Sara Linse

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 110

Top Venues

ACS chemical neuroscience

Proceedings of the National Academy of Sciences of the United States of America

Physical chemistry chemical physics : PCCP

Chemical science

Lund University

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Lund University Jan 01 2004

Sweden

Professor :: Department of Biochemistry and Structural Biology

Publications

Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Jiapeng Wei, Georg Meisl, Alexander Dear, Matthijs Oosterhuis, Ronald Melki, Cecilia Emanuelsson, Sara Linse, Tuomas P J Knowles
Kinetic models reveal the interplay of protein production and aggregation. Chemical science 15 (22) (2024)
Emil Axell, Jing Hu, Max Lindberg, Alexander J Dear, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Greta Šneiderienė, Dev Thacker, Tuomas P J Knowles, Emma Sparr, Sara Linse
The role of shear forces in primary and secondary nucleation of amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Catherine K Xu, Georg Meisl, Ewa A Andrzejewska, Georg Krainer, Alexander J Dear, Marta Castellana-Cruz, Soma Turi, Irina A Edu, Giorgio Vivacqua, Raphaël P B Jacquat, William E Arter, Maria Grazia Spillantini, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
α-Synuclein oligomers form by secondary nucleation. Nature communications 15 (1) (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Catherine K Xu, Georg Meisl, Ewa A Andrzejewska, Georg Krainer, Alexander J Dear, Marta Castellana-Cruz, Soma Turi, Irina A Edu, Giorgio Vivacqua, Raphaël P B Jacquat, William E Arter, Maria Grazia Spillantini, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
α-Synuclein oligomers form by secondary nucleation. Nature communications 15 (1) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Andreas Carlsson, Emil Axell, Cecilia Emanuelsson, Ulf Olsson, Sara Linse
The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State. ACS chemical neuroscience (2024)
Natalie C Golota, Brian Michael, Edward P Saliba, Sara Linse, Robert G Griffin
Structural characterization of E22G Aβ 1-42 fibrils via 1 H detected MAS NMR. Physical chemistry chemical physics : PCCP 26 (20) (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Katarzyna Makasewicz, Sara Linse, Emma Sparr
Interplay of α-synuclein with Lipid Membranes: Cooperative Adsorption, Membrane Remodeling and Coaggregation. JACS Au 4 (4) (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Natalie C Golota, Brian Michael, Edward P Saliba, Sara Linse, Robert G Griffin
Structural characterization of E22G Aβ 1-42 fibrils via 1 H detected MAS NMR. Physical chemistry chemical physics : PCCP (2024)
Céline Galvagnion, Abigail Barclay, Katarzyna Makasewicz, Frederik Ravnkilde Marlet, Martine Moulin, Juliette M Devos, Sara Linse, Anne Martel, Lionel Porcar, Emma Sparr, Martin Cramer Pedersen, Felix Roosen-Runge, Lise Arleth, Alexander K Buell
Structural characterisation of α-synuclein-membrane interactions and the resulting aggregation using small angle scattering. Physical chemistry chemical physics : PCCP (2024)
Katarzyna Makasewicz, Sara Linse, Emma Sparr
Interplay of α-synuclein with Lipid Membranes: Cooperative Adsorption, Membrane Remodeling and Coaggregation. JACS Au 4 (4) (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Céline Galvagnion, Abigail Barclay, Katarzyna Makasewicz, Frederik Ravnkilde Marlet, Martine Moulin, Juliette M Devos, Sara Linse, Anne Martel, Lionel Porcar, Emma Sparr, Martin Cramer Pedersen, Felix Roosen-Runge, Lise Arleth, Alexander K Buell
Structural characterisation of α-synuclein-membrane interactions and the resulting aggregation using small angle scattering. Physical chemistry chemical physics : PCCP 26 (14) (2024)
Andreas Carlsson, Emil Axell, Cecilia Emanuelsson, Ulf Olsson, Sara Linse
The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State. ACS chemical neuroscience 15 (9) (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience 15 (6) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Jiapeng Wei, Georg Meisl, Alexander Dear, Matthijs Oosterhuis, Ronald Melki, Cecilia Emanuelsson, Sara Linse, Tuomas P J Knowles
Kinetic models reveal the interplay of protein production and aggregation. Chemical science 15 (22) (2024)
Samo Curk, Johannes Krausser, Georg Meisl, Daan Frenkel, Sara Linse, Thomas C T Michaels, Tuomas P J Knowles, And Ela Šarić
Self-replication of A β 42 aggregates occurs on small and isolated fibril sites. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Céline Galvagnion, Abigail Barclay, Katarzyna Makasewicz, Frederik Ravnkilde Marlet, Martine Moulin, Juliette M Devos, Sara Linse, Anne Martel, Lionel Porcar, Emma Sparr, Martin Cramer Pedersen, Felix Roosen-Runge, Lise Arleth, Alexander K Buell
Structural characterisation of α-synuclein-membrane interactions and the resulting aggregation using small angle scattering. Physical chemistry chemical physics : PCCP 26 (14) (2024)
Andreas Carlsson, Emil Axell, Cecilia Emanuelsson, Ulf Olsson, Sara Linse
The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State. ACS chemical neuroscience 15 (9) (2024)
Andreas Carlsson, Emil Axell, Cecilia Emanuelsson, Ulf Olsson, Sara Linse
The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State. ACS chemical neuroscience 15 (9) (2024)
Sean Chia, Rodrigo Lessa Cataldi, Francesco Simone Ruggeri, Ryan Limbocker, Itzel Condado-Morales, Katarina Pisani, Andrea Possenti, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Benedetta Mannini, Christopher M Dobson
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions. ACS chemical neuroscience (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Céline Galvagnion, Abigail Barclay, Katarzyna Makasewicz, Frederik Ravnkilde Marlet, Martine Moulin, Juliette M Devos, Sara Linse, Anne Martel, Lionel Porcar, Emma Sparr, Martin Cramer Pedersen, Felix Roosen-Runge, Lise Arleth, Alexander K Buell
Structural characterisation of α-synuclein-membrane interactions and the resulting aggregation using small angle scattering. Physical chemistry chemical physics : PCCP 26 (14) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience 15 (11) (2024)
Natalie C Golota, Brian Michael, Edward P Saliba, Sara Linse, Robert G Griffin
Structural characterization of E22G Aβ 1-42 fibrils via 1 H detected MAS NMR. Physical chemistry chemical physics : PCCP 26 (20) (2024)
Natalie C Golota, Brian Michael, Edward P Saliba, Sara Linse, Robert G Griffin
Structural characterization of E22G Aβ 1-42 fibrils via 1 H detected MAS NMR. Physical chemistry chemical physics : PCCP 26 (20) (2024)
Andreas Carlsson, Emil Axell, Cecilia Emanuelsson, Ulf Olsson, Sara Linse
The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State. ACS chemical neuroscience 15 (9) (2024)
Andreas Carlsson, Emil Axell, Cecilia Emanuelsson, Ulf Olsson, Sara Linse
The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State. ACS chemical neuroscience 15 (9) (2024)
Alexander J Dear, Dev Thacker, Stefan Wennmalm, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Georg Meisl, Sara Linse, Tuomas P J Knowles
Aβ Oligomer Dissociation Is Catalyzed by Fibril Surfaces. ACS chemical neuroscience (2024)
Emil Axell, Jing Hu, Max Lindberg, Alexander J Dear, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Greta Šneiderienė, Dev Thacker, Tuomas P J Knowles, Emma Sparr, Sara Linse
The role of shear forces in primary and secondary nucleation of amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Natalie C Golota, Brian Michael, Edward P Saliba, Sara Linse, Robert G Griffin
Structural characterization of E22G Aβ 1-42 fibrils via 1 H detected MAS NMR. Physical chemistry chemical physics : PCCP 26 (20) (2024)
Emil Axell, Jing Hu, Max Lindberg, Alexander J Dear, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Greta Šneiderienė, Dev Thacker, Tuomas P J Knowles, Emma Sparr, Sara Linse
The role of shear forces in primary and secondary nucleation of amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Tinna Pálmadóttir, Christopher A Waudby, Katja Bernfur, John Christodoulou, Sara Linse, Anders Malmendal
Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils. International journal of molecular sciences 24 (6) (2023)
Lei Ortigosa-Pascual, Thom Leiding, Sara Linse, Tinna Pálmadóttir
Photo-Induced Cross-Linking of Unmodified α-Synuclein Oligomers. ACS chemical neuroscience (2023)
Tinna Pálmadóttir, Christopher A Waudby, Katja Bernfur, John Christodoulou, Sara Linse, Anders Malmendal
Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils. International journal of molecular sciences 24 (6) (2023)
Andreas Carlsson, Ulf Olsson, Sara Linse
On the micelle formation of DNAJB6b. QRB discovery 4 (2023)
Dev Thacker, Mohammad Barghouth, Mara Bless, Enming Zhang, Sara Linse
Direct observation of secondary nucleation along the fibril surface of the amyloid β 42 peptide. Proceedings of the National Academy of Sciences of the United States of America 120 (25) (2023)
Jing Hu, Sara Linse, Emma Sparr
Ganglioside Micelles Affect Amyloid β Aggregation by Coassembly. ACS chemical neuroscience (2023)
Sara Linse, Tuomas P J Knowles
Amyloids and protein aggregation. Chemical science 14 (24) (2023)
Tinna Pálmadóttir, Christopher A Waudby, Katja Bernfur, John Christodoulou, Sara Linse, Anders Malmendal
Morphology-Dependent Interactions between α-Synuclein Monomers and Fibrils. International journal of molecular sciences 24 (6) (2023)
Gabriel A Braun, Alexander J Dear, Kalyani Sanagavarapu, Henrik Zetterberg, Sara Linse
Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation. Chemical science 13 (8) (2022)
Katarzyna Makasewicz, Stefan Wennmalm, Sara Linse, Emma Sparr
α -Synuclein-induced deformation of small unilamellar vesicles. QRB discovery 3 (2022)
Sara Linse, Pietro Sormanni, David J O'Connell
An aggregation inhibitor specific to oligomeric intermediates of Aβ42 derived from phage display libraries of stable, small proteins. Proceedings of the National Academy of Sciences of the United States of America 119 (21) (2022)
Sean Chia, Z Faidon Brotzakis, Robert I Horne, Andrea Possenti, Benedetta Mannini, Rodrigo Cataldi, Magdalena Nowinska, Roxine Staats, Sara Linse, Tuomas P J Knowles, Johnny Habchi, Christopher M Dobson
Structure-Based Discovery of Small-Molecule Inhibitors of the Autocatalytic Proliferation of α-Synuclein Aggregates. Molecular pharmaceutics (2022)
Dev Thacker, Amanda Willas, Alexander J Dear, Sara Linse
Role of Hydrophobicity at the N-Terminal Region of Aβ42 in Secondary Nucleation. ACS chemical neuroscience 13 (23) (2022)
Marija Dubackic, Yun Liu, Elizabeth G Kelley, Crispin John Dakin Hetherington, Michael Haertlein, Juliette M Devos, Sara Linse, Emma Sparr, Ulf Olsson
α-Synuclein Interaction with Lipid Bilayer Discs. Langmuir : the ACS journal of surfaces and colloids 38 (33) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Dev Thacker, Mara Bless, Mohammad Barghouth, Enming Zhang, Sara Linse
A Palette of Fluorescent A β 42 Peptides Labelled at a Range of Surface-Exposed Sites. International journal of molecular sciences 23 (3) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Rebecca Frankel, Emma Sparr, Sara Linse
On the Aggregation of Apolipoprotein A-I. International journal of molecular sciences 23 (15) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Salima Bahri, Robert Silvers, Brian Michael, Kristaps Jaudzems, Daniela Lalli, Gilles Casano, Olivier Ouari, Anne Lesage, Guido Pintacuda, Sara Linse, Robert G Griffin
1 H detection and dynamic nuclear polarization-enhanced NMR of Aβ 1-42 fibrils. Proceedings of the National Academy of Sciences of the United States of America 119 (1) (2022)
Sara Linse
High-Efficiency Expression and Purification of DNAJB6b Based on the pH-Modulation of Solubility and Denaturant-Modulation of Size. Molecules (Basel, Switzerland) 27 (2) (2022)
Georg Meisl, Catherine K Xu, Jonathan D Taylor, Thomas C T Michaels, Aviad Levin, Daniel Erik Otzen, David Klenerman, Stephen J Matthews, Sara Linse, Maria Andreasen, Tuomas P J Knowles
Uncovering the universality of self-replication in protein aggregation and its link to disease. Science advances 8 (32) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience 14 (2) (2022)
Kevin N Baumann, Greta Šneiderienė, Michele Sanguanini, Matthias M Schneider, Oded Rimon, Alicia González Díaz, Heather Greer, Dev Thacker, Sara Linse, Tuomas P J Knowles, Christopher M Dobson
A Kinetic Map of the Influence of Biomimetic Lipid Model Membranes on Aβ 42 Aggregation. ACS chemical neuroscience (2022)
Sara Linse, Kyrre Thalberg, Tuomas P J Knowles
The unhappy chaperone. QRB discovery 2 (2021)
Mattias Törnquist, Sara Linse
Chiral Selectivity of Secondary Nucleation in Amyloid Fibril Propagation. Angewandte Chemie (International ed. in English) 60 (45) (2021)
Yuewen Zhang, Therese W Herling, Stefan Kreida, Quentin A E Peter, Tadas Kartanas, Susanna Törnroth-Horsefield, Sara Linse, Tuomas P J Knowles
A microfluidic strategy for the detection of membrane protein interactions. Lab on a chip 20 (17) (2021)
Manuela R Zimmermann, Subhas C Bera, Georg Meisl, Sourav Dasadhikari, Shamasree Ghosh, Sara Linse, Kanchan Garai, Tuomas P J Knowles
Mechanism of Secondary Nucleation at the Single Fibril Level from Direct Observations of Aβ42 Aggregation. Journal of the American Chemical Society 143 (40) (2021)
Veronica Lattanzi, Ingemar André, Urs Gasser, Marija Dubackic, Ulf Olsson, Sara Linse
Amyloid β 42 fibril structure based on small-angle scattering. Proceedings of the National Academy of Sciences of the United States of America 118 (48) (2021)
Katarzyna Makasewicz, Stefan Wennmalm, Björn Stenqvist, Marco Fornasier, Alexandra Andersson, Peter Jönsson, Sara Linse, Emma Sparr
Cooperativity of α-Synuclein Binding to Lipid Membranes. ACS chemical neuroscience 12 (12) (2021)
Diana C Rodriguez Camargo, Eimantas Sileikis, Sean Chia, Emil Axell, Katja Bernfur, Rodrigo L Cataldi, Samuel I A Cohen, Georg Meisl, Johnny Habchi, Tuomas P J Knowles, Christopher M Dobson, Sara Linse
Proliferation of Tau 304-380 Fragment Aggregates through Autocatalytic Secondary Nucleation. ACS chemical neuroscience 12 (23) (2021)
Tinna Pálmadóttir, Anders Malmendal, Thom Leiding, Mikael Lund, Sara Linse
Charge Regulation during Amyloid Formation of α-Synuclein. Journal of the American Chemical Society 143 (20) (2021)
Dev Thacker, Kalyani Sanagavarapu, Birgitta Frohm, Georg Meisl, Tuomas P J Knowles, Sara Linse
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America 117 (41) (2020)
Gabriel A Braun, Beatrice E Ary, Alexander J Dear, Matthew C H Rohn, Abigail M Payson, David S M Lee, Robert C Parry, Connie Friedman, Tuomas P J Knowles, Sara Linse, Karin S Åkerfeldt
On the Mechanism of Self-Assembly by a Hydrogel-Forming Peptide. Biomacromolecules 21 (12) (2020)
Alexander J Dear, Thomas C T Michaels, Georg Meisl, David Klenerman, Si Wu, Sarah Perrett, Sara Linse, Christopher M Dobson, Tuomas P J Knowles
Kinetic diversity of amyloid oligomers. Proceedings of the National Academy of Sciences of the United States of America 117 (22) (2020)
Thomas C T Michaels, And Ela Šarić, Samo Curk, Katja Bernfur, Paolo Arosio, Georg Meisl, Alexander J Dear, Samuel I A Cohen, Christopher M Dobson, Christopher M Dobson, Sara Linse, Tuomas P J Knowles
Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide. Nature chemistry 12 (5) (2020)
Ricardo Gaspar, Mikael Lund, Emma Sparr, Sara Linse
Anomalous Salt Dependence Reveals an Interplay of Attractive and Repulsive Electrostatic Interactions in α-synuclein Fibril Formation. QRB discovery 1 (2020)
Mattias Törnquist, Risto Cukalevski, Ulrich Weininger, Georg Meisl, Tuomas P J Knowles, Thom Leiding, Anders Malmendal, Mikael Akke, Sara Linse
Ultrastructural evidence for self-replication of Alzheimer-associated Aβ42 amyloid along the sides of fibrils. Proceedings of the National Academy of Sciences of the United States of America 117 (21) (2020)
Alessia Peduzzo, Sara Linse, Alexander K Buell
The Properties of α-Synuclein Secondary Nuclei Are Dominated by the Solution Conditions Rather than the Seed Fibril Strain. ACS chemical neuroscience 11 (6) (2020)
Alexander J Dear, Georg Meisl, And Ela Šarić, Thomas C T Michaels, Magnus Kjaergaard, Sara Linse, Tuomas P J Knowles
Identification of on- and off-pathway oligomers in amyloid fibril formation. Chemical science 11 (24) (2020)
Thomas C T Michaels, And Ela Šarić, Georg Meisl, Gabriella T Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M Dobson, Christopher M Dobson, Tuomas P J Knowles
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences of the United States of America 117 (39) (2020)
Sara Linse, Tom Scheidt, Katja Bernfur, Christopher M Dobson, Christopher M Dobson, Samuel I A Cohen, Eimantas Sileikis, Martin Lundqvist, Fang Qian, Tiernan T O'Malley, Thierry Bussiere, Paul H Weinreb, Catherine K Xu, Georg Meisl, Sean R A Devenish, Tuomas P J Knowles, Oskar Hansson
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies. Nature structural & molecular biology 27 (12) (2020)
Alexander J Dear, Georg Meisl, Thomas C T Michaels, Manuela R Zimmermann, Sara Linse, Tuomas P J Knowles
The catalytic nature of protein aggregation. The Journal of chemical physics 152 (4) (2020)
Tanja Weiffert, Georg Meisl, Patrick Flagmeier, Suman De, Christopher J R Dunning, Birgitta Frohm, Henrik Zetterberg, Kaj Blennow, Erik Portelius, David Klenerman, Christopher M Dobson, Tuomas P J Knowles, Sara Linse
Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42. ACS chemical neuroscience 10 (5) (2019)
Tom Scheidt, Urszula Łapińska, Janet R Kumita, Carolyn M Sue, David Klenerman, Mark R Wilson, Samuel I A Cohen, Sara Linse, Christopher M Dobson, Christopher M Dobson, Tuomas P J Knowles, Paolo Arosio
Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates. Science advances 5 (4) (2019)
Brett H Pogostin, Sara Linse, Ulf Olsson
Fibril Charge Affects α-Synuclein Hydrogel Rheological Properties. Langmuir : the ACS journal of surfaces and colloids 35 (50) (2019)
Ryan Limbocker, Sean Chia, Francesco S Ruggeri, Michele Perni, Roberta Cascella, Gabriella T Heller, Georg Meisl, Benedetta Mannini, Johnny Habchi, Thomas C T Michaels, Pavan K Challa, Minkoo Ahn, Samuel T Casford, Nilumi Fernando, Catherine K Xu, Nina D Kloss, Samuel I A Cohen, Janet R Kumita, Cristina Cecchi, Michael Zasloff, Sara Linse, Tuomas P J Knowles, Fabrizio Chiti, Michele Vendruscolo, Christopher M Dobson
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes. Nature communications 10 (1) (2019)
Kristine Steen Jensen, Sara Linse, Mathias Nilsson, Mikael Akke, Anders Malmendal
Revealing Well-Defined Soluble States during Amyloid Fibril Formation by Multilinear Analysis of NMR Diffusion Data. Journal of the American Chemical Society 141 (47) (2019)
Rebecca Frankel, Mattias Törnquist, Georg Meisl, Oskar Hansson, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, Birgitta Frohm, Tommy Cedervall, Tuomas P J Knowles, Thom Leiding, Sara Linse
Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid. Communications biology 2 (2019)
Céline Galvagnion, Daniel Topgaard, Katarzyna Makasewicz, Alexander K Buell, Sara Linse, Emma Sparr, Christopher M Dobson
Lipid Dynamics and Phase Transition within α-Synuclein Amyloid Fibrils. The journal of physical chemistry letters 10 (24) (2019)
Kristen L Kelly, Shannon R Dalton, Rebecca B Wai, Kanika Ramchandani, Rosalind J Xu, Sara Linse, Casey H Londergan
Conformational Ensembles of Calmodulin Revealed by Nonperturbing Site-Specific Vibrational Probe Groups. The journal of physical chemistry. A 122 (11) (2018)
Shannon R Dalton, Alice R Vienneau, Shana R Burstein, Rosalind J Xu, Sara Linse, Casey H Londergan
Cyanylated Cysteine Reports Site-Specific Changes at Protein-Protein-Binding Interfaces Without Perturbation. Biochemistry 57 (26) (2018)
Niamh Ní Mhurchú, Lioudmila Zoubak, Gavin McGauran, Sara Linse, Alexei Yeliseev, David J O'Connell
Simplifying G Protein-Coupled Receptor Isolation with a Calcium-Dependent Fragment Complementation Affinity System. Biochemistry 57 (30) (2018)
Xiaoting Yang, Georg Meisl, Birgitta Frohm, Eva Thulin, Tuomas P J Knowles, Sara Linse
On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations. Proceedings of the National Academy of Sciences of the United States of America 115 (26) (2018)
Sean Chia, Johnny Habchi, Thomas C T Michaels, Samuel I A Cohen, Sara Linse, Christopher M Dobson, Tuomas P J Knowles, Michele Vendruscolo
SAR by kinetics for drug discovery in protein misfolding diseases. Proceedings of the National Academy of Sciences of the United States of America 115 (41) (2018)
Samuel I A Cohen, Risto Cukalevski, Thomas C T Michaels, Anđela Šarić, Mattias Törnquist, Michele Vendruscolo, Christopher M Dobson, Alexander K Buell, Tuomas P J Knowles, Sara Linse
Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide. Nature chemistry 10 (5) (2018)
Johnny Habchi, Sean Chia, Céline Galvagnion, Thomas C T Michaels, Mathias M J Bellaiche, Francesco Simone Ruggeri, Michele Sanguanini, Ilaria Idini, Janet R Kumita, Emma Sparr, Sara Linse, Christopher M Dobson, Tuomas P J Knowles, Christopher M Dobson
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes. Nature chemistry 10 (6) (2018)
Cecilia Månsson, Remco T P van Cruchten, Ulrich Weininger, Xiaoting Yang, Risto Cukalevski, Paolo Arosio, Christopher M Dobson, Tuomas P J Knowles, Mikael Akke, Sara Linse, Cecilia Emanuelsson
Conserved S/T Residues of the Human Chaperone DNAJB6 Are Required for Effective Inhibition of Aβ42 Amyloid Fibril Formation. Biochemistry 57 (32) (2018)

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Sara Linse