David A Fidock (David Fidock, D A Fidock)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 67

Top Venues

Nature communications

Nature microbiology

mBio

Microbiology spectrum

Columbia University

Institut Pasteur (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Columbia University May 01 2007

United States

Professor :: Microbiology & Immunology, and Medicine

Albert Einstein College of Medicine, Yeshiva University Jan 01 2000 - Apr 30 2007

United States

Associate Professor :: Microbiology & Immunology

Institut Pasteur Apr 01 1992 - Dec 31 1999

France

Assistant/Charge de Recherche :: Parasitologie

Biotech Australia Feb 01 1987 - Mar 29 1989

Australia

Research Assistant :: Vaccines and Diagnostics

Education History

Institut Pasteur Jul 01 1989 - Nov 01 1994

France

PHD :: Parasitologie

Publications

Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Lucien Platon, Didier Leroy, David A Fidock, Didier Ménard
Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin. Microbiology spectrum 12 (4) (2024)
Jair Lage Siqueira-Neto, Kathryn J Wicht, Kelly Chibale, Jeremy N Burrows, David A Fidock, Elizabeth A Winzeler
Author Correction: Antimalarial drug discovery: progress and approaches. Nature reviews. Drug discovery (2024)
Jennifer L Small-Saunders, Ameya Sinha, Talia S Bloxham, Laura M Hagenah, Guangxin Sun, Peter Rainer Preiser, Peter C Dedon, David A Fidock
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nature microbiology (2024)
Lucien Platon, Didier Leroy, David A Fidock, Didier Ménard
Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin. Microbiology spectrum 12 (4) (2024)
Lucien Platon, Didier Leroy, David A Fidock, Didier Ménard
Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin. Microbiology spectrum 12 (4) (2024)
Jennifer L Small-Saunders, Ameya Sinha, Talia S Bloxham, Laura M Hagenah, Guangxin Sun, Peter Rainer Preiser, Peter C Dedon, David A Fidock
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nature microbiology 9 (6) (2024)
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Jennifer L Small-Saunders, Ameya Sinha, Talia S Bloxham, Laura M Hagenah, Guangxin Sun, Peter Rainer Preiser, Peter C Dedon, David A Fidock
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nature microbiology (2024)
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Jennifer L Small-Saunders, Ameya Sinha, Talia S Bloxham, Laura M Hagenah, Guangxin Sun, Peter Rainer Preiser, Peter C Dedon, David A Fidock
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nature microbiology 9 (6) (2024)
Lucien Platon, Didier Leroy, David A Fidock, Didier Ménard
Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin. Microbiology spectrum 12 (4) (2024)
Jennifer L Small-Saunders, Ameya Sinha, Talia S Bloxham, Laura M Hagenah, Guangxin Sun, Peter Rainer Preiser, Peter C Dedon, David A Fidock
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nature microbiology 9 (6) (2024)
Lucien Platon, Didier Leroy, David A Fidock, Didier Ménard
Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin. Microbiology spectrum (2024)
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Jennifer L Small-Saunders, Ameya Sinha, Talia S Bloxham, Laura M Hagenah, Guangxin Sun, Peter Rainer Preiser, Peter C Dedon, David A Fidock
tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum. Nature microbiology 9 (6) (2024)
Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A Djimde, Marcus Chee San Lee, Laurent Dembélé, David A Fidock, David S Khoury, Thomas Spangenberg
Author Correction: Propensity of selecting mutant parasites for the antimalarial drug cabamiquine. Nature communications 14 (1) (2023)
Sachel Mok, Tomas Yeo, Davin Hong, Melanie J Shears, Leila S Ross, Kurt E Ward, Satish K Dhingra, Mariko Kanai, Jessica L Bridgford, Abhai K Tripathi, Godfree Mlambo, Anna Y Burkhard, Kate J Fairhurst, Eva Gil-Iturbe, Heekuk Park, Felix D Rozenberg, Jonathan Kim, Filippo Mancia, Matthias Quick, Anne-Catrin Uhlemann, Photini Sinnis, David A Fidock
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness. bioRxiv : the preprint server for biology (2023)
Laura M Hagenah, Satish K Dhingra, Jennifer L Small-Saunders, Tarrick Qahash, Andreas Willems, Kyra A Schindler, Gabriel W Rangel, Eva Gil-Iturbe, Jonathan Kim, Emiliya Akhundova, Tomas Yeo, John Okombo, Filippo Mancia, Matthias Quick, Paul D Roepe, Manuel Llinás, David A Fidock
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology. mBio (2023)
Eva Stadler, Mohamed Maiga, Lukas Friedrich, Vandana Thathy, Claudia Demarta-Gatsi, Antoine Dara, Fanta Sogore, Josefine Striepen, Claude Oeuvray, Abdoulaye A Djimde, Marcus Chee San Lee, Laurent Dembélé, David A Fidock, David S Khoury, Thomas Spangenberg
Propensity of selecting mutant parasites for the antimalarial drug cabamiquine. Nature communications 14 (1) (2023)
Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R Luth, Johanna Hoshizaki, Mukul Rawat, Richard D Pearson, Kyra A Schindler, Sachel Mok, Heekuk Park, Anne-Catrin Uhlemann, Gouranga P Jana, Bikash C Maity, Benoît Laleu, Elodie Chenu, James Duffy, Sonia Moliner Cubel, Virginia Franco, Maria G Gomez-Lorenzo, Francisco Javier Gamo, Elizabeth A Winzeler, David A Fidock, Thanat Chookajorn, Marcus Chee San Lee
Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum. Nature communications 14 (1) (2023)
Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M Early, Amanda K Lukens, Danny Milner, Jeremy D Furtado, Francisco-Javier Gamo, Elizabeth A Winzeler, Sarah K Volkman, Maëlle Duffey, Benoît Laleu, David A Fidock, Susan Wyllie, Jacquin C Niles, Dyann F Wirth
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature communications 14 (1) (2023)
Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M Early, Amanda K Lukens, Danny Milner, Jeremy D Furtado, Francisco-Javier Gamo, Elizabeth A Winzeler, Sarah K Volkman, Maëlle Duffey, Benoît Laleu, David A Fidock, Susan Wyllie, Jacquin C Niles, Dyann F Wirth
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature communications 14 (1) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M Early, Amanda K Lukens, Danny Milner, Jeremy D Furtado, Francisco-Javier Gamo, Elizabeth A Winzeler, Sarah K Volkman, Maëlle Duffey, Benoît Laleu, David A Fidock, Susan Wyllie, Jacquin C Niles, Dyann F Wirth
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature communications 14 (1) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Jair Lage Siqueira-Neto, Kathryn J Wicht, Kelly Chibale, Jeremy N Burrows, David A Fidock, Elizabeth A Winzeler
Antimalarial drug discovery: progress and approaches. Nature reviews. Drug discovery (2023)
Sachel Mok, Tomas Yeo, Davin Hong, Melanie J Shears, Leila S Ross, Kurt E Ward, Satish K Dhingra, Mariko Kanai, Jessica L Bridgford, Abhai K Tripathi, Godfree Mlambo, Anna Y Burkhard, Megan R Ansbro, Kate J Fairhurst, Eva Gil Iturbe, Heekuk Park, Felix D Rozenberg, Jonathan Kim, Filippo Mancia, Rick M Fairhurst, Matthias Quick, Anne-Catrin Uhlemann, Photini Sinnis, David A Fidock
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness. Science advances 9 (45) (2023)
Leann Tilley, Stanley C Xie, Yinuo Wang, Craig J Morton, Riley Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse Dunn, Madeline Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Katie Fairhurst, Tomas Yeo, Okan Yildirim, Mathamsanqa Bhebhe, Dana Klug, Peter J Rutledge, Luiz Godoy, Sumanta Dey, Mariana De Souza, Jair Siqueira-Neto, Nutpakal Ketprasit, Yawei Du, Mona Amini, Gerald J Shami, Shuai Nie, Nicholas A Williamson, Gouranga Jana, Bikash Maity, Patrick Thomson, Thomas Foley, Duangkamon Loesbanluechai, Tanya Puhalovich, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus Lee, Elizabeth Winzeler, Michael D W Griffin, Matthew H Todd
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Research square (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Selam Mihreteab, Lucien Platon, Araia Berhane, Barbara H Stokes, Marian Warsame, Pascal Campagne, Alexis Criscuolo, Laurence Ma, Nathalie Petiot, Cécile Doderer-Lang, Eric Legrand, Kurt E Ward, Assefash Zehaie Kassahun, Pascal Ringwald, David A Fidock, Didier Ménard
Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea. The New England journal of medicine 389 (13) (2023)
Lauren B Arendse, James M Murithi, Tarrick Qahash, Charisse Flerida A Pasaje, Luiz C Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria Jose Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte E van der Watt, Janette Reader, Ayesha S Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R Luth, Sabine Ottilie, Elizabeth A Winzeler, Lizette Leonie Koekemoer, Lyn-Marié Birkholtz, Jacquin C Niles, Manuel Llinás, David A Fidock, Kelly Chibale
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages. Science translational medicine 14 (667) (2022)
Deyun Qiu, Jinxin V Pei, James E O Rosling, Vandana Thathy, Dongdi Li, Yi Xue, John D Tanner, Jocelyn Sietsma Penington, Yi Tong Vincent Aw, Jessica Yi Han Aw, Guoyue Xu, Abhai K Tripathi, Nina F Gnadig, Tomas Yeo, Kate J Fairhurst, Barbara H Stokes, James M Murithi, Krittikorn Kümpornsin, Heath Hasemer, Adelaide S M Dennis, Melanie C Ridgway, Esther K Schmitt, Judith Straimer, Anthony T Papenfuss, Marcus Chee San Lee, Ben Corry, Photini Sinnis, David A Fidock, Giel G van Dooren, Kiaran Kirk, Adele M Lehane
A G358S mutation in the Plasmodium falciparum Na + pump PfATP4 confers clinically-relevant resistance to cipargamin. Nature communications 13 (1) (2022)
Jennifer L Small-Saunders, Laura M Hagenah, Kathryn J Wicht, Satish K Dhingra, Ioanna Deni, Jonathan Kim, Jeremie Vendome, Eva Gil Iturbe, Paul D Roepe, Monica Mehta, Filippo Mancia, Matthias Quick, Margaret J Eppstein, David A Fidock
Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance. PLoS pathogens 18 (2) (2022)
Laura E de Vries, Patrick A M Jansen, Catalina Barcelo, Justin Munro, Julie M J Verhoef, Charisse Flerida A Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M Bolscher, Claudia Demarta-Gatsi, Rob W M Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K Tumwebaze, Tomas Yeo, Anna C C Aguiar, Inigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael Victorio Carvalho Guido, María Belén Jiménez-Diaz, Dhelio Batista Pereira, Rosemary Rochford, Camille Roesch, Laura Maria Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A Cooper, Philip J Rosenthal, Robert W Sauerwein, Joost Schalkwijk, Pedro H H Hermkens, Roger V Bonnert, Brice Campo, David A Fidock, Manuel Llinás, Jacquin C Niles, Taco W A Kooij, Koen J Dechering
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nature communications 13 (1) (2022)
John Okombo, Sachel Mok, Tarrick Qahash, Tomas Yeo, Jade Bath, Lindsey M Orchard, Edward Owens, Imhoi Koo, Istvan Albert, Manuel Llinás, David A Fidock
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages. PLoS pathogens 18 (10) (2022)
Shivang S Shah, David A Fidock, Alice S Prince
Hemozoin Promotes Lung Inflammation via Host Epithelial Activation. mBio 12 (1) (2021)
Barbara H Stokes, Satish K Dhingra, Kelly Rubiano, Sachel Mok, Judith Straimer, Nina F Gnädig, Ioanna Deni, Kyra A Schindler, Jade R Bath, Kurt E Ward, Josefine Striepen, Tomas Yeo, Leila S Ross, Eric Legrand, Frédéric Ariey, Clark H Cunningham, Issa M Souleymane, Adama Gansané, Romaric Nzoumbou-Boko, Claudette Ndayikunda, Abdunoor M Kabanywanyi, Aline Uwimana, Samuel J Smith, Olimatou Kolley, Mathieu Ndounga, Marian Warsame, Rithea Leang, Francois H Nosten, Timothy Jc Anderson, Philip J Rosenthal, Didier Ménard, David A Fidock
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness. eLife 10 (2021)
Sachel Mok, Barbara H Stokes, Nina F Gnädig, Leila S Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R Bottrill, Jaishree Tripathi, Rick M Fairhurst, Manuel Llinás, Zbynek Bozdech, Andrew B Tobin, David A Fidock
Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival. Nature communications 12 (1) (2021)
Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Craig J Morton, Yawei Du, Con Dogovski, Shih-Chung Huang, Jeffrey Ciavarri, Paul Hales, Robert J Griffin, Lawrence H Cohen, Bei-Ching Chuang, Sergio Wittlin, Ioanna Deni, Tomas Yeo, Kurt E Ward, Daniel C Barry, Boyin Liu, David L Gillett, Benigno F Crespo-Fernandez, Sabine Ottilie, Nimisha Mittal, Alisje Churchyard, Daniel Ferguson, Anna Caroline Campos Aguiar, Rafael Victorio Carvalho Guido, Jake Baum, Kirsten K Hanson, Elizabeth A Winzeler, Francisco Javier Gamo, David A Fidock, Delphine Baud, Michael W Parker, Stephen Brand, Lawrence R Dick, Michael D W Griffin, Alexandra E Gould, Leann Tilley
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proceedings of the National Academy of Sciences of the United States of America 118 (39) (2021)
James M Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, Nina F Gnädig, Charisse Flerida A Pasaje, Kelly Rubiano, Tomas Yeo, Sachel Mok, Sylvie Klieber, Paul Desert, María Belén Jiménez-Díaz, Jutta Marfurt, Melanie Rouillier, Mohammed H Cherkaoui-Rbati, Nathalie Gobeau, Sergio Wittlin, Anne-Catrin Uhlemann, Richard N Price, Grennady Wirjanata, Rintis Noviyanti, Patrick Tumwebaze, Roland A Cooper, Philip J Rosenthal, Laura M Sanz, Francisco Javier Gamo, Jayan Joseph, Shivendra Singh, Sridevi Bashyam, Jean Michel Augereau, Elie Giraud, Tanguy Bozec, Thierry Vermat, Gilles Tuffal, Jean-Michel Guillon, Jérôme Menegotto, Laurent Sallé, Guillaume Louit, Marie-José Cabanis, Marie Françoise Nicolas, Michel Doubovetzky, Rita Merino, Nadir Bessila, Inigo Angulo-Barturen, Delphine Baud, Lidiya Bebrevska, Fanny Escudie, Jacquin C Niles, Benjamin Blasco, Simon Campbell, Gilles Courtemanche, Laurent Fraisse, Alain Pellet, David A Fidock, Didier Leroy
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. Science translational medicine 13 (603) (2021)
Vandana Thathy, David A Fidock
Malaria parasite beats the heat. Nature microbiology 6 (9) (2021)
Nina F Gnädig, Barbara H Stokes, Rachel L Edwards, Gavreel F Kalantarov, Kim C Heimsch, Michal Kuderjavy, Audrey Crane, Marcus C S Lee, Judith Straimer, Katja Becker, Ilya N Trakht, Audrey R Odom John, Sachel Mok, David A Fidock
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13. PLoS pathogens 16 (4) (2020)
Jennifer L Small-Saunders, Laura M Hagenah, David A Fidock
Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum? Nature reviews. Microbiology 18 (5) (2020)
Clare R Harding, Saima M Sidik, Boryana Petrova, Nina F Gnädig, John Okombo, Alice L Herneisen, Kurt E Ward, Benedikt M Markus, Elizabeth A Boydston, David A Fidock, Sebastian Lourido
Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility. Nature communications 11 (1) (2020)
Dipak K Raj, Alok Das Mohapatra, Anup Jnawali, Jenna Zuromski, Ambrish Jha, Gerald Cham-Kpu, Brett Sherman, Rachel M Rudlaff, Christina E Nixon, Nicholas Hilton, Andrew V Oleinikov, Olga Chesnokov, Jordan Merritt, Sunthorn Pond-Tor, Lauren Burns, Grant Jolly, Choukri Ben Mamoun, Edward Kabyemela, Atis Muehlenbachs, Lynn Lambert, Sachy Orr-Gonzalez, Nina F Gnädig, David A Fidock, Sangshin Park, Jeffrey D Dvorin, Norbert Pardi, Drew Weissman, Barbara L Mui, Ying K Tam, Jennifer F Friedman, Michal Fried, Patrick Emmet Duffy, Jonathan D Kurtis
Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria. Nature 582 (7810) (2020)
Gregory M LaMonte, Frances Rocamora, Danushka S Marapana, Nina F Gnädig, Sabine Ottilie, Madeline R Luth, Tilla S Worgall, Gregory M Goldgof, Roxanne Mohunlal, T R Santha Kumar, Jennifer K Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M Williams, Bing Yu Zou, Andrea L Cheung, Prianka Kumar, Timothy J Egan, Marcus C S Lee, Dionicio Siegel, Alan F Cowman, David A Fidock, Elizabeth A Winzeler
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. Nature communications 11 (1) (2020)
Nelson Victor Simwela, Barbara H Stokes, Dana Aghabi, Matthew M Bogyo, David A Fidock, Andrew P Waters
Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition. mBio 11 (6) (2020)
Luana C Mathieu, Horace Cox, Angela M Early, Sachel Mok, Yassamine Lazrek, Jeanne-Celeste Paquet, Maria-Paz Ade, Naomi W Lucchi, Quacy Grant, Venkatachalam Udhayakumar, Jean Sf Alexandre, Magalie Demar, Pascal Ringwald, Daniel E Neafsey, David A Fidock, Lise Musset
Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance. eLife 9 (2020)
Tina S Skinner-Adams, Gillian M Fisher, Andrew G Riches, Oliver E Hutt, Karen E Jarvis, Tony Wilson, Mark von Itzstein, Pradeep Chopra, Yevgeniya Antonova-Koch, Stephan Meister, Elizabeth A Winzeler, Mary Clarke, David A Fidock, Jeremy N Burrows, John H Ryan, Katherine T Andrews
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone. Communications biology 2 (2019)
Satish K Dhingra, Stanislaw J Gabryszewski, Jennifer L Small-Saunders, Tomas Yeo, Philipp P Henrich, Sachel Mok, David A Fidock
Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness. mBio 10 (2) (2019)
Barbara H Stokes, Euna Yoo, James M Murithi, Madeline R Luth, Pavel Afanasyev, Paula C A da Fonseca, Elizabeth A Winzeler, Caroline L Ng, Matthew M Bogyo, David A Fidock
Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. PLoS pathogens 15 (6) (2019)
Kyle Jarrod McLean, Judith Straimer, Christine S Hopp, Joel Vega-Rodriguez, Jennifer L Small-Saunders, Sachie Kanatani, Abhai Tripathi, Godfree Mlambo, Peter C Dumoulin, Chantal T Harris, Xinran Tong, Melanie J Shears, Johan Ankarklev, Björn F C Kafsack, David A Fidock, Photini Sinnis
Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters. Scientific reports 9 (1) (2019)
Yevgeniya Antonova-Koch, Stephan Meister, Matthew Abraham, Madeline R Luth, Sabine Ottilie, Amanda K Lukens, Tomoyo Sakata-Kato, Manu Vanaerschot, Edward Owen, Juan Carlos Jado, Steven P Maher, Jaeson Santos Calla-Choque, David Plouffe, Yang Zhong, Kaisheng Chen, Victor Chaumeau, Amy J Conway, Case W McNamara, Maureen Ibanez, Kerstin Gagaring, Fernando Neria Serrano, Korina Eribez, Cullin McLean Taggard, Andrea L Cheung, Christie Lincoln, Biniam Ambachew, Melanie Rouillier, Dionicio Siegel, Francois H Nosten, Dennis E Kyle, Francisco-Javier Gamo, Yingyao Zhou, Manuel Llinás, David A Fidock, Dyann F Wirth, Jeremy N Burrows, Brice Campo, Elizabeth A Winzeler
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science (New York, N.Y.) 362 (6419) (2019)
Annie N Cowell, Eva S Istvan, Amanda K Lukens, Maria G Gomez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata-Kato, Erika L Flannery, Pamela Magistrado, Edward Owen, Matthew Abraham, Gregory LaMonte, Heather J Painter, Roy M Williams, Virginia Franco, María Linares, Ignacio Arriaga, Selina Bopp, Victoria C Corey, Nina F Gnädig, Olivia Coburn-Flynn, Christin Reimer, Purva Gupta, James M Murithi, Pedro A Moura, Olivia Fuchs, Erika Sasaki, Sang W Kim, Christine H Teng, Lawrence T Wang, Aslı Akidil, Sophie Adjalley, Paul A Willis, Dionicio Siegel, Olga Tanaseichuk, Yang Zhong, Yingyao Zhou, Manuel Llinás, Sabine Ottilie, Francisco-Javier Gamo, Marcus Chee San Lee, Daniel E Goldberg, David A Fidock, Dyann F Wirth, Elizabeth A Winzeler
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science (New York, N.Y.) 359 (6372) (2018)
Evelien M Bunnik, Kate B Cook, Nelle Varoquaux, Gayani Batugedara, Jacques Prudhomme, Anthony Cort, Lirong Shi, Chiara Andolina, Leila S Ross, Declan Brady, David A Fidock, Francois H Nosten, Rita Tewari, Photini Sinnis, Ferhat Ay, Jean-Philippe Vert, William Stafford Noble, Karine G Le Roch
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages. Nature communications 9 (1) (2018)
Satish K Dhingra, Devasha Redhi, Jill M Combrinck, Tomas Yeo, John Okombo, Philipp P Henrich, Annie N Cowell, Purva Gupta, Matthew L Stegman, Jonathan M Hoke, Roland A Cooper, Elizabeth Winzeler, Sachel Mok, Timothy J Egan, David A Fidock
A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine. mBio 8 (3) (2017)
Mahsa Rahbari, Stefan Rahlfs, Jude M Przyborski, Anna Katharina Schuh, Nicholas H Hunt, David A Fidock, Georges E Grau, Katja Becker
Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes. Scientific reports 7 (1) (2017)
L Dembele, X Ang, M Chavchich, Ghislain M C Bonamy, J J Selva, M Yi-Xiu Lim, C Bodenreider, B K S Yeung, Francois H Nosten, Bruce M Russell, M D Edstein, J Straimer, David A Fidock, T T Diagana, P Bifani
The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites. Scientific reports 7 (1) (2017)
Judith Straimer, Nina F Gnädig, Barbara H Stokes, Michelle Ehrenberger, Audrey A Crane, David A Fidock
Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro. mBio 8 (2) (2017)
Manu Vanaerschot, Leonardo Lucantoni, Tao Li, Jill M Combrinck, Andrea Ruecker, T R Santha Kumar, Kelly Rubiano, Pedro Eduardo Ferreira, Giulia Siciliano, Sonia Gulati, Philipp P Henrich, Caroline L Ng, James M Murithi, Victoria C Corey, Sandra Duffy, Ori J Lieberman, Maria Isabel Veiga, Robert E Sinden, Pietro Alano, Michael J Delves, Kim Lee Sim, Elizabeth A Winzeler, Timothy J Egan, Stephen L Hoffman, Vicky Marie Avery, David A Fidock
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity. Nature microbiology 2 (10) (2017)
Benjamin Blasco, Didier Leroy, David A Fidock
Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic. Nature medicine 23 (8) (2017)
Paul M O'Neill, Richard K Amewu, Susan A Charman, Sunil Sabbani, Nina F Gnädig, Judith Straimer, David A Fidock, Emma R Shore, Natalie L Roberts, Michael H-L Wong, W David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M Shackleford, Simon Campbell, Dennis A Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N Price, Jutta Marfurt, Michael J Palmer, Ian M Copple, Amy E Mercer, Andrea Ruecker, Michael J Delves, Robert E Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H M Kocken, Anne-Marie Zeeman, Gemma L Nixon, Giancarlo A Biagini, Stephen A Ward
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nature communications 8 (2017)
Ebere Sonoiki, Caroline L Ng, Marcus C S Lee, Denghui Guo, Yong-Kang Zhang, Yasheen Zhou, M R K Alley, Vida Ahyong, Laura M Sanz, Maria Jose Lafuente-Monasterio, Chen Dong, Patrick G Schupp, Jiri Gut, Jenny Legac, Roland A Cooper, Francisco-Javier Gamo, Joseph DeRisi, Yvonne R Freund, David A Fidock, Philip J Rosenthal
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nature communications 8 (2017)
Stanislaw J Gabryszewski, Satish K Dhingra, Jill M Combrinck, Ian A Lewis, Paul S Callaghan, Matthew R Hassett, Amila Siriwardana, Philipp P Henrich, Andrew H Lee, Nina F Gnädig, Lise Musset, Manuel Llinás, Timothy J Egan, Paul D Roepe, David A Fidock
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology. PLoS pathogens 12 (11) (2016)
Amélie Le Bihan, Ruben de Kanter, Iñigo Angulo-Barturen, Christoph Binkert, Christoph Boss, Reto Brun, Ralf Brunner, Stephan Buchmann, Jeremy N Burrows, Koen J Dechering, Michael Delves, Sonja Ewerling, Santiago Ferrer, Christoph Fischli, Francisco Javier Gamo-Benito, Nina F Gnädig, Bibia Heidmann, María Belén Jiménez-Díaz, Didier Leroy, Maria Santos Martínez, Solange Meyer, Joerg J Moehrle, Caroline L Ng, Rintis Noviyanti, Andrea Ruecker, Laura María Sanz, Robert W Sauerwein, Christian Scheurer, Sarah Schleiferboeck, Robert Sinden, Christopher Snyder, Judith Straimer, Grennady Wirjanata, Jutta Marfurt, Richard N Price, Thomas Weller, Walter Fischli, David A Fidock, Martine Clozel, Sergio Wittlin
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling. PLoS medicine 13 (10) (2016)
Shahul Hameed P, Suresh Solapure, Vikas Patil, Philipp P Henrich, Pamela A Magistrado, Sowmya Bharath, Kannan Murugan, Pavithra Viswanath, Jayashree Puttur, Abhishek Srivastava, Eknath Bellale, Vijender Panduga, Gajanan Shanbag, Disha Awasthy, Sudhir Landge, Sapna Morayya, Krishna Koushik, Ramanatha Saralaya, Anandkumar Raichurkar, Nikhil Rautela, Nilanjana Roy Choudhury, Anisha Ambady, Radha Nandishaiah, Jitendar Reddy, K R Prabhakar, Sreenivasaiah Menasinakai, Suresh Rudrapatna, Monalisa Chatterji, María Belén Jiménez-Díaz, María Santos Martínez, Laura María Sanz, Olivia Coburn-Flynn, David A Fidock, Amanda K Lukens, Dyann F Wirth, Balachandra Bandodkar, Kakoli Mukherjee, Robert E McLaughlin, David Waterson, Lyn Rosenbrier-Ribeiro, Kevin Hickling, V Balasubramanian, Peter Warner, Vinayak Hosagrahara, Adam Dudley, Pravin S Iyer, Shridhar Narayanan, Stefan Kavanagh, Vasan K Sambandamurthy
Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate. Nature communications 6 (2015)

David A Fidock (David Fidock, D A Fidock)

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