Jacob E Corn

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 31

Top Topics

Immune Response

Top Venues

Nature genetics

Nature communications

Nature biotechnology

This page only lists publications with an associated author ORCID identifier.

Publications

Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer, Maya M Arce, Ketrin Gjoni, Bence Daniel, Katalin D Sandor, Benjamin G Gowen, Vinh Nguyen, Dimitre R Simeonov, Christian M Garrido, Gemma L Curie, Ralf Schmidt, Zachary Steinhart, Ansuman T Satpathy, Katherine S Pollard, Jacob E Corn, Bradley E Bernstein, Chun Jimmie Ye, Alexander Marson
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells. Nature genetics 56 (6) (2024)
Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer, Maya M Arce, Ketrin Gjoni, Bence Daniel, Katalin D Sandor, Benjamin G Gowen, Vinh Nguyen, Dimitre R Simeonov, Christian M Garrido, Gemma L Curie, Ralf Schmidt, Zachary Steinhart, Ansuman T Satpathy, Katherine S Pollard, Jacob E Corn, Bradley E Bernstein, Chun Jimmie Ye, Alexander Marson
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells. Nature genetics 56 (6) (2024)
Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer, Maya M Arce, Ketrin Gjoni, Bence Daniel, Katalin D Sandor, Benjamin G Gowen, Vinh Nguyen, Dimitre R Simeonov, Christian M Garrido, Gemma L Curie, Ralf Schmidt, Zachary Steinhart, Ansuman T Satpathy, Katherine S Pollard, Jacob E Corn, Bradley E Bernstein, Chun Jimmie Ye, Alexander Marson
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells. Nature genetics (2024)
Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer, Maya M Arce, Ketrin Gjoni, Bence Daniel, Katalin D Sandor, Benjamin G Gowen, Vinh Nguyen, Dimitre R Simeonov, Christian M Garrido, Gemma L Curie, Ralf Schmidt, Zachary Steinhart, Ansuman T Satpathy, Katherine S Pollard, Jacob E Corn, Bradley E Bernstein, Chun Jimmie Ye, Alexander Marson
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells. Nature genetics 56 (6) (2024)
Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer, Maya M Arce, Ketrin Gjoni, Bence Daniel, Katalin D Sandor, Benjamin G Gowen, Vinh Nguyen, Dimitre R Simeonov, Christian M Garrido, Gemma L Curie, Ralf Schmidt, Zachary Steinhart, Ansuman T Satpathy, Katherine S Pollard, Jacob E Corn, Bradley E Bernstein, Chun Jimmie Ye, Alexander Marson
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells. Nature genetics 56 (6) (2024)
Cody T Mowery, Jacob W Freimer, Zeyu Chen, Salvador Casaní-Galdón, Jennifer M Umhoefer, Maya M Arce, Ketrin Gjoni, Bence Daniel, Katalin D Sandor, Benjamin G Gowen, Vinh Nguyen, Dimitre R Simeonov, Christian M Garrido, Gemma L Curie, Ralf Schmidt, Zachary Steinhart, Ansuman T Satpathy, Katherine S Pollard, Jacob E Corn, Bradley E Bernstein, Chun Jimmie Ye, Alexander Marson
Systematic decoding of cis gene regulation defines context-dependent control of the multi-gene costimulatory receptor locus in human T cells. Nature genetics 56 (6) (2024)
Jennifer M Umhoefer, Maya M Arce, Rama Dajani, Julia A Belk, Cody T Mowery, Vinh Nguyen, Benjamin G Gowen, Dimitre R Simeonov, Gemma L Curie, Jacob E Corn, Howard Y Chang, Alexander Marson
Deciphering regulation of FOXP3 expression in human conventional T cells. bioRxiv : the preprint server for biology (2024)
Mehmet E Karasu, Eléonore Toufektchan, Yanyang Chen, Alessandra Albertelli, Grégoire Cullot, John Maciejowski, Jacob E Corn
Removal of TREX1 activity enhances CRISPR-Cas9-mediated homologous recombination. Nature biotechnology (2024)
Romina Marone, Emmanuelle Landmann, Anna Devaux, Rosalba Lepore, Denis Seyres, Jessica Zuin, Thomas Burgold, Corinne Engdahl, Giuseppina Capoferri, Alessandro Dell'Aglio, Clément Larrue, Federico Simonetta, Julia Rositzka, Manuel Rhiel, Geoffroy Andrieux, Danielle N Gallagher, Markus S Schröder, Amélie Wiederkehr, Alessandro Sinopoli, Valentin Do Sacramento, Anna Haydn, Laura Garcia-Prat, Christopher Divsalar, Anna Camus, Liwen Xu, Lorenza Bordoli, Torsten Schwede, Matthew H Porteus, Jérome Tamburini, Jacob E Corn, Toni Cathomen, Tatjana I Cornu, Stefanie Urlinger, Lukas T Jeker
Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy. The Journal of experimental medicine 220 (12) (2023)
Mandy Y Boontanrart, Elia Mächler, Simone Ponta, Jan C Nelis, Viviana G Preiano, Jacob E Corn
Engineering of the endogenous HBD promoter increases HbA2. eLife 12 (2023)
Sebastian M Siegner, Laura Ugalde, Alexandra Clemens, Laura Garcia-Garcia, Juan Antonio Bueren, Paula Rio, Mehmet E Karasu, Jacob E Corn
Adenine base editing efficiently restores the function of Fanconi anemia hematopoietic stem and progenitor cells. Nature communications 13 (1) (2022)
Lukas Möller, Eric J Aird, Markus S Schröder, Lena Kobel, Lucas Kissling, Lilly van de Venn, Jacob E Corn
Recursive Editing improves homology-directed repair through retargeting of undesired outcomes. Nature communications 13 (1) (2022)
Nithin Sam Ravi, Beeke Wienert, Stacia K Wyman, Henry William Bell, Anila George, Gokulnath Mahalingam, Jonathan T Vu, Kirti Prasad, Bhanu Prasad Bandlamudi, Nivedhitha Devaraju, Vignesh Rajendiran, Nazar Syedbasha, Aswin Anand Pai, Yukio Nakamura, Ryo Kurita, Muthuraman Narayanasamy, Poonkuzhali Balasubramanian, Saravanabhavan Thangavel, Srujan Marepally, Shaji R Velayudhan, Alok Srivastava, Mark A DeWitt, Merlin Crossley, Jacob E Corn, Kumarasamypet M Mohankumar
Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin. eLife 11 (2022)
Sebastian M Siegner, Mehmet E Karasu, Markus S Schröder, Zacharias Kontarakis, Jacob E Corn
PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants. BMC bioinformatics 22 (1) (2021)
Beeke Wienert, Stacia K Wyman, Charles D Yeh, Bruce R Conklin, Jacob E Corn
CRISPR off-target detection with DISCOVER-seq. Nature protocols 15 (5) (2020)
Beeke Wienert, David N Nguyen, Alexis Guenther, Sharon J Feng, Melissa N Locke, Stacia K Wyman, Jiyung Shin, Katelynn R Kazane, Georgia L Gregory, Matthew A M Carter, Francis Wright, Bruce R Conklin, Alexander Marson, Christopher D Richardson, Jacob E Corn
Timed inhibition of CDC7 increases CRISPR-Cas9 mediated templated repair. Nature communications 11 (1) (2020)
John C Rose, Nicholas A Popp, Christopher D Richardson, Jason J Stephany, Julie Mathieu, Cindy T Wei, Jacob E Corn, Dustin J Maly, Douglas M Fowler
Suppression of unwanted CRISPR-Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs. Nature communications 11 (1) (2020)
Beeke Wienert, Stacia K Wyman, Christopher D Richardson, Charles D Yeh, Pinar Akcakaya, Michelle J Porritt, Michaela Morlock, Jonathan T Vu, Katelynn R Kazane, Hannah L Watry, Luke M Judge, Bruce R Conklin, Marcello Maresca, Jacob E Corn
Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq. Science (New York, N.Y.) 364 (6437) (2019)
Charles D Yeh, Christopher D Richardson, Jacob E Corn
Advances in genome editing through control of DNA repair pathways. Nature cell biology 21 (12) (2019)
Shaheen Kabir, Justin Cidado, Courtney L Andersen, Cortni Dick, Pei-Chun Lin, Therese Mitros, Hong Ma, Seung Hyun Baik, Matthew A Belmonte, Lisa Drew, Jacob E Corn
The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells. eLife 8 (2019)
Beeke Wienert, Jiyung Shin, Elena Zelin, Kathleen Pestal, Jacob E Corn
In vitro-transcribed guide RNAs trigger an innate immune response via the RIG-I pathway. PLoS biology 16 (7) (2018)
Chris D Richardson, Katelynn R Kazane, Sharon J Feng, Elena Zelin, Nicholas L Bray, Axel J Schäfer, Stephen N Floor, Jacob E Corn
CRISPR-Cas9 genome editing in human cells occurs via the Fanconi anemia pathway. Nature genetics 50 (8) (2018)
Jin-Soo Kim, Jacob E Corn
Sometimes you're the scooper, and sometimes you get scooped: How to turn both into something good. PLoS biology 16 (7) (2018)
Mikaela D Stewart, Elena Zelin, Abhinav Dhall, Tom Walsh, Esha Upadhyay, Jacob E Corn, Champak Chatterjee, Mary-Claire King, Rachel E Klevit
BARD1 is necessary for ubiquitylation of nucleosomal histone H2A and for transcriptional regulation of estrogen metabolism genes. Proceedings of the National Academy of Sciences of the United States of America 115 (6) (2018)
Jin Rui Liang, Emily Lingeman, Saba Ahmed, Jacob E Corn
Atlastins remodel the endoplasmic reticulum for selective autophagy. The Journal of cell biology 217 (10) (2018)
Kunwoo Lee, Vanessa A Mackley, Anirudh Rao, Anthony T Chong, Mark A Dewitt, Jacob E Corn, Niren Murthy
Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering. eLife 6 (2017)
Jiyung Shin, Fuguo Jiang, Jun-Jie Liu, Nicolas L Bray, Benjamin J Rauch, Seung Hyun Baik, Eva Nogales, Joseph Bondy-Denomy, Jacob E Corn, Jennifer A Doudna
Disabling Cas9 by an anti-CRISPR DNA mimic. Science advances 3 (7) (2017)
Maxwell R Mumbach, Ansuman T Satpathy, Evan August Boyle, Chao Dai, Benjamin G Gowen, Seung Woo Cho, Michelle L Nguyen, Adam J Rubin, Jeffrey M Granja, Katelynn R Kazane, Yuning Wei, Trieu Nguyen, Peyton G Greenside, M Ryan Corces, Josh Tycko, Dimitre R Simeonov, Nabeela Suliman, Rui Li, Jin Xu, Ryan A Flynn, Anshul Kundaje, Paul A Khavari, Alexander Marson, Jacob E Corn, Thomas Quertermous, William J Greenleaf, Howard Y Chang
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements. Nature genetics 49 (11) (2017)
Kunwoo Lee, Michael Conboy, Hyo Min Park, Fuguo Jiang, Hyun Jin Kim, Mark A Dewitt, Vanessa A Mackley, Kevin Chang, Anirudh Rao, Colin Skinner, Tamanna Shobha, Melod Mehdipour, Hui Liu, Wen-Chin Huang, Freeman Lan, Nicolas L Bray, Song Li, Jacob E Corn, Kazunori Kataoka, Jennifer A Doudna, Irina Conboy, Niren Murthy
Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair. Nature biomedical engineering 1 (2017)
Christopher D Richardson, Graham J Ray, Mark A DeWitt, Gemma L Curie, Jacob E Corn
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA. Nature biotechnology 34 (3) (2016)
Max A Horlbeck, Luke A Gilbert, Jacqueline E Villalta, Britt Adamson, Ryan A Pak, Yuwen Chen, Alexander P Fields, Chong Yon Park, Jacob E Corn, Martin Edward Kampmann, Jonathan S Weissman
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. eLife 5 (2016)