Afaf Helmy El-Sagheer (Afaf H El-Sagheer, Afaf El-Sagheer)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 40

Top Topics

Top Venues

Journal of the American Chemical Society

Nature communications

Chemical science

This page only lists publications with an associated author ORCID identifier.

Publications

Rebecca Roddan, William J Nathan, Joseph A Newman, Afaf Helmy El-Sagheer, David M Wilson, Tom Brown, Christopher J Schofield, Peter J McHugh
Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing. bioRxiv : the preprint server for biology (2024)
Gangshun Yi, Mingda Ye, Loic Carrique, Afaf Helmy El-Sagheer, Tom Brown, Chris J Norbury, Peijun Zhang, Robert C G Gilbert
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs. Nature structural & molecular biology (2024)
Gangshun Yi, Mingda Ye, Loic Carrique, Afaf Helmy El-Sagheer, Tom Brown, Chris J Norbury, Peijun Zhang, Robert C G Gilbert
Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs. Nature structural & molecular biology (2024)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society 145 (9) (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society 145 (9) (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Correction to "Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks". Journal of the American Chemical Society (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Correction to "Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks". Journal of the American Chemical Society (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society 145 (9) (2023)
Sarah R E Orsborne, Jeffrey Gorman, Leah R Weiss, Akshay Sridhar, Naitik A Panjwani, Giorgio Divitini, Peter Budden, David Palecek, Seán T J Ryan, Akshay Rao, Rosana Collepardo-Guevara, Afaf Helmy El-Sagheer, Tom Brown, Jan Behrends, Richard Henry Friend, Florian Auras
Photogeneration of Spin Quintet Triplet-Triplet Excitations in DNA-Assembled Pentacene Stacks. Journal of the American Chemical Society 145 (9) (2023)
Sven Epple, Afaf Helmy El-Sagheer, Tom Brown
Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology. Emerging topics in life sciences 5 (5) (2022)
Ysobel R Baker, Cameron Thorpe, Jinfeng Chen, Laura M Poller, Lina Cox, Pawan Kumar, Wooi Fang Lim, Lillian Lie, Graham McClorey, Sven Epple, Daniel Singleton, Michael A McDonough, Jack S Hardwick, Kirsten E Christensen, Matthew John Andrew Wood, James P Hall, Afaf Helmy El-Sagheer, Tom Brown
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides. Nature communications 13 (1) (2022)
Maria-Eleni Kyriazi, Afaf Helmy El-Sagheer, Igor L Medintz, Tom Brown, Antonios G Kanaras
An Investigation into the Resistance of Spherical Nucleic Acids against DNA Enzymatic Degradation. Bioconjugate chemistry 33 (1) (2022)
Konstantina Alexaki, Maria Eleni Kyriazi, Joshua Greening, Lapatrada Taemaitree, Afaf Helmy El-Sagheer, Tom Brown, Xunli Zhang, Otto L Muskens, Antonios G Kanaras
A SARS-Cov-2 sensor based on upconversion nanoparticles and graphene oxide. RSC advances 12 (29) (2022)
Miguel Xavier, Maria-Eleni Kyriazi, Stuart Lanham, Konstantina Alexaki, Elloise Matthews, Afaf Helmy El-Sagheer, Tom Brown, Antonios G Kanaras, Richard O C Oreffo
Enrichment of Skeletal Stem Cells from Human Bone Marrow Using Spherical Nucleic Acids. ACS nano 15 (4) (2021)
Sven Epple, Cameron Thorpe, Ysobel R Baker, Afaf Helmy El-Sagheer, Tom Brown
Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response. Chemical communications (Cambridge, England) 56 (41) (2021)
Anders Foller Füchtbauer, Moa S Wranne, Sangamesh Sarangamath, Mattias Bood, Afaf Helmy El-Sagheer, Tom Brown, Henrik Gradén, Morten Grøtli, L Marcus Wilhelmsson
Lighting Up DNA with the Environment-Sensitive Bright Adenine Analogue qAN4. ChemPlusChem 85 (2) (2021)
Damien J Downes, Robert A Beagrie, Matthew E Gosden, Jelena Telenius, Stephanie J Carpenter, Lea Nussbaum, Sara De Ornellas, Martin Sergeant, Chris Q Eijsbouts, Ron Schwessinger, Jon Kerry, Nigel A Roberts, Arun Shivalingam, Afaf Helmy El-Sagheer, A Marieke Oudelaar, Tom Brown, Veronica J Buckle, James O J Davies, Jim R Hughes
High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale. Nature communications 12 (1) (2021)
Shifali Shishodia, Marina Demetriades, Dong Zhang, Nok Yin Tam, Pratheesh Maheswaran, Caitlin Clunie-O'Connor, Anthony Tumber, Ivanhoe K H Leung, Yi Min Ng, Thomas M Leissing, Afaf Helmy El-Sagheer, Eidarus Salah, Tom Brown, Wei Shen Aik, Michael A McDonough, Christopher J Schofield
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. Journal of medicinal chemistry 64 (22) (2021)
Jeffrey Gorman, Sarah R E Orsborne, Akshay Sridhar, Raj Pandya, Peter Budden, Alexander Ohmann, Naitik A Panjwani, Yun Liu, Jake L Greenfield, Simon Dowland, Victor Gray, Seán T J Ryan, Sara De Ornellas, Afaf Helmy El-Sagheer, Tom Brown, Jonathan R Nitschke, Jan Behrends, Ulrich Felix Keyser, Akshay Rao, Rosana Collepardo-Guevara, Eugen Stulz, Richard Henry Friend, Florian Auras
Deoxyribonucleic Acid Encoded and Size-Defined π-Stacking of Perylene Diimides. Journal of the American Chemical Society 144 (1) (2021)
Sven Epple, Aman Modi, Ysobel R Baker, Ewa Wȩgrzyn, Diallo Traoré, Przemyslaw Wanat, Agnes E S Tyburn, Arun Shivalingam, Lapatrada Taemaitree, Afaf Helmy El-Sagheer, Tom Brown
A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility. Journal of the American Chemical Society 143 (39) (2021)
Ysobel R Baker, Liyiwen Yuan, Jinfeng Chen, Roman Belle, Robert Carlisle, Afaf Helmy El-Sagheer, Tom Brown
Expanding the chemical functionality of DNA nanomaterials generated by rolling circle amplification. Nucleic acids research 49 (16) (2021)
Alisina Bazrafshan, Maria-Eleni Kyriazi, Brandon Alexander Holt, Wenxiao Deng, Selma Piranej, Hanquan Su, Yuesong Hu, Afaf Helmy El-Sagheer, Tom Brown, Gabriel A Kwong, Antonios G Kanaras, Khalid Salaita
DNA Gold Nanoparticle Motors Demonstrate Processive Motion with Bursts of Speed Up to 50 nm Per Second. ACS nano 15 (5) (2021)
Nicoló Zuin Fantoni, Afaf Helmy El-Sagheer, Tom Brown
A Hitchhiker's Guide to Click-Chemistry with Nucleic Acids. Chemical reviews 121 (12) (2021)
Arun Shivalingam, Lapatrada Taemaitree, Afaf Helmy El-Sagheer, Tom Brown
Squaramides and Ureas: A Flexible Approach to Polymerase-Compatible Nucleic Acid Assembly. Angewandte Chemie (International ed. in English) 59 (28) (2020)
Nicoló Zuin Fantoni, Bríonna McGorman, Zara Molphy, Daniel Singleton, Sarah Walsh, Afaf Helmy El-Sagheer, Vickie McKee, Tom Brown, Andrew Kellett
Development of Gene-Targeted Polypyridyl Triplex-Forming Oligonucleotide Hybrids. Chembiochem : a European journal of chemical biology 21 (24) (2020)
A Marieke Oudelaar, Robert A Beagrie, Matthew E Gosden, Sara De Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf Helmy El-Sagheer, Jelena M Telenius, Tom Brown, Veronica J Buckle, Merav Socolovsky, Douglas R Higgs, Jim R Hughes
Dynamics of the 4D genome during in vivo lineage specification and differentiation. Nature communications 11 (1) (2020)
Piotr Klimkowski, Sara De Ornellas, Daniel Singleton, Afaf Helmy El-Sagheer, Tom Brown
Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting. Organic & biomolecular chemistry 17 (24) (2019)
Adam M Thomas, Sanja Brolih, Joanna F McGouran, Afaf Helmy El-Sagheer, Denis Ptchelkine, Morgan Jones, Neil Q McDonald, Peter J McHugh, Tom Brown
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors. Chemical communications (Cambridge, England) 55 (78) (2019)
Angela F De Fazio, Afaf Helmy El-Sagheer, Jason S Kahn, Iris Nandhakumar, Matthew Richard Burton, Tom Brown, Otto L Muskens, Oleg Gang, Antonios G Kanaras
Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices. ACS nano 13 (5) (2019)
Maria Moros, Maria-Eleni Kyriazi, Afaf Helmy El-Sagheer, Tom Brown, Claudia Tortiglione, Antonios G Kanaras
DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals. ACS applied materials & interfaces 11 (15) (2018)
Johanna Midelet, Afaf Helmy El-Sagheer, Tom Brown, Antonios G Kanaras, Anne Débarre, Martinus H V Werts
Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence. Chemphyschem : a European journal of chemical physics and physical chemistry 19 (7) (2018)
Mattias Bood, Anders Foller Füchtbauer, Moa S Wranne, Jong Jin Ro, Sangamesh Sarangamath, Afaf Helmy El-Sagheer, Déborah L M Rupert, Rachel S Fisher, Steven W Magennis, Anita C Jones, Fredrik Höök, Tom Brown, Byeang Hyean Kim, Anders Dahlén, L Marcus Wilhelmsson, Morten Grøtli
Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue. Chemical science 9 (14) (2018)
Jinfeng Chen, Ysobel R Baker, Asha Brown, Afaf Helmy El-Sagheer, Tom Brown
Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation. Chemical science 9 (42) (2018)
Julia Piccoli, Robert Hein, Afaf Helmy El-Sagheer, Tom Brown, Eduardo M Cilli, Paulo R Bueno, Jason J Davis
Redox Capacitive Assaying of C-Reactive Protein at a Peptide Supported Aptamer Interface. Analytical chemistry 90 (5) (2018)
Sarah Walsh, Afaf Helmy El-Sagheer, Tom Brown
Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above. Chemical science 9 (39) (2018)
Maria-Eleni Kyriazi, Davide Giust, Afaf Helmy El-Sagheer, Peter M Lackie, Otto L Muskens, Tom Brown, Antonios G Kanaras
Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers. ACS nano 12 (4) (2018)
Davide Giust, María Isabel Lucío, Afaf Helmy El-Sagheer, Tom Brown, Lorraine E Williams, Otto L Muskens, Antonios G Kanaras
Graphene Oxide-Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops. ACS nano 12 (6) (2018)
Françoise S Howe, Andrew Russell, Anna R Lamstaes, Afaf Helmy El-Sagheer, Anitha Nair, Tom Brown, Jane Mellor
CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape. eLife 6 (2017)
Moa S Wranne, Anders Foller Füchtbauer, Blaise Dumat, Mattias Bood, Afaf Helmy El-Sagheer, Tom Brown, Henrik Gradén, Morten Grøtli, L Marcus Wilhelmsson
Toward Complete Sequence Flexibility of Nucleic Acid Base Analogue FRET. Journal of the American Chemical Society 139 (27) (2017)