Lennart Brewitz

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 30

Top Topics

Mass Spectrometry

Respiratory Syndrome Coronavirus

Top Venues

Journal of medicinal chemistry

Chemical science

RSC chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

null Gayatri, Lennart Brewitz, Lewis Ibbotson, Eidarus Salah, Shyam Basak, Hani Choudhry, Christopher J Schofield
Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation. Chemical science 15 (20) (2024)
null Gayatri, Lennart Brewitz, Lewis Ibbotson, Eidarus Salah, Shyam Basak, Hani Choudhry, Christopher J Schofield
Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation. Chemical science 15 (20) (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry 67 (14) (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry 67 (14) (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry 67 (14) (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry 67 (14) (2024)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
H T Henry Chan, Lennart Brewitz, Petra Lukacik, Claire Strain-Damerell, Martin Austin Walsh, Christopher J Schofield, Fernanda Duarte
Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein. RSC chemical biology 5 (2) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
Anthony Tumber, Eidarus Salah, Lennart Brewitz, Thomas P Corner, Christopher J Schofield
Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5. RSC chemical biology 4 (6) (2023)
Lennart Brewitz, Yu Nakashima, Sonia K Piasecka, Eidarus Salah, Sally C Fletcher, Anthony Tumber, Thomas P Corner, Tristan J Kennedy, Giorgia Fiorini, Armin Thalhammer, Kirsten E Christensen, Mathew L Coleman, Christopher J Schofield
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. Journal of medicinal chemistry (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry (2023)
Mariska de Munnik, Jasper Lithgow, Lennart Brewitz, Kirsten E Christensen, Robert H Bates, Beatriz Rodríguez Miquel, Christopher J Schofield
αβ,α'β'-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes. Chemical communications (Cambridge, England) (2023)
H T Henry Chan, Lennart Brewitz, Petra Lukacik, Claire Strain-Damerell, Martin Austin Walsh, Christopher J Schofield, Fernanda Duarte
Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein. RSC chemical biology 5 (2) (2023)
Takashi Miura, Tika R Malla, C David Owen, Anthony Tumber, Lennart Brewitz, Michael A McDonough, Eidarus Salah, Naohiro Terasaka, Takayuki Katoh, Petra Lukacik, Claire Strain-Damerell, Halina Mikolajek, Martin Austin Walsh, Akane Kawamura, Christopher J Schofield, Hiroaki Suga
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ 2,4 -amino acids targeting the SARS-CoV-2 main protease. Nature chemistry (2023)
Thomas P Corner, Ryan Z R Teo, Yue Wu, Eidarus Salah, Yu Nakashima, Giorgia Fiorini, Anthony Tumber, Amelia Brasnett, James P Holt-Martyn, William D Figg, Xiaojin Zhang, Lennart Brewitz, Christopher J Schofield
Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chemical science 14 (43) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
Lennart Brewitz, Jos J A G Kamps, Petra Lukacik, Claire Strain-Damerell, Yilin Zhao, Anthony Tumber, Tika R Malla, Allen M Orville, Martin A Walsh, Christopher J Schofield
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS-CoV-2 Papain-Like Protease. ChemMedChem 17 (9) (2022)
Amelia Brasnett, Inga Pfeffer, Lennart Brewitz, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A McDonough, Christopher J Schofield
Human Oxygenase Variants Employing a Single Protein Fe II Ligand Are Catalytically Active. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (26) (2021)
Tika R Malla, Anthony Tumber, Tobias John, Lennart Brewitz, Claire Strain-Damerell, C David Owen, Petra Lukacik, H T Henry Chan, Pratheesh Maheswaran, Eidarus Salah, Fernanda Duarte, Haitao Yang, Zihe Rao, Martin Austin Walsh, Christopher J Schofield
Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors. Chemical communications (Cambridge, England) 57 (12) (2021)
Amelia Brasnett, Inga Pfeffer, Lennart Brewitz, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A McDonough, Christopher J Schofield
Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active. Angewandte Chemie (International ed. in English) 60 (26) (2021)
Amelia Brasnett, Inga Pfeffer, Lennart Brewitz, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A McDonough, Christopher J Schofield
Human Oxygenase Variants Employing a Single Protein Fe II Ligand Are Catalytically Active. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (26) (2021)
Yu Nakashima, Lennart Brewitz, Anthony Tumber, Eidarus Salah, Christopher J Schofield
2-Oxoglutarate derivatives can selectively enhance or inhibit the activity of human oxygenases. Nature communications 12 (1) (2021)
Lennart Brewitz, Yu Nakashima, Christopher J Schofield
Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase. Chemical science 12 (4) (2020)
Lennart Brewitz, Anthony Tumber, Armin Thalhammer, Eidarus Salah, Kirsten E Christensen, Christopher J Schofield
Synthesis of Novel Pyridine-Carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-β-Hydroxylase. ChemMedChem 15 (13) (2020)