Patrick Flagmeier

Publication Activity (10 Years)

Years Active: 2016-2021
Publications (10 Years): 15

Top Topics

Cognitive Decline

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Angewandte Chemie (International ed. in English)

ACS chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Ben J Eves, James J Doutch, Ann E Terry, Han Yin, Martine Moulin, Michael Haertlein, V Trevor Forsyth, Patrick Flagmeier, Tuomas P J Knowles, David M Dias, Gudrun Lotze, Annela M Seddon, Adam M Squires
Elongation rate and average length of amyloid fibrils in solution using isotope-labelled small-angle neutron scattering. RSC chemical biology 2 (4) (2021)
Patrick Flagmeier, Suman De, Thomas C T Michaels, Xiaoting Yang, Alexander J Dear, Cecilia Emanuelsson, Christopher M Dobson, Sara Linse, David Klenerman, Tuomas P J Knowles, Christopher M Dobson
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation. Nature structural & molecular biology 27 (10) (2020)
Francesco Simone Ruggeri, Patrick Flagmeier, Janet R Kumita, Georg Meisl, Dimitri Y Chirgadze, Marie N Bongiovanni, Tuomas P J Knowles, Christopher M Dobson
The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils. ACS nano 14 (5) (2020)
Tanja Weiffert, Georg Meisl, Patrick Flagmeier, Suman De, Christopher J R Dunning, Birgitta Frohm, Henrik Zetterberg, Kaj Blennow, Erik Portelius, David Klenerman, Christopher M Dobson, Tuomas P J Knowles, Sara Linse
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42. ACS chemical neuroscience 10 (5) (2019)
Suman De, David C Wirthensohn, Patrick Flagmeier, Craig Hughes, Francesco A Aprile, Francesco S Ruggeri, Carolyn M Sue, Derya Emin, Zengjie Xia, Juan A Varela, Pietro Sormanni, Franziska Kundel, Tuomas P J Knowles, Christopher M Dobson, Clare Bryant, Christopher M Dobson, David Klenerman
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms. Nature communications 10 (1) (2019)
Emil Dandanell Agerschou, Patrick Flagmeier, Theodora Saridaki, Céline Galvagnion, Daniel Komnig, Laetitia Heid, Vibha Prasad, Hamed Shaykhalishahi, Dieter Willbold, Christopher M Dobson, Aaron Voigt, Björn H Falkenburger, Wolfgang Hoyer, Alexander K Buell
An engineered monomer binding-protein for α-synuclein efficiently inhibits the proliferation of amyloid fibrils. eLife 8 (2019)
Franziska Kundel, Suman De, Patrick Flagmeier, Mathew H Horrocks, Magnus Kjaergaard, Sarah L Shammas, Sophie E Jackson, Christopher M Dobson, David Klenerman
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity. ACS chemical biology 13 (3) (2018)
Ji-Eun Lee, Jason C Sang, Margarida Rodrigues, Alexander R Carr, Mathew H Horrocks, Suman De, Marie N Bongiovanni, Patrick Flagmeier, Christopher M Dobson, David J Wales, Steven F Lee, David Klenerman
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale. Nano letters 18 (12) (2018)
Michele Perni, Patrick Flagmeier, Ryan Limbocker, Roberta Cascella, Francesco Antonio Aprile, Céline Galvagnion, Gabriella T Heller, Georg Meisl, Serene W Chen, Janet R Kumita, Pavan Kumar Challa, Julius B Kirkegaard, Samuel I A Cohen, Benedetta Mannini, Denise Barbut, Ellen A A Nollen, Cristina Cecchi, Nunilo Cremades, Tuomas P J Knowles, Fabrizio Chiti, Michael Zasloff, Christopher M Dobson, Christopher M Dobson
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology 13 (8) (2018)
Juan A Varela, Margarida Rodrigues, Suman De, Patrick Flagmeier, Sonia Gandhi, Christopher M Dobson, David Klenerman, Steven F Lee
Optical Structural Analysis of Individual α-Synuclein Oligomers. Angewandte Chemie (International ed. in English) 57 (18) (2018)
Marija Iljina, Alexander J Dear, Gonzalo A Garcia, Suman De, Laura Tosatto, Patrick Flagmeier, Daniel R Whiten, Thomas C T Michaels, Daan Frenkel, Christopher M Dobson, Tuomas P J Knowles, David Klenerman
Quantifying Co-Oligomer Formation by α-Synuclein. ACS nano 12 (11) (2018)
Sean Chia, Patrick Flagmeier, Johnny Habchi, Veronica Lattanzi, Sara Linse, Christopher M Dobson, Tuomas P J Knowles, Michele Vendruscolo
Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates. Proceedings of the National Academy of Sciences of the United States of America 114 (30) (2017)
Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B D Müller, Pavan K Challa, Julius B Kirkegaard, Patrick Flagmeier, Samuel I A Cohen, Roberta Cascella, Serene W Chen, Ryan Limbocker, Pietro Sormanni, Gabriella T Heller, Francesco A Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A A Nollen, Tuomas P J Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, Christopher M Dobson
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity. Proceedings of the National Academy of Sciences of the United States of America 114 (6) (2017)
Patrick Flagmeier, Suman De, David C Wirthensohn, Steven F Lee, Cécile Vincke, Serge Muyldermans, Tuomas P J Knowles, Sonia Gandhi, Christopher M Dobson, David Klenerman
Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates. Angewandte Chemie (International ed. in English) 56 (27) (2017)
Patrick Flagmeier, Georg Meisl, Michele Vendruscolo, Tuomas P J Knowles, Christopher M Dobson, Alexander K Buell, Céline Galvagnion
Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation. Proceedings of the National Academy of Sciences of the United States of America 113 (37) (2016)