela Valdés, Danzhi Huang, Amedeo Caflisch, Adriano Aguzzi
Rapid ex vivo reverse genetics identifies the essential determinants of prion protein toxicity. Brain pathology (Zurich, Switzerland) (2022)
Karl J Frontzek, Marco Bardelli, Assunta Senatore, Anna Henzi, Regina R Reimann, Seden Bedir, Marika Marino, Rohanah Hussain, Simon Jurt, Georg Meisl, Mattia Pedotti, Federica Mazzola, Giuliano Siligardi, Oliver Zerbe, Marco Losa, Tuomas P J Knowles, Asvin Lakkaraju, Caihong Zhu, Petra Schwarz, Simone Hornemann, Matthew G Holt, Luca Simonelli, Luca Varani, Adriano Aguzzi
A conformational switch controlling the toxicity of the prion protein. Nature structural & molecular biology 29 (8) (2022)
Yingjun Liu, Assunta Senatore, Silvia Sorce, Mario Nuvolone, Jingjing Guo, Zeynep Hülya Gümüş, Adriano Aguzzi
Author Correction: Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions. Communications biology 5 (1) (2022)
Merve Avar, Daniel Heinzer, Alana M Thackray, Yingjun Liu, Marian Hruska-Plochan, Stefano Sellitto, Elke Schaper, Daniel Patrick Pease, Jiang-An Yin, Asvin K K Lakkaraju, Marc Emmenegger, Marco Losa, Andra Chincisan, Simone Hornemann, Magdalini Polymenidou, Raymond Bujdoso, Adriano Aguzzi
An arrayed genome-wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate-limiting for prion propagation. The EMBO journal 41 (23) (2022)
Asvin K K Lakkaraju, Silvia Sorce, Assunta Senatore, Mario Nuvolone, Jingjing Guo, Petra Schwarz, Rita Moos, Pawel Pelczar, Adriano Aguzzi
Glial activation in prion diseases is selectively triggered by neuronal PrP Sc . Brain pathology (Zurich, Switzerland) 32 (5) (2022)
Jeff R Gehlhausen, Alicia J Little, Christine J Ko, Marc Emmenegger, Carolina Lucas, Patrick Wong, Jon Klein, Peiwen Lu, Tianyang Mao, Jillian Jaycox, Eric Wang, null null, Nelson Ugwu, Cate Muenker, Dilgash Mekael, Rhonda Q Klein, Robert Patrignelli, Richard Antaya, Jennifer McNiff, William Damsky, Kathy Kamath, John Shon, Aaron M Ring, Inci Yildirim, Saad B Omer, Albert I Ko, Adriano Aguzzi, Akiko Iwasak
Lack of association between pandemic chilblains and SARS-CoV-2 infection. Proceedings of the National Academy of Sciences of the United States of America 119 (9) (2022)
Anna Henzi, Adriano Aguzzi
The prion protein is not required for peripheral nerve de- and remyelination after crush injury. PloS one 16 (1) (2021)
Georg Meisl, Timothy Kurt, Itzel Condado-Morales, Cyrus Bett, Silvia Sorce, Mario Nuvolone, Thomas C T Michaels, Daniel Heinzer, Merve Avar, Samuel I A Cohen, Simone Hornemann, Adriano Aguzzi, Christopher M Dobson, Christina J Sigurdson, Tuomas P J Knowles
Scaling analysis reveals the mechanism and rates of prion replication in vivo. Nature structural & molecular biology 28 (4) (2021)
Caihong Zhu, Adriano Aguzzi
Prion protein and prion disease at a glance. Journal of cell science 134 (17) (2021)
Asvin K K Lakkaraju, Karl J Frontzek, Emina Lemes, Uli Herrmann, Marco Losa, Rajlakshmi Marpakwar, Adriano Aguzzi
Loss of PIKfyve drives the spongiform degeneration in prion diseases. EMBO molecular medicine 13 (9) (2021)
Luise Linsenmeier, Behnam Mohammadi, Mohsin Shafiq, Karl J Frontzek, Julia Bär, Amulya Nidhi Shrivastava, Markus Damme, Feizhi Song, Alexander Schwarz, Stefano Da Vela, Tania Massignan, Sebastian Jung, Angela Correia, Matthias Schmitz, Berta Puig, Simone Hornemann, Inga Zerr, Jörg Tatzelt, Emiliano Biasini, Paul Saftig, Michaela Schweizer, Dmitri I Svergun, Ladan Amin, Federica Mazzola, Luca Varani, Simrika Thapa, Sabine Gilch, Hermann M Schatzl, David A Harris, Antoine Triller, Marina Mikhaylova, Adriano Aguzzi, Hermann Clemens Altmeppen, Markus Glatzel
Ligands binding to the prion protein induce its proteolytic release with therapeutic potential in neurodegenerative proteinopathies. Science advances 7 (48) (2021)
Bei Li, Meiling Chen, Adriano Aguzzi, Caihong Zhu
The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of molecular medicine (Berlin, Germany) 99 (6) (2021)
Orsolya Török, Bettina Schreiner, Johanna Schaffenrath, Hsing-Chuan Tsai, Upasana Maheshwari, Sebastian A Stifter, Christina A Welsh, Ana Amorim, Sucheta Sridhar, Sebastian G Utz, Wiebke Mildenberger, Sina Nassiri, Mauro Delorenzi, Adriano Aguzzi, May H Han, Melanie Greter, Burkhard Becher, Annika Keller
Pericytes regulate vascular immune homeostasis in the CNS. Proceedings of the National Academy of Sciences of the United States of America 118 (10) (2021)
Matthias M Schneider, Marc Emmenegger, Catherine K Xu, Itzel Condado-Morales, Georg Meisl, Priscilla Turelli, Chrysoula Zografou, Manuela R Zimmermann, Beat M Frey, Sebastian Fiedler, Viola Denninger, Raphaël P B Jacquat, Lidia Madrigal, Alison Ilsley, Vasilis Kosmoliaptsis, Heike Fiegler, Didier Trono, Tuomas Pj Knowles, Adriano Aguzzi
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasma. Life science alliance 5 (2) (2021)
Marc Emmenegger, Elena De Cecco, Marian Hruska-Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa-Vergniory, Andrès Gonzalez-Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin C Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies. EMBO molecular medicine 13 (9) (2021)
Razieh Kamali-Jamil, Ester Vázquez-Fernández, Brian Tancowny, Vineet Rathod, Sara Amidian, Xiongyao Wang, Xinli Tang, Andrew Fang, Assunta Senatore, Simone Hornemann, Sandor Dudas, Adriano Aguzzi, Howard S Young, Holger Wille
The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models. PLoS pathogens 17 (6) (2021)
Daniel Heinzer, Merve Avar, Daniel Patrick Pease, Ashutosh Dhingra, Jiang-An Yin, Elke Schaper, Berre Doğançay, Marc Emmenegger, Anna Spinelli, Kevin Maggi, Andra Chincisan, Simon Mead, Simone Hornemann, Peter Heutink, Adriano Aguzzi
Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference. PLoS pathogens 17 (10) (2021)
Maximo Sanz-Hernandez, Joseph D Barritt, Jens Sobek, Simone Hornemann, Adriano Aguzzi, Alfonso De Simone
Mechanism of misfolding of the human prion protein revealed by a pathological mutation. Proceedings of the National Academy of Sciences of the United States of America 118 (12) (2021)
Karl J Frontzek, Manfredi Carta, Marco Losa, Mirka Epskamp, Georg Meisl, Alice Anane, Jean-Philippe Brandel, Ulrike Camenisch, Joaquín Castilla, Stéphane Haïk, Tuomas P J Knowles, Ewald Lindner, Andreas Lutterotti, Eric Vallabh Minikel, Ignazio Roiter, Jiri G Safar, Raquel Sanchez-Valle, Dana Žáková, Simone Hornemann, Adriano Aguzzi, null null
Autoantibodies against the prion protein in individuals with PRNP mutations. Neurology 95 (14) (2020)
Assunta Senatore, Karl J Frontzek, Marc Emmenegger, Andra Chincisan, Marco Losa, Regina Rose Reimann, Geraldine Horny, Jingjing Guo, Sylvie Fels, Silvia Sorce, Caihong Zhu, Nathalie George, Stefan Ewert, Thomas Pietzonka, Simone Hornemann, Adriano Aguzzi
Protective anti-prion antibodies in human immunoglobulin repertoires. EMBO molecular medicine 12 (9) (2020)
Elena De Cecco, Luigi Celauro, Silvia Vanni, Micaela Grandolfo, Edoardo Bistaffa, Fabio Moda, Adriano Aguzzi, Giuseppe Legname
The uptake of tau amyloid fibrils is facilitated by the cellular prion protein and hampers prion propagation in cultured cells. Journal of neurochemistry 155 (5) (2020)
Silvia Sorce, Mario Nuvolone, Giancarlo Russo, Andra Chincisan, Daniel Heinzer, Merve Avar, Manuela Pfammatter, Petra Schwarz, Mirzet Delic, Micha Müller, Simone Hornemann, Despina Sanoudou, Claudia Scheckel, Adriano Aguzzi
Genome-wide transcriptomics identifies an early preclinical signature of prion infection. PLoS pathogens 16 (6) (2020)
Claudia Scheckel, Marigona Imeri, Petra Schwarz, Adriano Aguzzi
Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons. eLife 9 (2020)
Merve Avar, Daniel Heinzer, Nicolas Steinke, Berre Doğançay, Rita Moos, Severine Lugan, Claudia Cosenza, Simone Hornemann, Olivier Andréoletti, Adriano Aguzzi
Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line. Life science alliance 3 (8) (2020)
Rahel Kastli, Rasmus Vighagen, Alexander van der Bourg, Ali Özgür Argunşah, Asim Iqbal, Fabian F Voigt, Daniel Kirschenbaum, Adriano Aguzzi, Fritjof Helmchen, Theofanis Karayannis
Developmental divergence of sensory stimulus representation in cortical interneurons. Nature communications 11 (1) (2020)
Juan A Gerez, Natalia C Prymaczok, Edward Rockenstein, Uli S Herrmann, Petra Schwarz, Anthony Adame, Radoslav I Enchev, Thibault Courtheoux, Paul J Boersema, Roland Riek, Matthias Peter, Adriano Aguzzi, Eliezer Masliah, Paola Picotti
A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology. Science translational medicine 11 (495) (2020)
Donal McHugh, Renier Myburgh, Nicole Caduff, Michael Spohn, Yik Lim Kok, Christian W Keller, Anita Murer, Bithi Chatterjee, Julia Rühl, Christine Engelmann, Obinna Chijioke, Isaak Quast, Mohaned Shilaih, Victoria P Strouvelle, Kathrin Neumann, Thomas Menter, Stephan Dirnhofer, Janice Kp Lam, Kwai Fung Hui, Simon Bredl, Erika Schlaepfer, Silvia Sorce, Andrea Zbinden, Riccarda Capaul, Jan D Lünemann, Adriano Aguzzi, Alan Kwok Shing Chiang, Werner Kempf, Alexandra Trkola, Karin J Metzner, Markus Gabriel Manz, Adam Grundhoff, Roberto F Speck, Christian Münz
EBV renders B cells susceptible to HIV-1 in humanized mice. Life science alliance 3 (8) (2020)
Claudia Scheckel, Adriano Aguzzi
Prions, prionoids and protein misfolding disorders. Nature reviews. Genetics 19 (7) (2019)
Simone Hornemann, Petra Schwarz, Elisabeth J Rushing, Michael D Connolly, Ronald N Zuckermann, Alice Y Yam, Adriano Aguzzi
Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads. PloS one 14 (9) (2019)
Fabian F Voigt, Daniel Kirschenbaum, Evgenia Platonova, Stéphane Pagès, Robert A A Campbell, Rahel Kastli, Martina Schaettin, Ladan Egolf, Alexander van der Bourg, Philipp Bethge, Karen Haenraets, Noémie Frézel, Thomas Topilko, Paola Perin, Daniel Hillier, Sven Hildebrand, Anna Schueth, Alard Roebroeck, Botond Roska, Esther T Stoeckli, Roberto Pizzala, Nicolas Renier, Hanns Ulrich Zeilhofer, Theofanis Karayannis, Urs Ziegler, Laura Batti, Anthony Holtmaat, Christian Lüscher, Adriano Aguzzi, Fritjof Helmchen
The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue. Nature methods 16 (11) (2019)
Caihong Zhu, Bei Li, Karl Frontzek, Yingjun Liu, Adriano Aguzzi
SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. The Journal of experimental medicine 216 (4) (2019)
Annika Keller, Mario Nuvolone, Irina Abakumova, Andra Chincisan, Regina Reimann, Merve Avar, Daniel Heinzer, Simone Hornemann, Josephin Wagner, Daniel Kirschenbaum, Fabian F Voigt, Caihong Zhu, Luca Regli, Fritjof Helmchen, Adriano Aguzzi
Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier. PLoS pathogens 14 (11) (2018)
William T Ralvenius, Elena Neumann, Martina Pagani, Mario A Acuña, Hendrik Wildner, Dietmar Benke, Nina Fischer, Ana Rostaher, Simon Schwager, Michael Detmar, Katrin Frauenknecht, Adriano Aguzzi, Jed Lee Hubbs, Uwe Rudolph, Claude Favrot, Hanns Ulrich Zeilhofer
Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors. Nature communications 9 (1) (2018)
Marco Bardelli, Karl J Frontzek, Luca Simonelli, Simone Hornemann, Mattia Pedotti, Federica Mazzola, Manfredi Carta, Valeria Eckhardt, Rocco D'Antuono, Tommaso Virgilio, Santiago F González, Adriano Aguzzi, Luca Varani
A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity. PLoS pathogens 14 (10) (2018)
Daniel Patrick Pease, Claudia Scheckel, Elke Schaper, Valeria Eckhardt, Marc Emmenegger, Ioannis Xenarios, Adriano Aguzzi
Genome-wide identification of microRNAs regulating the human prion protein. Brain pathology (Zurich, Switzerland) 29 (2) (2018)
Sarah D Ackerman, Rong Luo, Yannick Poitelon, Amit Mogha, Breanne L Harty, Mitchell D'Rozario, Nicholas E Sanchez, Asvin K K Lakkaraju, Paul Gamble, Jun Li, Jun Qu, Matthew R MacEwan, Wilson Zachary Ray, Adriano Aguzzi, M Laura Feltri, Xianhua Piao, Kelly R Monk
GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. The Journal of experimental medicine 215 (3) (2018)
Mario Nuvolone, Marta Paolucci, Silvia Sorce, Veronika Kana, Rita Moos, Takashi Matozaki, Adriano Aguzzi
Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling. PloS one 12 (5) (2017)
Mario Nuvolone, Nicolas Schmid, Gino Miele, Silvia Sorce, Rita Moos, Christian Schori, Roger R Beerli, Monika Bauer, Philippe Saudan, Klaus Dietmeier, Ingolf Lachmann, Michael Linnebank, Roland Martin, Ulf Kallweit, Veronika Kana, Elisabeth J Rushing, Herbert Budka, Adriano Aguzzi
Cystatin F is a biomarker of prion pathogenesis in mice. PloS one 12 (2) (2017)
Despoina Goniotaki, Asvin K K Lakkaraju, Amulya N Shrivastava, Pamela Bakirci, Silvia Sorce, Assunta Senatore, Rajlakshmi Marpakwar, Simone Hornemann, Fabrizio Gasparini, Antoine Triller, Adriano Aguzzi
Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity. PLoS pathogens 13 (11) (2017)
Adriano Aguzzi, Yingjun Liu
A role for astroglia in prion diseases. The Journal of experimental medicine 214 (12) (2017)
Mathew A Sherman, Michael LaCroix, Fatou Amar, Megan E Larson, Colleen L Forster, Adriano Aguzzi, David A Bennett, Martin Ramsden, Sylvain E Lesné
Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport. The Journal of neuroscience : the official journal of the Society for Neuroscience 36 (37) (2017)

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Adriano Aguzzi