Francesco Antonio Aprile (Francesco A Aprile)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 23

Top Venues

Journal of medicinal chemistry

International journal of molecular sciences

Biochemistry

Proceedings of the National Academy of Sciences of the United States of America

Imperial College London

University of Milano-Bicocca (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Imperial College London Jan 07 2020

United Kingdom

UKRI Future Leaders Fellow :: Department of Chemistry

University of Cambridge Jan 01 2017 - Jan 06 2020

United Kingdom

Senior Research Fellow of the Alzheimer’s Society :: Department of Chemistry

University of Cambridge Jan 01 2013 - Dec 31 2016

United Kingdom

Post-doctoral Researcher :: Department of Chemistry

Universita degli Studi di Milano-Bicocca Jan 01 2012 - Dec 31 2012

Italy

Post-doctoral Researcher :: Department of Biotechnology & Biosciences

Universita degli Studi di Milano-Bicocca Jan 16 2009 - Jan 12 2012

Italy

PhD Candidate :: Department of Biotechnology & Biosciences

Universita degli Studi di Milano-Bicocca Apr 15 2009 - Jun 12 2009

Italy

Research Assistant :: Department of Biotechnology & Biosciences

Education History

University of Milano-Bicocca Jan 16 2009 - Jan 12 2012

Italy

PHD :: Department of Biotechnology and Biosciences

University of Milano-Bicocca Oct 30 2006 - Oct 21 2008

Italy

MSC :: Department of Biotechnology and Biosciences

University of Milano-Bicocca Aug 05 2003 - Oct 24 2006

Italy

BSC :: Department of Biotechnology and Biosciences

Publications

Dimitra Gialama, Devkee M Vadukul, Rebecca J Thrush, Sheena E Radford, Francesco Antonio Aprile
A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region. Journal of medicinal chemistry 67 (12) (2024)
Dimitra Gialama, Devkee M Vadukul, Rebecca J Thrush, Sheena E Radford, Francesco Antonio Aprile
A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region. Journal of medicinal chemistry (2024)
Dimitra Gialama, Devkee M Vadukul, Rebecca J Thrush, Sheena E Radford, Francesco Antonio Aprile
A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region. Journal of medicinal chemistry 67 (12) (2024)
Dimitra Gialama, Devkee M Vadukul, Rebecca J Thrush, Sheena E Radford, Francesco Antonio Aprile
A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region. Journal of medicinal chemistry 67 (12) (2024)
Dimitra Gialama, Devkee M Vadukul, Rebecca J Thrush, Sheena E Radford, Francesco Antonio Aprile
A Potent Sybody Selectively Inhibits α-Synuclein Amyloid Formation by Binding to the P1 Region. Journal of medicinal chemistry 67 (12) (2024)
Devkee M Vadukul, Marcell Papp, Rebecca J Thrush, Jielei Wang, Yiyun Jin, Paolo Arosio, Francesco Antonio Aprile
α-Synuclein Aggregation Is Triggered by Oligomeric Amyloid-β 42 via Heterogeneous Primary Nucleation. Journal of the American Chemical Society (2023)
Paolo Tortora, Francesco Antonio Aprile
Natural Inhibitors of Amyloid Aggregation. International journal of molecular sciences 24 (17) (2023)
Thomas T C Yue, Ying Ge, Francesco Antonio Aprile, Michelle T Ma, Truc Thuy Pham, Nicholas J Long
Site-Specific 68 Ga Radiolabeling of Trastuzumab Fab via Methionine for ImmunoPET Imaging. Bioconjugate chemistry (2023)
Federica Raguseo, Yiran Wang, Jessica Li, Marija Petrić Howe, Rubika Balendra, Anouk Huyghebaert, Devkee M Vadukul, Diana A Tanase, Thomas E Maher, Layla Malouf, Roger Rubio-Sánchez, Francesco Antonio Aprile, Yuval Elani, Rickie Patani, Lorenzo Di Michele, Marco Di Antonio
The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes. Nature communications 14 (1) (2023)
Talia A Shmool, Laura K Martin, Andreas Jirkas, Richard P Matthews, Anna P Constantinou, Devkee M Vadukul, Theoni K Georgiou, Francesco Antonio Aprile, Jason P Hallett
Unveiling the Rational Development of Stimuli-Responsive Silk Fibroin-Based Ionogel Formulations. Chemistry of materials : a publication of the American Chemical Society 35 (15) (2023)
Ying Ge, Athina Masoura, Jingzhou Yang, Francesco Antonio Aprile
A Chemical Mutagenesis Approach to Insert Post-translational Modifications in Aggregation-Prone Proteins. ACS chemical neuroscience 13 (12) (2022)
Yiyun Jin, Devkee Mahesh Vadukul, Dimitra Gialama, Ying Ge, Rebecca Thrush, Joe Thomas White, Francesco Antonio Aprile
The Diagnostic Potential of Amyloidogenic Proteins. International journal of molecular sciences 22 (8) (2021)
Tom Scheidt, Jacqueline A Carozza, Carl C Kolbe, Francesco Antonio Aprile, Olga Tkachenko, Mathias M J Bellaiche, Georg Meisl, Quentin A E Peter, Therese W Herling, Samuel Ness, Marta Castellana-Cruz, Justin L P Benesch, Christopher M Dobson, Christopher M Dobson, Paolo Arosio, Tuomas P J Knowles
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces. Proceedings of the National Academy of Sciences of the United States of America 118 (38) (2021)
Tiffany G Chan, Carmen L Ruehl, Sophie V Morse, Michelle Simon, Viktoria Rakers, Helena Watts, Francesco Antonio Aprile, James J Choi, Ramon Vilar
Modulation of amyloid-β aggregation by metal complexes with a dual binding mode and their delivery across the blood-brain barrier using focused ultrasound. Chemical science 12 (27) (2021)
Anita Pras, Bert Houben, Francesco Antonio Aprile, Renée Seinstra, Rodrigo Gallardo, Leen Janssen, Wytse Hogewerf, Christian Gallrein, Matthias De Vleeschouwer, Alejandro Mata-Cabana, Mandy Koopman, Esther Stroo, Minke de Vries, Samantha Louise Edwards, Janine Kirstein, Christopher M Dobson, Salvatore Fabio Falsone, Frederic Rousseau, Joost Schymkowitz, Ellen A A Nollen
The cellular modifier MOAG-4/SERF drives amyloid formation through charge complementation. The EMBO journal 40 (21) (2021)
Ryan Limbocker, Benedetta Mannini, Rodrigo Cataldi, Shianne Chhangur, Aidan K Wright, Ryan P Kreiser, J Alex Albright, Sean Chia, Johnny Habchi, Pietro Sormanni, Janet R Kumita, Francesco Simone Ruggeri, Christopher M Dobson, Fabrizio Chiti, Francesco Antonio Aprile, Christopher M Dobson
Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers. International journal of molecular sciences 21 (12) (2020)
Gabriella T Heller, Francesco Antonio Aprile, Thomas C T Michaels, Ryan Limbocker, Michele Perni, Francesco Simone Ruggeri, Benedetta Mannini, Thomas Löhr, Massimiliano Bonomi, Carlo Camilloni, Alfonso De Simone, Isabella C Felli, Roberta Pierattelli, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease. Science advances 6 (45) (2020)
Francesco Antonio Aprile, Pietro Sormanni, Marina Podpolny, Shianne Chhangur, Lisa-Maria Needham, Francesco Simone Ruggeri, Michele Perni, Ryan Limbocker, Gabriella T Heller, Tomas Sneideris, Tom Scheidt, Benedetta Mannini, Johnny Habchi, Steven F Lee, Patricia C Salinas, Tuomas P J Knowles, Christopher M Dobson, Christopher M Dobson
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers. Proceedings of the National Academy of Sciences of the United States of America 117 (24) (2020)
Michele Perni, Patrick Flagmeier, Ryan Limbocker, Roberta Cascella, Francesco Antonio Aprile, Céline Galvagnion, Gabriella T Heller, Georg Meisl, Serene W Chen, Janet R Kumita, Pavan Kumar Challa, Julius B Kirkegaard, Samuel I A Cohen, Benedetta Mannini, Denise Barbut, Ellen A A Nollen, Cristina Cecchi, Nunilo Cremades, Tuomas P J Knowles, Fabrizio Chiti, Michael Zasloff, Christopher M Dobson, Christopher M Dobson
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine. ACS chemical biology 13 (8) (2018)
Maya A Wright, Francesco Antonio Aprile, Mathias M J Bellaiche, Thomas C T Michaels, Thomas Müller, Paolo Arosio, Christopher M Dobson, Christopher M Dobson, Tuomas P J Knowles
Cooperative Assembly of Hsp70 Subdomain Clusters. Biochemistry 57 (26) (2018)
Marie Nicole Bongiovanni, Francesco Antonio Aprile, Pietro Sormanni, Christopher M Dobson
A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells. International journal of molecular sciences 19 (5) (2018)
Sofia Giorgetti, Claudio Greco, Paolo Tortora, Francesco Antonio Aprile
Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms. International journal of molecular sciences 19 (9) (2018)
Francesco Antonio Aprile, Paolo Arosio, Giuliana Fusco, Serene W Chen, Janet R Kumita, Anne Dhulesia, Paolo Tortora, Tuomas P J Knowles, Michele Vendruscolo, Christopher M Dobson, Nunilo Cremades
Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species. Biochemistry 56 (9) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Francesco Antonio Aprile (Francesco A Aprile)