Steffen Boettcher

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 28

Top Topics

Acute Myeloid Leukemia

Allogeneic Hematopoietic Stem Cell Transplantation

Top Venues

Blood cancer journal

EMBO molecular medicine

This page only lists publications with an associated author ORCID identifier.

Publications

Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre Pa Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus Gabriel Manz, Steffen Boettcher
Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells. EMBO molecular medicine (2024)
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre Pa Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus Gabriel Manz, Steffen Boettcher
Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells. EMBO molecular medicine 16 (3) (2024)
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre Pa Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus Gabriel Manz, Steffen Boettcher
Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells. EMBO molecular medicine 16 (3) (2024)
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre Pa Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus Gabriel Manz, Steffen Boettcher
Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells. EMBO molecular medicine (2024)
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre Pa Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus Gabriel Manz, Steffen Boettcher
Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells. EMBO molecular medicine 16 (3) (2024)
Jan Mueller, Roman R Schimmer, Christian Koch, Florin Schneiter, Jonas Fullin, Veronika Lysenko, Christian Pellegrino, Nancy Klemm, Norman Russkamp, Renier Myburgh, Laura Volta, Alexandre Pa Theocharides, Kari J Kurppa, Benjamin L Ebert, Timm Schroeder, Markus Gabriel Manz, Steffen Boettcher
Targeting the mevalonate or Wnt pathways to overcome CAR T-cell resistance in TP53-mutant AML cells. EMBO molecular medicine 16 (3) (2024)
Peter Grant Miller, Adam S Sperling, Christina Mayerhofer, Marie McConkey, Jana Maria Ellegast, Carmen Da Silva, Drew Nathaniel Cohen, Chuqi Wang, Azeem Sharda, Ni Yan, Subha Saha, Cameron Schluter, Ilexa Ashley Schechter, Mikołaj Słabicki, Brittany Sandoval, Josephine Kahn, Steffen Boettcher, Christopher J Gibson, David T Scadden, Kimberly Stegmaier, Shruti Bhatt, R Coleman Lindsley, Benjamin L Ebert
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy. Blood (2023)
C Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D Park, George R Heaton, Pauline Hamon, Leanna Troncoso, Brooks P Scull, Diana Dangoor, Aymeric Silvin, Ryan Fleischmann, Meriem Belabed, Howard Lin, Elias Merad Taouli, Steffen Boettcher, Markus Gabriel Manz, Julia K Kofler, Zhenyu Yue, Sergio A Lira, Florent Ginhoux, John F Crary, Kenneth L McClain, Jennifer L Picarsic, Scott J Russo, Carl E Allen, Miriam Merad
Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration. bioRxiv : the preprint server for biology (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Warren C Fiskus, Christopher P Mill, Christine Birdwell, John A Davis, Kaberi Das, Steffen Boettcher, Tapan Mahendra Kadia, Courtney D D DiNardo, Koichi Takahashi, Sanam Loghavi, Michael J Soth, Tim Heffernan, Gerard M McGeehan, Xinjia Ruan, Xiaoping Su, Christopher R Vakoc, Naval G Daver, Kapil N Bhalla
Targeting of epigenetic co-dependencies enhances anti-AML efficacy of Menin inhibitor in AML with MLL1-r or mutant NPM1. Blood cancer journal 13 (1) (2023)
Bing Z Carter, Po Yee Mak, Muharrem Muftuoglu, Wenjing Tao, Ke Baozhen, Jingqi Pei, Andrea D Bedoy, Lauren B Ostermann, Yuki Nishida, Sevinj Isqandarova, Mary Sobieski, Nghi Nguyen, Reid T Powell, Margarita Martinez-Moczyemba, Clifford Stephen, Mahesh Basyal, Naveen Pemmaraju, Steffen Boettcher, Benjamin L Ebert, Elizabeth J Shpall, Barbara P Wallner, Robert Morgan, Georgios Ioannis Karras, Ute Moll, Michael Andreeff
Epichaperome inhibition targets TP53-mutant AML and AML stem/progenitor cells. Blood (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Yuki Nishida, Jo Ishizawa, Edward Ayoub, Rafael Heinz Montoya, Lauren B Ostermann, Muharrem Muftuoglu, Vivian R Ruvolo, Tallie Patsilevas, Darah A Scruggs, Shayaun Khazaei, Po Yee Mak, Wenjing Tao, Bing Z Carter, Steffen Boettcher, Benjamin L Ebert, Naval G Daver, Marina Konopleva, Takahiko Seki, Kensuke Kojima, Michael Andreeff
Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias. Science advances 9 (48) (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Correction: Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Bing Z Carter, Po Yee Mak, Wenjing Tao, Edward Ayoub, Lauren B Ostermann, Xuelin Huang, Sanam Loghavi, Steffen Boettcher, Yuki Nishida, Vivian Ruvolo, Paul E Hughes, Phuong K Morrow, Torsten Haferlach, Steven Mitchell Kornblau, Muharrem Muftuoglu, Michael Andreeff
Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics. Blood cancer journal 13 (1) (2023)
Francisco Caiado, Larisa V Kovtonyuk, Nagihan G Gonullu, Jonas Fullin, Steffen Boettcher, Markus Gabriel Manz
Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling. Blood (2022)
Warren C Fiskus, Steffen Boettcher, Naval G Daver, Christopher P Mill, Koiji Sasaki, Christine E Birdwell, John A Davis, Koichi Takahashi, Tapan Mahendra Kadia, Courtney D DiNardo, Qi Jin, Yuan Qi, Xiaoping Su, Gerard M McGeehan, Joseph D Khoury, Benjamin L Ebert, Kapil N Bhalla
Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c). Blood cancer journal 12 (1) (2022)
Rahel C Gerosa, Steffen Boettcher, Larisa V Kovtonyuk, Annika Hausmann, Wolf-Dietrich Hardt, Juan Hidalgo, César Nombela-Arrieta, Markus G Manz
CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis. Blood advances 5 (23) (2022)
Roman R Schimmer, Larisa V Kovtonyuk, Nancy Klemm, Jonas Fullin, Sebastian M Stolz, Jan Mueller, Francisco Caiado, Kari J Kurppa, Benjamin L Ebert, Markus G Manz, Steffen Boettcher
TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms. Blood advances 6 (11) (2022)
Warren C Fiskus, Naval G Daver, Steffen Boettcher, Christopher P Mill, Koiji Sasaki, Christine E Birdwell, John A Davis, Kaberi Das, Koichi Takahashi, Tapan Mahendra Kadia, Courtney D D DiNardo, Francis Burrows, Sanam Loghavi, Joseph D Khoury, Benjamin L Ebert, Kapil N Bhalla
Activity of menin inhibitor ziftomenib (KO-539) as monotherapy or in combinations against AML cells with MLL1 rearrangement or mutant NPM1. Leukemia 36 (11) (2022)
Larisa Vladimirovna Kovtonyuk, Francisco Caiado, Santiago Garcia-Martin, Eva-Maria Manz, Patrick Michael Helbling, Hitoshi Takizawa, Steffen Boettcher, Fátima Al-Shahrour, Cesar Nombela-Arrieta, Emma M C Slack, Markus G Manz
IL-1 Mediates Microbiome-Induced Inflamm-Ageing of Hematopoietic Stem Cells in Mice. Blood (2021)
Steffen Boettcher, Peter Grant Miller, Rohan Sharma, Marie McConkey, Matthew Joseph Leventhal, Andrei V Krivtsov, Andrew O Giacomelli, Waihay J Wong, Jesi Kim, Sherry Chao, Kari J Kurppa, Xiaoping Yang, Kirsten Milenkowic, Frederica Piccioni, David E Root, Frank G Rücker, Yael Flamand, Donna S Neuberg, R Coleman Lindsley, Pasi A Jänne, William C Hahn, Tyler Jacks, Hartmut Döhner, Scott A Armstrong, Benjamin L Ebert
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies. Science (New York, N.Y.) 365 (6453) (2020)