Your account is not claimed yet. You can sign up with ORCID to claim your account.

Brian James Patrick Huntly (Brian Huntly, Brian J Huntly, Brian J P Huntly)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2015-2023
Publications (10 Years): 28

Top Venues

Nature communications

Blood

Nature genetics

Leukemia

University of Cambridge

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Cambridge Oct 1o 2016

United Kingdom

Professor of Leukaemia Stem Cell Biology :: Department of Haematology & Stem Cell Institute

Publications

Raquel S Pereira, Rahul Kumar, Alessia Cais, Lara Paulini, Alisa Kahler, Jimena Bravo, Valentina R Minciacchi, Theresa Krack, Eric Kowarz, Costanza Zanetti, Parimala Sonika Godavarthy, Fabian Hoeller, Pablo Llavona, Tabea Stark, Georg Tascher, Daniel Nowak, Eshwar Meduri, Brian James Patrick Huntly, Christian Münch, Francesco Pampaloni, Rolf Marschalek, Daniela S Krause
Distinct and targetable role of calcium-sensing receptor in leukaemia. Nature communications 14 (1) (2023)
Shuchi Agrawal-Singh, Jaana Bagri, Nathalie Sakakini, Brian James Patrick Huntly
A guide to epigenetics in leukaemia stem cells. Molecular oncology (2023)
Keith Woodley, Laura S Dillingh, George Giotopoulos, Pedro Madrigal, Kevin M Rattigan, Céline Philippe, Vilma Dembitz, Aoife M S Magee, Ryan Asby, Louie N van de Lagemaat, Christopher Mapperley, Sophie C James, Jochen H M Prehn, Konstantinos Tzelepis, Kevin Rouault-Pierre, George S Vassiliou, Kamil R Kranc, G Vignir Helgason, Brian James Patrick Huntly, Paolo Gallipoli
Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death. Nature communications 14 (1) (2023)
David Lara-Astiaso, Ainhoa Goñi-Salaverri, Julen Mendieta-Esteban, Nisha Narayan, Cynthia Del Valle, Torsten Gross, George Giotopoulos, Tumas Beinortas, Mar Navarro-Alonso, Laura Pilar Aguado-Alvaro, Jon Zazpe, Francesco Marchese, Natalia Torrea, Isabel A Calvo, Cecile K Lopez, Diego Alignani, Aitziber Lopez, Borja Saez, Jake P Taylor-King, Felipe Prosper, Nikolaus Fortelny, Brian James Patrick Huntly
In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis. Nature genetics (2023)
Georgina S F Anderson, José Ballester Beltrán, George Giotopoulos, Jose A Guerrero, Sylvanie Surget, James C Williamson, Tsz So, David Bloxham, Anna Aubareda, Ryan J Asby, Ieuan Walker, Lesley Jenkinson, Elizabeth J Soilleux, James P Roy, Ana Teodosio, Catherine Ficken, Leah Officer, Sara Nasser, Sheri Skerget, Jonathan J Keats, Peter Greaves, Yu-Tzu Tai, Kenneth C Anderson, Marion MacFarlane, James E D Thaventhiran, Brian James Patrick Huntly, Paul J Lehner, Michael A Chapman
Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma. Blood 139 (16) (2022)
Mark A Dawson, Gautam Borthakur, Brian James Patrick Huntly, Anastasios Karadimitris, Adrian Alegre, Aristeidis Chaidos, Dan T Vogl, Daniel A Pollyea, Faith E Davies, Gareth J Morgan, Jacob Lowell Glass, Manali Kamdar, Maria-Victoria Mateos-Manteca, Natalia Tovar, Paul Yeh, Regina García Delgado, Faisal Basheer, Ludovica Marando, Paolo Gallipoli, Anastasia Wyce, Anu Shilpa Krishnatry, Olena Barbash, Evi Bakirtzi, Geraldine Ferron-Brady, Natalie O Karpinich, Michael T McCabe, Shawn W Foley, Thierry Horner, Arindam Dhar, Brandon E Kremer, Michael J Dickinson
A phase I/II open-label study of molibresib for the treatment of relapsed/refractory hematologic malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan Azazi, Sarah J Horton, Cecile K Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W Houghton, George S Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D Whetton, Brian James Patrick Huntly
HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. Blood (2022)
Yanis Tazi, Juan E Arango-Ossa, Yangyu Zhou, Elsa Bernard, Ian Thomas, Amanda Gilkes, Sylvie D Freeman, Yoann Pradat, Sean J Johnson, Robert Hills, Richard Dilon, Max Fine Levine, Daniel A Leongamornlert, Adam Butler, Arnold Ganser, Lars Bullinger, Konstanze Döhner, Oliver Ottmann, Richard A Adams, Hartmut Döhner, Peter J Campbell, Alan K Burnett, Michael Dennis, Nigel H Russell, Sean M Devlin, Brian James Patrick Huntly, Elli Papaemmanuil
Unified classification and risk-stratification in Acute Myeloid Leukemia. Nature communications 13 (1) (2022)
Nisha Narayan, Brian James Patrick Huntly
Targeting AML at the intersection of epigenetics and signaling. Science signaling 15 (730) (2022)
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan Azazi, Sarah J Horton, Cecile K Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W Houghton, George S Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D Whetton, Brian James Patrick Huntly
HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. Blood (2022)
Bryann Pardieu, Justine Pasanisi, Frank Ling, Reinaldo Dal Bello, Justine Penneroux, Angela Su, Romane Joudinaud, Laureen Chat, Hsin Chieh Wu, Matthieu Duchmann, Gaetano Sodaro, Clémentine Chauvel, Florence A Castelli, Loic Vasseur, Kim Pacchiardi, Yannis Belloucif, Marie-Charlotte Laiguillon, Eshwar Meduri, Camille Vaganay, Gabriela Alexe, Jeannig Berrou, Chaima Benaksas, Antoine Forget, Thorsten Braun, Claude Gardin, Emmanuel Raffoux, Emmanuelle Clappier, Lionel Ades, Hugues de Thé, François Fenaille, Brian James Patrick Huntly, Kimberly Stegmaier, Hervé Dombret, Nina Fenouille, Camille Lobry, Alexandre Puissant, Raphaël A Itzykson
Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia. Leukemia 36 (6) (2022)
Shuchi Agrawal-Singh, Jaana Bagri, George Giotopoulos, Dhoyazan Azazi, Sarah J Horton, Cecile K Lopez, Shubha Anand, Anne-Sophie Bach, Frances Stedham, Robin Antrobus, Jack W Houghton, George S Vassiliou, Daniel Sasca, Haiyang Yun, Anthony D Whetton, Brian James Patrick Huntly
HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia. Blood (2022)
Shikha Gupta, Oliver M Dovey, Ana Filipa Domingues, Oliwia W Cyran, Caitlin M Cash, George Giotopoulos, Justyna Rak, Jonathan Cooper, Malgorzata Gozdecka, Liza Dijkhuis, Ryan J Asby, Noor Al-Jabery, Victor Hernandez-Hernandez, Sudhakaran Prabakaran, Brian James Patrick Huntly, George S Vassiliou, Cristina Pina
Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis. Science advances 8 (31) (2022)
Liliana Arede, Elena Foerner, Selinde Sterre Wind, Rashmi Kulkarni, Ana Filipa Domingues, George Giotopoulos, Svenja Kleinwächter, Maximilian Mollenhauer-Starkl, Holly Davison, Aditya Chandru, Ryan J Asby, Ralph Samarista, Shikha Gupta, Dorian Forte, Antonio Curti, Elisabeth Scheer, Brian James Patrick Huntly, Làszlò Tora, Cristina Pina
KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia. Blood advances (2021)
Haiyang Yun, Nisha Narayan, Shabana Vohra, George Giotopoulos, Annalisa Mupo, Pedro Madrigal, Daniel Sasca, David Lara-Astiaso, Sarah J Horton, Shuchi Agrawal-Singh, Eshwar Meduri, Faisal Basheer, Ludovica Marando, Malgorzata Gozdecka, Oliver M Dovey, Aracely Castillo-Venzor, Xiaonan Wang, Paolo Gallipoli, Carsten Muller-Tidow, Cameron S Osborne, George S Vassiliou, Brian James Patrick Huntly
Mutational synergy during leukemia induction remodels chromatin accessibility, histone modifications and three-dimensional DNA topology to alter gene expression. Nature genetics 53 (10) (2021)
Ludovica Marando, Brian James Patrick Huntly
BETs Need Greens: Folate Deficiency and Resistance to MYC-Targeted Therapies. Cancer discovery 10 (12) (2021)
Silvia Basilico, Xiaonan Wang, Alison Kennedy, Konstantinos Tzelepis, George Giotopoulos, Sarah J Kinston, Pedro M Quiros, Kim Wong, David J Adams, Larissa S Carnevalli, Brian James Patrick Huntly, George S Vassiliou, Fernando J Calero-Nieto, Berthold Göttgens
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML. Nature communications 11 (1) (2020)
Yan Zi Au, Muxin Gu, Etienne De Braekeleer, Malgorzata Gozdecka, Demetrios Aspris, Yusuke Tarumoto, Jonathan Cooper, Jason S L Yu, Swee Hoe Ong, Xi Chen, Konstantinos Tzelepis, Brian James Patrick Huntly, George S Vassiliou, Kosuke Yusa
KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements. Leukemia 35 (4) (2020)
Alan K Burnett, Nigel H Russell, Robert K Hills, Stephen Knapper, Sylvie D Freeman, Brian James Patrick Huntly, Richard E Clark, Ian F Thomas, Lars Kjeldsen, Mary Frances Frances McMullin, Mark Drummond, Jonathan Kell, Ruth Spearing
Defining the Optimal Total Number of Chemotherapy Courses in Younger Patients With Acute Myeloid Leukemia: A Comparison of Three Versus Four Courses. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 39 (8) (2020)
Natalie Burrows, Rachael J M Bashford-Rogers, Vijesh J Bhute, Ana Peñalver, John R Ferdinand, Benjamin J Stewart, Joscelin E G Smith, Mukta Deobagkar-Lele, Girolamo Giudice, Thomas M Connor, Akimichi Inaba, Laura Bergamaschi, Sam Smith, Maxine G B Tran, Evangelia Petsalaki, Paul A Lyons, Marion Espeli, Brian James Patrick Huntly, Kenneth G C Smith, Richard J Cornall, Menna R Clatworthy, Patrick H Maxwell
Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development. Nature immunology 21 (11) (2020)
Rebecca Caeser, Miriam Di Re, Joanna A Krupka, Jie Gao, Maribel Lara-Chica, Joao M L Dias, Susanna L Cooke, Rachel Fenner, Zelvera Usheva, Hendrik Friedrich Peter Runge, Philip A Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S Vassiliou, Brian James Patrick Huntly, Annalisa Mupo, Rachael J M Bashford-Rogers, Daniel James Hodson
Genetic modification of primary human B cells to model high-grade lymphoma. Nature communications 10 (1) (2019)
Sarah Horton, Brian James Patrick Huntly
Kinase Networks Regulate Metabolism: I'D(H1) Never Have Guessed! Cancer discovery 9 (6) (2019)
Faisal Basheer, George Giotopoulos, Eshwar Meduri, Haiyang Yun, Milena Mazan, Daniel Sasca, Paolo Gallipoli, Ludovica Marando, Malgorzata Gozdecka, Ryan J Asby, Olivia Sheppard, Monika Dudek, Lars Bullinger, Hartmut Döhner, Richard Dillon, Sylvie Freeman, Oliver Ottmann, Alan Burnett, Nigel Russell, Elli Papaemmanuil, Robert Hills, Peter Campbell, George S Vassiliou, Brian James Patrick Huntly
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML. The Journal of experimental medicine 216 (4) (2019)
Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, Konstantinos Tzelepis, Monika Dudek, Andrew J Knights, Mercedes Calvo Pardo, Lu Yu, Jyoti S Choudhary, Emmanouil Metzakopian, Vivek Iyer, Haiyang Yun, Naomi Park, Ignacio Varela, Ruben Bautista, Grace Collord, Oliver Dovey, Dimitrios A Garyfallos, Etienne De Braekeleer, Saki Kondo, Jonathan Cooper, Berthold Göttgens, Lars Bullinger, Paul A Northcott, David Adams, George S Vassiliou, Brian James Patrick Huntly
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. Nature genetics 50 (6) (2018)
Paolo Gallipoli, George Giotopoulos, Konstantinos Tzelepis, Ana S H Costa, Shabana Vohra, Paula Medina-Perez, Faisal Basheer, Ludovica Marando, Lorena Di Lisio, Joao M L Dias, Haiyang Yun, Daniel Sasca, Sarah J Horton, George Vassiliou, Christian Frezza, Brian James Patrick Huntly
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition. Blood 131 (15) (2018)
Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M S Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D Toop, Monika Dudek, Samuel C Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A Garyfallos, Hannes Ponstingl, Joao M L Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J Bannister, Roland Rad, Rabinder K Prinjha, John C Marioni, Brian James Patrick Huntly, Jennifer Batson, Jonathan C Morris, Cristina Pina, Allan Bradley, Irmela Jeremias, David O Bates, Kosuke Yusa, Tony Kouzarides, George S Vassiliou
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. Nature communications 9 (1) (2018)
Sarah J Horton, George Giotopoulos, Haiyang Yun, Shabana Vohra, Olivia Sheppard, Rachael Bashford-Rogers, Mamunur Rashid, Alexandra Clipson, Wai-In Chan, Daniel Sasca, Loukia Yiangou, Hikari Osaki, Faisal Basheer, Paolo Gallipoli, Natalie Burrows, Ayşegül Erdem, Anastasiya Sybirna, Sarah Foerster, Wanfeng Zhao, Tonci Sustic, Anna Petrunkina Harrison, Elisa Laurenti, Jessica Okosun, Daniel Hodson, Penny Wright, Ken G Smith, Patrick Maxwell, Jude Fitzgibbon, Ming Q Du, David J Adams, Brian James Patrick Huntly
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors. Nature cell biology 19 (9) (2017)
David Grimwade, Adam Ivey, Brian James Patrick Huntly
Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance. Blood 127 (1) (2015)

Brian James Patrick Huntly.css-eqlu8i{font-size:small;padding-left:4px;} (Brian Huntly, Brian J Huntly, Brian J P Huntly)

Publication Activity (10 Years)

Top Topics

Top Venues

Brian James Patrick Huntly (Brian Huntly, Brian J Huntly, Brian J P Huntly)