Douglas M Fowler (D M Fowler)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 47

Top Venues

bioRxiv : the preprint server for biology

Nature communications

Circulation. Genomic and precision medicine

Nature chemical biology

University of Washington

Scripps Research Institute (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Washington Jul 01 2018

United States

Associate Professor :: Genome Sciences

University of Washington

United States

Assistant Professor :: Genome Sciences

University of Washington

United States

Postdoctoral Fellow :: Genome Sciences

Education History

Scripps Research Institute

United States

PHD :: Chemistry

Publications

Jessica J Simon, Douglas M Fowler, Dustin J Maly
Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq. bioRxiv : the preprint server for biology (2024)
Jessica J Simon, Douglas M Fowler, Dustin J Maly
Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq. bioRxiv : the preprint server for biology (2024)
Clayton E Friedman, Shawn Fayer, Sriram Pendyala, Wei-Ming Chien, Alexander M Loiben, Linda Tran, Leslie S Chao, Ashley McKinstry, Dania Ahmed, Stephen D Farris, April Stempien-Otero, Erica C Jonlin, Charles E Murry, Joshua T Schiffer, Douglas M Fowler, Kai-Chun Yang
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes. Circulation. Genomic and precision medicine 17 (2) (2024)
Jessica J Simon, Douglas M Fowler, Dustin J Maly
Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq. bioRxiv : the preprint server for biology (2024)
Clayton E Friedman, Shawn Fayer, Sriram Pendyala, Wei-Ming Chien, Alexander M Loiben, Linda Tran, Leslie S Chao, Ashley McKinstry, Dania Ahmed, Stephen D Farris, April Stempien-Otero, Erica C Jonlin, Charles E Murry, Joshua T Schiffer, Douglas M Fowler, Kai-Chun Yang
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes. Circulation. Genomic and precision medicine 17 (2) (2024)
Jessica J Simon, Douglas M Fowler, Dustin J Maly
Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq. bioRxiv : the preprint server for biology (2024)
Martin Grønbæk-Thygesen, Vasileios Voutsinos, Kristoffer Enøe Johansson, Thea K Schulze, Matteo Cagiada, Line Pedersen, Lene Clausen, Snehal Nariya, Rachel L Powell, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants. Nature communications 15 (1) (2024)
Jessica J Simon, Douglas M Fowler, Dustin J Maly
Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq. bioRxiv : the preprint server for biology (2024)
Jessica J Simon, Douglas M Fowler, Dustin J Maly
Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq. bioRxiv : the preprint server for biology (2024)
Clayton E Friedman, Shawn Fayer, Sriram Pendyala, Wei-Ming Chien, Alexander M Loiben, Linda Tran, Leslie S Chao, Ashley McKinstry, Dania Ahmed, Stephen D Farris, April Stempien-Otero, Erica C Jonlin, Charles E Murry, Joshua T Schiffer, Douglas M Fowler, Kai-Chun Yang
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes. Circulation. Genomic and precision medicine 17 (2) (2024)
Martin Grønbæk-Thygesen, Vasileios Voutsinos, Kristoffer Enøe Johansson, Thea K Schulze, Matteo Cagiada, Line Pedersen, Lene Clausen, Snehal Nariya, Rachel L Powell, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants. Nature communications 15 (1) (2024)
Clayton E Friedman, Shawn Fayer, Sriram Pendyala, Wei-Ming Chien, Alexander M Loiben, Linda Tran, Leslie S Chao, Ashley McKinstry, Dania Ahmed, Stephen D Farris, April Stempien-Otero, Erica C Jonlin, Charles E Murry, Joshua T Schiffer, Douglas M Fowler, Kai-Chun Yang
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes. Circulation. Genomic and precision medicine 17 (2) (2024)
Clayton E Friedman, Shawn Fayer, Sriram Pendyala, Wei-Ming Chien, Alexander M Loiben, Linda Tran, Leslie S Chao, Ashley McKinstry, Dania Ahmed, Stephen D Farris, April Stempien-Otero, Erica C Jonlin, Charles E Murry, Joshua T Schiffer, Douglas M Fowler, Kai-Chun Yang
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes. Circulation. Genomic and precision medicine 17 (2) (2024)
Clayton E Friedman, Shawn Fayer, Sriram Pendyala, Wei-Ming Chien, Alexander M Loiben, Linda Tran, Leslie S Chao, Ashley McKinstry, Dania Ahmed, Stephen D Farris, April Stempien-Otero, Erica C Jonlin, Charles E Murry, Joshua T Schiffer, Douglas M Fowler, Kai-Chun Yang
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes. Circulation. Genomic and precision medicine (2024)
Clayton E Friedman, Shawn Fayer, Sriram Pendyala, Wei-Ming Chien, Alexander M Loiben, Linda Tran, Leslie S Chao, Ashley McKinstry, Dania Ahmed, Stephen D Farris, April Stempien-Otero, Erica C Jonlin, Charles E Murry, Joshua T Schiffer, Douglas M Fowler, Kai-Chun Yang
Multiplexed Functional Assessments of MYH7 Variants in Human Cardiomyocytes. Circulation. Genomic and precision medicine 17 (2) (2024)
Moez Dawood, Shawn Fayer, Sriram Pendyala, Mason Post, Divya Kalra, Karynne E Patterson, Eric Venner, Lara A Muffley, Douglas M Fowler, Alan F Rubin, Jennifer E Posey, Sharon E Plon, James R. Lupski, Richard A Gibbs, Joshua T Schiffer, Carla Daniela Robles-Espinoza, Willow Coyote-Maestas, Irene Gallego Romero
Defining and Reducing Variant Classification Disparities. medRxiv : the preprint server for health sciences (2024)
Nobuhiko Hamazaki, Wei Yang, Connor A Kubo, Chengxiang Qiu, Beth K Martin, Riddhiman K Garge, Samuel G Regalado, Eva K Nichols, Sriram Pendyala, Nicholas Bradley, Douglas M Fowler, Choli Lee, Riza M Daza, Sanjay Srivatsan, Jay Shendure
Retinoic acid induces human gastruloids with posterior embryo-like structures. Nature cell biology (2024)
Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer Enøe Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
A mutational atlas for Parkin proteostasis. Nature communications 15 (1) (2024)
Jessica J Simon, Douglas M Fowler, Dustin J Maly
Multiplexed, multimodal profiling of the intracellular activity, interactions, and druggability of protein variants using LABEL-seq. bioRxiv : the preprint server for biology (2024)
Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer Enøe Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
A mutational atlas for Parkin proteostasis. Nature communications 15 (1) (2024)
Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer Enøe Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
A mutational atlas for Parkin proteostasis. Nature communications 15 (1) (2024)
Martin Grønbæk-Thygesen, Vasileios Voutsinos, Kristoffer Enøe Johansson, Thea K Schulze, Matteo Cagiada, Line Pedersen, Lene Clausen, Snehal Nariya, Rachel L Powell, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants. Nature communications 15 (1) (2024)
Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer Enøe Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
A mutational atlas for Parkin proteostasis. Nature communications 15 (1) (2024)
Ayesha Muhammad, Maria E Calandranis, Bian Li, Tao Yang, Daniel J Blackwell, M Lorena Harvey, Jeremy E Smith, Ashli E Chew, Anthony Capra, Kenneth A Matreyek, Douglas M Fowler, Dan M Roden, Andrew M Glazer
High-throughput functional mapping of variants in an arrhythmia gene, KCNE1 , reveals novel biology. bioRxiv : the preprint server for biology (2023)
Ayesha Muhammad, Maria E Calandranis, Bian Li, Tao Yang, Daniel J Blackwell, M Lorena Harvey, Jeremy E Smith, Ashli E Chew, Anthony Capra, Kenneth A Matreyek, Douglas M Fowler, Dan M Roden, Andrew M Glazer
High-throughput functional mapping of variants in an arrhythmia gene, KCNE1 , reveals novel biology. bioRxiv : the preprint server for biology (2023)
Cindy T Wei, Nicholas A Popp, Omri Peleg, Rachel L Powell, Elhanan Borenstein, Dustin J Maly, Douglas M Fowler
A chemically controlled Cas9 switch enables temporal modulation of diverse effectors. Nature chemical biology (2023)
Cindy T Wei, Nicholas A Popp, Omri Peleg, Rachel L Powell, Elhanan Borenstein, Dustin J Maly, Douglas M Fowler
A chemically controlled Cas9 switch enables temporal modulation of diverse effectors. Nature chemical biology (2023)
Michael Rappleye, Sarah J Wait, Justin Daho Lee, Jamison C Siebart, Lily Torp, Netta Smith, Jeanot Muster, Kenneth A Matreyek, Douglas M Fowler, Andre Berndt
Optogenetic Microwell Array Screening System: A High-Throughput Engineering Platform for Genetically Encoded Fluorescent Indicators. ACS sensors (2023)
Clayton E Friedman, Shawn Fayer, Sriram Pendyala, Wei-Ming Chien, Linda Tran, Leslie Chao, Ashley Mckinstry, Elaheh Karbassi, Aidan M Fenix, Alexander Loiben, Charles E Murry, Joshua T Schiffer, Douglas M Fowler, Kai-Chun Yang
CRaTER enrichment for on-target gene-editing enables generation of variant libraries in hiPSCs. bioRxiv : the preprint server for biology (2023)
Lucian DiPeso, Sriram Pendyala, Heather Z Huang, Douglas M Fowler, Emily M Hatch
Machine vision reveals micronucleus rupture as a potential driver of the transcriptomic response to aneuploidy. bioRxiv : the preprint server for biology (2023)
Douglas M Fowler, David J Adams, Anna L Gloyn, William C Hahn, Debora S Marks, Lara A Muffley, James T Neal, Frederick P Roth, Alan F Rubin, Joshua T Schiffer, Matthew E Hurles
An Atlas of Variant Effects to understand the genome at nucleotide resolution. Genome biology 24 (1) (2023)
Ayesha Muhammad, Maria E Calandranis, Bian Li, Tao Yang, Daniel J Blackwell, M Lorena Harvey, Jeremy E Smith, Ashli E Chew, Anthony Capra, Kenneth A Matreyek, Douglas M Fowler, Dan M Roden, Andrew M Glazer
High-throughput functional mapping of variants in an arrhythmia gene, KCNE1 , reveals novel biology. bioRxiv : the preprint server for biology (2023)
Lucian DiPeso, Sriram Pendyala, Heather Z Huang, Douglas M Fowler, Emily M Hatch
Machine vision reveals micronucleus rupture as a potential driver of the transcriptomic response to aneuploidy. bioRxiv : the preprint server for biology (2023)
John Z Chen, Douglas M Fowler, Nobuhiko Tokuriki
Environmental selection and epistasis in an empirical phenotype-environment-fitness landscape. Nature ecology & evolution 6 (4) (2022)
Nicholas Hasle, Anthony Cooke, Sanjay Srivatsan, Heather Z Huang, Jason J Stephany, Zachary Krieger, Dana Jackson, Weiliang Tang, Sriram Pendyala, Raymond J Monnat, Cole Trapnell, Emily M Hatch, Douglas M Fowler
High-throughput, microscope-based sorting to dissect cellular heterogeneity. Molecular systems biology 16 (6) (2021)
Willow Coyote-Maestas, David Nedrud, Antonio Suma, Yungui He, Kenneth A Matreyek, Douglas M Fowler, Vincenzo Carnevale, Chad L Myers, Daniel Schmidt
Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling. Nature communications 12 (1) (2021)
John Z Chen, Douglas M Fowler, Nobuhiko Tokuriki
Comprehensive exploration of the translocation, stability and substrate recognition requirements in VIM-2 lactamase. eLife 9 (2020)
Melissa A Chiasson, Nathan J Rollins, Jason J Stephany, Katherine A Sitko, Kenneth A Matreyek, Marta Verby, Song Sun, Frederick P Roth, Daniel DeSloover, Debora S Marks, Allan E Rettie, Douglas M Fowler
Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact. eLife 9 (2020)
Jesse T Chao, Rocio Hollman, Warren M Meyers, Fabian Meili, Kenneth A Matreyek, Pamela Dean, Douglas M Fowler, Kurt Haas, Calvin D Roskelley, Christopher J R Loewen
A Premalignant Cell-Based Model for Functionalization and Classification of PTEN Variants. Cancer research 80 (13) (2020)
Melissa Chiasson, Douglas M Fowler
Mutagenesis-based protein structure determination. Nature genetics 51 (7) (2020)
John C Rose, Nicholas A Popp, Christopher D Richardson, Jason J Stephany, Julie Mathieu, Cindy T Wei, Jacob E Corn, Dustin J Maly, Douglas M Fowler
Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs. Nature communications 11 (1) (2020)
Vanessa E Gray, Katherine Sitko, Floriane Z Ngako Kameni, Miriam Williamson, Jason J Stephany, Nicholas Hasle, Douglas M Fowler
Elucidating the Molecular Determinants of Aβ Aggregation with Deep Mutational Scanning. G3 (Bethesda, Md.) 9 (11) (2019)
Melissa Chiasson, Maitreya J Dunham, Allan E Rettie, Douglas M Fowler
Applying Multiplex Assays to Understand Variation in Pharmacogenes. Clinical pharmacology and therapeutics 106 (2) (2019)
Kenneth A Matreyek, Lea M Starita, Jason J Stephany, Beth K Martin, Melissa A Chiasson, Vanessa E Gray, Martin Kircher, Arineh Khechaduri, Jennifer N Dines, Ronald J Hause, Smita Bhatia, Williams E Evans, Mary V Relling, Wenjian Yang, Jay Shendure, Douglas M Fowler
Multiplex assessment of protein variant abundance by massively parallel sequencing. Nature genetics 50 (6) (2018)
John C Rose, Jason J Stephany, William J Valente, Bridget M Trevillian, Ha V Dang, Jason H Bielas, Dustin J Maly, Douglas M Fowler
Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics. Nature methods 14 (9) (2017)
Vanessa E Gray, Ronald J Hause, Douglas M Fowler
Analysis of Large-Scale Mutagenesis Data To Assess the Impact of Single Amino Acid Substitutions. Genetics 207 (1) (2017)
Barbara Taskinen, Evandro Ferrada, Douglas M Fowler
Early emergence of negative regulation of the tyrosine kinase Src by the C-terminal Src kinase. The Journal of biological chemistry 292 (45) (2017)

Douglas M Fowler.css-eqlu8i{font-size:small;padding-left:4px;} (D M Fowler)

Publication Activity (10 Years)

Top Topics

Top Venues

Douglas M Fowler (D M Fowler)