M Madan Babu

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 42

Top Topics

Molecular Dynamics Simulations

Top Venues

Science (New York, N.Y.)

Nature structural & molecular biology

Nature communications

Molecular systems biology

This page only lists publications with an associated author ORCID identifier.

Publications

Xiao-Han Li, Conny W H Yu, Natalia Gomez-Navarro, Viktoriya G Stancheva, Hongni Zhu, Andal Murthy, Michael R Wozny, Ketan Malhotra, Christopher M Johnson, Martin Blackledge, Balaji Santhanam, Wei Liu, Jinqing Huang, Stefan M V Freund, Elizabeth A Miller, M Madan Babu
Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties. PNAS nexus 3 (1) (2024)
Xiao-Han Li, Conny W H Yu, Natalia Gomez-Navarro, Viktoriya G Stancheva, Hongni Zhu, Andal Murthy, Michael R Wozny, Ketan Malhotra, Christopher M Johnson, Martin Blackledge, Balaji Santhanam, Wei Liu, Jinqing Huang, Stefan M V Freund, Elizabeth A Miller, M Madan Babu
Dynamic conformational changes of a tardigrade group-3 late embryogenesis abundant protein modulate membrane biophysical properties. PNAS nexus 3 (1) (2024)
Duccio Malinverni, M Madan Babu
Data-driven design of orthogonal protein-protein interactions. Science signaling 16 (774) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Duccio Malinverni, M Madan Babu
Data-driven design of orthogonal protein-protein interactions. Science signaling 16 (774) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
P Alexander Gunnarsson, M Madan Babu
Predicting evolutionary outcomes through the probability of accessing sequence variants. Science advances 9 (30) (2023)
Benjamin J Leslie, Benjamin Lang, M Madan Babu
A genome-wide view of disordered proteins. Nature biotechnology (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Swarnendu Tripathi, Hazheen K Shirnekhi, Scott D Gorman, Bappaditya Chandra, David W Baggett, Cheon-Gil Park, Ramiz Somjee, Benjamin Lang, Seyed Mohammad Hadi Hosseini, Brittany J Pioso, Yongsheng Li, Ilaria Iacobucci, Qingsong Gao, Michael N Edmonson, Stephen V Rice, Xin Zhou, John Bollinger, Diana M Mitrea, Michael R White, Daniel J McGrail, Daniel F Jarosz, S Stephen Yi, M Madan Babu, Charles G Mullighan, Jinghui Zhang, Nidhi Sahni, Richard W Kriwacki
Defining the condensate landscape of fusion oncoproteins. Nature communications 14 (1) (2023)
Matthew Bell, Shannon Lange, Besian I Sejdiu, Jorge Ibañez-Vega, Hao Shi, Xiang Sun, Xiaoxi Meng, Phuong Nguyen, Morgan Sutton, Jessica Wagner, Anil Kc, Deanna M Langfitt, Sagar L Patil, Haiyan Tan, Ram Vinay Pandey, Yuxin Li, Zuo-Fei Yuan, Alejandro Allo Anido, Mitchell Ho, Heather Sheppard, Peter Vogel, Jiyang Yu, Junmin Peng, Hongbo Chi, M Madan Babu, Giedre Krenciute, Stephen Gottschalk
Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling. Nature biomedical engineering (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Franziska Marie Heydenreich, Maria Marti-Solano, Manbir Sandhu, Brian K Kobilka, Michel Bouvier, M Madan Babu
Molecular determinants of ligand efficacy and potency in GPCR signaling. Science (New York, N.Y.) 382 (6677) (2023)
Constance Baer, Shunsuke Kimura, Mitra Shumsher Rana, Andrew B Kleist, Tim Flerlage, Thomas P Loughran, Peter J Chockley, Wencke Walter, Manja Meggendorfer, Thomas L Olson, HeeJin Cheon, Kristine C Olson, Aakrosh Ratan, Martha-Lena Mueller, James M Foran, Laura J Janke, Chunxu Qu, Shaina N Porter, Shondra M Pruett-Miller, Ravi C Kalathur, Claudia Haferlach, Wolfgang Kern, Elisabeth Paietta, Paul Glyndwr Thomas, M Madan Babu, Thomas P Loughran, Ilaria Iacobucci, Torsten Haferlach, Charles G Mullighan
CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk. Nature genetics 54 (5) (2022)
Andrew B Kleist, Shawn Jenjak, Andrija Sente, Lauren J Laskowski, Martyna Szpakowska, Maggie M Calkins, Emilie I Anderson, Lisa M McNally, Raimond Heukers, Vladimir Bobkov, Francis C Peterson, Monica A Thomas, Andy Chevigné, Martine J Smit, John D McCorvy, M Madan Babu, Brian F Volkman
Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor. Science (New York, N.Y.) 377 (6602) (2022)
Manbir Sandhu, Aaron Cho, Ning Ma, Elizaveta Mukhaleva, Yoon Namkung, Sangbae Lee, Soumadwip Ghosh, John H Lee, David E Gloriam, Stéphane A Laporte, M Madan Babu, Nagarajan Vaidehi
Dynamic spatiotemporal determinants modulate GPCR:G protein coupling selectivity and promiscuity. Nature communications 13 (1) (2022)
Min Pan, William C Wright, Richard H Chapple, Asif Zubair, Manbir Sandhu, Jake E Batchelder, Brandt C Huddle, Jonathan Low, Kaley B Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel L Brady, Sivaraman Natarajan, Matthew J Posgai, John Schuetz, Darcie Miller, Ravi C Kalathur, Siquan Chen, Jon Patrick Connelly, M Madan Babu, Michael A Dyer, Shondra M Pruett-Miller, Burgess B Freeman, Taosheng Chen, Lucy A Godley, Scott C Blanchard, Elizabeth A Stewart, John Easton, Paul Geeleher
The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. Nature communications 12 (1) (2021)
Acacia F Dishman, Robert C Tyler, Jamie C Fox, Andrew B Kleist, Kenneth E Prehoda, M Madan Babu, Francis C Peterson, Brian F Volkman
Evolution of fold switching in a metamorphic protein. Science (New York, N.Y.) 371 (6524) (2021)
Benjamin Lang, M Madan Babu
A community effort to bring structure to disorder. Nature methods 18 (5) (2021)
Alexander Sebastian Hauser, Albert Jelke Kooistra, Christian Munk, Franziska Marie Heydenreich, Dmitry B Veprintsev, Michel Bouvier, M Madan Babu, David E Gloriam
GPCR activation mechanisms across classes and macro/microscales. Nature structural & molecular biology 28 (11) (2021)
Su Datt Lam, M Madan Babu, Jonathan Lees, Christine A Orengo
Biological impact of mutually exclusive exon switching. PLoS computational biology 17 (3) (2021)
Thomas Lemberger, M Madan Babu
Enabling next generation systems biology: a conversation with M. Madan Babu. Molecular systems biology 15 (12) (2020)
Charles N J Ravarani, Tilman Flock, Sreenivas Chavali, Madhanagopal Anandapadamanaban, M Madan Babu, Santhanam Balaji
Molecular determinants underlying functional innovations of TBP and their impact on transcription initiation. Nature communications 11 (1) (2020)
Alexander Heifetz, Inaki Morao, M Madan Babu, Tim James, Michelle W Y Southey, Dmitri G Fedorov, Matteo Aldeghi, Michael J Bodkin, Andrea Townsend-Nicholson
Characterizing Interhelical Interactions of G-Protein Coupled Receptors with the Fragment Molecular Orbital Method. Journal of chemical theory and computation 16 (4) (2020)
Sreenivas Chavali, Anjali Kumari Singh, Santhanam Balaji, M Madan Babu
Amino acid homorepeats in proteins. Nature reviews. Chemistry 4 (8) (2020)
Maria Marti-Solano, Stephanie E Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Abigail Pearce, Tezz Quon, Amanda E Mackenzie, Xusheng Wang, Junmin Peng, Andrew B Tobin, Graham Ladds, Graeme Milligan, David E Gloriam, Manojkumar A Puthenveedu, M Madan Babu
Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses. Nature (2020)
Maria Marti-Solano, Stephanie E Crilly, Duccio Malinverni, Christian Munk, Matthew Harris, Abigail Pearce, Tezz Quon, Amanda E Mackenzie, Xusheng Wang, Junmin Peng, Andrew B Tobin, Graham Ladds, Graeme Milligan, David E Gloriam, Manojkumar A Puthenveedu, M Madan Babu
Combinatorial expression of GPCR isoforms affects signalling and drug responses. Nature 587 (7835) (2020)
Denise Wootten, Arthur Christopoulos, Maria Marti-Solano, M Madan Babu, Patrick M Sexton
Mechanisms of signalling and biased agonism in G protein-coupled receptors. Nature reviews. Molecular cell biology 19 (10) (2019)
Natalia Sanchez de Groot, Marc Torrent, Charles Nj Ravarani, Ala Trusina, Salvador Ventura, M Madan Babu
The fitness cost and benefit of phase-separated protein deposits. Molecular systems biology 15 (4) (2019)
Shane C Wright, Pawel Kozielewicz, Maria Kowalski-Jahn, Julian Petersen, Carl-Fredrik Bowin, Greg Slodkowicz, Maria Marti-Solano, David Rodríguez, Belma Hot, Najeah Okashah, Katerina Strakova, Jana Valnohova, M Madan Babu, Nevin A Lambert, Jens Carlsson, Gunnar Schulte
A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection. Nature communications 10 (1) (2019)
Eviatar Natan, Tamaki Endoh, Liora Haim-Vilmovsky, Tilman Flock, Guilhem Chalancon, Jonathan T S Hopper, Bálint Kintses, Peter Horvath, Lejla Daruka, Gergely Fekete, Csaba Pál, Balázs Papp, Erika Oszi, Zoltán Magyar, Joseph A Marsh, Adrian H Elcock, M Madan Babu, Carol V Robinson, Naoki Sugimoto, Sarah A Teichmann
Cotranslational protein assembly imposes evolutionary constraints on homomeric proteins. Nature structural & molecular biology 25 (3) (2018)
Marc Torrent, Guilhem Chalancon, Natalia Sanchez de Groot, Arthur Wuster, M Madan Babu
Cells alter their tRNA abundance to selectively regulate protein synthesis during stress conditions. Science signaling 11 (546) (2018)
Charles Nj Ravarani, Tamara Y Erkina, Greet De Baets, Daniel C Dudman, Alexandre M Erkine, M Madan Babu
High-throughput discovery of functional disordered regions: investigation of transactivation domains. Molecular systems biology 14 (5) (2018)
Melis Kayikci, A J Venkatakrishnan, James Scott-Brown, Charles N J Ravarani, Tilman Flock, M Madan Babu
Visualization and analysis of non-covalent contacts using the Protein Contacts Atlas. Nature structural & molecular biology 25 (2) (2018)
Andrija Sente, Raphael Peer, Ashish Srivastava, Mithu Baidya, Arthur M Lesk, Santhanam Balaji, Arun K Shukla, M Madan Babu, Tilman Flock
Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation. Nature structural & molecular biology 25 (6) (2018)
Xiao-Han Li, Pavithra L Chavali, Rita Pancsa, Sreenivas Chavali, M Madan Babu
Function and Regulation of Phase-Separated Biological Condensates. Biochemistry 57 (17) (2018)
Greg Slodkowicz, M Madan Babu
From prioritisation to understanding: mechanistic predictions of variant effects. Molecular systems biology 14 (12) (2018)
Sreenivas Chavali, Pavithra L Chavali, Guilhem Chalancon, Natalia Sanchez de Groot, Rita Gemayel, Natasha S Latysheva, Elizabeth Ing-Simmons, Kevin J Verstrepen, Santhanam Balaji, M Madan Babu
Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins. Nature structural & molecular biology 24 (9) (2017)