Jacquin C Niles (Jacquin Niles)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 32

Top Topics

Protein Protein

Plasmodium Falciparum

Endoscopic Submucosal Dissection

Top Venues

Nature communications

Science translational medicine

Journal of medicinal chemistry

ACS infectious diseases

This page only lists publications with an associated author ORCID identifier.

Publications

Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry 67 (13) (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry 67 (13) (2024)
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry 67 (13) (2024)
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Stanley C Xie, Yinuo Wang, Craig J Morton, Riley D Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse A Dunn, Madeline R Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Kate J Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N Bhebhe, Dana M Klug, Peter J Rutledge, Luiz C Godoy, Sumanta Dey, Mariana Laureano de Souza, Jair L Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerald J Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas A Williamson, Gouranga P Jana, Bikash C Maity, Patrick Thomson, Thomas Foley, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus C S Lee, Elizabeth A Winzeler, Michael D W Griffin, Matthew H Todd, Leann Tilley
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature communications 15 (1) (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry 67 (13) (2024)
Godwin Akpeko Dziwornu, Tswene D Seanego, Stephen Fienberg, Monica Clements, Jasmin Ferreira, Venkata S Sypu, Sauvik Samanta, Ashlyn D Bhana, Constance M Korkor, Larnelle F Garnie, Nicole Teixeira, Kathryn J Wicht, Dale Taylor, Ronald Olckers, Mathew Njoroge, Liezl Gibhard, Nicolaas Salomane, Sergio Wittlin, Rohit Mahato, Arnish Chakraborty, Nicole Sevilleno, Rachael Coyle, Marcus C S Lee, Luiz C Godoy, Charisse Flerida Pasaje, Jacquin C Niles, Janette Reader, Mariette van der Watt, Lyn-Marié Birkholtz, Judith M Bolscher, Marloes H C de Bruijni, Lauren B Coulson, Gregory S Basarab, Sandeep R Ghorpade, Kelly Chibale
2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy. Journal of medicinal chemistry (2024)
Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M Early, Amanda K Lukens, Danny Milner, Jeremy D Furtado, Francisco-Javier Gamo, Elizabeth A Winzeler, Sarah K Volkman, Maëlle Duffey, Benoît Laleu, David A Fidock, Susan Wyllie, Jacquin C Niles, Dyann F Wirth
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature communications 14 (1) (2023)
Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M Early, Amanda K Lukens, Danny Milner, Jeremy D Furtado, Francisco-Javier Gamo, Elizabeth A Winzeler, Sarah K Volkman, Maëlle Duffey, Benoît Laleu, David A Fidock, Susan Wyllie, Jacquin C Niles, Dyann F Wirth
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature communications 14 (1) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Selina Bopp, Charisse Flerida A Pasaje, Robert L Summers, Pamela Magistrado-Coxen, Kyra A Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S Nasamu, Allison R Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M Early, Amanda K Lukens, Danny Milner, Jeremy D Furtado, Francisco-Javier Gamo, Elizabeth A Winzeler, Sarah K Volkman, Maëlle Duffey, Benoît Laleu, David A Fidock, Susan Wyllie, Jacquin C Niles, Dyann F Wirth
Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature communications 14 (1) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Dylan Valleau, Saima M Sidik, Luiz C Godoy, Yamilex Acevedo-Sánchez, Charisse Flerida A Pasaje, My-Hang Huynh, Vern B Carruthers, Jacquin C Niles, Sebastian Lourido
A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma. The EMBO journal (2023)
Leann Tilley, Stanley C Xie, Yinuo Wang, Craig J Morton, Riley Metcalfe, Con Dogovski, Charisse Flerida A Pasaje, Elyse Dunn, Madeline Luth, Krittikorn Kumpornsin, Eva S Istvan, Joon Sung Park, Katie Fairhurst, Tomas Yeo, Okan Yildirim, Mathamsanqa Bhebhe, Dana Klug, Peter J Rutledge, Luiz Godoy, Sumanta Dey, Mariana De Souza, Jair Siqueira-Neto, Nutpakal Ketprasit, Yawei Du, Mona Amini, Gerald J Shami, Shuai Nie, Nicholas A Williamson, Gouranga Jana, Bikash Maity, Patrick Thomson, Thomas Foley, Duangkamon Loesbanluechai, Tanya Puhalovich, Derek S Tan, Jacquin C Niles, Byung Woo Han, Daniel E Goldberg, Jeremy N Burrows, David A Fidock, Marcus Lee, Elizabeth Winzeler, Michael D W Griffin, Matthew H Todd
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Research square (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Lauren B Arendse, James M Murithi, Tarrick Qahash, Charisse Flerida A Pasaje, Luiz C Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria Jose Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte E van der Watt, Janette Reader, Ayesha S Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R Luth, Sabine Ottilie, Elizabeth A Winzeler, Lizette Leonie Koekemoer, Lyn-Marié Birkholtz, Jacquin C Niles, Manuel Llinás, David A Fidock, Kelly Chibale
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages. Science translational medicine 14 (667) (2022)
Stanley C Xie, Riley D Metcalfe, Elyse A Dunn, Craig J Morton, Shih-Chung Huang, Tanya Puhalovich, Yawei Du, Sergio Wittlin, Shuai Nie, Madeline R Luth, Liting Ma, Mi-Sook Kim, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Carlo Giannangelo, Fiona J Houghton, Alisje Churchyard, Mufuliat T Famodimu, Daniel C Barry, David L Gillett, Sumanta Dey, Clara C Kosasih, William Newman, Jacquin C Niles, Marcus Chee San Lee, Jake Baum, Sabine Ottilie, Elizabeth A Winzeler, Darren John Creek, Nicholas A Williamson, Michael W Parker, Stephen Brand, Steven P Langston, Lawrence R Dick, Michael D W Griffin, Alexandra E Gould, Leann Tilley
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science (New York, N.Y.) 376 (6597) (2022)
Marvin Chew, Weijian Ye, Radoslaw Igor Omelianczyk, Charisse Flerida A Pasaje, Regina Hoo, Qingfeng Chen, Jacquin C Niles, Jianzhu Chen, Peter Rainer Preiser
Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo. Nature communications 13 (1) (2022)
Thomas Hollin, Steven Abel, Alejandra Falla, Charisse Flerida A Pasaje, Anil Bhatia, Manhoi Hur, Jay S Kirkwood, Anita Saraf, Jacques Prudhomme, Amancio De Souza, Laurence A Florens, Jacquin C Niles, Karine Le Roch
Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum. Nature communications 13 (1) (2022)
Laura E de Vries, Patrick A M Jansen, Catalina Barcelo, Justin Munro, Julie M J Verhoef, Charisse Flerida A Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M Bolscher, Claudia Demarta-Gatsi, Rob W M Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K Tumwebaze, Tomas Yeo, Anna C C Aguiar, Inigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael Victorio Carvalho Guido, María Belén Jiménez-Diaz, Dhelio Batista Pereira, Rosemary Rochford, Camille Roesch, Laura Maria Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A Cooper, Philip J Rosenthal, Robert W Sauerwein, Joost Schalkwijk, Pedro H H Hermkens, Roger V Bonnert, Brice Campo, David A Fidock, Manuel Llinás, Jacquin C Niles, Taco W A Kooij, Koen J Dechering
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nature communications 13 (1) (2022)
Ian C Michelow, Sangshin Park, Shu-Whei Tsai, Bonnie Rayta, Charisse Flerida A Pasaje, Sara Nelson, Angela M Early, Anne E P Frosch, George Ayodo, Dipak K Raj, Christina E Nixon, Christian P Nixon, Sunthorn Pond-Tor, Jennifer F Friedman, Michal Fried, Patrick Emmet Duffy, Karine Le Roch, Jacquin C Niles, Jonathan D Kurtis
A newly characterized malaria antigen on erythrocyte and merozoite surfaces induces parasite inhibitory antibodies. The Journal of experimental medicine 218 (9) (2021)
Masanori Okaniwa, Akira Shibata, Atsuko Ochida, Yuichiro Akao, Karen L White, David M Shackleford, Sandra Duffy, Leonardo Lucantoni, Sumanta Dey, Josefine Striepen, Tomas Yeo, Sachel Mok, Anna Caroline C Aguiar, Angelika Sturm, Benigno Crespo, Laura M Sanz, Alisje Churchyard, Jake Baum, Dhelio B Pereira, Rafael V C Guido, Koen J Dechering, Sergio Wittlin, Anne-Catrin Uhlemann, David A Fidock, Jacquin C Niles, Vicky M Avery, Susan A Charman, Benoît Laleu
Repositioning and Characterization of 1-(Pyridin-4-yl)pyrrolidin-2-one Derivatives as Plasmodium Cytoplasmic Prolyl-tRNA Synthetase Inhibitors. ACS infectious diseases 7 (6) (2021)
James M Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, Nina F Gnädig, Charisse Flerida A Pasaje, Kelly Rubiano, Tomas Yeo, Sachel Mok, Sylvie Klieber, Paul Desert, María Belén Jiménez-Díaz, Jutta Marfurt, Melanie Rouillier, Mohammed H Cherkaoui-Rbati, Nathalie Gobeau, Sergio Wittlin, Anne-Catrin Uhlemann, Richard N Price, Grennady Wirjanata, Rintis Noviyanti, Patrick Tumwebaze, Roland A Cooper, Philip J Rosenthal, Laura M Sanz, Francisco Javier Gamo, Jayan Joseph, Shivendra Singh, Sridevi Bashyam, Jean Michel Augereau, Elie Giraud, Tanguy Bozec, Thierry Vermat, Gilles Tuffal, Jean-Michel Guillon, Jérôme Menegotto, Laurent Sallé, Guillaume Louit, Marie-José Cabanis, Marie Françoise Nicolas, Michel Doubovetzky, Rita Merino, Nadir Bessila, Inigo Angulo-Barturen, Delphine Baud, Lidiya Bebrevska, Fanny Escudie, Jacquin C Niles, Benjamin Blasco, Simon Campbell, Gilles Courtemanche, Laurent Fraisse, Alain Pellet, David A Fidock, Didier Leroy
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. Science translational medicine 13 (603) (2021)
Barbara Forte, Sabine Ottilie, Andrew Plater, Brice Campo, Koen J Dechering, Francisco Javier Gamo, Daniel E Goldberg, Eva S Istvan, Marcus Lee, Amanda K Lukens, Case W MacNamara, Jacquin C Niles, John Okombo, Charisse Flerida A Pasaje, Miles G Siegel, Dyann Wirth, Susan Wyllie, David A Fidock, Beatriz Baragaña, Elizabeth A Winzeler, Ian H Gilbert
Prioritization of Molecular Targets for Antimalarial Drug Discovery. ACS infectious diseases 7 (10) (2021)
Alexander J Polino, Armiyaw S Nasamu, Jacquin C Niles, Daniel E Goldberg
Assessment of Biological Role and Insight into Druggability of the Plasmodium falciparum Protease Plasmepsin V. ACS infectious diseases 6 (4) (2020)
Ankit Gupta, Abdullah A B Bokhari, Ajay D Pillai, Anna K Crater, Jeanine Gezelle, Gagandeep Saggu, Armiyaw S Nasamu, Suresh M Ganesan, Jacquin C Niles, Sanjay Arvind Desai
Complex nutrient channel phenotypes despite Mendelian inheritance in a Plasmodium falciparum genetic cross. PLoS pathogens 16 (2) (2020)
Kuan-Yi Lu, Charisse Flerida A Pasaje, Tamanna Srivastava, David R Loiselle, Jacquin C Niles, Emily R Derbyshire
Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death. eLife 9 (2020)
Armiyaw S Nasamu, Svetlana Glushakova, Ilaria Russo, Barbara Vaupel, Anna Oksman, Arthur S Kim, Daved H Fremont, Niraj Tolia, Josh R Beck, Marvin J Meyers, Jacquin C Niles, Joshua Zimmerberg, Daniel E Goldberg
Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion. Science (New York, N.Y.) 358 (6362) (2018)
Matthias Garten, Armiyaw S Nasamu, Jacquin C Niles, Joshua Zimmerberg, Daniel E Goldberg, Josh R Beck
EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX. Nature microbiology 3 (10) (2018)