Wulf Blankenfeldt (W Blankenfeldt)

ResearcherID Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 43

Top Topics

Pseudomonas Aeruginosa

Crystal Structure

Cystic Fibrosis

Top Venues

Scientific reports

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Nature communications

Molecular microbiology

This page only lists publications with an associated author ORCID identifier.

Publications

Maria Braun-Cornejo, Camilla Ornago, Vidhisha Sonawane, Jörg Haupenthal, Andreas Martin Kany, Eleonora Diamanti, Gwenaëlle Jézéquel, Norbert Reiling, Wulf Blankenfeldt, Peter Maas, Anna Katharina Herta Hirsch
Target-Directed Dynamic Combinatorial Chemistry Affords Binders of Mycobacterium tuberculosis IspE. ACS omega 9 (36) (2024)
Chengzhang Fu, Yunkun Liu, Christine Walt, Sari Rasheed, Chantal D Bader, Peer Lukat, Markus Neuber, F P Jake Haeckl, Wulf Blankenfeldt, Olga V Kalinina, Daniel Krug
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins. Nature communications 15 (1) (2024)
Chengzhang Fu, Yunkun Liu, Christine Walt, Sari Rasheed, Chantal D Bader, Peer Lukat, Markus Neuber, F P Jake Haeckl, Wulf Blankenfeldt, Olga V Kalinina, Daniel Krug
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins. Nature communications 15 (1) (2024)
Chengzhang Fu, Yunkun Liu, Christine Walt, Sari Rasheed, Chantal D Bader, Peer Lukat, Markus Neuber, F P Jake Haeckl, Wulf Blankenfeldt, Olga V Kalinina, Daniel Krug
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins. Nature communications 15 (1) (2024)
Christian Behlendorf, Maurice Diwo, Meina Neumann-Schaal, Manuela Fuchs, Dominik Körner, Lothar Jänsch, Franziska Faber, Wulf Blankenfeldt
Formation of the pyruvoyl-dependent proline reductase Prd from Clostridioides difficile requires the maturation enzyme PrdH. PNAS nexus 3 (7) (2024)
Christian Behlendorf, Maurice Diwo, Meina Neumann-Schaal, Manuela Fuchs, Dominik Körner, Lothar Jänsch, Franziska Faber, Wulf Blankenfeldt
Formation of the pyruvoyl-dependent proline reductase Prd from Clostridioides difficile requires the maturation enzyme PrdH. PNAS nexus 3 (7) (2024)
Fangfang Chen, Israfil Yalcin, Mingming Zhao, Chutao Chen, Wulf Blankenfeldt, Frank Pessler, Konrad Büssow
Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1. Scientific reports 13 (1) (2023)
Hella Schwanke, Vladimir G Magalhães, Stefan Schmelz, Emanuel Wyler, Thomas Hennig, Thomas Günther, Adam Grundhoff, Lars Dölken, Markus Landthaler, Marco van Ham, Lothar Jänsch, Konrad Büssow, Joop van den Heuvel, Wulf Blankenfeldt, Caroline C Friedel, Florian Erhard, Melanie M Brinkmann
The Cytomegalovirus M35 Protein Directly Binds to the Interferon-β Enhancer and Modulates Transcription of Ifnb1 and Other IRF3-Driven Genes. Journal of virology (2023)
Fangfang Chen, Israfil Yalcin, Mingming Zhao, Chutao Chen, Wulf Blankenfeldt, Frank Pessler, Konrad Büssow
Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1. Scientific reports 13 (1) (2023)
Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas Martin Kany, Teresa Röhrig, Stefan Schmelz, Wulf Blankenfeldt, Alejandro Arce Rodriguez, José Manuel Borrero-de Acuña, Dieter Jahn, Jessica Rademacher, Felix C C Ringshausen, Nina Cramer, Burkhard Tümmler, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Martin Empting
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10 (5) (2023)
Miriam Hiller, Maurice Diwo, Sabrina Wamp, Thomas Gutsmann, Christina Lang, Wulf Blankenfeldt, Antje Flieger
Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA. Molecular microbiology 121 (3) (2023)
Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas Martin Kany, Teresa Röhrig, Stefan Schmelz, Wulf Blankenfeldt, Alejandro Arce Rodriguez, José Manuel Borrero-de Acuña, Dieter Jahn, Jessica Rademacher, Felix C C Ringshausen, Nina Cramer, Burkhard Tümmler, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Martin Empting
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10 (5) (2023)
Miriam Hiller, Maurice Diwo, Sabrina Wamp, Thomas Gutsmann, Christina Lang, Wulf Blankenfeldt, Antje Flieger
Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA. Molecular microbiology 121 (3) (2023)
Miriam Hiller, Maurice Diwo, Sabrina Wamp, Thomas Gutsmann, Christina Lang, Wulf Blankenfeldt, Antje Flieger
Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA. Molecular microbiology 121 (3) (2023)
Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas Martin Kany, Teresa Röhrig, Stefan Schmelz, Wulf Blankenfeldt, Alejandro Arce Rodriguez, José Manuel Borrero-de Acuña, Dieter Jahn, Jessica Rademacher, Felix C C Ringshausen, Nina Cramer, Burkhard Tümmler, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Martin Empting
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas Martin Kany, Teresa Röhrig, Stefan Schmelz, Wulf Blankenfeldt, Alejandro Arce Rodriguez, José Manuel Borrero-de Acuña, Dieter Jahn, Jessica Rademacher, Felix C C Ringshausen, Nina Cramer, Burkhard Tümmler, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Martin Empting
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10 (5) (2023)
Tatiana E Gorelik, Peer Lukat, Christian Kleeberg, Wulf Blankenfeldt, Rolf Mueller
Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution. Acta crystallographica. Section A, Foundations and advances (2023)
Fangfang Chen, Israfil Yalcin, Mingming Zhao, Chutao Chen, Wulf Blankenfeldt, Frank Pessler, Konrad Büssow
Amino acid positions near the active site determine the reduced activity of human ACOD1 compared to murine ACOD1. Scientific reports 13 (1) (2023)
Miriam Hiller, Maurice Diwo, Sabrina Wamp, Thomas Gutsmann, Christina Lang, Wulf Blankenfeldt, Antje Flieger
Structure-function relationships underpin disulfide loop cleavage-dependent activation of Legionella pneumophila lysophospholipase A PlaA. Molecular microbiology (2023)
Sebastian Roman Borgert, Steffi Henke, Florian Witzgall, Stefan Schmelz, Susanne Zur Lage, Sven-Kevin Hotop, Steffi Stephen, Dennis Lübken, Jonas Krüger, Nicolas Oswaldo Gomez, Marco van Ham, Lothar Jänsch, Markus Kalesse, Andreas Pich, Mark Brönstrup, Susanne Häußler, Wulf Blankenfeldt
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa. Nature communications 13 (1) (2022)
Fangfang Chen, Walid A M Elgaher, M Winterhoff, Konrad Büssow, Syed Fakhar-Ul-Hassnain Waqas, E Graner, Y Pires-Afonso, L Casares Perez, Laureano de la Vega, N Sahini, L Czichon, W Zobl, Thomas Zillinger, M Shehata, Stephan Pleschka, H Bähre, C Falk, Alessandro Michelucci, S Schuchardt, Wulf Blankenfeldt, Anna Katharina Herta Hirsch, Frank Pessler
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism. Nature metabolism 4 (5) (2022)
Florian J Gisdon, Christian G Feiler, Oxana Kempf, Johannes M Foerster, Jonathan Haiss, Wulf Blankenfeldt, G Matthias Ullmann, Elisa Bombarda
Structural and Biophysical Analysis of the Phytochelatin-Synthase-Like Enzyme from Nostoc sp. Shows That Its Protease Activity is Sensitive to the Redox State of the Substrate. ACS chemical biology 17 (4) (2022)
Christian Schütz, Duy-Khiet Ho, Mostafa Mohamed Hamed, Ahmed Saad Abdelsamie, Teresa Röhrig, Christian Herr, Andreas Martin Kany, Katharina Rox, Stefan Schmelz, Lorenz Siebenbürger, Marius Wirth, Carsten Börger, Samir Yahiaoui, Robert Bals, Andrea Scrima, Wulf Blankenfeldt, Justus Constantin Horstmann, Rebekka Christmann, Xabier Murgia, Marcus Koch, Aylin Berwanger, Brigitta Loretz, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Claus-Michael Lehr, Martin Empting
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (12) (2021)
Carsten Schotte, Peer Lukat, Adrian Deuschmann, Wulf Blankenfeldt, Russell J Cox
Understanding and Engineering the Stereoselectivity of Humulene Synthase. Angewandte Chemie (International ed. in English) 60 (37) (2021)
Maurice Diwo, Wiebke Michel, Philipp Aurass, Katja Kuhle-Keindorf, Jan Pippel, Joern Krausze, Sabrina Wamp, Christina Lang, Wulf Blankenfeldt, Antje Flieger
NAD(H)-mediated tetramerization controls the activity of Legionella pneumophila phospholipase PlaB. Proceedings of the National Academy of Sciences of the United States of America 118 (23) (2021)
Paweena Chaoprasid, Peer Lukat, Sabrina Mühlen, Thomas V Heidler, Emerich-Mihai Gazdag, Shuangshuang Dong, Wenjie Bi, Christian Rüter, Marco Kirchenwitz, Annika Steffen, Lothar Jänsch, Theresia E B Stradal, Petra Dersch, Wulf Blankenfeldt
Crystal structure of bacterial cytotoxic necrotizing factor CNFY reveals molecular building blocks for intoxication. The EMBO journal 40 (4) (2021)
Simone Höfler, Peer Lukat, Wulf Blankenfeldt, Teresa Carlomagno
High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain. RNA (New York, N.Y.) 27 (4) (2021)
Christian G Feiler, Manfred S Weiss, Wulf Blankenfeldt
The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure. Acta crystallographica. Section F, Structural biology communications 76 (Pt 12) (2020)
Jhon Alexander Rodriguez Buitrago, Thomas Klünemann, Wulf Blankenfeldt, Anett Schallmey
Expression, purification and crystal structure determination of a ferredoxin reductase from the actinobacterium Thermobifida fusca. Acta crystallographica. Section F, Structural biology communications 76 (Pt 8) (2020)
Thomas Klünemann, Manfred Nimtz, Lothar Jänsch, Gunhild Layer, Wulf Blankenfeldt
Crystal structure of NirF: insights into its role in heme d1 biosynthesis. The FEBS journal 288 (1) (2020)
Thomas Klünemann, Wulf Blankenfeldt
Structure of heme d1-free cd1 nitrite reductase NirS. Acta crystallographica. Section F, Structural biology communications 76 (Pt 6) (2020)
Jennifer Solarczek, Thomas Klünemann, Felix Brandt, Patrick Schrepfer, Mario Wolter, Christoph R Jacob, Wulf Blankenfeldt, Anett Schallmey
Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity. Scientific reports 9 (1) (2019)
Matthias Schaks, Hermann Döring, Frieda Kage, Anika Steffen, Thomas Klünemann, Wulf Blankenfeldt, Theresia E B Stradal, Klemens Rottner
RhoG and Cdc42 can contribute to Rac-dependent lamellipodia formation through WAVE regulatory complex-binding. Small GTPases 12 (2) (2019)
Kwang Hoon Sung, Jörn Josewski, Stefan Dübel, Wulf Blankenfeldt, Udo Rau
Structural insights into antigen recognition of an anti-β-(1,6)-β-(1,3)-D-glucan antibody. Scientific reports 8 (1) (2018)
Laëtitia Misson, Reto Burn, Allegra Vit, Julia Hildesheim, Mariia A Beliaeva, Wulf Blankenfeldt, Florian P Seebeck
Inhibition and Regulation of the Ergothioneine Biosynthetic Methyltransferase EgtD. ACS chemical biology 13 (5) (2018)
Juliane Poppe, Joachim Reichelt, Wulf Blankenfeldt
Pseudomonas aeruginosa pyoverdine maturation enzyme PvdP has a noncanonical domain architecture and affords insight into a new subclass of tyrosinases. The Journal of biological chemistry 293 (38) (2018)
Florian Witzgall, Tobias Depke, Michael Hoffmann, Martin Empting, Mark Brönstrup, Daniel Krug, Wulf Blankenfeldt
The Alkylquinolone Repertoire of Pseudomonas aeruginosa is Linked to Structural Flexibility of the FabH-like 2-Heptyl-3-hydroxy-4(1H)-quinolone (PQS) Biosynthesis Enzyme PqsBC. Chembiochem : a European journal of chemical biology 19 (14) (2018)
Kristina Friedel, Monika A Popp, Julian C J Matern, Emerich M Gazdag, Ilka V Thiel, Gerrit Volkmann, Wulf Blankenfeldt, Henning D Mootz
A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine. Chemical science 10 (1) (2018)
Peer Lukat, Yohei Katsuyama, Silke Wenzel, Tina Maria Binz, Claudia König, Wulf Blankenfeldt, Mark Brönstrup, Daniel Krug
Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity. Chemical science 8 (11) (2017)
Stephen K Dolan, Tobias Bock, Vanessa Hering, Rebecca A Owens, Gary W Jones, Wulf Blankenfeldt, Sean Doyle
Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus. Open biology 7 (2) (2017)
Florian Witzgall, Wiebke Ewert, Wulf Blankenfeldt
Structures of the N-Terminal Domain of PqsA in Complex with Anthraniloyl- and 6-Fluoroanthraniloyl-AMP: Substrate Activation in Pseudomonas Quinolone Signal (PQS) Biosynthesis. Chembiochem : a European journal of chemical biology 18 (20) (2017)
Tobias Bock, Eva Luxenburger, Judith Hoffmann, Vlad Schütza, Christian Feiler, Daniel Krug, Wulf Blankenfeldt
AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus. Angewandte Chemie (International ed. in English) 56 (33) (2017)
Christina Diederich, Mario Leypold, Martin Culka, Hansjörg Weber, Rolf Breinbauer, G Matthias Ullmann, Wulf Blankenfeldt
Mechanisms and Specificity of Phenazine Biosynthesis Protein PhzF. Scientific reports 7 (1) (2017)