Simon C C Lucas

ORCID

Publication Activity (10 Years)

Years Active: 2021-2024
Publications (10 Years): 14

Top Venues

Journal of medicinal chemistry

RSC medicinal chemistry

ACS medicinal chemistry letters

This page only lists publications with an associated author ORCID identifier.

Publications

Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G Milbradt, Mark J Bostock, Samiyah Ahmed, Kevin Beaumont, Tony Cheung, Sylvain Demanze, Andrea Gohlke, Carine Guerot, Afreen Haider, Vasudev Kantae, Gregory W Kauffman, Olaf Kinzel, Lea Kupcova, Michael D Lainchbury, Michelle L Lamb, Leonardo Leon, Adeline Palisse, Claudia Sacchetto, R Ian Storer, Nancy Su, Clare Thomson, John Vales, Yunhua Chen, Xiaolong Hu
Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors. Journal of medicinal chemistry (2024)
Simon C C Lucas, Afshan Ahmed, S Neha Ashraf, Argyrides Argyrou, Matthias R Bauer, Gian Marco De Donatis, Sylvain Demanze, Frederik Eisele, Lucia Fusani, Andreas Hock, Ganesh Kadamur, Shuyou Li, Abigail Macmillan-Jones, Iacovos N Michaelides, Christopher Phillips, Marie Rehnström, Magdalena Richter, Monica C Rodrigo-Brenni, Fiona Shilliday, Peng Wang, R Ian Storer
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. Journal of medicinal chemistry (2024)
Simon C C Lucas, Afshan Ahmed, S Neha Ashraf, Argyrides Argyrou, Matthias R Bauer, Gian Marco De Donatis, Sylvain Demanze, Frederik Eisele, Lucia Fusani, Andreas Hock, Ganesh Kadamur, Shuyou Li, Abigail Macmillan-Jones, Iacovos N Michaelides, Christopher Phillips, Marie Rehnström, Magdalena Richter, Monica C Rodrigo-Brenni, Fiona Shilliday, Peng Wang, R Ian Storer
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. Journal of medicinal chemistry 67 (7) (2024)
Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, Silvia Bonomo, Andrew Brierley, Doyle J Cassar, Jared Freeman, Thomas E Hadfield, Lucas A Morrill, Rick Riemens, Sunil Sarda, Stefan Schiesser, Daniel Wiktelius, Samiyah Ahmed, Mark J Bostock, Ulf Börjesson, Claudia De Fusco, Carine Guerot, David Hargreaves, Sarah Hewitt, Michelle L Lamb, Nancy Su, Ryan Whatling, Matthew Wheeler, Jason G Kettle
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1. Journal of medicinal chemistry 67 (13) (2024)
Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, Silvia Bonomo, Andrew Brierley, Doyle J Cassar, Jared Freeman, Thomas E Hadfield, Lucas A Morrill, Rick Riemens, Sunil Sarda, Stefan Schiesser, Daniel Wiktelius, Samiyah Ahmed, Mark J Bostock, Ulf Börjesson, Claudia De Fusco, Carine Guerot, David Hargreaves, Sarah Hewitt, Michelle L Lamb, Nancy Su, Ryan Whatling, Matthew Wheeler, Jason G Kettle
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1. Journal of medicinal chemistry 67 (13) (2024)
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G Milbradt, Samiyah Ahmed, Mark J Bostock, Carine Guerot, Andrea Gohlke, Olaf Kinzel, Michelle L Lamb, Nidhal Selmi, Christopher J Stubbs, Nancy Su, Qibin Su, Haiou Luo, Ting Xiong, Xiaoqian Zuo, Sana Bazzaz, Corey Bienstock, Paolo A Centrella, Kyle E Denton, Diana Gikunju, Marie-Aude Guié, John P Guilinger, Christopher Hupp, Anthony D Keefe, Takashi Satoh, Ying Zhang, Emma L Rivers
Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen. ACS medicinal chemistry letters 15 (6) (2024)
Simon C C Lucas, J Henry Blackwell, Ulf Börjesson, David Hargreaves, Alexander G Milbradt, Samiyah Ahmed, Mark J Bostock, Carine Guerot, Andrea Gohlke, Olaf Kinzel, Michelle L Lamb, Nidhal Selmi, Christopher J Stubbs, Nancy Su, Qibin Su, Haiou Luo, Ting Xiong, Xiaoqian Zuo, Sana Bazzaz, Corey Bienstock, Paolo A Centrella, Kyle E Denton, Diana Gikunju, Marie-Aude Guié, John P Guilinger, Christopher Hupp, Anthony D Keefe, Takashi Satoh, Ying Zhang, Emma L Rivers
Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen. ACS medicinal chemistry letters 15 (6) (2024)
Simon C C Lucas, Afshan Ahmed, S Neha Ashraf, Argyrides Argyrou, Matthias R Bauer, Gian Marco De Donatis, Sylvain Demanze, Frederik Eisele, Lucia Fusani, Andreas Hock, Ganesh Kadamur, Shuyou Li, Abigail Macmillan-Jones, Iacovos N Michaelides, Christopher Phillips, Marie Rehnström, Magdalena Richter, Monica C Rodrigo-Brenni, Fiona Shilliday, Peng Wang, R Ian Storer
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders. Journal of medicinal chemistry 67 (7) (2024)
Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, Silvia Bonomo, Andrew Brierley, Doyle J Cassar, Jared Freeman, Thomas E Hadfield, Lucas A Morrill, Rick Riemens, Sunil Sarda, Stefan Schiesser, Daniel Wiktelius, Samiyah Ahmed, Mark J Bostock, Ulf Börjesson, Claudia De Fusco, Carine Guerot, David Hargreaves, Sarah Hewitt, Michelle L Lamb, Nancy Su, Ryan Whatling, Matthew Wheeler, Jason G Kettle
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1. Journal of medicinal chemistry (2024)
Simon C C Lucas, Ulf Börjesson, Mark J Bostock, John Cuff, Fredrik Edfeldt, Kevin J Embrey, Per-Olof Eriksson, Andrea Gohlke, Anders Gunnarson, Michael Lainchbury, Alexander G Milbradt, Rachel Moore, Philip B Rawlins, Ian Sinclair, Christopher Stubbs, R Ian Storer
Fragment screening at AstraZeneca: developing the next generation biophysics fragment set. RSC medicinal chemistry 13 (9) (2022)
S Paul Jones, James D Firth, Mary C Wheldon, Masakazu Atobe, Roderick Eliot Hubbard, David C Blakemore, Claudia De Fusco, Simon C C Lucas, Stephen D Roughley, Lewis R Vidler, Maria Ann Whatton, Alison J-A Woolford, Gail L Wrigley, Peter O'Brien
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates. RSC medicinal chemistry 13 (12) (2022)
S Paul Jones, James D Firth, Mary C Wheldon, Masakazu Atobe, Roderick Eliot Hubbard, David C Blakemore, Claudia De Fusco, Simon C C Lucas, Stephen D Roughley, Lewis R Vidler, Maria Ann Whatton, Alison J-A Woolford, Gail L Wrigley, Peter O'Brien
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates. RSC medicinal chemistry 13 (12) (2022)
Simon C C Lucas, Stephen J Atkinson, Chun-Wa Chung, Rob Davis, Laurie Gordon, Paola Grandi, James J R Gray, Thomas Grimes, Alexander Phillipou, Alex G S Preston, Rab K Prinjha, Inmaculada Rioja, Simon Taylor, Nicholas C O Tomkinson, Ian Wall, Robert J Watson, James Woolven, Emmanuel H Demont
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors. Journal of medicinal chemistry 64 (15) (2021)
Matthias R Bauer, Paolo Di Fruscia, Simon C C Lucas, Iacovos N Michaelides, Jennifer E Nelson, R Ian Storer, Benjamin C Whitehurst
Put a ring on it: application of small aliphatic rings in medicinal chemistry. RSC medicinal chemistry 12 (4) (2021)

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Publication Activity (10 Years)

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Simon C C Lucas