Anastassis Perrakis

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 48

Top Venues

Journal of cell science

ACS chemical biology

Acta crystallographica. Section D, Structural biology

The Journal of biological chemistry

Oncode Institute

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Oncode Institute Jan 01 2019

Netherlands

Principal Investigator

Netherlands Cancer Institute Nov 01 2000

Netherlands

Project Leader :: Biochemistry

European Molecular Biology Laboratory Oct 01 1998 - Oct 31 2000

Germany

Staff Scientist :: Grenoble Unit

Publications

Wei Wang, Paul Atherton, Maaike Kreft, Lisa Te Molder, Sabine van der Poel, Liesbeth Hoekman, Patrick H N Celie, Robbie P Joosten, Reinhard Fässler, Anastassis Perrakis, Arnoud Sonnenberg
Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility. Journal of cell science 137 (9) (2024)
Jitske Bak, Thijn R Brummelkamp, Anastassis Perrakis
Decoding microtubule detyrosination: enzyme families, structures, and functional implications. FEBS letters 598 (12) (2024)
Wei Wang, Paul Atherton, Maaike Kreft, Lisa Te Molder, Sabine van der Poel, Liesbeth Hoekman, Patrick H N Celie, Robbie P Joosten, Reinhard Fässler, Anastassis Perrakis, Arnoud Sonnenberg
Caskin2 is a novel talin and Abi1-binding protein that promotes cell motility. Journal of cell science (2024)
Wei Wang, Paul Atherton, Maaike Kreft, Lisa Te Molder, Sabine van der Poel, Liesbeth Hoekman, Patrick H N Celie, Robbie P Joosten, Reinhard Fässler, Anastassis Perrakis, Arnoud Sonnenberg
Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility. Journal of cell science 137 (9) (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Jitske Bak, Thijn R Brummelkamp, Anastassis Perrakis
Decoding microtubule detyrosination: enzyme families, structures, and functional implications. FEBS letters 598 (12) (2024)
Wei Wang, Paul Atherton, Maaike Kreft, Lisa Te Molder, Sabine van der Poel, Liesbeth Hoekman, Patrick H N Celie, Robbie P Joosten, Reinhard Fässler, Anastassis Perrakis, Arnoud Sonnenberg
Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility. Journal of cell science 137 (9) (2024)
Wei Wang, Paul Atherton, Maaike Kreft, Lisa Te Molder, Sabine van der Poel, Liesbeth Hoekman, Patrick H N Celie, Robbie P Joosten, Reinhard Fässler, Anastassis Perrakis, Arnoud Sonnenberg
Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility. Journal of cell science 137 (9) (2024)
Wei Wang, Paul Atherton, Maaike Kreft, Lisa Te Molder, Sabine van der Poel, Liesbeth Hoekman, Patrick H N Celie, Robbie P Joosten, Reinhard Fässler, Anastassis Perrakis, Arnoud Sonnenberg
Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility. Journal of cell science 137 (9) (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Jitske Bak, Thijn R Brummelkamp, Anastassis Perrakis
Decoding microtubule detyrosination: enzyme families, structures, and functional implications. FEBS letters (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Nadide Altincekic, Nathalie Jores, Frank Loehr, Christian Richter, Claus Ehrhardt, Marcel J J Blommers, Hannes Berg, Sare Öztürk, Santosh L Gande, Verena Linhard, Julien Orts, Marie Jose Abi Saad, Matthias Bütikofer, Janina Kaderli, B Göran Karlsson, Ulrika Brath, Mattias Hedenström, Gerhard Gröbner, Uwe H Sauer, Anastassis Perrakis, Julian D Langer, Lucia Banci, Francesca Cantini, Marco Fragai, Deborah Grifagni, Tatjana Barthel, Jan Wollenhaupt, Manfred S Weiss, Angus Robertson, Adriaan Bax, Sridhar Sreeramulu, Harald Schwalbe
Targeting the Main Protease (M pro , nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies. ACS chemical biology 19 (2) (2024)
Jon Agirre, Mihaela Atanasova, Haroldas Bagdonas, Charles B Ballard, Arnaud Baslé, James Beilsten-Edmands, Rafael Junqueira Borges, David G Brown, J Javier Burgos-Mármol, John M Berrisford, Paul S Bond, Iracema Caballero, Lucrezia Catapano, Grzegorz Chojnowski, Atlanta G Cook, Kathryn D Cowtan, Tristan I Croll, Judit É Debreczeni, Nicholas E Devenish, Eleanor J Dodson, Tarik R Drevon, Paul Emsley, Gwyndaf Evans, Phil R Evans, Maria Fando, James Foadi, Luis Fuentes-Montero, Elspeth F Garman, Markus Gerstel, Richard J Gildea, Kaushik Hatti, Maarten L Hekkelman, Philipp Heuser, Soon Wen Hoh, Michael A Hough, Huw T Jenkins, Elisabet Jiménez, Robbie P Joosten, Ronan M Keegan, Nicholas H Keep, Eugene B Krissinel, Petr Kolenko, Oleg Kovalevskiy, Victor S Lamzin, David M Lawson, Andrey A Lebedev, Andrew G W Leslie, Bernhard Lohkamp, Fei Long, Martin Malý, Airlie J McCoy, Stuart J McNicholas, Ana Medina, Claudia Millán, James W Murray, Garib N Murshudov, Robert A Nicholls, Martin E M Noble, Robert D Oeffner, Navraj S Pannu, James M Parkhurst, Nicholas Pearce, Joana Pereira, Anastassis Perrakis, Harold R Powell, Randy J Read, Daniel J Rigden, William Rochira, Massimo D Sammito, Filomeno Sánchez Rodríguez, George M Sheldrick, Kathryn L Shelley, Felix Simkovic, Adam J Simpkin, Pavol Skubák, Egor Sobolev, Roberto A Steiner, Kyle Stevenson, Ivo Tews, Jens M H Thomas, Andrea Thorn, Josep Triviño Valls, Ville Uski, Isabel Usón, Alexei Vagin, Sameer Velankar, Melanie Vollmar, Helen Walden, David Geoffrey Waterman, Keith S Wilson, Martyn David Winn, Graeme Winter, Marcin Wojdyr, Keitaro Yamashita
The CCP4 suite: integrative software for macromolecular crystallography. Acta crystallographica. Section D, Structural biology 79 (Pt 6) (2023)
Xiao-Chen Bai, Tamir Gonen, Angela M Gronenborn, Anastassis Perrakis, Andrea Thorn, Jianyi Yang
Challenges and opportunities in macromolecular structure determination. Nature reviews. Molecular cell biology (2023)
Ida de Vries, Danique Ammerlaan, Tatjana Heidebrecht, Patrick H N Celie, Daan P Geerke, Robbie P Joosten, Anastassis Perrakis
Distant sequence regions of JBP1 contribute to J-DNA binding. Life science alliance 6 (9) (2023)
Lisa Landskron, Jitske Bak, Athanassios Adamopoulos, Konstantina Kaplani, Maria Moraiti, Lisa G van den Hengel, Ji-Ying Song, Onno B Bleijerveld, Joppe Nieuwenhuis, Tatjana Heidebrecht, Linda Henneman, Marie Jo Moutin, Marin Barisic, Stavros Taraviras, Anastassis Perrakis, Thijn R Brummelkamp
Posttranslational modification of microtubules by the MATCAP detyrosinase. Science (New York, N.Y.) 376 (6595) (2022)
Richell Booijink, Fernando Salgado-Polo, Craig Jamieson, Anastassis Perrakis, Ruchi Bansal
A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis. EMBO molecular medicine 14 (9) (2022)
Abhijeet Pataskar, Julien Champagne, Remco Nagel, Juliana Kenski, Maarja Laos, Justine Michaux, Hui Song Pak, Onno B Bleijerveld, Kelly Mordente, Jasmine Montenegro Navarro, Naomi Blommaert, Morten M Nielsen, Domenica Lovecchio, Everett Stone, George Georgiou, Mark Cornelis de Gooijer, Olaf van Tellingen, Maarten Altelaar, Robbie P Joosten, Anastassis Perrakis, Johanna Olweus, Michal Bassani-Sternberg, Daniel S Peeper, Reuven Agami
Tryptophan depletion results in tryptophan-to-phenylalanine substitutants. Nature 603 (7902) (2022)
Maarten L Hekkelman, Ida de Vries, Robbie P Joosten, Anastassis Perrakis
AlphaFill: enriching AlphaFold models with ligands and cofactors. Nature methods (2022)
Ennio A d'Amico, Misbha Ud Din Ahmad, Verena Cmentowski, Mathias Girbig, Franziska Mueller, Sabine Wohlgemuth, Andreas Brockmeyer, Stefano Maffini, Petra Janning, Ingrid R Vetter, Andrew P Carter, Anastassis Perrakis, Andrea Musacchio
Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin. The Journal of cell biology 221 (11) (2022)
Jennifer M Clark, Fernando Salgado-Polo, Simon J F Macdonald, Tim N Barrett, Anastassis Perrakis, Craig J Jamieson
Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators. Journal of medicinal chemistry 65 (8) (2022)
Ida de Vries, Tim Kwakman, Xiang-Jun Lu, Maarten L Hekkelman, Mandar S Deshpande, Sameer Velankar, Anastassis Perrakis, Robbie P Joosten
New restraints and validation approaches for nucleic acid structures in PDB-REDO. Acta crystallographica. Section D, Structural biology 77 (Pt 9) (2021)
Ilona van Alen, Aleksandra Chikunova, Adil A Safeer, Misbha Ud Din Ahmad, Anastassis Perrakis, Marcellus Ubbink
The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis β-Lactamase against Sulbactam. Biochemistry 60 (28) (2021)
Andrea Giovanni Murachelli, George Damaskos, Anastassis Perrakis
CCD2: design constructs for protein expression, the easy way. Acta crystallographica. Section D, Structural biology 77 (Pt 8) (2021)
Anastassis Perrakis, Titia K Sixma
AI revolutions in biology: The joys and perils of AlphaFold. EMBO reports 22 (11) (2021)
Bart van Beusekom, George Damaskos, Maarten L Hekkelman, Fernando Salgado-Polo, Yoshitaka Hiruma, Anastassis Perrakis, Robbie P Joosten
LAHMA: structure analysis through local annotation of homology-matched amino acids. Acta crystallographica. Section D, Structural biology 77 (Pt 1) (2021)
Xiaoyun Deng, Fernando Salgado-Polo, Tuo Shao, Zhiwei Xiao, Richard Van, Jiahui Chen, Jian Rong, Ahmed Haider, Yihan Shao, Lee Josephson, Anastassis Perrakis, Steven H Liang
Imaging Autotaxin In Vivo with 18F-Labeled Positron Emission Tomography Ligands. Journal of medicinal chemistry 64 (20) (2021)
Fernando Salgado-Polo, Wouter H Moolenaar, Bram van den Broek, Kees Jalink, Daniela Leyton-Puig, Anastassis Perrakis, Elisa Matas-Rico
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation. Journal of cell science 133 (3) (2020)
Christine Orengo, Sameer Velankar, Shoshana Wodak, Vincent Zoete, Alexandre M J J Bonvin, Arne Elofsson, K Anton Feenstra, Dietland L Gerloff, Thomas Hamelryck, John M Hancock, Manuela Helmer-Citterich, Adam Hospital, Modesto Orozco, Anastassis Perrakis, Matthias Rarey, Claudio Soares, Joel L Sussman, Janet M Thornton, Pierre Tuffery, Gabor Tusnady, Rikkert Wierenga, Tiina Salminen, Bohdan Schneider
A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community). F1000Research 9 (2020)
Bart van Beusekom, Natasja Wezel, Maarten L Hekkelman, Anastassis Perrakis, Paul Emsley, Robbie P Joosten
Building and rebuilding N-glycans in protein structure models. Acta crystallographica. Section D, Structural biology 75 (Pt 4) (2019)
Athanassios Adamopoulos, Lisa Landskron, Tatjana Heidebrecht, Foteini Tsakou, Onno B Bleijerveld, Maarten Altelaar, Joppe Nieuwenhuis, Patrick H N Celie, Thijn R Brummelkamp, Anastassis Perrakis
Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP. Nature structural & molecular biology 26 (7) (2019)
Athanassios Adamopoulos, Tatjana Heidebrecht, Jeroen Roosendaal, Wouter G Touw, Isabelle Q Phan, Jos Beijnen, Anastassis Perrakis
The domain architecture of the protozoan protein J-DNA-binding protein 1 suggests synergy between base J DNA binding and thymidine hydroxylase activity. The Journal of biological chemistry 294 (34) (2019)
Fernando Salgado-Polo, Anastassis Perrakis
The Structural Binding Mode of the Four Autotaxin Inhibitor Types that Differentially Affect Catalytic and Non-Catalytic Functions. Cancers 11 (10) (2019)
Jacomina C Roorda, Robbie P Joosten, Anastassis Perrakis, Yoshitaka Hiruma
A crystal structure of the human protein kinase Mps1 reveals an ordered conformation of the activation loop. Proteins 87 (4) (2019)
Akiyo Hayashi, Nickolaos Nikiforos Giakoumakis, Tatjana Heidebrecht, Takashi Ishii, Andreas Panagopoulos, Christophe Caillat, Michiyo Takahara, Richard G Hibbert, Naohiro Suenaga, Magda Stadnik-Spiewak, Tatsuro S Takahashi, Yasushi Shiomi, Stavros Taraviras, Eleonore von Castelmur, Zoi Lygerou, Anastassis Perrakis, Hideo Nishitani
Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1. Life science alliance 1 (6) (2018)
Elisabetta Argenzio, Jeffrey Klarenbeek, Katarzyna M Kedziora, Leila Nahidiazar, Tadamoto Isogai, Anastassis Perrakis, Kees Jalink, Wouter H Moolenaar, Metello Innocenti
Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA-mDia2 signaling and filopodium formation. The Journal of biological chemistry 293 (50) (2018)
Bart van Beusekom, Krista Joosten, Maarten L Hekkelman, Robbie P Joosten, Anastassis Perrakis
Homology-based loop modeling yields more complete crystallographic protein structures. IUCrJ 5 (Pt 5) (2018)
Fernando Salgado-Polo, Alex Fish, Minos-Timotheos Matsoukas, Tatjana Heidebrecht, Willem-Jan Keune, Anastassis Perrakis
Lysophosphatidic acid produced by autotaxin acts as an allosteric modulator of its catalytic efficiency. The Journal of biological chemistry 293 (37) (2018)
Bart van Beusekom, Tatjana Heidebrecht, Athanassios Adamopoulos, Alexander Fish, Els Pardon, Jan Steyaert, Robbie P Joosten, Anastassis Perrakis
Characterization and structure determination of a llama-derived nanobody targeting the J-base binding protein 1. Acta crystallographica. Section F, Structural biology communications 74 (Pt 11) (2018)
Carlos Sacristan, Misbha Ud Din Ahmad, Jenny Keller, Job Fermie, Vincent Groenewold, Eelco C Tromer, Alexander Fish, Roberto Melero, José María Carazo, Judith Klumperman, Andrea Musacchio, Anastassis Perrakis, Geert J P L Kops
Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis. Nature cell biology 20 (7) (2018)
Bart van Beusekom, Wouter G Touw, Mahidhar Tatineni, Sandeep Somani, Gunaretnam Rajagopal, Jinquan Luo, Gary L Gilliland, Anastassis Perrakis, Robbie P Joosten
Homology-based hydrogen bond information improves crystallographic structures in the PDB. Protein science : a publication of the Protein Society 27 (3) (2017)
Joppe Nieuwenhuis, Athanassios Adamopoulos, Onno B Bleijerveld, Abdelghani Mazouzi, Elmer Stickel, Patrick Celie, A F Maarten Altelaar, Puck Knipscheer, Anastassis Perrakis, Vincent A Blomen, Thijn R Brummelkamp
Vasohibins encode tubulin detyrosinating activity. Science (New York, N.Y.) 358 (6369) (2017)
Michiel van Veen, Elisa Matas-Rico, Koen van de Wetering, Daniela Leyton-Puig, Katarzyna M Kedziora, Valentina De Lorenzi, Yvette Stijf-Bultsma, Bram van den Broek, Kees Jalink, Nicolai Sidenius, Anastassis Perrakis, Wouter H Moolenaar
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. eLife 6 (2017)
Yoshitaka Hiruma, Andre Koch, Nazila Hazraty, Foteini Tsakou, René H Medema, Robbie P Joosten, Anastassis Perrakis
Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures. The Journal of biological chemistry 292 (35) (2017)
Yoshitaka Hiruma, Andre Koch, Shreya Dharadhar, Robbie P Joosten, Anastassis Perrakis
Structural basis of reversine selectivity in inhibiting Mps1 more potently than aurora B kinase. Proteins 84 (12) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Anastassis Perrakis