Peter J McHugh

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 24

Top Topics

African American

Single Molecule

Klebsiella Pneumoniae

Top Venues

The EMBO journal

Nature communications

Chemical science

Nucleic acids research

This page only lists publications with an associated author ORCID identifier.

Publications

Lonnie P Swift, B Christoffer Lagerholm, Lucy R Henderson, Malitha Ratnaweera, Hannah T Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D Ulrich, Joseph A Newman, Christopher J Schofield, Peter J McHugh
SNM1A is crucial for efficient repair of complex DNA breaks in human cells. Nature communications 15 (1) (2024)
Lonnie P Swift, B Christoffer Lagerholm, Lucy R Henderson, Malitha Ratnaweera, Hannah T Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D Ulrich, Joseph A Newman, Christopher J Schofield, Peter J McHugh
SNM1A is crucial for efficient repair of complex DNA breaks in human cells. Nature communications 15 (1) (2024)
Rebecca Roddan, William J Nathan, Joseph A Newman, Afaf Helmy El-Sagheer, David M Wilson, Tom Brown, Christopher J Schofield, Peter J McHugh
Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing. bioRxiv : the preprint server for biology (2024)
Lonnie P Swift, B Christoffer Lagerholm, Lucy R Henderson, Malitha Ratnaweera, Hannah T Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D Ulrich, Joseph A Newman, Christopher J Schofield, Peter J McHugh
SNM1A is crucial for efficient repair of complex DNA breaks in human cells. Nature communications 15 (1) (2024)
Lonnie P Swift, B Christoffer Lagerholm, Lucy R Henderson, Malitha Ratnaweera, Hannah T Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D Ulrich, Joseph A Newman, Christopher J Schofield, Peter J McHugh
SNM1A is crucial for efficient repair of complex DNA breaks in human cells. Nature communications 15 (1) (2024)
Marcin Bielinski, Lucy R Henderson, Yuliana Yosaatmadja, Lonnie P Swift, Hannah T Baddock, Matthew J Bowen, Jürgen Brem, Philip S Jones, Stuart P McElroy, Angus Morrison, Michael Speake, Stan van Boeckel, Els van Doornmalen, Jan van Groningen, Helma van den Hurk, Opher Gileadi, Joseph A Newman, Peter J McHugh, Christopher J Schofield
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chemical science 15 (21) (2024)
Marcin Bielinski, Lucy R Henderson, Yuliana Yosaatmadja, Lonnie P Swift, Hannah T Baddock, Matthew J Bowen, Jürgen Brem, Philip S Jones, Stuart P McElroy, Angus Morrison, Michael Speake, Stan van Boeckel, Els van Doornmalen, Jan van Groningen, Helma van den Hurk, Opher Gileadi, Joseph A Newman, Peter J McHugh, Christopher J Schofield
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chemical science 15 (21) (2024)
Vicki L Emms, Liam A Lewis, Lilla Beja, Natasha F A Bulman, Elisabete Pires, Frederick W Muskett, James S O McCullagh, Lonnie P Swift, Peter J McHugh, Richard J Hopkinson
N -Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells. Chemical science 14 (44) (2023)
Valentina Mengoli, Ilaria Ceppi, Aurore Sanchez, Elda Cannavo, Swagata Halder, Sarah Scaglione, Pierre-Henri L Gaillard, Peter J McHugh, Nathalie Riesen, Piergiorgio Pettazzoni, Peter Cejka
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures. The EMBO journal 42 (3) (2022)
Valentina Mengoli, Ilaria Ceppi, Aurore Sanchez, Elda Cannavo, Swagata Halder, Sarah Scaglione, Pierre-Henri L Gaillard, Peter J McHugh, Nathalie Riesen, Piergiorgio Pettazzoni, Peter Cejka
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures. The EMBO journal (2022)
Valentina Mengoli, Ilaria Ceppi, Aurore Sanchez, Elda Cannavo, Swagata Halder, Sarah Scaglione, Pierre-Henri L Gaillard, Peter J McHugh, Nathalie Riesen, Piergiorgio Pettazzoni, Peter Cejka
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures. The EMBO journal 42 (3) (2022)
Valentina Mengoli, Ilaria Ceppi, Aurore Sanchez, Elda Cannavo, Swagata Halder, Sarah Scaglione, Pierre-Henri L Gaillard, Peter J McHugh, Nathalie Riesen, Piergiorgio Pettazzoni, Peter Cejka
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures. The EMBO journal 42 (3) (2022)
Valentina Mengoli, Ilaria Ceppi, Aurore Sanchez, Elda Cannavo, Swagata Halder, Sarah Scaglione, Pierre-Henri L Gaillard, Peter J McHugh, Nathalie Riesen, Piergiorgio Pettazzoni, Peter Cejka
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures. The EMBO journal 42 (3) (2022)
Valentina Mengoli, Ilaria Ceppi, Aurore Sanchez, Elda Cannavo, Swagata Halder, Sarah Scaglione, Pierre-Henri L Gaillard, Peter J McHugh, Nathalie Riesen, Piergiorgio Pettazzoni, Peter Cejka
WRN helicase and mismatch repair complexes independently and synergistically disrupt cruciform DNA structures. The EMBO journal 42 (3) (2022)
Hannah T Baddock, Sanja Brolih, Yuliana Yosaatmadja, Malitha Ratnaweera, Marcin Bielinski, Lonnie P Swift, Abimael Cruz-Migoni, Haitian Fan, Jeremy R Keown, Alexander P Walker, Garrett M Morris, Jonathan M Grimes, Ervin Fodor, Christopher J Schofield, Opher Gileadi, Peter J McHugh
Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification. Nucleic acids research 50 (3) (2022)
Yuliana Yosaatmadja, Hannah T Baddock, Joseph A Newman, Marcin Bielinski, Angeline E Gavard, Shubhashish M M Mukhopadhyay, Adam A Dannerfjord, Christopher J Schofield, Peter J McHugh, Opher Gileadi
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition. Nucleic acids research 49 (16) (2021)
Tabitha Jenkins, Sarah J Northall, Denis Ptchelkine, Rebecca Lever, Andrew Cubbon, Hannah Betts, Vincenzo Taresco, Christopher D O Cooper, Peter J McHugh, Panos Soultanas, Edward L Bolt
The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core. NAR cancer 3 (1) (2021)
Wei Wu, Sarah E Kargbo-Hill, William J Nathan, Jacob Paiano, Elsa Callen, Dongpeng Wang, Kenta Shinoda, Niek van Wietmarschen, Jennifer M Colón-Mercado, Dali Zong, Raffaella De Pace, Han-Yu Shih, Steven L Coon, Maia Parsadanian, Raphael Pavani, Hana Hanzlikova, Solji Park, Seol Kyoung Jung, Peter J McHugh, Andres Canela, Chongyi Chen, Rafael Casellas, Keith W Caldecott, Michael Emmerson Ward, Andrè Nussenzweig
Neuronal enhancers are hotspots for DNA single-strand break repair. Nature 593 (7859) (2021)
Hannah T Baddock, Joseph A Newman, Yuliana Yosaatmadja, Marcin Bielinski, Christopher J Schofield, Opher Gileadi, Peter J McHugh
A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family. Nucleic acids research 49 (16) (2021)
Niek van Wietmarschen, Sriram Sridharan, William J Nathan, Anthony Tubbs, Edmond M Chan, Elsa Callen, Wei Wu, Frida Belinky, Veenu Tripathi, Nancy Wong, Kyla Foster, Javad Noorbakhsh, Kiran Garimella, Abimael Cruz-Migoni, Joshua A Sommers, Yongqing Huang, Ashir A Borah, Jonathan T Smith, Jeremie Kalfon, Nikolas Kesten, Kasper Fugger, Robert L Walker, Egor Dolzhenko, Michael A Eberle, Bruce E Hayward, Karen Usdin, Catherine H Freudenreich, Robert M Brosh, Stephen C West, Peter J McHugh, Paul S Meltzer, Adam J Bass, Andrè Nussenzweig
Repeat expansions confer WRN dependence in microsatellite-unstable cancers. Nature 586 (7828) (2020)
Peter J McHugh
XPF-ERCC1: Linchpin of DNA crosslink repair. PLoS genetics 16 (4) (2020)
Adam M Thomas, Sanja Brolih, Joanna F McGouran, Afaf Helmy El-Sagheer, Denis Ptchelkine, Morgan Jones, Neil Q McDonald, Peter J McHugh, Tom Brown
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors. Chemical communications (Cambridge, England) 55 (78) (2019)
Ummi B Abdullah, Joanna F McGouran, Sanja Brolih, Denis Ptchelkine, Afaf H El-Sagheer, Tom Brown, Peter J McHugh
RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks. The EMBO journal 36 (14) (2017)
Erkin Erdal, Syed Haider, Jan Rehwinkel, Adrian L Harris, Peter J McHugh
A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1. Genes & development 31 (4) (2017)