Jürgen Brem

Scopus Author ID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 27

Top Topics

Escherichia Coli

Multidrug Resistant

Structural Basis

Top Venues

Antimicrobial agents and chemotherapy

ACS infectious diseases

Chemical science

Chemistry (Weinheim an der Bergstrasse, Germany)

This page only lists publications with an associated author ORCID identifier.

Publications

Mariska de Munnik, Pauline A Lang, Karina Calvopiña, Patrick Rabe, Jürgen Brem, Christopher J Schofield
Biochemical and crystallographic studies of L,D-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate. Communications biology 7 (1) (2024)
Marcin Bielinski, Lucy R Henderson, Yuliana Yosaatmadja, Lonnie P Swift, Hannah T Baddock, Matthew J Bowen, Jürgen Brem, Philip S Jones, Stuart P McElroy, Angus Morrison, Michael Speake, Stan van Boeckel, Els van Doornmalen, Jan van Groningen, Helma van den Hurk, Opher Gileadi, Joseph A Newman, Peter J McHugh, Christopher J Schofield
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chemical science 15 (21) (2024)
Marcin Bielinski, Lucy R Henderson, Yuliana Yosaatmadja, Lonnie P Swift, Hannah T Baddock, Matthew J Bowen, Jürgen Brem, Philip S Jones, Stuart P McElroy, Angus Morrison, Michael Speake, Stan van Boeckel, Els van Doornmalen, Jan van Groningen, Helma van den Hurk, Opher Gileadi, Joseph A Newman, Peter J McHugh, Christopher J Schofield
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chemical science 15 (21) (2024)
Mariska de Munnik, Pauline A Lang, Francisco De Dios Anton, Mónica Cacho, Robert H Bates, Jürgen Brem, Beatriz Rodríguez Miquel, Christopher J Schofield
High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors. Chemical science 14 (26) (2023)
Cheng Chen, Yinsui Xu, Peter Oelschlaeger, Jürgen Brem, Lu Liu, Dongmei Wang, Hongzhe Sun, Ke-Wu Yang
A dual covalent binder for labelling and inhibiting serine and metallo-carbapenemases. Chemical communications (Cambridge, England) (2023)
Anka Lucic, Tika R Malla, Karina Calvopiña, Catherine L Tooke, Jürgen Brem, Michael A McDonough, James Spencer, Christopher J Schofield
Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2. Antibiotics (Basel, Switzerland) 11 (3) (2022)
Alistair J M Farley, Yuri Ermolovich, Karina Calvopiña, Patrick Rabe, Tharindi Panduwawala, Jürgen Brem, Fredrik Björkling, Christopher J Schofield
Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates. ACS infectious diseases 7 (6) (2021)
You-Cai Xiao, Xiao-Pan Chen, Ji Deng, Yu-Hang Yan, Kai-Rong Zhu, Gen Li, Jun-Lin Yu, Jürgen Brem, Fener Chen, Christopher J Schofield, Guo-Bo Li
Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance. Chemical communications (Cambridge, England) 57 (62) (2021)
Pauline A Lang, Thomas M Leissing, Malcolm G P Page, Christopher J Schofield, Jürgen Brem
Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes. Antimicrobial agents and chemotherapy 65 (2) (2021)
Jürgen Brem, Tharindi D Panduwawala, Jon Ulf Hansen, Joanne Hewitt, Edgars Liepins, Pawel Donets, Laura Espina, Alistair J M Farley, Kirill Shubin, Gonzalo Gomez Campillos, Paula S Kiuru, Shifali Shishodia, Daniel Krahn, Robert K Leśniak, Juliane Schmidt Adrian, Karina Calvopiña, María-Carmen Turrientes, Madeline E Kavanagh, Dmitrijs Lubriks, Philip Hinchliffe, Gareth W Langley, Ali F Aboklaish, Anders Eneroth, Maria Backlund, Andrei G Baran, Elisabet I Nielsen, Michael Speake, Janis Kuka, John Robinson, Solveiga Grinberga, Lindsay Robinson, Michael A McDonough, Anna M Rydzik, Thomas M Leissing, Juan Carlos Jimenez-Castellanos, Matthew B Avison, Solange Da Silva Pinto, Andrew D Pannifer, Marina Martjuga, Emma Widlake, Martins Priede, Iva Hopkins Navratilova, Marek Gniadkowski, Anna Karin Belfrage, Peter Brandt, Jari T Yli-Kauhaluoma, Eric Bacque, Malcolm G P Page, Fredrik Björkling, Jonathan M Tyrrell, James Spencer, Pauline A Lang, Pawel Baranczewski, Rafael Cantón, Stuart P McElroy, Philip S Jones, Fernando Baquero, Edgars Suna, Angus Morrison, Timothy R Walsh, Christopher J Schofield
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors. Nature chemistry 14 (1) (2021)
Patrick Rabe, Jos J A G Kamps, Kyle D Sutherlin, James D S Linyard, Pierre Aller, Cindy C Pham, Hiroki Makita, Ian J Clifton, Michael A McDonough, Thomas M Leissing, Denis Shutin, Pauline A Lang, Agata Butryn, Jürgen Brem, Sheraz Gul, Franklin D Fuller, In-Sik Kim, Mun Hon Cheah, Thomas Fransson, Asmit Bhowmick, Iris D Young, Lee J O'Riordan, Aaron S Brewster, Ilaria Pettinati, Margaret Doyle, Yasumasa Joti, Shigeki Owada, Kensure Tono, Alexander Batyuk, Mark S Hunter, Roberto Alonso Mori, Uwe Bergmann, Robin L Owen, Nicholas K Sauter, Timothy D W Claridge, Carol V Robinson, Vittal K Yachandra, Junko Yano, Jan F Kern, Allen M Orville, Christopher J Schofield
X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis. Science advances 7 (34) (2021)
Hector Newman, Alen Krajnc, Dom Bellini, Charles J Eyermann, Grant A Boyle, Neil G Paterson, Katherine E McAuley, Robert Lesniak, Mukesh Gangar, Frank von Delft, Jürgen Brem, Kelly Chibale, Christopher J Schofield, Christopher G Dowson
High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes. Journal of medicinal chemistry 64 (15) (2021)
Alistair J M Farley, Yuri Ermolovich, Karina Calvopiña, Patrick Rabe, Tharindi Panduwawala, Jürgen Brem, Fredrik Björkling, Christopher J Schofield
Correction to "Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates". ACS infectious diseases 7 (11) (2021)
Agata Butryn, Philipp S Simon, Pierre Aller, Philip Hinchliffe, Ramzi N Massad, Gabriel Leen, Catherine L Tooke, Isabel Bogacz, In-Sik Kim, Asmit Bhowmick, Aaron S Brewster, Nicholas E Devenish, Jürgen Brem, Jos J A G Kamps, Pauline A Lang, Patrick Rabe, Danny N Axford, John H Beale, Bradley Davy, Ali Ebrahim, Julien Orlans, Selina L S Storm, Tiankun Zhou, Shigeki Owada, Rie Tanaka, Kensuke Tono, Gwyndaf Evans, Robin L Owen, Frances A Houle, Nicholas K Sauter, Christopher J Schofield, James Spencer, Vittal K Yachandra, Junko Yano, Jan F Kern, Allen M Orville
An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography. Nature communications 12 (1) (2021)
Anna M Rydzik, Jürgen Brem, Shane A Chandler, Justin L P Benesch, Timothy D W Claridge, Christopher J Schofield
Monitoring protein-metal binding by 19F NMR - a case study with the New Delhi metallo-β-lactamase 1. RSC medicinal chemistry 11 (3) (2020)
Anete Parkova, Anka Lucic, Alen Krajnc, Jürgen Brem, Karina Calvopiña, Gareth W Langley, Michael A McDonough, Peteris Trapencieris, Christopher J Schofield
Broad Spectrum β-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate. ACS infectious diseases 6 (6) (2020)
Pauline A Lang, Anete Parkova, Thomas M Leissing, Karina Calvopiña, Ricky Cain, Alen Krajnc, Tharindi D Panduwawala, Jules Philippe, Colin W G Fishwick, Peteris Trapencieris, Malcolm G P Page, Christopher J Schofield, Jürgen Brem
Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli. Biomolecules 10 (6) (2020)
Catherine L Tooke, Philip Hinchliffe, Alen Krajnc, Adrian J Mulholland, Jürgen Brem, Christopher J Schofield, James Spencer
Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition. RSC medicinal chemistry 11 (4) (2020)
Christopher T Lohans, Emily I Freeman, Emma van Groesen, Catherine L Tooke, Philip Hinchliffe, James Spencer, Jürgen Brem, Christopher J Schofield
Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation. Scientific reports 9 (1) (2019)
Alen Krajnc, Jürgen Brem, Philip Hinchliffe, Karina Calvopiña, Tharindi D Panduwawala, Pauline A Lang, Jos J A G Kamps, Jonathan M Tyrrell, Emma Widlake, Benjamin G Saward, Timothy R Walsh, James Spencer, Christopher J Schofield
Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. Journal of medicinal chemistry 62 (18) (2019)
Mariska de Munnik, Christopher T Lohans, Gareth W Langley, Corentin Bon, Jürgen Brem, Christopher J Schofield
A Fluorescence-Based Assay for Screening β-Lactams Targeting the Mycobacterium tuberculosis Transpeptidase LdtMt2. Chembiochem : a European journal of chemical biology 21 (3) (2019)
Catherine L Tooke, Philip Hinchliffe, Pauline A Lang, Adrian J Mulholland, Jürgen Brem, Christopher J Schofield, James Spencer
Molecular Basis of Class A β-Lactamase Inhibition by Relebactam. Antimicrobial agents and chemotherapy 63 (10) (2019)
Christopher T Lohans, H T Henry Chan, Tika R Malla, Kiran Kumar, Jos J A G Kamps, Darius J B McArdle, Emma van Groesen, Mariska de Munnik, Catherine L Tooke, James Spencer, Robert S Paton, Jürgen Brem, Christopher J Schofield
Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants. Angewandte Chemie (International ed. in English) 58 (7) (2019)
Emma van Groesen, Christopher T Lohans, Jürgen Brem, Kristina M J Aertker, Timothy D W Claridge, Christopher J Schofield
19 F NMR Monitoring of Reversible Protein Post-Translational Modifications: Class D β-Lactamase Carbamylation and Inhibition. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (51) (2019)
Christopher T Lohans, Emma van Groesen, Kiran Kumar, Catherine L Tooke, James Spencer, Robert S Paton, Jürgen Brem, Christopher J Schofield
A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation. Angewandte Chemie (International ed. in English) 57 (5) (2018)
Martine I Abboud, Magda Kosmopoulou, Anthony P Krismanich, Jarrod W Johnson, Philip Hinchliffe, Jürgen Brem, Timothy D W Claridge, James Spencer, Christopher J Schofield, Gary I Dmitrienko
Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (22) (2018)
Christopher T Lohans, Jürgen Brem, Christopher J Schofield
New Delhi Metallo-β-Lactamase 1 Catalyzes Avibactam and Aztreonam Hydrolysis. Antimicrobial agents and chemotherapy 61 (12) (2017)