Nagarajan Vaidehi

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 43

Top Venues

Nature

Nature structural & molecular biology

Nature communications

bioRxiv : the preprint server for biology

Beckman Research Institute, City of Hope

Indian Institute of Technology Madras (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Beckman Research Institute, City of Hope

United States

Professor

Education History

Indian Institute of Technology Madras

India

PHD :: Chemistry

Publications

Kevin M Knight, Brian E Krumm, Nicholas J Kapolka, W Grant Ludlam, Meng Cui, Sepehr Mani, Iya Prytkova, Elizabeth G Obarow, Tyler J Lefevre, Wenyuan Wei, Ning Ma, Xi Ping Huang, Jonathan F Fay, Nagarajan Vaidehi, Alan V Smrcka, Paul A Slesinger, Diomedes E Logothetis, Kirill A Martemyanov, Bryan L Roth, Henrik G Dohlman
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nature communications 15 (1) (2024)
Kevin M Knight, Brian E Krumm, Nicholas J Kapolka, W Grant Ludlam, Meng Cui, Sepehr Mani, Iya Prytkova, Elizabeth G Obarow, Tyler J Lefevre, Wenyuan Wei, Ning Ma, Xi Ping Huang, Jonathan F Fay, Nagarajan Vaidehi, Alan V Smrcka, Paul A Slesinger, Diomedes E Logothetis, Kirill A Martemyanov, Bryan L Roth, Henrik G Dohlman
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nature communications 15 (1) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology 31 (3) (2024)
Anthony K C Chan, Li Han, Christopher D Delaney, Xueer Wang, Elizaveta Mukhaleva, Mingli Li, Lu Yang, Sheela Pangeni Pokharel, Nicole M Mattson, Michelle Garcia, Bintao Wang, Xiaobao Xu, Leisi Zhang, Priyanka Singh, Zeinab Elsayed, Renee Chen, Benjamin Z Kuang, Jinhui Wang, Yate-Ching Yuan, Bryan Chen, Lai N Chan, Steven T Rosen, David A Horne, Markus Müschen, Jianjun Chen, Nagarajan Vaidehi, Scott A Armstrong, Rui Su, Chun-Wei David Chen
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Science advances 10 (8) (2024)
Anthony K C Chan, Li Han, Christopher D Delaney, Xueer Wang, Elizaveta Mukhaleva, Mingli Li, Lu Yang, Sheela Pangeni Pokharel, Nicole M Mattson, Michelle Garcia, Bintao Wang, Xiaobao Xu, Leisi Zhang, Priyanka Singh, Zeinab Elsayed, Renee Chen, Benjamin Z Kuang, Jinhui Wang, Yate-Ching Yuan, Bryan Chen, Lai N Chan, Steven T Rosen, David A Horne, Markus Müschen, Jianjun Chen, Nagarajan Vaidehi, Scott A Armstrong, Rui Su, Chun-Wei David Chen
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Science advances 10 (8) (2024)
Anastasiia Gusach, Yang Lee, Armin Nikpour Khoshgrudi, Elizaveta Mukhaleva, Ning Ma, Eline J Koers, Qingchao Chen, Patricia C Edwards, Fanglu Huang, Jonathan Kim, Filippo Mancia, Dmitry B Veprintsev, Nagarajan Vaidehi, Simone N Weyand, Christopher G Tate
Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f. Nature communications 15 (1) (2024)
Anastasiia Gusach, Yang Lee, Armin Nikpour Khoshgrudi, Elizaveta Mukhaleva, Ning Ma, Eline J Koers, Qingchao Chen, Patricia C Edwards, Fanglu Huang, Jonathan Kim, Filippo Mancia, Dmitry B Veprintsev, Nagarajan Vaidehi, Simone N Weyand, Christopher G Tate
Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f. Nature communications 15 (1) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology (2024)
Anthony K C Chan, Li Han, Christopher D Delaney, Xueer Wang, Elizaveta Mukhaleva, Mingli Li, Lu Yang, Sheela Pangeni Pokharel, Nicole M Mattson, Michelle Garcia, Bintao Wang, Xiaobao Xu, Leisi Zhang, Priyanka Singh, Zeinab Elsayed, Renee Chen, Benjamin Z Kuang, Jinhui Wang, Yate-Ching Yuan, Bryan Chen, Lai N Chan, Steven T Rosen, David A Horne, Markus Müschen, Jianjun Chen, Nagarajan Vaidehi, Scott A Armstrong, Rui Su, Chun-Wei David Chen
Therapeutic targeting Tudor domains in leukemia via CRISPR-Scan Assisted Drug Discovery. Science advances 10 (8) (2024)
Kevin M Knight, Brian E Krumm, Nicholas J Kapolka, W Grant Ludlam, Meng Cui, Sepehr Mani, Iya Prytkova, Elizabeth G Obarow, Tyler J Lefevre, Wenyuan Wei, Ning Ma, Xi Ping Huang, Jonathan F Fay, Nagarajan Vaidehi, Alan V Smrcka, Paul A Slesinger, Diomedes E Logothetis, Kirill A Martemyanov, Bryan L Roth, Henrik G Dohlman
A neurodevelopmental disorder mutation locks G proteins in the transitory pre-activated state. Nature communications 15 (1) (2024)
Nicole M Mattson, Anthony K C Chan, Kazuya Miyashita, Elizaveta Mukhaleva, Wen-Han Chang, Lu Yang, Ning Ma, Yingyu Wang, Sheela Pangeni Pokharel, Mingli Li, Qiao Liu, Xiaobao Xu, Renee Chen, Priyanka Singh, Leisi Zhang, Zeinab Elsayed, Bryan Chen, Denise Keen, Patrick Pirrotte, Steven T Rosen, Jianjun Chen, Mark A LaBarge, John E Shively, Nagarajan Vaidehi, Russell C Rockne, Mingye Feng, Chun-Wei David Chen
A novel class of inhibitors that disrupts the stability of integrin heterodimers identified by CRISPR-tiling-instructed genetic screens. Nature structural & molecular biology (2024)
Fredrik Sadler, Ning Ma, Michael Ritt, Yatharth Sharma, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan
Autoregulation of GPCR signalling through the third intracellular loop. Nature 615 (7953) (2023)
Christian B Billesbølle, Claire A de March, Wijnand J C van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas Del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik
Structural basis of odorant recognition by a human odorant receptor. Nature 615 (7953) (2023)
Fredrik Sadler, Ning Ma, Michael Ritt, Yatharth Sharma, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan
Autoregulation of GPCR signalling through the third intracellular loop. Nature 615 (7953) (2023)
Yubo Cao, Wijnand J C van der Velden, Yoon Namkung, Anita K Nivedha, Aaron Cho, Dana Sedki, Brian Holleran, Nicholas Lee, Richard Leduc, Sanychen Muk, Keith Le, Supriyo Bhattacharya, Nagarajan Vaidehi, Stéphane A Laporte
Unraveling allostery within the angiotensin II type 1 receptor for Gα q and β-arrestin coupling. Science signaling 16 (797) (2023)
Tyler J Lefevre, Wenyuan Wei, Elizaveta Mukhaleva, Sai Pranathi Meda Venkata, Naincy R Chandan, Saji Abraham, Yong Li, Carmen W Dessauer, Nagarajan Vaidehi, Alan V Smrcka
Stabilization of Interdomain Interactions in G protein α i Subunits Determines Gα i Subtype Signaling Specificity. bioRxiv : the preprint server for biology (2023)
Fredrik Sadler, Ning Ma, Michael Ritt, Yatharth Sharma, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan
Autoregulation of GPCR signalling through the third intracellular loop. Nature 615 (7953) (2023)
Claire A de March, Ning Ma, Christian B Billesbølle, Jeevan Tewari, Claudia Llinas Del Torrent, Wijnand J C van der Velden, Ichie Ojiro, Ikumi Takayama, Bryan Faust, Linus Li, Nagarajan Vaidehi, Aashish Manglik, Hiroaki Matsunami
Engineered odorant receptors illuminate structural principles of odor discrimination. bioRxiv : the preprint server for biology (2023)
Christian B Billesbølle, Claire A de March, Wijnand J C van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas Del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik
Structural basis of odorant recognition by a human odorant receptor. Nature 615 (7953) (2023)
Christian B Billesbølle, Claire A de March, Wijnand J C van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas Del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik
Structural basis of odorant recognition by a human odorant receptor. Nature (2023)
Martin Sattler, Isa Mambetsariev, Jeremy Fricke, Tingting Tan, Sariah Liu, Nagarajan Vaidehi, Evan Pisick, Tamara Mirzapoiazova, Adam G Rock, Amartej Merla, Sunil Sharma, Ravi Salgia
A Closer Look at EGFR Inhibitor Resistance in Non-Small Cell Lung Cancer through the Lens of Precision Medicine. Journal of clinical medicine 12 (5) (2023)
Martin Sattler, Isa Mambetsariev, Jeremy Fricke, Tingting Tan, Sariah Liu, Nagarajan Vaidehi, Evan Pisick, Tamara Mirzapoiazova, Adam G Rock, Amartej Merla, Sunil Sharma, Ravi Salgia
A Closer Look at EGFR Inhibitor Resistance in Non-Small Cell Lung Cancer through the Lens of Precision Medicine. Journal of clinical medicine 12 (5) (2023)
Elizaveta Mukhaleva, Ning Ma, Wijnand J C van der Velden, Grigoriy Gogoshin, Sergio Branciamore, Supriyo Bhattacharya, Andrei S Rodin, Nagarajan Vaidehi
Bayesian network models identify co-operative GPCR:G protein interactions that contribute to G protein coupling. bioRxiv : the preprint server for biology (2023)
Elizaveta Mukhaleva, Tianyi Yang, Fredrik Sadler, Sivaraj Sivaramakrishnan, Ning Ma, Nagarajan Vaidehi
Cellular Lipids Regulate the Conformational Ensembles of the Disordered Intracellular Loop 3 in β2 Adrenergic Receptor. bioRxiv : the preprint server for biology (2023)
Fredrik Sadler, Ning Ma, Michael Ritt, Yatharth Sharma, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan
Autoregulation of GPCR signalling through the third intracellular loop. Nature (2023)
Manbir Sandhu, Aaron Cho, Ning Ma, Elizaveta Mukhaleva, Yoon Namkung, Sangbae Lee, Soumadwip Ghosh, John H Lee, David E Gloriam, Stéphane A Laporte, M Madan Babu, Nagarajan Vaidehi
Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity. Nature communications 13 (1) (2022)
Vaithish Velazhahan, Ning Ma, Nagarajan Vaidehi, Christopher G Tate
Activation mechanism of the class D fungal GPCR dimer Ste2. Nature 603 (7902) (2022)
Ning Ma, Anita K Nivedha, Nagarajan Vaidehi
Allosteric communication regulates ligand-specific GPCR activity. The FEBS journal 288 (8) (2021)
Keehun Kim, Shayla Paulekas, Fredrik Sadler, Tejas M Gupte, Michael Ritt, Matthew Dysthe, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan
β2-adrenoceptor ligand efficacy is tuned by a two-stage interaction with the Gαs C terminus. Proceedings of the National Academy of Sciences of the United States of America 118 (11) (2021)
Jaewoong Lee, Mark E Robinson, Ning Ma, Dewan Artadji, Mohamed A Ahmed, Gang Xiao, Teresa Sadras, Gauri Deb, Janet Winchester, Kadriye Nehir Cosgun, Huimin Geng, Lai N Chan, Kohei Kume, Teemu P Miettinen, Ye Zhang, Matthew A Nix, Lars Klemm, Chun-Wei David Chen, Jianjun Chen, Vishal Khairnar, Arun P Wiita, Andrei Thomas-Tikhonenko, Michael Farzan, Jae U Jung, David M Weinstock, Scott R Manalis, Michael S. Diamond, Nagarajan Vaidehi, Markus Müschen
IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells. Nature 588 (7838) (2020)
Sangbae Lee, Soumadwip Ghosh, Suvamay Jana, Nathan Robertson, Christopher G Tate, Nagarajan Vaidehi
How Do Branched Detergents Stabilize GPCRs in Micelles? Biochemistry 59 (23) (2020)
Ning Ma, Sangbae Lee, Nagarajan Vaidehi
Activation Microswitches in Adenosine Receptor A2A Function as Rheostats in the Cell Membrane. Biochemistry 59 (42) (2020)
Vaithish Velazhahan, Ning Ma, Gáspár Pándy-Szekeres, Albert J Kooistra, Yang Lee, David E Gloriam, Nagarajan Vaidehi, Christopher G Tate
Structure of the class D GPCR Ste2 dimer coupled to two G proteins. Nature 589 (7840) (2020)
Suvamay Jana, Soumadwip Ghosh, Sanychen Muk, Benjamin Levy, Nagarajan Vaidehi
Prediction of Conformation Specific Thermostabilizing Mutations for Class A G Protein-Coupled Receptors. Journal of chemical information and modeling 59 (9) (2019)
Buddhinie S Jayathilake, Supriyo Bhattacharya, Nagarajan Vaidehi, Sri R Narayan
Efficient and Selective Electrochemically Driven Enzyme-Catalyzed Reduction of Carbon Dioxide to Formate using Formate Dehydrogenase and an Artificial Cofactor. Accounts of chemical research 52 (3) (2019)
Ning Ma, Lisa G Lippert, Titu Devamani, Benjamin Levy, Sangbae Lee, Manbir Sandhu, Nagarajan Vaidehi, Sivaraj Sivaramakrishnan
Bitopic Inhibition of ATP and Substrate Binding in Ser/Thr Kinases through a Conserved Allosteric Mechanism. Biochemistry 57 (45) (2018)
Soumadwip Ghosh, Tobias Bierig, Sangbae Lee, Suvamay Jana, Adelheid Löhle, Gisela Schnapp, Christofer S Tautermann, Nagarajan Vaidehi
Engineering Salt Bridge Networks between Transmembrane Helices Confers Thermostability in G-Protein-Coupled Receptors. Journal of chemical theory and computation 14 (12) (2018)
Christofer S Tautermann, Florian Binder, Frank H Büttner, Christian Eickmeier, Dennis Fiegen, Ulrike Gross, Marc A Grundl, Ralf Heilker, Scott Hobson, Stefan Hoerer, Andreas Luippold, Volker Mack, Florian Montel, Stefan Peters, Supriyo Bhattacharya, Nagarajan Vaidehi, Gisela Schnapp, Sven Thamm, Markus Zeeb
Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. Journal of medicinal chemistry 62 (1) (2018)
Hubert Li, Manbir Sandhu, Linda H Malkas, Robert J Hickey, Nagarajan Vaidehi
How Does the Proliferating Cell Nuclear Antigen Modulate Binding Specificity to Multiple Partner Proteins? Journal of chemical information and modeling 57 (12) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Nagarajan Vaidehi