Bernhard Wünsch

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 89

Top Venues

ChemMedChem

Biological chemistry

Journal of medicinal chemistry

Archiv der Pharmazie

Westfalische Wilhelms Universität Munster

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Westfalische Wilhelms Universität Munster Oct 01 2002

Germany

Professor :: Chemie und Pharmazie

Publications

Friederike Rathing, Dirk Schepmann, Bernhard Wünsch
Quinolone bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists. Archiv der Pharmazie 357 (9) (2024)
Tobias Winge, Ben Perry, An Matheeussen, Guy Caljon, Bernhard Wünsch
Late-Stage Diversification of Pyrazoles as Antileishmanial Agents. ChemMedChem (2024)
Tobias Winge, Lukas Imberg, Ben Perry, An Matheeussen, Guy Caljon, Dmitrii Kalinin, Bernhard Wünsch
N-Pyrazolyl- and N-Triazolylamines and -Ureas as Antileishmanial and Antitrypanosomal Drugs. ChemMedChem 19 (15) (2024)
Tobias Winge, Ben Perry, An Matheeussen, Guy Caljon, Bernhard Wünsch
Late-Stage Diversification of Pyrazoles as Antileishmanial Agents. ChemMedChem 19 (8) (2024)
Tobias Winge, Lukas Imberg, Ben Perry, An Matheeussen, Guy Caljon, Dmitrii Kalinin, Bernhard Wünsch
N-Pyrazolyl- and N-Triazolylamines and -Ureas as Antileishmanial and Antitrypanosomal Drugs. ChemMedChem (2024)
Friederike Rathing, Dirk Schepmann, Bernhard Wünsch
Quinolone bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists. Archiv der Pharmazie (2024)
Friedrich-Alexander Ludwig, Erik Laurini, Judith Schmidt, Sabrina Pricl, Winnie Deuther-Conrad, Bernhard Wünsch
[ 18 F]Fluspidine-A PET Tracer for Imaging of σ 1 Receptors in the Central Nervous System. Pharmaceuticals (Basel, Switzerland) 17 (2) (2024)
Tobias Winge, Ben Perry, An Matheeussen, Guy Caljon, Bernhard Wünsch
Late-Stage Diversification of Pyrazoles as Antileishmanial Agents. ChemMedChem 19 (8) (2024)
Friedrich-Alexander Ludwig, Erik Laurini, Judith Schmidt, Sabrina Pricl, Winnie Deuther-Conrad, Bernhard Wünsch
[ 18 F]Fluspidine-A PET Tracer for Imaging of σ 1 Receptors in the Central Nervous System. Pharmaceuticals (Basel, Switzerland) 17 (2) (2024)
Luca Blicker, Rafael González-Cano, Erik Laurini, Francisco R Nieto, Judith Schmidt, Dirk Schepmann, Sabrina Pricl, Bernhard Wünsch
Conformationally Restricted σ 1 Receptor Antagonists from (-)-Isopulegol. Journal of medicinal chemistry (2023)
Marvin Korff, Judith Lüken, Judith Schmidt, Dirk Schepmann, Gunnar Goerges, Nadine Ritter, Paul Disse, Julian A Schreiber, Guiscard Seebohm, Bernhard Wünsch
Negative allosteric modulators of NMDA receptors with GluN2B subunit: synthesis of β-aminoalcohols by epoxide opening and subsequent rearrangement. Organic & biomolecular chemistry (2023)
Tobias Winge, Dirk Schepmann, Judith Schmidt, Constantin Gabriel Daniliuc, Ernst-Ulrich Würthwein, Bernhard Wünsch
Diastereoselective synthesis and structure-affinity relationships of σ 1 receptor ligands with spirocyclic scaffold. Organic & biomolecular chemistry (2023)
Marvin Korff, Ahmad Chaudhary, Yinlong Li, Xin Zhou, Chunyu Zhao, Jian Rong, Jiahui Chen, Zhiwei Xiao, Nehal H Elghazawy, Wolfgang Sippl, April T Davenport, James B Daunais, Lu Wang, Carmen Abate, Hazem Ahmed, Ron Crowe, Thomas J Schmidt, Steven H Liang, Simon M Ametamey, Bernhard Wünsch, Ahmed Haider
Synthesis and Biological Evaluation of Enantiomerically Pure ( R ) - and ( S ) - [18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors. Journal of medicinal chemistry (2023)
Paul Disse, Isabel Aymanns, Nadine Ritter, Stefan Peischard, Lisanne Korn, Heinz Wiendl, Matthias Pawlowski, Stjepana Kovac, Sven Guenther Meuth, Thomas Budde, Nathalie Strutz-Seebohm, Bernhard Wünsch, Guiscard Seebohm
A novel NMDA receptor test model based on hiPSC-derived neural cells. Biological chemistry 404 (4) (2023)
Bernhard Wünsch
Highlight: chemical biology of ion channels. Biological chemistry 404 (4) (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Maurice Dellin, Ina Rohrbeck, Purva Asrani, Julian A Schreiber, Nadine Ritter, Frank Glorius, Bernhard Wünsch, Thomas Budde, Louisa Temme, Timo Strünker, Birgit Stallmeyer, Frank Tüttelmann, Sven G Meuth, Marc Spehr, Johann Matschke, Andrea Steinbicker, Christos Gatsogiannis, Raphael Stoll, Nathalie Strutz-Seebohm, Guiscard Seebohm
The second PI(3,5)P 2 binding site in the S0 helix of KCNQ1 stabilizes PIP 2 -at the primary PI1 site with potential consequences on intermediate-to-open state transition. Biological chemistry (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Maurice Dellin, Ina Rohrbeck, Purva Asrani, Julian A Schreiber, Nadine Ritter, Frank Glorius, Bernhard Wünsch, Thomas Budde, Louisa Temme, Timo Strünker, Birgit Stallmeyer, Frank Tüttelmann, Sven G Meuth, Marc Spehr, Johann Matschke, Andrea Steinbicker, Christos Gatsogiannis, Raphael Stoll, Nathalie Strutz-Seebohm, Guiscard Seebohm
The second PI(3,5)P 2 binding site in the S0 helix of KCNQ1 stabilizes PIP 2 -at the primary PI1 site with potential consequences on intermediate-to-open state transition. Biological chemistry 404 (4) (2023)
Paul Disse, Isabel Aymanns, Nadine Ritter, Stefan Peischard, Lisanne Korn, Heinz Wiendl, Matthias Pawlowski, Stjepana Kovac, Sven Guenther Meuth, Thomas Budde, Nathalie Strutz-Seebohm, Bernhard Wünsch, Guiscard Seebohm
A novel NMDA receptor test model based on hiPSC-derived neural cells. Biological chemistry 404 (4) (2023)
Bengisu Turgutalp, Prabesh Bhattarai, Tugba Ercetin, Chiara Luise, Rengin Reis, Enise Ece Gurdal, Andreas Isaak, Derya Biriken, Elisabeth Dinter, Hande Sipahi, Dirk Schepmann, Anna Junker, Bernhard Wünsch, Wolfgang Sippl, Hayrettin Ozan Gulcan, Caghan Kizil, Mine Yarim
Correction to "Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease". Journal of medicinal chemistry (2023)
Amal El Daibani, Joseph M Paggi, Kuglae Kim, Yianni D Laloudakis, Petr Popov, Sarah M Bernhard, Brian E Krumm, Reid H J Olsen, Jeffrey Diberto, F Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O Dror, Tao Che
Molecular mechanism of biased signaling at the kappa opioid receptor. Nature communications 14 (1) (2023)
Judith Lüken, Gunnar Goerges, Nadine Ritter, Paul Disse, Julian A Schreiber, Judith Schmidt, Bastian Frehland, Dirk Schepmann, Guiscard Seebohm, Bernhard Wünsch
Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists. Journal of medicinal chemistry (2023)
Paul Disse, Isabel Aymanns, Nadine Ritter, Stefan Peischard, Lisanne Korn, Heinz Wiendl, Matthias Pawlowski, Stjepana Kovac, Sven Guenther Meuth, Thomas Budde, Nathalie Strutz-Seebohm, Bernhard Wünsch, Guiscard Seebohm
A novel NMDA receptor test model based on hiPSC-derived neural cells. Biological chemistry 404 (4) (2023)
Maurice Dellin, Ina Rohrbeck, Purva Asrani, Julian A Schreiber, Nadine Ritter, Frank Glorius, Bernhard Wünsch, Thomas Budde, Louisa Temme, Timo Strünker, Birgit Stallmeyer, Frank Tüttelmann, Sven G Meuth, Marc Spehr, Johann Matschke, Andrea Steinbicker, Christos Gatsogiannis, Raphael Stoll, Nathalie Strutz-Seebohm, Guiscard Seebohm
The second PI(3,5)P 2 binding site in the S0 helix of KCNQ1 stabilizes PIP 2 -at the primary PI1 site with potential consequences on intermediate-to-open state transition. Biological chemistry 404 (4) (2023)
Bernhard Wünsch
Highlight: chemical biology of ion channels. Biological chemistry (2023)
Bengisu Turgutalp, Prabesh Bhattarai, Tugba Ercetin, Chiara Luise, Rengin Reis, Enise Ece Gurdal, Andreas Isaak, Derya Biriken, Elisabeth Dinter, Hande Sipahi, Dirk Schepmann, Anna Junker, Bernhard Wünsch, Wolfgang Sippl, Hayrettin Ozan Gulcan, Caghan Kizil, Mine Yarim
Correction to "Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease". Journal of medicinal chemistry 66 (2) (2023)
Paul Disse, Isabel Aymanns, Nadine Ritter, Stefan Peischard, Lisanne Korn, Heinz Wiendl, Matthias Pawlowski, Stjepana Kovac, Sven Guenther Meuth, Thomas Budde, Nathalie Strutz-Seebohm, Bernhard Wünsch, Guiscard Seebohm
A novel NMDA receptor test model based on hiPSC-derived neural cells. Biological chemistry (2023)
Giacomo Rossino, Annamaria Marra, Roberta Listro, Marco Peviani, Elena Poggio, Daniela Curti, Giorgia Pellavio, Umberto Laforenza, Giulio Dondio, Dirk Schepmann, Bernhard Wünsch, Martina Bedeschi, Noemi Marino, Anna Tesei, Hee-Jin Ha, Young Ho Kim, Jihyae Ann, Jeewoo Lee, Pasquale Linciano, Marcello Di Giacomo, Daniela Rossi, Simona Collina
Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain. Pharmaceuticals (Basel, Switzerland) 16 (7) (2023)
Bernhard Wünsch
Highlight: chemical biology of ion channels. Biological chemistry 404 (4) (2023)
Nadine Ritter, Paul Disse, Bernhard Wünsch, Guiscard Seebohm, Nathalie Strutz-Seebohm
Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes. Biomedicines 11 (5) (2023)
Maurice Dellin, Ina Rohrbeck, Purva Asrani, Julian A Schreiber, Nadine Ritter, Frank Glorius, Bernhard Wünsch, Thomas Budde, Louisa Temme, Timo Strünker, Birgit Stallmeyer, Frank Tüttelmann, Sven G Meuth, Marc Spehr, Johann Matschke, Andrea Steinbicker, Christos Gatsogiannis, Raphael Stoll, Nathalie Strutz-Seebohm, Guiscard Seebohm
The second PI(3,5)P 2 binding site in the S0 helix of KCNQ1 stabilizes PIP 2 -at the primary PI1 site with potential consequences on intermediate-to-open state transition. Biological chemistry 404 (4) (2023)
Bernhard Wünsch
Highlight: chemical biology of ion channels. Biological chemistry 404 (4) (2023)
Christian Paul Konken, Kathrin Heßling, Insa Thale, Sonja Schelhaas, Jennifer Dabel, Sarah Maskri, Etmar Bulk, Thomas Budde, Oliver Koch, Albrecht Schwab, Michael Schäfers, Bernhard Wünsch
Imaging of the calcium activated potassium channel 3.1 (K Ca 3.1) in vivo using a senicapoc-derived positron emission tomography tracer. Archiv der Pharmazie 355 (12) (2022)
Insa Thale, Sarah Maskri, Lucie Grey, Luca Matteo Todesca, Thomas Budde, Ivan Maisuls, Cristian A Strassert, Oliver Koch, Albrecht Schwab, Bernhard Wünsch
Imaging of K Ca 3.1 Channels in Tumor Cells with PET and Small-Molecule Fluorescent Probes. ChemMedChem (2022)
Tobias Schierling, Beatrice Tosi, Clara Eisenhardt, Sophie Reining, Constantin Gabriel Daniliuc, Christoph Brenker, Timo Strünker, Bernhard Wünsch
Synthesis and Functional Characterization of Novel RU1968-Derived CatSper Inhibitors with Reduced Stereochemical Complexity. ACS pharmacology & translational science 6 (1) (2022)
Catharina Holtschulte, Frederik Börgel, Stefanie Westphälinger, Dirk Schepmann, Gianluca Civenni, Erik Laurini, Domenico Marson, Carlo V Catapano, Sabrina Pricl, Bernhard Wünsch
Synthesis of Aminoethyl-Substituted Piperidine Derivatives as σ 1 Receptor Ligands with Antiproliferative Properties. ChemMedChem 17 (7) (2022)
Julian Alexander Schreiber, Melina Möller, Mark Zaydman, Lu Zhao, Zachary Beller, Sebastian Becker, Nadine Ritter, Panpan Hou, Jingyi Shi, Jon Silva, Eva Wrobel, Nathalie Strutz-Seebohm, Niels Decher, Nicole Schmitt, Sven G Meuth, Martina Düfer, Bernhard Wünsch, Jianmin Cui, Guiscard Seebohm
A benzodiazepine activator locks K v 7.1 channels open by electro-mechanical uncoupling. Communications biology 5 (1) (2022)
Alexander Markus, Bastian Frehland, Dirk Schepmann, Bernhard Wünsch
Negative allosteric modulators of NMDA receptors with GluN2B subunit: Alanine-derived benzoxazolone bioisosteres of 2-methyl-3-benzazepine-1,7-diols. Archiv der Pharmazie 355 (9) (2022)
Ruben Steigerwald, Tsung-Han Chou, Hiro Furukawa, Bernhard Wünsch
GluN2A-Selective NMDA Receptor Antagonists: Mimicking the U-Shaped Bioactive Conformation of TCN-201 by a [2.2]Paracyclophane System. ChemMedChem 17 (21) (2022)
Alexander Markus, Julian Alexander Schreiber, Gunnar Goerges, Bastian Frehland, Guiscard Seebohm, Dirk Schepmann, Bernhard Wünsch
Phenol-Benzoxazolone bioisosteres: Synthesis and biological evaluation of tricyclic GluN2B-selective N-methyl- d-aspartate receptor antagonists. Archiv der Pharmazie 355 (9) (2022)
Alexander Markus, Julian A Schreiber, Gunnar Goerges, Bastian Frehland, Dirk Schepmann, Constantin Daniliuc, Roland Fröhlich, Guiscard Seebohm, Bernhard Wünsch
Phenol-benzoxazolone bioisosteres of GluN2B-NMDA receptor antagonists: Unexpected rearrangement during reductive alkylation with phenylcyclohexanone. Archiv der Pharmazie 355 (11) (2022)
Elena Bechthold, Lucie Grey, Emil Diamant, Judith Schmidt, Ruben Steigerwald, Fabao Zhao, Kasper B Hansen, Lennart Bunch, Rasmus P Clausen, Bernhard Wünsch
In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs. Biological chemistry (2022)
Denise Ilari, Sarah Maskri, Dirk Schepmann, Jens Köhler, Constantin Gabriel Daniliuc, Oliver Koch, Bernhard Wünsch
Diastereoselective synthesis of conformationally restricted KOR agonists. Organic & biomolecular chemistry 19 (18) (2022)
Alexander Markus, Dirk Schepmann, Bernhard Wünsch
Synthesis of oxazolo-annulated 3-benzazepines designed by merging two negative allosteric NMDA receptor modulators. Archiv der Pharmazie 355 (6) (2022)
Tobias Schierling, Beatrice Tosi, Clara Eisenhardt, Sophie Reining, Constantin Gabriel Daniliuc, Christoph Brenker, Timo Strünker, Bernhard Wünsch
Synthesis and Functional Characterization of Novel RU1968-Derived CatSper Inhibitors with Reduced Stereochemical Complexity. ACS pharmacology & translational science 6 (1) (2022)
Bengisu Turgutalp, Prabesh Bhattarai, Tugba Ercetin, Chiara Luise, Rengin Reis, Enise Ece Gurdal, Andreas Isaak, Derya Biriken, Elisabeth Dinter, Hande Sipahi, Dirk Schepmann, Anna Junker, Bernhard Wünsch, Wolfgang Sippl, Hayrettin Ozan Gulcan, Caghan Kizil, Mine Yarim
Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease. Journal of medicinal chemistry 65 (18) (2022)
Marvin Korff, Tiffany O Paulisch, Frank Glorius, Nikos L Doltsinis, Bernhard Wünsch
Photocatalytic Isomerization of ( E )-Anethole to ( Z )-Anethole. Molecules (Basel, Switzerland) 27 (16) (2022)
Daniele Aiello, Hendrik Jonas, Anna Carbone, Daniela Carbone, Camilla Pecoraro, Luisa Tesoriere, Jens Köhler, Bernhard Wünsch, Patrizia Diana
Synthesis and Antioxidative Properties of 1,2,3,4-Tetrahydropyridine Derivatives with Different Substituents in 4-Position. Molecules (Basel, Switzerland) 27 (21) (2022)
Marvin Korff, Ruben Steigerwald, Elena Bechthold, Dirk Schepmann, Julian Alexander Schreiber, Sven Guenther Meuth, Guiscard Seebohm, Bernhard Wünsch
Chemical, pharmacodynamic and pharmacokinetic characterization of the GluN2B receptor antagonist 3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1 H -3-benzazepine-1,7-diol - starting point for PET tracer development. Biological chemistry (2022)
Hendrik Jonas, Daniele Aiello, Bastian Frehland, Kirstin Lehmkuhl, Dirk Schepmann, Jens Köhler, Patrizia Diana, Bernhard Wünsch
Synthesis and pharmacological evaluation of enantiomerically pure endo-configured KOR agonists with 2-azabicyclo[3.2.1]octane scaffold. Organic & biomolecular chemistry 19 (38) (2021)
Jan-Frederik Uth, Frederik Börgel, Kirstin Lehmkuhl, Dirk Schepmann, Marcel Kaiser, Valquiria A P Jabor, Maria Cristina Nonato, R Luise Krauth-Siegel, Thomas Jürgen Schmidt, Bernhard Wünsch
Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents. Journal of medicinal chemistry 64 (9) (2021)
Melanie Bergkemper, Dirk Schepmann, Bernhard Wünsch
Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers. ChemMedChem 16 (7) (2021)
Friederike M Wunsch, Bernhard Wünsch, Freddy A Bernal, Thomas Jürgen Schmidt
Quantitative Structure-Activity Relationships of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents. Molecules (Basel, Switzerland) 26 (17) (2021)
Elena Bechthold, Julian A Schreiber, Kirstin Lehmkuhl, Bastian Frehland, Dirk Schepmann, Freddy A Bernal, Constantin Gabriel Daniliuc, Inés Álvarez, Cristina Val Garcia, Thomas Jürgen Schmidt, Guiscard Seebohm, Bernhard Wünsch
Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity. Journal of medicinal chemistry 64 (2) (2021)
Rareş-Petru Moldovan, Daniel Gündel, Rodrigo Teodoro, Friedrich-Alexander Ludwig, Steffen Fischer, Magali Toussaint, Dirk Schepmann, Bernhard Wünsch, Peter Brust, Winnie Deuther-Conrad
Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant 18F-Labelled σ2 Receptor Ligand. International journal of molecular sciences 22 (11) (2021)
Giacomo Rossino, Marta Rui, Pasquale Linciano, Daniela Rossi, Massimo Boiocchi, Marco Peviani, Elena Poggio, Daniela Curti, Dirk Schepmann, Bernhard Wünsch, Mariela González-Avendaño, Ariela Vergara-Jaque, Julio Caballero, Simona Collina
Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization. Journal of medicinal chemistry 64 (20) (2021)
Hector Torres-Gomez, Constantin Gabriel Daniliuc, Dirk Schepmann, Erik Laurini, Sabrina Pricl, Bernhard Wünsch
Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity. International journal of molecular sciences 22 (11) (2021)
Kathrin Brömmel, Christian Paul Konken, Frederik Börgel, Henry Obeng-Darko, Sonja Schelhaas, Etmar Bulk, Thomas Budde, Albrecht Schwab, Michael Schäfers, Bernhard Wünsch
Synthesis and biological evaluation of PET tracers designed for imaging of calcium activated potassium channel 3.1 (K Ca 3.1) channels in vivo . RSC advances 11 (48) (2021)
Remya Rajan, Dirk Schepmann, Ruben Steigerwald, Julian A Schreiber, Ehab El-Awaad, Joachim Jose, Guiscard Seebohm, Bernhard Wünsch
[2.2]Paracyclophane-Based TCN-201 Analogs as GluN2A-Selective NMDA Receptor Antagonists. ChemMedChem 16 (20) (2021)
Kathrin Brömmel, Sarah Maskri, Etmar Bulk, Zoltan Pethő, Marius Rieke, Thomas Budde, Oliver Koch, Albrecht Schwab, Bernhard Wünsch
Co-staining of KCa 3.1 Channels in NSCLC Cells with a Small-Molecule Fluorescent Probe and Antibody-Based Indirect Immunofluorescence. ChemMedChem 15 (24) (2020)
Carlo Cifani, Emanuela Micioni Di Bonaventura, Luca Botticelli, Fabio Del Bello, Gianfabio Giorgioni, Pegi Pavletić, Alessandro Piergentili, Wilma Quaglia, Alessandro Bonifazi, Dirk Schepmann, Bernhard Wünsch, Vistoli Giulio, Maria Vittoria Micioni Di Bonaventura
Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats. ACS chemical neuroscience 11 (19) (2020)
Simone Thum, Dirk Schepmann, Raquel F Reinoso, Inés Alvarez, Simon M Ametamey, Bernhard Wünsch
Synthesis and pharmacological evaluation of fluorinated benzo[7]annulen-7-amines as GluN2B-selective NMDA receptor antagonists. Journal of labelled compounds & radiopharmaceuticals 62 (8) (2020)
Elisabeth Kronenberg, Frauke Weber, Dirk Schepmann, Bernhard Wünsch
Synthesis and σ receptor affinity of spiro[[2]benzopyran-1,1'-cyclohexanes] with an exocyclic amino moiety in the 3'-position. RSC medicinal chemistry 12 (2) (2020)
Giovanni Tangherlini, Frederik Börgel, Dirk Schepmann, Samuel Slocum, Tao Che, Stefan Wagner, Katrin Schwegmann, Sven Hermann, Nadine Mykicki, Karin Loser, Bernhard Wünsch
Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline-Based κ-Opioid Receptor (KOR) Agonists Designed for PET Studies. ChemMedChem 15 (19) (2020)
Lukas Kröger, Constantin G Daniliuc, Deeba Ensan, Sebastian Borgert, Christian Nienberg, Miriam Lauwers, Michaela Steinkrüger, Joachim Jose, Markus Pietsch, Bernhard Wünsch
Synthesis and SAR of Tetracyclic Inhibitors of Protein Kinase CK2 Derived from Furocarbazole W16. ChemMedChem 15 (10) (2020)
Benedikt Martin, Dirk Schepmann, Freddy A Bernal, Thomas J Schmidt, Tao Che, Karin Loser, Bernhard Wünsch
Enantiomerically Pure Quinoline-Based κ-Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation. ChemMedChem 15 (15) (2020)
Kathrin Brömmel, Sarah Maskri, Ivan Maisuls, Christian Paul Konken, Marius Rieke, Zoltan Pethő, Cristian A Strassert, Oliver Koch, Albrecht Schwab, Bernhard Wünsch
Synthesis of Small-Molecule Fluorescent Probes for the In Vitro Imaging of Calcium-Activated Potassium Channel KCa 3.1. Angewandte Chemie (International ed. in English) 59 (21) (2020)
Donglin Gao, Christian Penno, Bernhard Wünsch
Rigid Scaffolds: Synthesis of 2,6-Bridged Piperazines with Functional Groups in all three Bridges. ChemistryOpen 9 (8) (2020)
Dirk Schepmann, Christina Neue, Stefanie Westphälinger, Christoph Müller, Franz Bracher, Carsten Lange, Patrick Bednarski, Carmen Almansa, Kristina Friedland, Vivien Räbiger, Martina Düfer, Bernhard Wünsch
Pharmacological characterization of high-affinity σ1 receptor ligands with spirocyclic thienopyran and thienofuran scaffold. The Journal of pharmacy and pharmacology 72 (2) (2019)
Giacomo Rossino, Ivana Orellana, Julio Caballero, Dirk Schepmann, Bernhard Wünsch, Marta Rui, Daniela Rossi, Mariela González-Avendaño, Simona Collina, Ariela Vergara-Jaque
New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative. Journal of chemical information and modeling 60 (2) (2019)
Elisabeth Kronenberg, Frauke Weber, Stefanie Brune, Dirk Schepmann, Carmen Almansa, Kristina Friedland, Erik Laurini, Sabrina Pricl, Bernhard Wünsch
Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety. Journal of medicinal chemistry 62 (8) (2019)
Giovanni Tangherlini, Dmitrii V Kalinin, Dirk Schepmann, Tao Che, Nadine Mykicki, Sonja Ständer, Karin Loser, Bernhard Wünsch
Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation. Journal of medicinal chemistry 62 (2) (2019)
Julian A Schreiber, Dirk Schepmann, Bastian Frehland, Simone Thum, Maia Datunashvili, Thomas Budde, Michael Hollmann, Nathalie Strutz-Seebohm, Bernhard Wünsch, Guiscard Seebohm
A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors. Communications biology 2 (2019)
Sören Baumeister, Dirk Schepmann, Bernhard Wünsch
Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold. MedChemComm 10 (2) (2019)
Fabio Del Bello, Maria Vittoria Micioni Di Bonaventura, Alessandro Bonifazi, Bernhard Wünsch, Dirk Schepmann, JoLynn B Giancola, Emanuela Micioni Di Bonaventura, Vistoli Giulio, Gianfabio Giorgioni, Wilma Quaglia, Alessandro Piergentili, Carlo Cifani
Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane. ACS chemical neuroscience 10 (8) (2019)
Melanie Bergkemper, Elisabeth Kronenberg, Dirk Schepmann, Friedrich-Alexander Ludwig, Peter Brust, Bernhard Wünsch
Structure-Affinity Relationships of Fluorinated Spirocyclic σ2 Receptor Ligands with an Exocyclic Benzylamino Moiety. ChemMedChem 14 (15) (2019)
Freddy A Bernal, Marcel Kaiser, Bernhard Wünsch, Thomas Jürgen Schmidt
Structure-Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents. ChemMedChem 15 (1) (2019)
Hazem Ahmed, Ahmed Haider, Jasmine Varisco, Maja Stanković, Rahel Wallimann, Stefan Gruber, Irina Iten, Surya Häne, Adrienne Müller Herde, Claudia Keller, Roger Schibli, Dirk Schepmann, Linjing Mu, Bernhard Wünsch, Simon M Ametamey
Structure-Affinity Relationships of 2,3,4,5-Tetrahydro-1H-3-benzazepine and 6,7,8,9-Tetrahydro-5H-benzo[7]annulen-7-amine Analogues and the Discovery of a Radiofluorinated 2,3,4,5-Tetrahydro-1H-3-benzazepine Congener for Imaging GluN2B Subunit-Containing N-Methyl-d-aspartate Receptors. Journal of medicinal chemistry 62 (21) (2019)
Paul Bunse, Christoph Schlepphorst, Frank Glorius, Masato Kitamura, Bernhard Wünsch
Short and Atom-Economic Enantioselective Synthesis of the σ1-Receptor Ligands (S)- and (R)-Fluspidine-Important Tools for Positron Emission Tomography Studies. The Journal of organic chemistry 84 (21) (2019)
Louisa Temme, Dirk Schepmann, Julian A Schreiber, Bastian Frehland, Bernhard Wünsch
Comparative Pharmacological Study of Common NMDA Receptor Open Channel Blockers Regarding Their Affinity and Functional Activity toward GluN2A and GluN2B NMDA Receptors. ChemMedChem 13 (5) (2018)
Marina Szermerski, Frederik Börgel, Dirk Schepmann, Ahmed Haider, Thomas Betzel, Simon M Ametamey, Bernhard Wünsch
Fluorinated GluN2B Receptor Antagonists with a 3-Benzazepine Scaffold Designed for PET Studies. ChemMedChem 13 (10) (2018)
Melanie Bergkemper, Elisabeth Kronenberg, Simone Thum, Frederik Börgel, Constantin Daniliuc, Dirk Schepmann, Francisco Rafael Nieto, Peter Brust, Raquel F Reinoso, Inés Alvarez, Bernhard Wünsch
Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety. Journal of medicinal chemistry 61 (21) (2018)
Simone Thum, Dirk Schepmann, Dmitrii V Kalinin, Simon M Ametamey, Bernhard Wünsch
Replacement of the Benzylpiperidine Moiety with Fluorinated Phenylalkyl Side Chains for the Development of GluN2B Receptor Ligands. ChemMedChem 13 (23) (2018)
Frederik Börgel, Marina Szermerski, Julian A Schreiber, Louisa Temme, Nathalie Strutz-Seebohm, Kirstin Lehmkuhl, Dirk Schepmann, Simon M Ametamey, Guiscard Seebohm, Thomas J Schmidt, Bernhard Wünsch
Synthesis and Pharmacological Evaluation of Enantiomerically Pure GluN2B Selective NMDA Receptor Antagonists. ChemMedChem 13 (15) (2018)
Sandeep Gawaskar, Louisa Temme, Julian A Schreiber, Dirk Schepmann, Alessandro Bonifazi, Dina Robaa, Wolfgang Sippl, Nathalie Strutz-Seebohm, Guiscard Seebohm, Bernhard Wünsch
Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold. ChemMedChem 12 (15) (2017)
Artur K Kokornaczyk, Dirk Schepmann, Junichiro Yamaguchi, Kenichiro Itami, Erik Laurini, Maurizio Fermeglia, Sabrina Pricl, Bernhard Wünsch
Thiazole-Based σ1 Receptor Ligands: Diversity by Late-Stage C-H Arylation of Thiazoles, Structure-Affinity and Selectivity Relationships, and Molecular Interactions. ChemMedChem 12 (13) (2017)
Yoshihiro Shuto, Simone Thum, Louisa Temme, Dirk Schepmann, Masato Kitamura, Bernhard Wünsch
Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain? MedChemComm 8 (5) (2017)
Lena Fanter, Dirk Schepmann, Bernhard Wünsch
Solid-phase organic synthesis of chiral, non-racemic 1,2,4-trisubstituted 1,4-diazepanes with high σ1 receptor affinity. Archiv der Pharmazie 351 (1) (2017)

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Bernhard Wünsch