Manfred S Weiss

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 39

Top Venues

Acta crystallographica. Section D, Structural biology

ACS chemical biology

ChemMedChem

Acta crystallographica. Section F, Structural biology communications

Helmholtz-Zentrum Berlin für Materialien und Energie GmbH

University of Freiburg (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Helmholtz-Zentrum Berlin für Materialien und Energie GmbH Nov 01 2009

Germany

Group Leader :: Macromolecular Crystallography

EMBL Hamburg Oct 01 2001 - Oct 31 2009

Germany

Team Leader :: Macromolecular Crystallography

Institute of Molecular Biotechnology Apr 01 1996 - Sep 30 2001

Germany

Staff Scientist :: Structural Biology

University of California Los Angeles Nov 01 1992 - Mar 31 1996

United States

Postdoc :: Molecular Biology

University of Freiburg Aug 01 1992 - Oct 31 1992

Germany

Postdoc :: Chemistry and Biochemistry

Education History

University of Freiburg Jul 01 1989 - Jul 31 1992

Germany

PHD :: Chemistry and Biochemistry

Publications

Piotr Neumann, Jana L Heidemann, Jan Wollenhaupt, Achim Dickmanns, Michael Agthe, Manfred S Weiss, Ralf Ficner
A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA. Acta crystallographica. Section D, Structural biology 80 (Pt 5) (2024)
Subhadra Dalwani, Alexander Metz, Franziska U Huschmann, Manfred S Weiss, Rikkert K Wierenga, Rajaram Venkatesan
Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta crystallographica. Section D, Structural biology (2024)
Subhadra Dalwani, Alexander Metz, Franziska U Huschmann, Manfred S Weiss, Rikkert K Wierenga, Rajaram Venkatesan
Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta crystallographica. Section D, Structural biology 80 (Pt 8) (2024)
Roman W Lange, Konstantin Bloch, Miriam Ruth Heindl, Jan Wollenhaupt, Manfred S Weiss, Katharina Häussermann, Gerhard Klebe, Franco H Falcone, Eva Böttcher-Friebertshäuser, Sven O Dahms, Torsten Steinmetzer
Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. ChemMedChem 19 (9) (2024)
Roman W Lange, Konstantin Bloch, Miriam Ruth Heindl, Jan Wollenhaupt, Manfred S Weiss, Katharina Häussermann, Gerhard Klebe, Franco H Falcone, Eva Böttcher-Friebertshäuser, Sven O Dahms, Torsten Steinmetzer
Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. ChemMedChem (2024)
Subhadra Dalwani, Alexander Metz, Franziska U Huschmann, Manfred S Weiss, Rikkert K Wierenga, Rajaram Venkatesan
Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta crystallographica. Section D, Structural biology 80 (Pt 8) (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Tim Benedict Garbers, Piotr Neumann, Jan Wollenhaupt, Achim Dickmanns, Manfred S Weiss, Ralf Ficner
Crystallographic fragment screen of the c-di-AMP-synthesizing enzyme CdaA from Bacillus subtilis. Acta crystallographica. Section F, Structural biology communications (2024)
Piotr Neumann, Jana L Heidemann, Jan Wollenhaupt, Achim Dickmanns, Michael Agthe, Manfred S Weiss, Ralf Ficner
A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA. Acta crystallographica. Section D, Structural biology 80 (Pt 5) (2024)
Subhadra Dalwani, Alexander Metz, Franziska U Huschmann, Manfred S Weiss, Rikkert K Wierenga, Rajaram Venkatesan
Crystallographic fragment-binding studies of the Mycobacterium tuberculosis trifunctional enzyme suggest binding pockets for the tails of the acyl-CoA substrates at its active sites and a potential substrate-channeling path between them. Acta crystallographica. Section D, Structural biology 80 (Pt 8) (2024)
Piotr Neumann, Jana L Heidemann, Jan Wollenhaupt, Achim Dickmanns, Michael Agthe, Manfred S Weiss, Ralf Ficner
A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA. Acta crystallographica. Section D, Structural biology 80 (Pt 5) (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Piotr Neumann, Jana L Heidemann, Jan Wollenhaupt, Achim Dickmanns, Michael Agthe, Manfred S Weiss, Ralf Ficner
A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA. Acta crystallographica. Section D, Structural biology (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Piotr Neumann, Jana L Heidemann, Jan Wollenhaupt, Achim Dickmanns, Michael Agthe, Manfred S Weiss, Ralf Ficner
A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA. Acta crystallographica. Section D, Structural biology 80 (Pt 5) (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Marina Gárdonyi, Christian Hasewinkel, Johanna Wallbaum, Jan Wollenhaupt, Manfred S Weiss, Gerhard Klebe, Klaus Reuter, Andreas Heine
Crystallographic Fragment Screening on the Shigella Type III Secretion System Chaperone IpgC. ACS omega 8 (48) (2023)
Friederike Theresa Füsser, Jan Wollenhaupt, Manfred S Weiss, Daniel Kümmel, Oliver Koch
Novel starting points for fragment-based drug design against mycobacterial thioredoxin reductase identified using crystallographic fragment screening. Acta crystallographica. Section D, Structural biology (2023)
Alix Tröster, Michael DiPrima, Nathalie Jores, Denis Kudlinzki, Sridhar Sreeramulu, Santosh L Gande, Verena Linhard, Damian Ludig, Alexander Schug, Krishna Saxena, Maria Reinecke, Stephanie Wilhelm, Matthias S Leisegang, Jan Wollenhaupt, Frank Lennartz, Manfred S Weiss, Bernhard Kuster, Giovanna Tosato, Harald Schwalbe
Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor. Chemistry (Weinheim an der Bergstrasse, Germany) (2023)
Frank Lennartz, Jae Hun Jeoung, Stefan Ruenger, Holger Dobbek, Manfred S Weiss
Determining the oxidation state of elements by X-ray crystallography. Acta crystallographica. Section D, Structural biology 78 (Pt 2) (2022)
Manfred S Weiss, Jan Wollenhaupt, Galen J Correy, Brian K Shoichet, Andreas Heine, Gerhard Klebe, Tobias Krojer, Marjolein Thunissen, Nicholas M Pearce
Of problems and opportunities-How to treat and how to not treat crystallographic fragment screening data. Protein science : a publication of the Protein Society 31 (9) (2022)
Tatjana Barthel, Jan Wollenhaupt, Gustavo M A Lima, Markus C Wahl, Manfred S Weiss
Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. Journal of medicinal chemistry 65 (21) (2022)
Simon Krause, Jack D Evans, Volodymyr Bon, Stefano Crespi, Wojciech Danowski, Wesley R Browne, Sebastian Ehrling, Francesco Walenszus, Dirk Wallacher, Nico Grimm, Daniel M Többens, Manfred S Weiss, Stefan Kaskel, Ben L Feringa
Cooperative light-induced breathing of soft porous crystals via azobenzene buckling. Nature communications 13 (1) (2022)
Friederike Ebner, Katja Lindner, Katharina Janek, Agathe Niewienda, Piotr H Malecki, Manfred S Weiss, Tara E Sutherland, Arnd Heuser, Anja A Kühl, Jürgen Zentek, Andreas Hofmann, Susanne Hartmann
A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease. Journal of immunology research 2021 (2021)
Emma R Scaletti, Franziska U Huschmann, Uwe Mueller, Manfred S Weiss, Norbert Sträter
Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic signalling (2021)
Sebastian Günther, Patrick Y A Reinke, Yaiza Fernández-García, Julia Lieske, Thomas J Lane, Helen Mary Ginn, Faisal H M Koua, Christiane Ehrt, Wiebke Ewert, Dominik Oberthür, Oleksandr Yefanov, Susanne Meier, Kristina Lorenzen, Boris Krichel, Janine-Denise Kopicki, Luca Gelisio, Wolfgang Brehm, Ilona Dunkel, Brandon Seychell, Henry Gieseler, Brenna Norton-Baker, Beatriz Escudero-Pérez, Martin Domaracky, Sofiane Saouane, Alexandra Tolstikova, Thomas A White, Anna Hänle, Michael Groessler, Holger Fleckenstein, Fabian Trost, Marina Galchenkova, Yaroslav Gevorkov, Chufeng Li, Salah Awel, Ariana Peck, Miriam Barthelmess, Frank Schlünzen, Paul Lourdu Xavier, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Sven Falke, Vasundara Srinivasan, Bruno Alves França, Martin Schwinzer, Hévila Brognaro, Cromarte Rogers, Diogo Melo, Joanna J Zaitseva-Doyle, Juraj Knoška, Gisel Esperanza Pena Murillo, Aida Rahmani Mashhour, Vincent Hennicke, Pontus Fischer, Johanna Hakanpää, Jan Meyer, Philip Gribbon, Bernhard Ellinger, Maria Kuzikov, Markus Wolf, Andrea Rosario Beccari, Gleb Bourenkov, David von Stetten, Guillaume Pompidor, Isabel Bento, Saravanan Panneerselvam, Ivars Karpics, Thomas R Schneider, Maria Marta Garcia-Alai, Stephan Niebling, Christian Günther, Christina Schmidt, Robin Schubert, Huijong Han, Juliane Boger, Diana C F Monteiro, Linlin Zhang, Xinyuanyuan Sun, Jonathan Pletzer-Zelgert, Jan Wollenhaupt, Christian G Feiler, Manfred S Weiss, Eike-Christian Schulz, Pedram Mehrabi, Katarina Karničar, Aleksandra Usenik, Jure Loboda, Henning Tidow, Ashwin Chari, Rolf Hilgenfeld, Charlotte Uetrecht, Russell J Cox, Andrea Zaliani, Tobias Beck, Matthias Rarey, Stephan Gunther, Dusan Turk, Winfried Hinrichs, Henry N Chapman, Arwen R Pearson, Christian Betzel, Alke Meents
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science (New York, N.Y.) 372 (6542) (2021)
Mizuki Takenaka, Sachi Takenaka, Tatjana Barthel, Brody Frink, Sascha Haag, Daniil Verbitskiy, Bastian Oldenkott, Mareike Schallenberg-Rüdinger, Christian G Feiler, Manfred S Weiss, Gottfried J Palm, Gert Weber
DYW domain structures imply an unusual regulation principle in plant organellar RNA editing catalysis. Nature catalysis 4 (6) (2021)
Alexander Metz, Jan Wollenhaupt, Steffen Glöckner, Niki Messini, Simon Huber, Tatjana Barthel, Ahmed Merabet, Hans Dieter Gerber, Andreas Heine, Gerhard Klebe, Manfred S Weiss
Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking. Acta crystallographica. Section D, Structural biology 77 (Pt 9) (2021)
Gustavo M A Lima, Elmir Jagudin, Vladimir O Talibov, Laila S Benz, Costantino Marullo, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Uwe Mueller
FragMAXapp: crystallographic fragment-screening data-analysis and project-management system. Acta crystallographica. Section D, Structural biology 77 (Pt 6) (2021)
Tatjana Barthel, Franziska U Huschmann, Dirk Wallacher, Christian G Feiler, Gerhard Klebe, Manfred S Weiss, Jan Wollenhaupt
Facilitated crystal handling using a simple device for evaporation reduction in microtiter plates. Journal of applied crystallography 54 (Pt 1) (2021)
Christian G Feiler, Manfred S Weiss, Wulf Blankenfeldt
The hypothetical periplasmic protein PA1624 from Pseudomonas aeruginosa folds into a unique two-domain structure. Acta crystallographica. Section F, Structural biology communications 76 (Pt 12) (2020)
Anna Kluza, Zuzanna Wojdyla, Beata Mrugała, Katarzyna Kurpiewska, Przemyslaw Jerzy Porebski, Ewa Niedzialkowska, Wladek Minor, Manfred S Weiss, Tomasz Borowski
Regioselectivity of hyoscyamine 6β-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations. Dalton transactions (Cambridge, England : 2003) 49 (14) (2020)
Rajasri Bhattacharyya, Jesmita Dhar, Shubhra Ghosh Dastidar, Pinak Chakrabarti, Manfred S Weiss
The susceptibility of disulfide bonds towards radiation damage may be explained by S⋯O interactions. IUCrJ 7 (Pt 5) (2020)
Simon Krause, Jack D Evans, Volodymyr Bon, Irena Senkovska, Sebastian Ehrling, Paul Iacomi, Daniel M Többens, Dirk Wallacher, Manfred S Weiss, Bin Zheng, Pascal G Yot, Guillaume Maurin, Philip L Llewellyn, François-Xavier Coudert, Stefan Kaskel
Engineering micromechanics of soft porous crystals for negative gas adsorption. Chemical science 11 (35) (2020)
Dimitris-Panagiotis Triandafillidis, Nikolaos Parthenios, Maria Spiliopoulou, Alexandros Valmas, Christos Kosinas, Fabia Gozzo, Mathilde L Reinle-Schmitt, Detlef Beckers, Thomas Degen, Mihaela Pop, Andrew N Fitch, Jan Wollenhaupt, Manfred S Weiss, Fotini Karavassili, Irene Margiolaki
Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction. Acta crystallographica. Section D, Structural biology 76 (Pt 11) (2020)
Elżbieta Wątor, Maria Rutkiewicz, Manfred S Weiss, Piotr Wilk
Co-expression with chaperones can affect protein 3D structure as exemplified by loss-of-function variants of human prolidase. FEBS letters 594 (18) (2020)
Piotr H Małecki, Nicole Rüger, Martin Roatsch, Oxana Krylova, Andreas Link, Manfred Jung, Udo Heinemann, Manfred S Weiss
Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases. ChemMedChem 14 (21) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Manfred S Weiss