Michael Emmerson Ward (Michael E Ward, Michael Ward)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 72

Top Topics

Amyotrophic Lateral Sclerosis

Gene Expression

Endothelial Cells

Dna Damage Response

Top Venues

Science translational medicine

bioRxiv : the preprint server for biology

Nature neuroscience

Cellular and molecular life sciences : CMLS

This page only lists publications with an associated author ORCID identifier.

Publications

Christopher Grunseich, Veronica H Ryan, James Hawrot, Sydney Lawton, Daniel M Ramos, Y Andy Qi, Kory R Johnson, Xylena Reed, Nicholas L Johnson, Aaron W Kollasch, Megan F Duffy, Lawren VandeVrede, J Nicholas Cochran, Bruce L Miller, Camilo Toro, Bibiana Bielekova, Debora S Marks, Jennifer S Yokoyama, Justin Y Kwan, Mark R Cookson, Michael Emmerson Ward
An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association 20 (8) (2024)
Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Jordan D Marks, Virginia Estades Ayuso, Yari Carlomagno, Mei Yue, Tiffany W Todd, Ying Hao, Ziyi Li, Zachary T McEachin, Anantharaman Shantaraman, Duc M Duong, Lillian M Daughrity, Karen R Jansen-West, Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano, Michael A DeTure, Bailey Rawlinson, Monica Castanedes Casey, Meredith T Lilley, Megan H Donahue, Vidhya Maheswari Jawahar, Bradley F Boeve, Ronald C Petersen, David S Knopman, Björn E Oskarsson, Neill R Graff-Radford, Zbigniew K Wszolek, Gourisankar Ghosh, Keith Anthony Josephs, Yue A Qi, Nicholas T Seyfried, Michael Emmerson Ward, Yong-Jie Zhang, Mercedes Prudencio, Leonard Petrucelli, Casey N Cook
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science translational medicine 16 (730) (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine 16 (734) (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine 16 (734) (2024)
Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Sam Bryce-Smith, Anna-Leigh Brown, Puja R Mehta, Francesca Mattedi, Alla Mikheenko, Simone Barattucci, Matteo Zanovello, Dario Dattilo, Matthew Yome, Sarah E Kargbo-Hill, Yue A Qi, Oscar G Wilkins, Kai Sun, Eugeni M Ryadnov, Yixuan Wan, null null, Jose Norberto S Vargas, Nicol Birsa, Towfique Raj, Jack Humphrey, Matthew J Keuss, Michael Emmerson Ward, Maria Secrier, Pietro Fratta
TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD. bioRxiv : the preprint server for biology (2024)
Christopher Grunseich, Veronica H Ryan, James Hawrot, Sydney Lawton, Daniel M Ramos, Y Andy Qi, Kory R Johnson, Xylena Reed, Nicholas L Johnson, Aaron W Kollasch, Megan F Duffy, Lawren VandeVrede, J Nicholas Cochran, Bruce L Miller, Camilo Toro, Bibiana Bielekova, Debora S Marks, Jennifer S Yokoyama, Justin Y Kwan, Mark R Cookson, Michael Emmerson Ward
An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association 20 (8) (2024)
Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Christopher Grunseich, Veronica H Ryan, James Hawrot, Sydney Lawton, Daniel M Ramos, Y Andy Qi, Kory R Johnson, Xylena Reed, Nicholas L Johnson, Aaron W Kollasch, Megan F Duffy, Lawren VandeVrede, J Nicholas Cochran, Bruce L Miller, Camilo Toro, Bibiana Bielekova, Debora S Marks, Jennifer S Yokoyama, Justin Y Kwan, Mark R Cookson, Michael Emmerson Ward
Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Raffaella De Pace, Saikat Ghosh, Veronica H Ryan, Mira Sohn, Michal Jarnik, Paniz Rezvan Sangsari, Nicole Y Morgan, Ryan K Dale, Michael Emmerson Ward, Juan S Bonifacino
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration. Nature neuroscience 27 (6) (2024)
Raffaella De Pace, Saikat Ghosh, Veronica H Ryan, Mira Sohn, Michal Jarnik, Paniz Rezvan Sangsari, Nicole Y Morgan, Ryan K Dale, Michael Emmerson Ward, Juan S Bonifacino
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration. Nature neuroscience 27 (6) (2024)
Jordan D Marks, Virginia Estades Ayuso, Yari Carlomagno, Mei Yue, Tiffany W Todd, Ying Hao, Ziyi Li, Zachary T McEachin, Anantharaman Shantaraman, Duc M Duong, Lillian M Daughrity, Karen R Jansen-West, Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano, Michael A DeTure, Bailey Rawlinson, Monica Castanedes Casey, Meredith T Lilley, Megan H Donahue, Vidhya Maheswari Jawahar, Bradley F Boeve, Ronald C Petersen, David S Knopman, Björn E Oskarsson, Neill R Graff-Radford, Zbigniew K Wszolek, Gourisankar Ghosh, Keith Anthony Josephs, Yue A Qi, Nicholas T Seyfried, Michael Emmerson Ward, Yong-Jie Zhang, Mercedes Prudencio, Leonard Petrucelli, Casey N Cook
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science translational medicine 16 (730) (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine 16 (734) (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine (2024)
Christopher Grunseich, Veronica H Ryan, James Hawrot, Sydney Lawton, Daniel M Ramos, Y Andy Qi, Kory R Johnson, Xylena Reed, Nicholas L Johnson, Aaron W Kollasch, Megan F Duffy, Lawren VandeVrede, J Nicholas Cochran, Bruce L Miller, Camilo Toro, Bibiana Bielekova, Debora S Marks, Jennifer S Yokoyama, Justin Y Kwan, Mark R Cookson, Michael Emmerson Ward
An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine 16 (734) (2024)
Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine 16 (734) (2024)
Anna-Leigh Brown, Oscar G Wilkins, Matthew J Keuss, Sarah E Kargbo-Hill, Matteo Zanovello, Weaverly Colleen Lee, Alexander Bampton, Flora C Y Lee, Laura Masino, Yue A Qi, Sam Bryce-Smith, Ariana Gatt, Martina Hallegger, Delphine Fagegaltier, Hemali Phatnani, null null, Jia Newcombe, Emil Karl Gustavsson, Sahba Seddighi, Joel F Reyes, Steven L Coon, Daniel Ramos, Giampietro Schiavo, Elizabeth M C Fisher, Towfique Raj, Maria Secrier, Tammaryn Lashley, Jernej Ule, Emanuele Buratti, Jack Humphrey, Michael Emmerson Ward, Pietro Fratta
Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. Nature (2024)
Christopher Grunseich, Veronica H Ryan, James Hawrot, Sydney Lawton, Daniel M Ramos, Y Andy Qi, Kory R Johnson, Xylena Reed, Nicholas L Johnson, Aaron W Kollasch, Megan F Duffy, Lawren VandeVrede, J Nicholas Cochran, Bruce L Miller, Camilo Toro, Bibiana Bielekova, Debora S Marks, Jennifer S Yokoyama, Justin Y Kwan, Mark R Cookson, Michael Emmerson Ward
An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine 16 (734) (2024)
Jordan D Marks, Virginia Estades Ayuso, Yari Carlomagno, Mei Yue, Tiffany W Todd, Ying Hao, Ziyi Li, Zachary T McEachin, Anantharaman Shantaraman, Duc M Duong, Lillian M Daughrity, Karen R Jansen-West, Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano, Michael A DeTure, Bailey Rawlinson, Monica Castanedes Casey, Meredith T Lilley, Megan H Donahue, Vidhya Maheswari Jawahar, Bradley F Boeve, Ronald C Petersen, David S Knopman, Björn E Oskarsson, Neill R Graff-Radford, Zbigniew K Wszolek, Gourisankar Ghosh, Keith Anthony Josephs, Yue A Qi, Nicholas T Seyfried, Michael Emmerson Ward, Yong-Jie Zhang, Mercedes Prudencio, Leonard Petrucelli, Casey N Cook
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science translational medicine 16 (730) (2024)
Raffaella De Pace, Saikat Ghosh, Veronica H Ryan, Mira Sohn, Michal Jarnik, Paniz Rezvan Sangsari, Nicole Y Morgan, Ryan K Dale, Michael Emmerson Ward, Juan S Bonifacino
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration. Nature neuroscience 27 (6) (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine 16 (734) (2024)
Megan M Dykstra, Kaitlin Weskamp, Nicolás B Gómez, Jacob Waksmacki, Elizabeth Tank, M Rebecca Glineburg, Allison Snyder, Emile Pinarbasi, Michael Bekier, Xingli Li, Jen Bai, Shameena Shahzad, Juno Nedumaran, Clare Wieland, Corey Stewart, Sydney Willey, Nikolas Grotewold, Jonathon McBride, John J Moran, Aditya V Suryakumar, Michael Lucas, Peter Tessier, Michael Emmerson Ward, Peter K Todd, Sami J Barmada
TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms. bioRxiv : the preprint server for biology (2024)
Jordan D Marks, Virginia Estades Ayuso, Yari Carlomagno, Mei Yue, Tiffany W Todd, Ying Hao, Ziyi Li, Zachary T McEachin, Anantharaman Shantaraman, Duc M Duong, Lillian M Daughrity, Karen R Jansen-West, Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano, Michael A DeTure, Bailey Rawlinson, Monica Castanedes Casey, Meredith T Lilley, Megan H Donahue, Vidhya Maheswari Jawahar, Bradley F Boeve, Ronald C Petersen, David S Knopman, Björn E Oskarsson, Neill R Graff-Radford, Zbigniew K Wszolek, Gourisankar Ghosh, Keith Anthony Josephs, Yue A Qi, Nicholas T Seyfried, Michael Emmerson Ward, Yong-Jie Zhang, Mercedes Prudencio, Leonard Petrucelli, Casey N Cook
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science translational medicine 16 (730) (2024)
Megan M Dykstra, Kaitlin Weskamp, Nicolás B Gómez, Jacob Waksmacki, Elizabeth Tank, M Rebecca Glineburg, Allison Snyder, Emile Pinarbasi, Michael Bekier, Xingli Li, Jen Bai, Shameena Shahzad, Juno Nedumaran, Clare Wieland, Corey Stewart, Sydney Willey, Nikolas Grotewold, Jonathon McBride, John J Moran, Aditya V Suryakumar, Michael Lucas, Peter Tessier, Michael Emmerson Ward, Peter K Todd, Sami J Barmada
TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms. bioRxiv : the preprint server for biology (2024)
Jordan D Marks, Virginia Estades Ayuso, Yari Carlomagno, Mei Yue, Tiffany W Todd, Ying Hao, Ziyi Li, Zachary T McEachin, Anantharaman Shantaraman, Duc M Duong, Lillian M Daughrity, Karen R Jansen-West, Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano, Michael A DeTure, Bailey Rawlinson, Monica Castanedes Casey, Meredith T Lilley, Megan H Donahue, Vidhya Maheswari Jawahar, Bradley F Boeve, Ronald C Petersen, David S Knopman, Björn E Oskarsson, Neill R Graff-Radford, Zbigniew K Wszolek, Gourisankar Ghosh, Keith Anthony Josephs, Yue A Qi, Nicholas T Seyfried, Michael Emmerson Ward, Yong-Jie Zhang, Mercedes Prudencio, Leonard Petrucelli, Casey N Cook
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science translational medicine 16 (730) (2024)
Megan M Dykstra, Kaitlin Weskamp, Nicolás B Gómez, Jacob Waksmacki, Elizabeth Tank, M Rebecca Glineburg, Allison Snyder, Emile Pinarbasi, Michael Bekier, Xingli Li, Jen Bai, Shameena Shahzad, Juno Nedumaran, Clare Wieland, Corey Stewart, Sydney Willey, Nikolas Grotewold, Jonathon McBride, John J Moran, Aditya V Suryakumar, Michael Lucas, Peter Tessier, Michael Emmerson Ward, Peter K Todd, Sami J Barmada
TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms. bioRxiv : the preprint server for biology (2024)
Raffaella De Pace, Saikat Ghosh, Veronica H Ryan, Mira Sohn, Michal Jarnik, Paniz Rezvan Sangsari, Nicole Y Morgan, Ryan K Dale, Michael Emmerson Ward, Juan S Bonifacino
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration. Nature neuroscience (2024)
Raffaella De Pace, Saikat Ghosh, Veronica H Ryan, Mira Sohn, Michal Jarnik, Paniz Rezvan Sangsari, Nicole Y Morgan, Ryan K Dale, Michael Emmerson Ward, Juan S Bonifacino
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration. Nature neuroscience 27 (6) (2024)
Jordan D Marks, Virginia Estades Ayuso, Yari Carlomagno, Mei Yue, Tiffany W Todd, Ying Hao, Ziyi Li, Zachary T McEachin, Anantharaman Shantaraman, Duc M Duong, Lillian M Daughrity, Karen R Jansen-West, Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano, Michael A DeTure, Bailey Rawlinson, Monica Castanedes Casey, Meredith T Lilley, Megan H Donahue, Vidhya Maheswari Jawahar, Bradley F Boeve, Ronald C Petersen, David S Knopman, Björn E Oskarsson, Neill R Graff-Radford, Zbigniew K Wszolek, Gourisankar Ghosh, Keith Anthony Josephs, Yue A Qi, Nicholas T Seyfried, Michael Emmerson Ward, Yong-Jie Zhang, Mercedes Prudencio, Leonard Petrucelli, Casey N Cook
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science translational medicine 16 (730) (2024)
Jordan D Marks, Virginia Estades Ayuso, Yari Carlomagno, Mei Yue, Tiffany W Todd, Ying Hao, Ziyi Li, Zachary T McEachin, Anantharaman Shantaraman, Duc M Duong, Lillian M Daughrity, Karen R Jansen-West, Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano, Michael A DeTure, Bailey Rawlinson, Monica Castanedes Casey, Meredith T Lilley, Megan H Donahue, Vidhya Maheswari Jawahar, Bradley F Boeve, Ronald C Petersen, David S Knopman, Björn E Oskarsson, Neill R Graff-Radford, Zbigniew K Wszolek, Gourisankar Ghosh, Keith Anthony Josephs, Yue A Qi, Nicholas T Seyfried, Michael Emmerson Ward, Yong-Jie Zhang, Mercedes Prudencio, Leonard Petrucelli, Casey N Cook
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science translational medicine 16 (730) (2024)
Sam Bryce-Smith, Anna-Leigh Brown, Puja R Mehta, Francesca Mattedi, Alla Mikheenko, Simone Barattucci, Matteo Zanovello, Dario Dattilo, Matthew Yome, Sarah E Kargbo-Hill, Yue A Qi, Oscar G Wilkins, Kai Sun, Eugeni M Ryadnov, Yixuan Wan, null null, Jose Norberto S Vargas, Nicol Birsa, Towfique Raj, Jack Humphrey, Matthew J Keuss, Michael Emmerson Ward, Maria Secrier, Pietro Fratta
TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD. bioRxiv : the preprint server for biology (2024)
Jordan D Marks, Virginia Estades Ayuso, Yari Carlomagno, Mei Yue, Tiffany W Todd, Ying Hao, Ziyi Li, Zachary T McEachin, Anantharaman Shantaraman, Duc M Duong, Lillian M Daughrity, Karen R Jansen-West, Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano, Michael A DeTure, Bailey Rawlinson, Monica Castanedes Casey, Meredith T Lilley, Megan H Donahue, Vidhya Maheswari Jawahar, Bradley F Boeve, Ronald C Petersen, David S Knopman, Björn E Oskarsson, Neill R Graff-Radford, Zbigniew K Wszolek, Gourisankar Ghosh, Keith Anthony Josephs, Yue A Qi, Nicholas T Seyfried, Michael Emmerson Ward, Yong-Jie Zhang, Mercedes Prudencio, Leonard Petrucelli, Casey N Cook
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science translational medicine 16 (730) (2024)
Jordan D Marks, Virginia Estades Ayuso, Yari Carlomagno, Mei Yue, Tiffany W Todd, Ying Hao, Ziyi Li, Zachary T McEachin, Anantharaman Shantaraman, Duc M Duong, Lillian M Daughrity, Karen R Jansen-West, Wei Shao, Anna Calliari, Jesus Gonzalez Bejarano, Michael A DeTure, Bailey Rawlinson, Monica Castanedes Casey, Meredith T Lilley, Megan H Donahue, Vidhya Maheswari Jawahar, Bradley F Boeve, Ronald C Petersen, David S Knopman, Björn E Oskarsson, Neill R Graff-Radford, Zbigniew K Wszolek, Gourisankar Ghosh, Keith Anthony Josephs, Yue A Qi, Nicholas T Seyfried, Michael Emmerson Ward, Yong-Jie Zhang, Mercedes Prudencio, Leonard Petrucelli, Casey N Cook
TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science translational medicine 16 (730) (2024)
Mallory Ryan, Justin A McDonough, Michael Emmerson Ward, Mark R Cookson, William C Skarnes, Florian T Merkle
Large structural variants in KOLF2.1J are unlikely to compromise neurological disease modelling. bioRxiv : the preprint server for biology (2024)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen C Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah R Pickles, Sarah E Kargbo-Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jennifer M Colón-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey N Cook, Ziyi Li, Laurel A Screven, Justin Y Kwan, Puja R Mehta, Matteo Zanovello, Martina Hallegger, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Björn E Oskarsson, Nathan P Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jernej Ule, Steven Jacobson, Daniel S Reich, Jonathan Daniel Rohrer, Andrea Malaspina, Gourisankar Ghosh, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine 16 (734) (2024)
Raffaella De Pace, Saikat Ghosh, Veronica H Ryan, Mira Sohn, Michal Jarnik, Paniz Rezvan Sangsari, Nicole Y Morgan, Ryan K Dale, Michael Emmerson Ward, Juan S Bonifacino
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration. Nature neuroscience 27 (6) (2024)
Megan M Dykstra, Kaitlin Weskamp, Nicolás B Gómez, Jacob Waksmacki, Elizabeth Tank, M Rebecca Glineburg, Allison Snyder, Emile Pinarbasi, Michael Bekier, Xingli Li, Jen Bai, Shameena Shahzad, Juno Nedumaran, Clare Wieland, Corey Stewart, Sydney Willey, Nikolas Grotewold, Jonathon McBride, John J Moran, Aditya V Suryakumar, Michael Lucas, Peter Tessier, Michael Emmerson Ward, Peter K Todd, Sami J Barmada
TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms. bioRxiv : the preprint server for biology (2024)
Christopher Grunseich, Veronica H Ryan, James Hawrot, Sydney Lawton, Daniel M Ramos, Y Andy Qi, Kory R Johnson, Xylena Reed, Nicholas L Johnson, Aaron W Kollasch, Megan F Duffy, Lawren VandeVrede, J Nicholas Cochran, Bruce L Miller, Camilo Toro, Bibiana Bielekova, Debora S Marks, Jennifer S Yokoyama, Justin Y Kwan, Mark R Cookson, Michael Emmerson Ward
An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Li Xuan Tan, Frederike Cosima Oertel, An Cheng, Yann Cobigo, Azeen Keihani, Daniel J Bennett, Ahmed Abdelhak, Shivany Condor Montes, Makenna Chapman, Robert Y Chen, Christian Cordano, Michael Emmerson Ward, Kaitlin Casaletto, Joel H Kramer, Howard J Rosen, Adam Boxer, Bruce L Miller, Ari J Green, Fanny M Elahi, Aparna Lakkaraju
Targeting complement C3a receptor resolves mitochondrial hyperfusion and subretinal microglial activation in progranulin-deficient frontotemporal dementia. bioRxiv : the preprint server for biology (2024)
Christopher Grunseich, Veronica H Ryan, James Hawrot, Sydney Lawton, Daniel M Ramos, Y Andy Qi, Kory R Johnson, Xylena Reed, Nicholas L Johnson, Aaron W Kollasch, Megan F Duffy, Lawren VandeVrede, J Nicholas Cochran, Bruce L Miller, Camilo Toro, Bibiana Bielekova, Debora S Marks, Jennifer S Yokoyama, Justin Y Kwan, Mark R Cookson, Michael Emmerson Ward
An ANXA11 P93S variant dysregulates TDP-43 and causes corticobasal syndrome. Alzheimer's & dementia : the journal of the Alzheimer's Association 20 (8) (2024)
Sam Bryce-Smith, Anna-Leigh Brown, Puja R Mehta, Francesca Mattedi, Alla Mikheenko, Simone Barattucci, Matteo Zanovello, Dario Dattilo, Matthew Yome, Sarah E Kargbo-Hill, Yue A Qi, Oscar G Wilkins, Kai Sun, Eugeni M Ryadnov, Yixuan Wan, null null, Jose Norberto S Vargas, Nicol Birsa, Towfique Raj, Jack Humphrey, Matthew J Keuss, Michael Emmerson Ward, Maria Secrier, Pietro Fratta
TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTD. bioRxiv : the preprint server for biology (2024)
Jenny Serra-Vinardell, Maxwell B Sandler, Raffaella De Pace, Javier Manzella-Lapeira, Antony C Cougnoux, Keyvan Keyvanfar, Wendy J Introne, Joseph A Brzostowski, Michael Emmerson Ward, William A Gahl, Prashant Sharma, May Christine C Malicdan
LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size. Cellular and molecular life sciences : CMLS 80 (2) (2023)
Jenny Serra-Vinardell, Maxwell B Sandler, Raffaella De Pace, Javier Manzella-Lapeira, Antony C Cougnoux, Keyvan Keyvanfar, Wendy J Introne, Joseph A Brzostowski, Michael Emmerson Ward, William A Gahl, Prashant Sharma, May Christine V Malicdan
Correction: LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size. Cellular and molecular life sciences : CMLS 80 (3) (2023)
Jenny Serra-Vinardell, Maxwell B Sandler, Raffaella De Pace, Javier Manzella-Lapeira, Antony C Cougnoux, Keyvan Keyvanfar, Wendy J Introne, Joseph A Brzostowski, Michael Emmerson Ward, William A Gahl, Prashant Sharma, May Christine C Malicdan
LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size. Cellular and molecular life sciences : CMLS 80 (2) (2023)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen Bereda, Cedric Belair, Yongjie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah Pickles, Sarah E Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jenn Colon-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey Cook, Ziyi Li, Laurel Screven, Justin Y Kwan, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Bj Rn Oskarsson, Nathan Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jerneg Ule, Steven Jacobson, Jonathan Rohrer, Andrea Malaspina, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. bioRxiv : the preprint server for biology (2023)
Jenny Serra-Vinardell, Maxwell B Sandler, Raffaella De Pace, Javier Manzella-Lapeira, Antony C Cougnoux, Keyvan Keyvanfar, Wendy J Introne, Joseph A Brzostowski, Michael Emmerson Ward, William A Gahl, Prashant Sharma, May Christine C Malicdan
LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size. Cellular and molecular life sciences : CMLS 80 (2) (2023)
Jonathon Nixon-Abell, Francesco Simone Ruggeri, Seema Qamar, Therese W Herling, Magdalena A Czekalska, Yi Shen, Guozhen Wang, Christopher King, Michael S Fernandopulle, Tomas Šneideris, Joseph L Watson, Visakh V S Pillai, William Meadows, James W Henderson, Joseph E Chambers, Jane L Wagstaff, Sioned H Williams, Helena Coyle, Yuqian Lu, Shuyuan Zhang, Stefan John Marciniak, Stefan M V Freund, Emmanuel Derivery, Michael Emmerson Ward, Christopher M Dobson, Tuomas P J Knowles, Peter St George-Hyslop
ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes. bioRxiv : the preprint server for biology (2023)
Jenny Serra-Vinardell, Maxwell B Sandler, Raffaella De Pace, Javier Manzella-Lapeira, Antony C Cougnoux, Keyvan Keyvanfar, Wendy J Introne, Joseph A Brzostowski, Michael Emmerson Ward, William A Gahl, Prashant Sharma, May Christine V Malicdan
LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size. Cellular and molecular life sciences : CMLS 80 (2) (2023)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen Bereda, Cedric Belair, Yongjie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah Pickles, Sarah E Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jenn Colon-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey Cook, Ziyi Li, Laurel Screven, Justin Y Kwan, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Bj Rn Oskarsson, Nathan Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jerneg Ule, Steven Jacobson, Jonathan Rohrer, Andrea Malaspina, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. bioRxiv : the preprint server for biology (2023)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen Bereda, Cedric Belair, Yongjie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah Pickles, Sarah E Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jenn Colon-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey Cook, Ziyi Li, Laurel Screven, Justin Y Kwan, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Bj Rn Oskarsson, Nathan Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jerneg Ule, Steven Jacobson, Jonathan Rohrer, Andrea Malaspina, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. bioRxiv : the preprint server for biology (2023)
Jenny Serra-Vinardell, Maxwell B Sandler, Raffaella De Pace, Javier Manzella-Lapeira, Antony C Cougnoux, Keyvan Keyvanfar, Wendy J Introne, Joseph A Brzostowski, Michael Emmerson Ward, William A Gahl, Prashant Sharma, May Christine V Malicdan
Correction: LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size. Cellular and molecular life sciences : CMLS 80 (3) (2023)
Jenny Serra-Vinardell, Maxwell B Sandler, Raffaella De Pace, Javier Manzella-Lapeira, Antony C Cougnoux, Keyvan Keyvanfar, Wendy J Introne, Joseph A Brzostowski, Michael Emmerson Ward, William A Gahl, Prashant Sharma, May Christine C Malicdan
LYST deficiency impairs autophagic lysosome reformation in neurons and alters lysosome number and size. Cellular and molecular life sciences : CMLS 80 (2) (2023)
Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen Bereda, Cedric Belair, Yongjie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, Sarah Pickles, Sarah E Hill, James Hawrot, Daniel M Ramos, Hebao Yuan, Jessica Roberts, Erika Kelmer Sacramento, Syed I Shah, Mike A Nalls, Jenn Colon-Mercado, Joel F Reyes, Veronica H Ryan, Matthew P Nelson, Casey Cook, Ziyi Li, Laurel Screven, Justin Y Kwan, Anantharaman Shantaraman, Lingyan Ping, Yuka Koike, Bj Rn Oskarsson, Nathan Staff, Duc M Duong, Aisha Ahmed, Maria Secrier, Jerneg Ule, Steven Jacobson, Jonathan Rohrer, Andrea Malaspina, Jonathan D Glass, Alessandro Ori, Nicholas T Seyfried, Manolis Maragkakis, Leonard Petrucelli, Pietro Fratta, Michael Emmerson Ward
Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. bioRxiv : the preprint server for biology (2023)
Dongpeng Wang, Wei Wu, Elsa Callen, Raphael S Pavani, Nicholas Zolnerowich, Srikanth Kodali, Dali Zong, Nancy Wong, Santiago Noriega, William J Nathan, Gabriel E Matos-Rodrigues, Raj Chari, Michael J Kruhlak, Ferenc Livak, Michael Emmerson Ward, Keith W Caldecott, Bruno Di Stefano, Andrè Nussenzweig
Active DNA demethylation promotes cell fate specification and the DNA damage response. Science (New York, N.Y.) 378 (6623) (2022)
Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael Emmerson Ward, Luke A Gilbert, Martin Edward Kampmann, Jonathan S Weissman, Marco Jost
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. eLife 11 (2022)
Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael Emmerson Ward, Luke A Gilbert, Martin Edward Kampmann, Jonathan S Weissman, Marco Jost
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. eLife 11 (2022)
Caroline Cvetkovic, Rajan Patel, Arya Shetty, Matthew K Hogan, Morgan Anderson, Nupur Basu, Samira Aghlara-Fotovat, Srivathsan Ramesh, Debosmita Sardar, Omid Veiseh, Michael Emmerson Ward, Benjamin Deneen, Philip J Horner, Robert Krencik
Assessing Gq-GPCR-induced human astrocyte reactivity using bioengineered neural organoids. The Journal of cell biology 221 (4) (2022)
Keith W Caldecott, Michael Emmerson Ward, Andrè Nussenzweig
The threat of programmed DNA damage to neuronal genome integrity and plasticity. Nature genetics 54 (2) (2022)
Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael Emmerson Ward, Luke A Gilbert, Martin Edward Kampmann, Jonathan S Weissman, Marco Jost
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. eLife 11 (2022)
Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael Emmerson Ward, Luke A Gilbert, Martin Edward Kampmann, Jonathan S Weissman, Marco Jost
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. eLife 11 (2022)
Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael Emmerson Ward, Luke A Gilbert, Martin Edward Kampmann, Jonathan S Weissman, Marco Jost
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. eLife 11 (2022)
Nina M Dräger, Sydney M Sattler, Cindy Tzu-Ling Huang, Olivia M Teter, Kun Leng, Sayed Hadi Hashemi, Jason Hong, Giovanni Aviles, Claire Dudley Clelland, Lihong Zhan, Joe C Udeochu, Lay Kodama, Andrew B Singleton, Mike A Nalls, Justin Ichida, Michael Emmerson Ward, Faraz Faghri, Li Gan, Martin Edward Kampmann
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nature neuroscience 25 (9) (2022)
Joseph M Replogle, Jessica L Bonnar, Angela N Pogson, Christina R Liem, Nolan K Maier, Yufang Ding, Baylee J Russell, Xingren Wang, Kun Leng, Alina Guna, Thomas M Norman, Ryan A Pak, Daniel M Ramos, Michael Emmerson Ward, Luke A Gilbert, Martin Edward Kampmann, Jonathan S Weissman, Marco Jost
Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. eLife 11 (2022)
Wei Wu, Sarah E Kargbo-Hill, William J Nathan, Jacob Paiano, Elsa Callen, Dongpeng Wang, Kenta Shinoda, Niek van Wietmarschen, Jennifer M Colón-Mercado, Dali Zong, Raffaella De Pace, Han-Yu Shih, Steven L Coon, Maia Parsadanian, Raphael Pavani, Hana Hanzlikova, Solji Park, Seol Kyoung Jung, Peter J McHugh, Andres Canela, Chongyi Chen, Rafael Casellas, Keith W Caldecott, Michael Emmerson Ward, Andrè Nussenzweig
Neuronal enhancers are hotspots for DNA single-strand break repair. Nature 593 (7859) (2021)
Michael S Fernandopulle, Jennifer Lippincott-Schwartz, Michael Emmerson Ward
RNA transport and local translation in neurodevelopmental and neurodegenerative disease. Nature neuroscience 24 (5) (2021)
Yong-Jie Zhang, Lin Guo, Patrick K Gonzales, Tania F Gendron, Yanwei Wu, Karen Jansen-West, Aliesha D O'Raw, Sarah R Pickles, Mercedes Prudencio, Yari Carlomagno, Mariam A Gachechiladze, Connor Ludwig, Ruilin Tian, Jeannie Chew, Michael A DeTure, Wen-Lang Lin, Jimei Tong, Lillian M Daughrity, Mei Yue, Yuping Song, Jonathan W Andersen, Monica Castanedes Casey, Aishe Kurti, Abhishek Datta, Giovanna Antognetti, Alexander McCampbell, Rosa Rademakers, Björn E Oskarsson, Gourisankar Ghosh, Martin Edward Kampmann, Michael Emmerson Ward, John D Fryer, Christopher D Link, James Shorter, Leonard Petrucelli
Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Science (New York, N.Y.) 363 (6428) (2019)
Michael Emmerson Ward, Robert Chen, Hsin-Yi Huang, Connor Ludwig, Maria A Telpoukhovskaia, Ali Taubes, Helene Boudin, Sakura S Minami, Meredith Reichert, Philipp Albrecht, Jeffrey Marc Gelfand, Andres Cruz-Herranz, Christian Cordano, Marcel V Alavi, Shannon Leslie, William W Seeley, Bruce L Miller, Eileen Bigio, Marek-Marsel Mesulam, Matthew M Bogyo, Ian R A Mackenzie, John F Staropoli, Susan L Cotman, Eric J Huang, Li Gan, Ari J Green
Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis. Science translational medicine 9 (385) (2017)