Stefan A Laufer (Stefan Laufer)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 100

Top Venues

Journal of medicinal chemistry

International journal of molecular sciences

ACS pharmacology & translational science

Nature communications

Eberhard Karls Universität Tübingen

Universität Regensburg (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Eberhard Karls Universität Tübingen

Germany

Chairman Pharmaceutical / Medicinal Chemistry :: Institute of Pharmacy

Asahi Merckle Pharma GmbH

Germany

Managing Director

Merckle GmbH

Germany

Research&Development Director, Board Member :: R&D

Merckle GmbH

Germany

General Manager Dept. Drug Research :: Drug Research

Goethe-Universität Frankfurt am Main

Germany

Postdoc :: Pharmaceutical Chemitry & Biopharmacy

Education History

Universität Regensburg

Germany

PHD :: Faculty of Chemistry and Pharmacy

Publications

Alp Bayrak, Martyna Szpakowska, Valerie Dicenta, Manuel Counson, Alexander Rasch, Anne-Katrin Rohlfing, Andy Chevigné, Meinrad Gawaz, Stefan A Laufer, Thanigaimalai Pillaiyar
Novel Small-Molecule Atypical Chemokine Receptor 3 Agonists: Design, Synthesis, and Pharmacological Evaluation for Antiplatelet Therapy. Journal of medicinal chemistry 67 (16) (2024)
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A Laufer, Christa Elisabeth Müller, Michael Gütschow, Thanigaimalai Pillaiyar
Correction to "Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity". ACS pharmacology & translational science 7 (4) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A Laufer, Christa Elisabeth Müller, Michael Gütschow, Thanigaimalai Pillaiyar
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. ACS pharmacology & translational science 7 (2) (2024)
Alp Bayrak, Martyna Szpakowska, Valerie Dicenta, Manuel Counson, Alexander Rasch, Anne-Katrin Rohlfing, Andy Chevigné, Meinrad Gawaz, Stefan A Laufer, Thanigaimalai Pillaiyar
Novel Small-Molecule Atypical Chemokine Receptor 3 Agonists: Design, Synthesis, and Pharmacological Evaluation for Antiplatelet Therapy. Journal of medicinal chemistry (2024)
Alp Bayrak, Martyna Szpakowska, Valerie Dicenta, Manuel Counson, Alexander Rasch, Anne-Katrin Rohlfing, Andy Chevigné, Meinrad Gawaz, Stefan A Laufer, Thanigaimalai Pillaiyar
Novel Small-Molecule Atypical Chemokine Receptor 3 Agonists: Design, Synthesis, and Pharmacological Evaluation for Antiplatelet Therapy. Journal of medicinal chemistry 67 (16) (2024)
Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Heike Bantel, Markus Templin, Nisar P Malek, Antti Poso, Michael Bitzer
The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma. Nature communications 15 (1) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Heike Bantel, Markus Templin, Nisar P Malek, Antti Poso, Michael Bitzer
The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma. Nature communications 15 (1) (2024)
Stefan A Laufer, Alexander Titz, Alexander Titz
Journal of Medicinal Chemistry Collection: Drug Discovery in Germany. Journal of medicinal chemistry (2024)
Moritz Schwarz, Maksym Kurkunov, Florian Wittlinger, Ramona Rudalska, Guiqun Wang, Martin Peter Schwalm, Alexander Rasch, Benedikt Wagner, Stefan A Laufer, Stefan Knapp, Daniel Dauch, Alexander Titz
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S N Ar Electrophiles. Journal of medicinal chemistry (2024)
Stefan A Laufer, Alexander Titz, Alexander Titz
Journal of Medicinal Chemistry Collection: Drug Discovery in Germany. Journal of medicinal chemistry 67 (4) (2024)
Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Heike Bantel, Markus Templin, Nisar P Malek, Antti Poso, Michael Bitzer
The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma. Nature communications 15 (1) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Stefan A Laufer, Alexander Titz, Alexander Titz
Journal of Medicinal Chemistry Collection: Drug Discovery in Germany. Journal of medicinal chemistry 67 (4) (2024)
Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Heike Bantel, Markus Templin, Nisar P Malek, Antti Poso, Michael Bitzer
The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma. Nature communications 15 (1) (2024)
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A Laufer, Christa Elisabeth Müller, Michael Gütschow, Thanigaimalai Pillaiyar
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. ACS pharmacology & translational science 7 (2) (2024)
Florian Wittlinger, Blessing C Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin D Pham, Ilse K Schaeffner, Brandon T Oligny, Surbhi P Chitnis, Tyler S Beyett, Alexander Rasch, Brian Buckley, Daniel A Urul, Tatiana Shaurova, Earl W May, Erik M Schaefer, Michael J Eck, Pamela A Hershberger, Antti Poso, Stefan A Laufer, David E Heppner
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Communications chemistry 7 (1) (2024)
Moritz Schwarz, Maksym Kurkunov, Florian Wittlinger, Ramona Rudalska, Guiqun Wang, Martin Peter Schwalm, Alexander Rasch, Benedikt Wagner, Stefan A Laufer, Stefan Knapp, Daniel Dauch, Alexander Titz
Development of Highly Potent and Selective Covalent FGFR4 Inhibitors Based on S N Ar Electrophiles. Journal of medicinal chemistry 67 (8) (2024)
Philipp Flury, Julian Breidenbach, Nadine Krüger, Rabea Voget, Laura Schäkel, Yaoyao Si, Vesa Krasniqi, Sara Calistri, Matthias Olfert, Katharina Sylvester, Cheila Rocha, Raphael Ditzinger, Alexander Rasch, Stefan Pöhlmann, Thales Kronenberger, Antti Poso, Katharina Rox, Stefan A Laufer, Christa Elisabeth Müller, Michael Gütschow, Thanigaimalai Pillaiyar
Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity. ACS pharmacology & translational science 7 (2) (2024)
Leon Katzengruber, Pascal Sander, Stefan A Laufer
MKK4 Inhibitors-Recent Development Status and Therapeutic Potential. International journal of molecular sciences 24 (8) (2023)
Fatma Al-Rubaiai, Zakiya Zahran Al-Shariqi, Khalsa S Al-Shabibi, John Husband, Asmaa M Al-Hattali, Marcia Goettert, Stefan A Laufer, Younis Baqi, Syed Imran Hasan, Majekodunmi O Fatope
Isolation and Identification of Phytocompounds from Maytenus dhofarensis and Their Biological Potentials. Molecules (Basel, Switzerland) 28 (16) (2023)
Julian Laux, Mariella Martorelli, Simon Strass, Dieter Schollmeyer, Florian Maier, Michael Burnet, Stefan A Laufer
Inherent Fluorescence Demonstrates Immunotropic Properties for Novel Janus Kinase 3 Inhibitors. ACS pharmacology & translational science 6 (10) (2023)
Kristopher W Hoyt, Daniel A Urul, Blessing C Ogboo, Florian Wittlinger, Stefan A Laufer, Erik M Schaefer, Earl W May, David E Heppner
Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors. Journal of medicinal chemistry 67 (1) (2023)
Kristopher W Hoyt, Daniel A Urul, Blessing C Ogboo, Florian Wittlinger, Stefan A Laufer, Erik M Schaefer, Earl W May, David E Heppner
Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors. Journal of medicinal chemistry 67 (1) (2023)
Débora Bublitz Anton, Júlia G B Pedreira, Maria Luiza Zvirtes, Stefan A Laufer, Rodrigo Gay Ducati, Márcia Goettert, Luis Fernando Saraiva Macedo Timmers
Targeting SARS-CoV-2 Main Protease (MPro) with Kinase Inhibitors: A Promising Approach for Discovering Antiviral and Anti-inflammatory Molecules against SARS-CoV-2. Journal of chemical information and modeling (2023)
Kristopher W Hoyt, Daniel A Urul, Blessing C Ogboo, Florian Wittlinger, Stefan A Laufer, Erik M Schaefer, Earl W May, David E Heppner
Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors. Journal of medicinal chemistry (2023)
Leon Katzengruber, Pascal Sander, Stefan A Laufer
MKK4 Inhibitors-Recent Development Status and Therapeutic Potential. International journal of molecular sciences 24 (8) (2023)
Kristopher W Hoyt, Daniel A Urul, Blessing C Ogboo, Florian Wittlinger, Stefan A Laufer, Erik M Schaefer, Earl W May, David E Heppner
Pitfalls and Considerations in Determining the Potency and Mutant Selectivity of Covalent Epidermal Growth Factor Receptor Inhibitors. Journal of medicinal chemistry 67 (1) (2023)
Julian Laux, Mariella Martorelli, Nadja Späth, Florian Maier, Michael Burnet, Stefan A Laufer
Selective Inhibitors of Janus Kinase 3 Modify Responses to Lipopolysaccharides by Increasing the Interleukin-10-to-Tumor Necrosis Factor α Ratio. ACS pharmacology & translational science 6 (6) (2023)
Leon Katzengruber, Pascal Sander, Stefan A Laufer
MKK4 Inhibitors-Recent Development Status and Therapeutic Potential. International journal of molecular sciences 24 (8) (2023)
David E Heppner, Florian Wittlinger, Blessing Ogboo, Ekaterina Shevchenko, Tahereh Damghani, Calvin Pham, Ilse Schaeffner, Brandon T Oligny, Surbhi Chitnis, Tyler Beyett, Alexander Rasch, Brian Buckley, Daniel Urul, Tatiana Shaurova, Earl May, Erik Schaefer, Michael J Eck, Pamela Hershberger, Antti Poso, Stefan A Laufer
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Research square (2023)
Valentin R Wydra, Raphael B Ditzinger, Nico J Seidler, Frederik W Hacker, Stefan A Laufer
A patent review of MAPK inhibitors (2018 - present). Expert opinion on therapeutic patents (2023)
Nadine Krüger, Thales Kronenberger, Hang Xie, Cheila Rocha, Stefan H Pöhlmann, Haixia Su, Yechun Xu, Stefan A Laufer, Thanigaimalai Pillaiyar
Discovery of Polyphenolic Natural Products as SARS-CoV-2 M pro Inhibitors for COVID-19. Pharmaceuticals (Basel, Switzerland) 16 (2) (2023)
Leon Katzengruber, Pascal Sander, Stefan A Laufer
MKK4 Inhibitors-Recent Development Status and Therapeutic Potential. International journal of molecular sciences 24 (8) (2023)
Leon Katzengruber, Pascal Sander, Stefan A Laufer
MKK4 Inhibitors-Recent Development Status and Therapeutic Potential. International journal of molecular sciences 24 (8) (2023)
Thanigaimalai Pillaiyar, Monika Wozniak, Dayana Abboud, Alexander Rasch, Aenne-Dorothea Liebing, Antti Poso, Thales Kronenberger, Claudia Stäubert, Stefan A Laufer, Julien Hanson
Development of Ligands for the Super Conserved Orphan G Protein-Coupled Receptor GPR27 with Improved Efficacy and Potency. Journal of medicinal chemistry (2023)
Jean Quancard, Anna Vulpetti, Anders Bach, Brian Cox, Stéphanie M Guéret, Ingo V Hartung, Hannes F Koolman, Stefan A Laufer, Josef Messinger, Gianluca Sbardella, Russell Craft
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit Generation. ChemMedChem (2023)
Teodor Dimitrov, Athina Anastasia Moschopoulou, Lennart Seidel, Thales Kronenberger, Mark Kudolo, Antti Poso, Christian Geibel, Pascal Wölffing, Daniel Dauch, Lars Zender, Dieter Schollmeyer, Jürgen Bajorath, Michael Forster, Stefan A Laufer
Design and Optimization of Novel Benzimidazole- and Imidazo[4,5- b ]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities. Journal of medicinal chemistry (2023)
Philipp Flury, Olga Eppler, Dieter Schollmeyer, Stefan A Laufer, Thanigaimalai Pillaiyar
2,2,2-Trifluoroethanol-mediated hydroarylation of fluorinated alkynes with indoles: Application to diindolylmethanes. Archiv der Pharmazie 355 (8) (2022)
Thanigaimalai Pillaiyar, Philipp Flury, Nadine Krüger, Haixia Su, Laura Schäkel, Elany Barbosa da Silva, Olga Eppler, Thales Kronenberger, Tianqing Nie, Stephanie Luedtke, Cheila Rocha, Katharina Sylvester, Marvin R I Petry, James H McKerrow, Antti Poso, Stefan Pöhlmann, Michael Gütschow, Anthony J O'Donoghue, Yechun Xu, Christa Elisabeth Müller, Stefan A Laufer
Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure-Activity Relationships, Antiviral Activity, and X-ray Structure Determination. Journal of medicinal chemistry 65 (13) (2022)
Stephanie Cristine Hepp Rehfeldt, Joana Silva, Celso Alves, Susete Pintéus, Rui Pedrosa, Stefan A Laufer, Márcia Inês Goettert
Neuroprotective Effect of Luteolin-7-O-Glucoside against 6-OHDA-Induced Damage in Undifferentiated and RA-Differentiated SH-SY5Y Cells. International journal of molecular sciences 23 (6) (2022)
Stefan A Laufer, Jürgen Bajorath, Alexander Titz, Nathanael S Gray, Stephen V Frye, Dennis C Liotta
Publication Criteria and Requirements for Studies on Protein Kinase Inhibitors─What Is Expected? Journal of medicinal chemistry 65 (10) (2022)
Anne-Katrin Rohlfing, Kyra Kolb, Manuel Sigle, Melanie Ziegler, Alexander Bild, Patrick Münzer, Jessica Sudmann, Valerie Dicenta, Tobias Harm, Mailin-Christin Manke, Sascha Geue, Marcel Kremser, Madhumita Chatterjee, Chunguang Liang, Hendrik von Eysmondt, Thomas Dandekar, David Heinzmann, Manina Günter, Saskia von Ungern-Sternberg, Manuela Büttcher, Tatsiana Castor, Stine Mencl, Friederike Langhauser, Katharina S Kommoss, Diyaa Ashour, Mustafa Caglar Beker, Michael Lämmerhofer, Stella E Autenrieth, Tilman E Schäffer, Stefan A Laufer, Paulina Szklanna, Patricia Maguire, Mathias F Heikenwälder, Karin Anne Lydia Müller, Dirk M Hermann, Ertugrul Kilic, Ralf Stumm, Gustavo Ramos, Christoph Kleinschnitz, Oliver Borst, Harald F Langer, Dominik Rath, Meinrad Paul Gawaz
ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nature communications 13 (1) (2022)
Alp Bayrak, Julien Hanson, Stefan A Laufer, Thanigaimalai Pillaiyar
Super-conserved receptors expressed in the brain: biology and medicinal chemistry efforts. Future medicinal chemistry 14 (12) (2022)
Juliana Andréa Dörr, Fernanda Majolo, Luísa Bortoluzzi, Evelin Zen de Vargas, Joana Silva, Manoela Pasini, Stefani Natali Stoll, Rafael Lopes da Rosa, Mariana Moreira Figueira, Márcio Fronza, Walter O Beys-da-Silva, Alice Martins, Héléna A Gaspar, Rui P Pedrosa, Stefan A Laufer, Márcia Inês Goettert
Antiulcerogenic Potential of the Ethanolic Extract of Ceiba speciosa (A. St.-Hil.) Ravenna Evaluated by In Vitro and In Vivo Studies. International journal of molecular sciences 23 (24) (2022)
Enni-Kaisa Mustonen, Tatu Pantsar, Azam Rashidian, Juliander Reiner, Matthias Schwab, Stefan A Laufer, Oliver Burk
Target Hopping from Protein Kinases to PXR: Identification of Small-Molecule Protein Kinase Inhibitors as Selective Modulators of Pregnane X Receptor from TüKIC Library. Cells 11 (8) (2022)
Thomas Pflieger, Rakesh Venkatesh, Markus Dachtler, Karin Eggenreich, Stefan A Laufer, Dominique Jasmin Lunter
Novel Approach to Pharmaceutical 3D-Printing Omitting the Need for Filament-Investigation of Materials, Process, and Product Characteristics. Pharmaceutics 14 (11) (2022)
Juliana Andréa Dörr, Fernanda Majolo, Luísa Bortoluzzi, Evelin Zen de Vargas, Joana Silva, Manoela Pasini, Stefani Natali Stoll, Rafael Lopes da Rosa, Mariana Moreira Figueira, Márcio Fronza, Walter O Beys-da-Silva, Alice Martins, Héléna A Gaspar, Rui P Pedrosa, Stefan A Laufer, Márcia Inês Goettert
Antiulcerogenic Potential of the Ethanolic Extract of Ceiba speciosa (A. St.-Hil.) Ravenna Evaluated by In Vitro and In Vivo Studies. International journal of molecular sciences 23 (24) (2022)
Juliana Andréa Dörr, Fernanda Majolo, Luísa Bortoluzzi, Evelin Zen de Vargas, Joana Silva, Manoela Pasini, Stefani Natali Stoll, Rafael Lopes da Rosa, Mariana Moreira Figueira, Márcio Fronza, Walter O Beys-da-Silva, Alice Martins, Héléna A Gaspar, Rui P Pedrosa, Stefan A Laufer, Márcia Inês Goettert
Antiulcerogenic Potential of the Ethanolic Extract of Ceiba speciosa (A. St.-Hil.) Ravenna Evaluated by In Vitro and In Vivo Studies. International journal of molecular sciences 23 (24) (2022)
Juliana Andréa Dörr, Fernanda Majolo, Luísa Bortoluzzi, Evelin Zen de Vargas, Joana Silva, Manoela Pasini, Stefani Natali Stoll, Rafael Lopes da Rosa, Mariana Moreira Figueira, Márcio Fronza, Walter O Beys-da-Silva, Alice Martins, Héléna A Gaspar, Rui P Pedrosa, Stefan A Laufer, Márcia Inês Goettert
Antiulcerogenic Potential of the Ethanolic Extract of Ceiba speciosa (A. St.-Hil.) Ravenna Evaluated by In Vitro and In Vivo Studies. International journal of molecular sciences 23 (24) (2022)
David E Heppner, Florian Wittlinger, Tyler S Beyett, Tatiana Shaurova, Daniel A Urul, Brian Buckley, Calvin D Pham, Ilse K Schaeffner, Bo Yang, Blessing C Ogboo, Earl W May, Erik M Schaefer, Michael J Eck, Stefan A Laufer, Pamela A Hershberger
Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448). ACS medicinal chemistry letters 13 (12) (2022)
Carine M Abdelmalek, Zexi Hu, Thales Kronenberger, Jenni Küblbeck, Franziska J M Kinnen, Salma S Hesse, Afsin Malik, Mark Kudolo, Raimund Niess, Alexander Titz, Lars Zender, Paula A Witt-Enderby, Darius P Zlotos, Stefan A Laufer
Gefitinib-Tamoxifen Hybrid Ligands as Potent Agents against Triple-Negative Breast Cancer. Journal of medicinal chemistry 65 (6) (2022)
Darius P Zlotos, Thales Kronenberger, Stefan A Laufer
Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands. Pharmaceutics 15 (1) (2022)
Darius P Zlotos, Thales Kronenberger, Stefan A Laufer
Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands. Pharmaceutics 15 (1) (2022)
Alp Bayrak, Florian Mohr, Kyra Kolb, Martyna Szpakowska, Ekaterina Shevchenko, Valerie Dicenta, Anne-Katrin Rohlfing, Mark Kudolo, Tatu Pantsar, Marcel Günther, Agnieszka A Kaczor, Antti Poso, Andy Chevigné, Thanigaimalai Pillaiyar, Meinrad Gawaz, Stefan A Laufer
Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation. Journal of medicinal chemistry 65 (19) (2022)
Ricardo A M Serafim, André da Silva Santiago, Martin P Schwalm, Zexi Hu, Caio V Dos Reis, Jessica E Takarada, Priscila Mezzomo, Katlin B Massirer, Mark Kudolo, Stefan Gerstenecker, Apirat Chaikuad, Lars Zender, Stefan Knapp, Stefan A Laufer, Rafael Miguez Couñago, Alexander Titz
Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. Journal of medicinal chemistry 65 (4) (2022)
Julian Laux, Michael Forster, Laura Riexinger, Anna Schwamborn, Jamil Guezguez, Christina Pokoj, Mark Kudolo, Lena Marie Berger, Stefan Knapp, Dieter Schollmeyer, Jan Guse, Michael Burnet, Stefan A Laufer
Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells. ACS pharmacology & translational science 5 (8) (2022)
Tatu Pantsar, Philipp D Kaiser, Mark Kudolo, Michael Forster, Ulrich Rothbauer, Stefan A Laufer
Decisive role of water and protein dynamics in residence time of p38α MAP kinase inhibitors. Nature communications 13 (1) (2022)
Darius P Zlotos, Thales Kronenberger, Stefan A Laufer
Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands. Pharmaceutics 15 (1) (2022)
Darius P Zlotos, Thales Kronenberger, Stefan A Laufer
Anticancer Drug Conjugates Incorporating Estrogen Receptor Ligands. Pharmaceutics 15 (1) (2022)
David E Heppner, Florian Wittlinger, Tyler S Beyett, Tatiana Shaurova, Daniel A Urul, Brian Buckley, Calvin D Pham, Ilse K Schaeffner, Bo Yang, Blessing C Ogboo, Earl W May, Erik M Schaefer, Michael J Eck, Stefan A Laufer, Pamela A Hershberger
Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448). ACS medicinal chemistry letters 13 (12) (2022)
Ricardo A M Serafim, Jonathan M Elkins, William J Zuercher, Stefan A Laufer, Alexander Titz
Chemical Probes for Understudied Kinases: Challenges and Opportunities. Journal of medicinal chemistry (2021)
Max Borgolte, Oliver Riester, Tereza Kacerova, Simone Rentschler, Magnus S Schmidt, Susanne Jacksch, Markus Egert, Stefan A Laufer, Rene Csuk, Hans-Peter Deigner
Methacryloyl-GlcNAc Derivatives Copolymerized with Dimethacrylamide as a Novel Antibacterial and Biocompatible Coating. Pharmaceutics 13 (10) (2021)
Florian Wittlinger, David E Heppner, Ciric To, Marcel Günther, Bo Hee Shin, Jaimin K Rana, Anna M Schmoker, Tyler S Beyett, Lena Marie Berger, Benedict-Tilmann Berger, Nicolas Bauer, James D Vasta, Cesear R Corona, Matthew B Robers, Stefan Knapp, Pasi A Jänne, Michael J Eck, Stefan A Laufer
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. Journal of medicinal chemistry (2021)
Dennis C Liotta, James C Barrow, Kelly Chibale, Maria Laura Bolognesi, Stuart J Conway, William Alexander Denny, Ke Ding, Stefan A Laufer, Luhua Lai, Hong Liu, Nouri Neamati, Takayoshi Suzuki, Nicholas A Meanwell, Wendy B Young
Simplifying Submission Requirements for the Journal of Medicinal Chemistry. Journal of medicinal chemistry 64 (12) (2021)
Stephanie Cristine Hepp Rehfeldt, Stefan A Laufer, Márcia Ines Goettert
A Highly Selective In Vitro JNK3 Inhibitor, FMU200, Restores Mitochondrial Membrane Potential and Reduces Oxidative Stress and Apoptosis in SH-SY5Y Cells. International journal of molecular sciences 22 (7) (2021)
Carmen Carrillo García, Cora Becker, Michael Forster, Stefan Lohmann, Patricia Freitag, Stefan A Laufer, Sonja Sievers, Bernd K Fleischmann, Michael Hesse, Dennis Schade
High-Throughput Screening Platform in Postnatal Heart Cells and Chemical Probe Toolbox to Assess Cardiomyocyte Proliferation. Journal of medicinal chemistry (2021)
Niklas M Tormählen, Mariella Martorelli, Annette Kuhn, Florian Maier, Jamil Guezguez, Michael Burnet, Wolfgang Albrecht, Stefan A Laufer, Pierre Koch
Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors. Journal of medicinal chemistry (2021)
Fernanda Majolo, Guilherme Liberato da Silva, Lucas Vieira, Cetin Anli, Luís Fernando Saraiva Macedo Timmers, Stefan A Laufer, Márcia Ines Goettert
Neuropsychiatric Disorders and COVID-19: What We Know So Far. Pharmaceuticals (Basel, Switzerland) 14 (9) (2021)
Luis Fernando Saraiva Macedo Timmers, Julia Vasconcellos Peixoto, Rodrigo Gay Ducati, José Fernando Ruggiero Bachega, Leandro de Mattos Pereira, Rafael Andrade Caceres, Fernanda Majolo, Guilherme Liberato da Silva, Débora Bublitz Anton, Odir Antônio Dellagostin, João Antônio Pegas Henriques, Léder Leal Xavier, Márcia Inês Goettert, Stefan A Laufer
SARS-CoV-2 mutations in Brazil: from genomics to putative clinical conditions. Scientific reports 11 (1) (2021)
Jean Quancard, Anders Bach, Brian Cox, Russell Craft, Dirk Finsinger, Stéphanie M Guéret, Ingo V Hartung, Stefan A Laufer, Josef Messinger, Gianluca Sbardella, Hannes F Koolman
The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery. ChemMedChem 16 (11) (2021)
Martin Reynders, Apirat Chaikuad, Benedict-Tilmann Berger, Katharina Bauer, Pierre Koch, Stefan A Laufer, Stefan Knapp, Dirk H Trauner
Controlling the Covalent Reactivity of a Kinase Inhibitor with Light. Angewandte Chemie (International ed. in English) 60 (37) (2021)
Sandra Röhm, Benedict-Tilmann Berger, Martin Schröder, Deep Chatterjee, Sebastian Mathea, Andreas C Joerger, Daniel M Pinkas, Joshua C Bufton, Amelie Tjaden, Lohitesh Kovooru, Mark Kudolo, Christian Pohl, Alex N Bullock, Susanne Müller, Stefan A Laufer, Stefan Knapp
Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. Journal of medicinal chemistry 64 (18) (2021)
Stanislav Andreev, Tatu Pantsar, Roberta Tesch, Niclas Kahlke, Ahmed El-Gokha, Francesco Ansideri, Lukas Grätz, Jenny Romasco, Giulia Sita, Christian Geibel, Michael Lämmerhofer, Andrea Tarozzi, Stefan Knapp, Stefan A Laufer, Pierre Koch
Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors. Journal of medicinal chemistry (2021)
Saeb Aliwaini, Bassam Abu Thaher, Ihab Al-Masri, Nabil Shurrab, Said El-Kurdi, Dieter Schollmeyer, Basem Qeshta, Mariam Ghunaim, Rene Csuk, Stefan A Laufer, Lars Kaiser, Hans-Peter Deigner
Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents. Molecules (Basel, Switzerland) 26 (13) (2021)
Débora Bublitz Anton, Rodrigo Gay Ducati, Luís Fernando Saraiva Macedo Timmers, Stefan A Laufer, Márcia Ines Goettert
A Special View of What Was Almost Forgotten: p38δ MAPK. Cancers 13 (9) (2021)
Thanigaimalai Pillaiyar, Stefan A Laufer
Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy. Journal of medicinal chemistry (2021)
Stefan A Laufer, Jürgen Bajorath
New Horizons in Drug Discovery - Understanding and Advancing Different Types of Kinase Inhibitors: Seven Years in Kinase Inhibitor Research with Impressive Achievements and New Future Prospects. Journal of medicinal chemistry 65 (2) (2021)
Stefan Gerstenecker, Lisa Haarer, Martin Schröder, Mark Kudolo, Martin Peter Schwalm, Valentin Wydra, Ricardo A M Serafim, Apirat Chaikuad, Stefan Knapp, Stefan A Laufer, Alexander Titz
Discovery of a Potent and Highly Isoform-Selective Inhibitor of the Neglected Ribosomal Protein S6 Kinase Beta 2 (S6K2). Cancers 13 (20) (2021)
David E Heppner, Marcel Günther, Florian Wittlinger, Stefan A Laufer, Michael J Eck
Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. Journal of medicinal chemistry 63 (8) (2020)
Stefan A Laufer, Karin Briner, Jürgen Bajorath, Gunda I Georg, Shaomeng Wang
New Horizons in Drug Discovery - Understanding and Advancing Kinase Inhibitors. Journal of medicinal chemistry 63 (15) (2020)
Jean Quancard, Brian Cox, Dirk Finsinger, Stéphanie M Guéret, Ingo V Hartung, Hannes F Koolman, Josef Messinger, Gianluca Sbardella, Stefan A Laufer
The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes. ChemMedChem 15 (24) (2020)
Stanislav Andreev, Tatu Pantsar, Ahmed El-Gokha, Francesco Ansideri, Mark Kudolo, Débora Bublitz Anton, Giulia Sita, Jenny Romasco, Christian Geibel, Michael Lämmerhofer, Márcia Ines Goettert, Andrea Tarozzi, Stefan A Laufer, Pierre Koch
Discovery and Evaluation of Enantiopure 9H-pyrimido[4,5-b]indoles as Nanomolar GSK-3β Inhibitors with Improved Metabolic Stability. International journal of molecular sciences 21 (21) (2020)
Júlia G B Pedreira, Philipp Nahidino, Mark Kudolo, Tatu Pantsar, Benedict-Tilmann Berger, Michael Forster, Stefan Knapp, Stefan A Laufer, Eliezer Jesus Barreiro
Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors. Journal of medicinal chemistry 63 (13) (2020)
Fernando Rodrigues de Sá Alves, Rafael Miguez Couñago, Stefan A Laufer
Chemical Space Exploration of Oxetanes. International journal of molecular sciences 21 (21) (2020)
Michael Forster, Xiaojun Julia Liang, Martin Schröder, Stefan Gerstenecker, Apirat Chaikuad, Stefan Knapp, Stefan A Laufer, Alexander Titz
Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK. International journal of molecular sciences 21 (23) (2020)
Stanislav Andreev, Tatu Pantsar, Francesco Ansideri, Mark Kudolo, Michael Forster, Dieter Schollmeyer, Stefan A Laufer, Pierre Koch
Design, Synthesis and Biological Evaluation of 7-Chloro-9H-pyrimido[4,5-b]indole-based Glycogen Synthase Kinase-3β Inhibitors. Molecules (Basel, Switzerland) 24 (12) (2019)
Alexander Titz, Stefan A Laufer
Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology. Journal of medicinal chemistry 62 (12) (2019)
Diorge Jônatas Marmitt, Celso Alves, Joana Silva, Susete Pintéus, Taiane Schneider, Roberto Christ Vianna Santos, Elisete Maria de Freitas, Rui Pedrosa, Stefan A Laufer, Márcia Ines Goettert
Neuroprotective potential of Myrciaria plinioides D. Legrand extract in an in vitro human neuroblastoma model. Inflammopharmacology 28 (3) (2019)
Anja Dullius, Claudia Monfroni Rocha, Stefan A Laufer, Claucia Fernanda Volken de Souza, Márcia Ines Goettert
Are peptides a solution for the treatment of hyperactivated JAK3 pathways? Inflammopharmacology 27 (3) (2019)
Sandra Röhm, Benedict-Tilman Berger, Martin Schröder, Apirat Chaikuad, Rob Winkel, Koen F W Hekking, Jorg J C Benningshof, Gerhard Müller, Roberta Tesch, Mark Kudolo, Michael Forster, Stefan A Laufer, Stefan Knapp
Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. Journal of medicinal chemistry 62 (23) (2019)
Pierre Koch, Stefan A Laufer
Special Issue: Kinase inhibitors. Molecules (Basel, Switzerland) 23 (7) (2018)
Michael Forster, Apirat Chaikuad, Teodor Dimitrov, Eva Döring, Julia Holstein, Benedict-Tilman Berger, Alexander Titz, Kamran Ghoreschi, Susanne Müller, Stefan Knapp, Stefan A Laufer
Development, Optimization, and Structure-Activity Relationships of Covalent-Reversible JAK3 Inhibitors Based on a Tricyclic Imidazo[5,4- d]pyrrolo[2,3- b]pyridine Scaffold. Journal of medicinal chemistry 61 (12) (2018)
Michael Juchum, Marcel Günther, Eva Döring, Adrian Sievers-Engler, Michael Lämmerhofer, Stefan A Laufer
Trisubstituted Imidazoles with a Rigidized Hinge Binding Motif Act As Single Digit nM Inhibitors of Clinically Relevant EGFR L858R/T790M and L858R/T790M/C797S Mutants: An Example of Target Hopping. Journal of medicinal chemistry 60 (11) (2017)
Niklas M Walter, Heike K Wentsch, Mike Bührmann, Silke M Bauer, Eva Döring, Svenja Mayer-Wrangowski, Adrian Sievers-Engler, Nicole Willemsen-Seegers, Guido Zaman, Rogier Buijsman, Michael Lämmerhofer, Daniel Rauh, Stefan A Laufer
Design, Synthesis, and Biological Evaluation of Novel Type I1/2 p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine. Journal of medicinal chemistry 60 (19) (2017)
Marcel Günther, Jonas Lategahn, Michael Juchum, Eva Döring, Marina Keul, Julian Engel, Hannah L Tumbrink, Daniel Rauh, Stefan A Laufer
Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site. Journal of medicinal chemistry 60 (13) (2017)
Wolfgang Albrecht, Anke Unger, Silke M Bauer, Stefan A Laufer
Discovery of N-{4-[5-(4-Fluorophenyl)-3-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-acetamide (CBS-3595), a Dual p38α MAPK/PDE-4 Inhibitor with Activity against TNFα-Related Diseases. Journal of medicinal chemistry 60 (13) (2017)
Felix Muth, Ahmed El-Gokha, Francesco Ansideri, Michael Eitel, Eva Döring, Adrian Sievers-Engler, Andreas Lange, Frank M Boeckler, Michael Lämmerhofer, Pierre Koch, Stefan A Laufer
Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3. Journal of medicinal chemistry 60 (2) (2017)

Stefan A Laufer.css-eqlu8i{font-size:small;padding-left:4px;} (Stefan Laufer)

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Stefan A Laufer (Stefan Laufer)