Rolf Wolfgang Hartmann (Rolf Hartmann, Rolf W Hartmann)

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 28

Top Topics

Pseudomonas Aeruginosa

Biofilm Formation

Acinetobacter Baumannii

Multidrug Resistant

Top Venues

Journal of medicinal chemistry

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

ACS infectious diseases

ACS chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas Martin Kany, Teresa Röhrig, Stefan Schmelz, Wulf Blankenfeldt, Alejandro Arce Rodriguez, José Manuel Borrero-de Acuña, Dieter Jahn, Jessica Rademacher, Felix C C Ringshausen, Nina Cramer, Burkhard Tümmler, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Martin Empting
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10 (5) (2023)
Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas Martin Kany, Teresa Röhrig, Stefan Schmelz, Wulf Blankenfeldt, Alejandro Arce Rodriguez, José Manuel Borrero-de Acuña, Dieter Jahn, Jessica Rademacher, Felix C C Ringshausen, Nina Cramer, Burkhard Tümmler, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Martin Empting
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10 (5) (2023)
Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas Martin Kany, Teresa Röhrig, Stefan Schmelz, Wulf Blankenfeldt, Alejandro Arce Rodriguez, José Manuel Borrero-de Acuña, Dieter Jahn, Jessica Rademacher, Felix C C Ringshausen, Nina Cramer, Burkhard Tümmler, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Martin Empting
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Jelena Konstantinović, Andreas Martin Kany, Alaa Alhayek, Ahmed S Abdelsamie, Asfandyar Sikandar, Katrin Voos, Yiwen Yao, Anastasia Andreas, Roya Shafiei, Brigitta Loretz, Esther Schönauer, Robert Bals, Hans Brandstetter, Rolf Wolfgang Hartmann, Christian Ducho, Claus-Michael Lehr, Christoph Beisswenger, Rolf Müller, Katharina Rox, Jörg Haupenthal, Anna Katharina Herta Hirsch
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections. ACS central science 9 (12) (2023)
Mostafa M Hamed, Ahmed S Abdelsamie, Katharina Rox, Christian Schütz, Andreas Martin Kany, Teresa Röhrig, Stefan Schmelz, Wulf Blankenfeldt, Alejandro Arce Rodriguez, José Manuel Borrero-de Acuña, Dieter Jahn, Jessica Rademacher, Felix C C Ringshausen, Nina Cramer, Burkhard Tümmler, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Martin Empting
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10 (5) (2023)
Jelena Konstantinović, Andreas Martin Kany, Alaa Alhayek, Ahmed S Abdelsamie, Asfandyar Sikandar, Katrin Voos, Yiwen Yao, Anastasia Andreas, Roya Shafiei, Brigitta Loretz, Esther Schönauer, Robert Bals, Hans Brandstetter, Rolf Wolfgang Hartmann, Christian Ducho, Claus-Michael Lehr, Christoph Beisswenger, Rolf Müller, Katharina Rox, Jörg Haupenthal, Anna Katharina Herta Hirsch
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections. ACS central science 9 (12) (2023)
Cansu Kaya, Isabell Walter, Alaa Alhayek, Roya Shafiei, Gwenaëlle Jézéquel, Anastasia Andreas, Jelena Konstantinović, Esther Schönauer, Asfandyar Sikandar, Jörg Haupenthal, Daniel Krug, Hans Brandstetter, Rolf Wolfgang Hartmann, Anna Katharina Herta Hirsch
Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa . ACS infectious diseases 8 (5) (2022)
Cansu Kaya, Jelena Konstantinović, Andreas M Kany, Anastasia Andreas, Jan S Kramer, Steffen Brunst, Lilia Weizel, Marco J Rotter, Denia Frank, Samir Yahiaoui, Daniel Krug, Rolf Wolfgang Hartmann, Jörg Haupenthal, Ewgenij Proschak, Thomas A Wichelhaus, Anna Katharina Herta Hirsch
N -Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases. Journal of medicinal chemistry 65 (5) (2022)
Emanuele M Gargano, Abdelrahman Mohamed, Ahmed S Abdelsamie, Giuseppe Felice Mangiatordi, Hanna Drzewiecka, Paweł P Jagodziński, Arcangela Mazzini, Chris J van Koppen, Matthias W Laschke, Nicolotti Orazio, Angelo Carotti, Sandrine Marchais-Oberwinkler, Rolf Wolfgang Hartmann, Martin Frotscher
17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer. ACS medicinal chemistry letters 12 (12) (2021)
Katrin Voos, Esther Schönauer, Alaa Alhayek, Jörg Haupenthal, Anastasia Andreas, Daniel Krug, Rolf Wolfgang Hartmann, Katharina Häussermann, Anna Katharina Herta Hirsch, Christian Ducho
Phosphonate as a Stable Zinc-Binding Group for "Pathoblocker" Inhibitors of Clostridial Collagenase H (ColH). ChemMedChem 16 (8) (2021)
Christian Schütz, Duy-Khiet Ho, Mostafa Mohamed Hamed, Ahmed Saad Abdelsamie, Teresa Röhrig, Christian Herr, Andreas Martin Kany, Katharina Rox, Stefan Schmelz, Lorenz Siebenbürger, Marius Wirth, Carsten Börger, Samir Yahiaoui, Robert Bals, Andrea Scrima, Wulf Blankenfeldt, Justus Constantin Horstmann, Rebekka Christmann, Xabier Murgia, Marcus Koch, Aylin Berwanger, Brigitta Loretz, Anna Katharina Herta Hirsch, Rolf Wolfgang Hartmann, Claus-Michael Lehr, Martin Empting
A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8 (12) (2021)
Mohammad Abdel-Halim, Sara Sigler, Nora A S Racheed, Amr Hefnawy, Reem K Fathalla, Mennatallah A Hammam, Ahmed Maher, Yulia Maxuitenko, Adam B Keeton, Rolf Wolfgang Hartmann, Matthias Engel, Gary A Piazza, Ashraf H Abadi
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity. Journal of medicinal chemistry 64 (8) (2021)
Walid A M Elgaher, Mostafa M Hamed, Sascha Baumann, Jennifer Herrmann, Lorenz Siebenbürger, Jana Krull, Katarina Cirnski, Andreas Kirschning, Mark Brönstrup, Rolf Müller, Rolf Wolfgang Hartmann
Cystobactamid 507: Concise Synthesis, Mode of Action, and Optimization toward More Potent Antibiotics. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (32) (2020)
Jörg Haupenthal, Yannik Kautz, Walid A M Elgaher, Linda Pätzold, Teresa Röhrig, Matthias W Laschke, Thomas Tschernig, Anna Katharina Herta Hirsch, Vadim Molodtsov, Katsuhiko S Murakami, Rolf Wolfgang Hartmann, Markus Bischoff
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice. ACS infectious diseases 6 (10) (2020)
Jelena Konstantinović, Samir Yahiaoui, Alaa Alhayek, Jörg Haupenthal, Esther Schönauer, Anastasia Andreas, Andreas M Kany, Rolf Müller, Jesko Koehnke, Fabian K Berger, Markus Bischoff, Rolf Wolfgang Hartmann, Katharina Häussermann, Anna Katharina Herta Hirsch
N-Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting Pseudomonas aeruginosa Elastase and Clostridium Collagenases. Journal of medicinal chemistry 63 (15) (2020)
Roman Sommer, Katharina Rox, Stefanie Wagner, Dirk Hauck, Sarah S Henrikus, Shelby Newsad, Tatjana Arnold, Thomas Ryckmans, Mark Brönstrup, Anne Imberty, Annabelle Varrot, Rolf Wolfgang Hartmann, Alexander Titz
Anti-biofilm Agents against Pseudomonas aeruginosa: A Structure-Activity Relationship Study of C-Glycosidic LecB Inhibitors. Journal of medicinal chemistry 62 (20) (2019)
Benoît Bestgen, Isabelle Krimm, Irina Kufareva, Ahmed Ashraf Moustafa Kamal, Wei-Guang Seetoh, Chris Abell, Rolf Wolfgang Hartmann, Ruben Abagyan, Claude Cochet, Marc Le Borgne, Matthias Engel, Thierry Lomberget
2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site. Journal of medicinal chemistry 62 (4) (2019)
Benoît Bestgen, Irina Kufareva, Wei-Guang Seetoh, Chris Abell, Rolf Wolfgang Hartmann, Ruben Abagyan, Marc Le Borgne, Odile Filhol-Cochet, Claude Cochet, Thierry Lomberget, Matthias Engel
2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action. Journal of medicinal chemistry 62 (4) (2019)
Ahmed S Abdelsamie, Mohamed Salah, Lorenz Siebenbürger, Ahmed Merabet, Claudia Scheuer, Martin Frotscher, Sebastian T Müller, Oliver Zierau, Günter Vollmer, Michael D Menger, Matthias W Laschke, Chris J van Koppen, Sandrine Marchais-Oberwinkler, Rolf Wolfgang Hartmann
Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis. Journal of medicinal chemistry 62 (15) (2019)
Ahmed S Abdelsamie, Steven Herath, Yannik Biskupek, Carsten Börger, Lorenz Siebenbürger, Mohamed Salah, Claudia Scheuer, Sandrine Marchais-Oberwinkler, Martin Frotscher, Tim Pohlemann, Michael D Menger, Rolf Wolfgang Hartmann, Matthias W Laschke, Chris J van Koppen
Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing. Journal of medicinal chemistry 62 (3) (2019)
Andreas Martin Kany, Asfandyar Sikandar, Samir Yahiaoui, Jörg Haupenthal, Isabell Walter, Martin Empting, Jesko Koehnke, Rolf Wolfgang Hartmann
Tackling Pseudomonas aeruginosa Virulence by a Hydroxamic Acid-Based LasB Inhibitor. ACS chemical biology 13 (9) (2018)
Andreas Martin Kany, Asfandyar Sikandar, Jörg Haupenthal, Samir Yahiaoui, Christine K Maurer, Ewgenij Proschak, Jesko Koehnke, Rolf Wolfgang Hartmann
Binding Mode Characterization and Early in Vivo Evaluation of Fragment-Like Thiols as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa. ACS infectious diseases 4 (6) (2018)
Lorenz Siebenbuerger, Victor Hernandez-Olmos, Ahmed S Abdelsamie, Martin Frotscher, Chris J van Koppen, Sandrine Marchais-Oberwinkler, Claudia Scheuer, Matthias W Laschke, Michael D Menger, Carsten Boerger, Rolf Wolfgang Hartmann
Highly Potent 17β-HSD2 Inhibitors with a Promising Pharmacokinetic Profile for Targeted Osteoporosis Therapy. Journal of medicinal chemistry 61 (23) (2018)
Roman Sommer, Stefanie Wagner, Katharina Rox, Annabelle Varrot, Dirk Hauck, Eike-Christian Wamhoff, Janine Schreiber, Thomas Ryckmans, Thomas Brunner, Christoph Rademacher, Rolf Wolfgang Hartmann, Mark Brönstrup, Anne Imberty, Alexander Titz
Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa. Journal of the American Chemical Society 140 (7) (2018)
Florian Graef, Robert Richter, Verena Fetz, Xabier Murgia, Chiara De Rossi, Nicole Schneider-Daum, Giuseppe Allegretta, Walid Elgaher, Jörg Haupenthal, Martin Empting, Felix Beckmann, Mark Brönstrup, Rolf Wolfgang Hartmann, Sarah Gordon, Claus-Michael Lehr
In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics. ACS infectious diseases 4 (8) (2018)
Esther Schönauer, Andreas Martin Kany, Jörg Haupenthal, Kristina Hüsecken, Isabel J Hoppe, Katrin Voos, Samir Yahiaoui, Brigitta Elsässer, Christian Ducho, Katharina Häussermann, Rolf Wolfgang Hartmann
Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases. Journal of the American Chemical Society 139 (36) (2017)
Juliette Emmerich, Chris J van Koppen, Jens L Burkhart, Qingzhong Hu, Lorenz Siebenbürger, Carsten Boerger, Claudia Scheuer, Matthias W Laschke, Michael D Menger, Rolf Wolfgang Hartmann
Lead Optimization Generates CYP11B1 Inhibitors of Pyridylmethyl Isoxazole Type with Improved Pharmacological Profile for the Treatment of Cushing's Disease. Journal of medicinal chemistry 60 (12) (2017)
Frank Surup, Konrad Viehrig, Shwan Rachid, Alberto Plaza, Christine K Maurer, Rolf Wolfgang Hartmann, Daniel Krug
Crocadepsins-Depsipeptides from the Myxobacterium Chondromyces crocatus Found by a Genome Mining Approach. ACS chemical biology 13 (1) (2017)