James S Scott

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 37

Top Venues

Journal of medicinal chemistry

Expert opinion on therapeutic patents

Beilstein journal of organic chemistry

ACS chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Markus Schade, James S Scott, Thomas G Hayhow, Andy Pike, Ina Terstiege, Marie Ahlqvist, Johan R Johansson, Coura R Diene, Charlene Fallan, Amber Y S Balazs, Elisabetta Chiarparin, David Wilson
Structural and Physicochemical Features of Oral PROTACs. Journal of medicinal chemistry 67 (15) (2024)
James S Scott, Teresa C M Klinowska
Selective estrogen receptor degraders (SERDs) and covalent antagonists (SERCAs): a patent review (July 2021-December 2023). Expert opinion on therapeutic patents 34 (5) (2024)
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T Collie, Ian L Dale, Claudia De Fusco, Keith Dillman, Laura Evans, Lyman J Feron, Alison J Foster, Michael Grondine, Vasudev Kantae, Gillian M Lamont, Scott Lamont, James T Lynch, Sten Nilsson Lill, Graeme R Robb, Jamal Saeh, Marianne Schimpl, James S Scott, James M Smith, Bharath Srinivasan, Sharon Tentarelli, Mercedes Vazquez-Chantada, David J Wagner, Jarrod J Walsh, David Watson, Beth Williamson
Development of a Series of Pyrrolopyridone MAT2A Inhibitors. Journal of medicinal chemistry 67 (6) (2024)
Sharan K Bagal, Peter C Astles, Coura R Diene, Argyrides Argyrou, Claire Crafter, Doyle J Cassar, Charlene Fallan, Andreas Hock, Thomas Jones, Kevin Moreau, Gillian M Lamont, Scott Lamont, Chrysiis Michaloglou, Martin J Packer, Andy Pike, Antonio Ramos-Montoya, James S Scott, Joseph Shaw, Ziyanda Shologu
Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. Journal of medicinal chemistry 67 (14) (2024)
James M Smith, Bernard Barlaam, David Beattie, Lauren Bradshaw, Ho Man Chan, Elisabetta Chiarparin, Olga Collingwood, Sophie L Cooke, Anna Cronin, Iain Cumming, Emma Dean, Judit É Debreczeni, Iván Del Barco Barrantes, Coura R Diene, Davide Gianni, Carine Guerot, Xiaoxiao Guo, Sinem Guven, Thomas G Hayhow, Ted Hong, Paul D Kemmitt, Gillian M Lamont, Scott Lamont, James T Lynch, Lisa McWilliams, Shaun Moore, Piotr Raubo, Graeme R Robb, James Robinson, James S Scott, Bharath Srinivasan, Oliver Steward, Christopher J Stubbs, Karl Syson, Lixiang Tan, Oliver Turner, Elizabeth Underwood, Jelena Urosevic, Mercedes Vazquez-Chantada, Amy L Whittaker, David M Wilson, Jon J Winter-Holt
Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. Journal of medicinal chemistry 67 (16) (2024)
James S Scott, Teresa C M Klinowska
Selective estrogen receptor degraders (SERDs) and covalent antagonists (SERCAs): a patent review (July 2021 - December 2023). Expert opinion on therapeutic patents (2024)
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T Collie, Ian L Dale, Claudia De Fusco, Keith Dillman, Laura Evans, Lyman J Feron, Alison J Foster, Michael Grondine, Vasudev Kantae, Gillian M Lamont, Scott Lamont, James T Lynch, Sten Nilsson Lill, Graeme R Robb, Jamal Saeh, Marianne Schimpl, James S Scott, James M Smith, Bharath Srinivasan, Sharon Tentarelli, Mercedes Vazquez-Chantada, David J Wagner, Jarrod J Walsh, David Watson, Beth Williamson
Development of a Series of Pyrrolopyridone MAT2A Inhibitors. Journal of medicinal chemistry 67 (6) (2024)
Sharan K Bagal, Peter C Astles, Coura R Diene, Argyrides Argyrou, Claire Crafter, Doyle J Cassar, Charlene Fallan, Andreas Hock, Thomas Jones, Kevin Moreau, Gillian M Lamont, Scott Lamont, Chrysiis Michaloglou, Martin J Packer, Andy Pike, Antonio Ramos-Montoya, James S Scott, Joseph Shaw, Ziyanda Shologu
Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. Journal of medicinal chemistry 67 (14) (2024)
James S Scott, Teresa C M Klinowska
Selective estrogen receptor degraders (SERDs) and covalent antagonists (SERCAs): a patent review (July 2021-December 2023). Expert opinion on therapeutic patents (2024)
Sharan K Bagal, Peter C Astles, Coura R Diene, Argyrides Argyrou, Claire Crafter, Doyle J Cassar, Charlene Fallan, Andreas Hock, Thomas Jones, Kevin Moreau, Gillian M Lamont, Scott Lamont, Chrysiis Michaloglou, Martin J Packer, Andy Pike, Antonio Ramos-Montoya, James S Scott, Joseph Shaw, Ziyanda Shologu
Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. Journal of medicinal chemistry 67 (14) (2024)
Markus Schade, James S Scott, Thomas G Hayhow, Andy Pike, Ina Terstiege, Marie Ahlqvist, Johan R Johansson, Coura R Diene, Charlene Fallan, Amber Y S Balazs, Elisabetta Chiarparin, David Wilson
Structural and Physicochemical Features of Oral PROTACs. Journal of medicinal chemistry 67 (15) (2024)
James M Smith, Bernard Barlaam, David Beattie, Lauren Bradshaw, Ho Man Chan, Elisabetta Chiarparin, Olga Collingwood, Sophie L Cooke, Anna Cronin, Iain Cumming, Emma Dean, Judit É Debreczeni, Iván Del Barco Barrantes, Coura R Diene, Davide Gianni, Carine Guerot, Xiaoxiao Guo, Sinem Guven, Thomas G Hayhow, Ted Hong, Paul D Kemmitt, Gillian M Lamont, Scott Lamont, James T Lynch, Lisa McWilliams, Shaun Moore, Piotr Raubo, Graeme R Robb, James Robinson, James S Scott, Bharath Srinivasan, Oliver Steward, Christopher J Stubbs, Karl Syson, Lixiang Tan, Oliver Turner, Elizabeth Underwood, Jelena Urosevic, Mercedes Vazquez-Chantada, Amy L Whittaker, David M Wilson, Jon J Winter-Holt
Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. Journal of medicinal chemistry 67 (16) (2024)
Sharan K Bagal, Peter C Astles, Coura R Diene, Argyrides Argyrou, Claire Crafter, Doyle J Cassar, Charlene Fallan, Andreas Hock, Thomas Jones, Kevin Moreau, Gillian M Lamont, Scott Lamont, Chrysiis Michaloglou, Martin J Packer, Andy Pike, Antonio Ramos-Montoya, James S Scott, Joseph Shaw, Ziyanda Shologu
Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. Journal of medicinal chemistry (2024)
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T Collie, Ian L Dale, Claudia De Fusco, Keith Dillman, Laura Evans, Lyman J Feron, Alison J Foster, Michael Grondine, Vasudev Kantae, Gillian M Lamont, Scott Lamont, James T Lynch, Sten Nilsson Lill, Graeme R Robb, Jamal Saeh, Marianne Schimpl, James S Scott, James M Smith, Bharath Srinivasan, Sharon Tentarelli, Mercedes Vazquez-Chantada, David J Wagner, Jarrod J Walsh, David Watson, Beth Williamson
Development of a Series of Pyrrolopyridone MAT2A Inhibitors. Journal of medicinal chemistry (2024)
James M Smith, Bernard Barlaam, David Beattie, Lauren Bradshaw, Ho Man Chan, Elisabetta Chiarparin, Olga Collingwood, Sophie L Cooke, Anna Cronin, Iain Cumming, Emma Dean, Judit É Debreczeni, Iván Del Barco Barrantes, Coura R Diene, Davide Gianni, Carine Guerot, Xiaoxiao Guo, Sinem Guven, Thomas G Hayhow, Ted Hong, Paul D Kemmitt, Gillian M Lamont, Scott Lamont, James T Lynch, Lisa McWilliams, Shaun Moore, Piotr Raubo, Graeme R Robb, James Robinson, James S Scott, Bharath Srinivasan, Oliver Steward, Christopher J Stubbs, Karl Syson, Lixiang Tan, Oliver Turner, Elizabeth Underwood, Jelena Urosevic, Mercedes Vazquez-Chantada, Amy L Whittaker, David M Wilson, Jon J Winter-Holt
Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity. Journal of medicinal chemistry (2024)
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T Collie, Ian L Dale, Claudia De Fusco, Keith Dillman, Laura Evans, Lyman J Feron, Alison J Foster, Michael Grondine, Vasudev Kantae, Gillian M Lamont, Scott Lamont, James T Lynch, Sten Nilsson Lill, Graeme R Robb, Jamal Saeh, Marianne Schimpl, James S Scott, James M Smith, Bharath Srinivasan, Sharon Tentarelli, Mercedes Vazquez-Chantada, David J Wagner, Jarrod J Walsh, David Watson, Beth Williamson
Development of a Series of Pyrrolopyridone MAT2A Inhibitors. Journal of medicinal chemistry (2024)
Markus Schade, James S Scott, Thomas G Hayhow, Andy Pike, Ina Terstiege, Marie Ahlqvist, Johan R Johansson, Coura R Diene, Charlene Fallan, Amber Y S Balazs, Elisabetta Chiarparin, David Wilson
Structural and Physicochemical Features of Oral PROTACs. Journal of medicinal chemistry (2024)
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R J Davey, David I Fisher, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J Hughes, Thomas A Hunt, Tony Johnson, Stefan L Kavanagh, Teresa C M Klinowska, Carrie J B Larner, Mandy Lawson, Andrew S Lister, David Longmire, Stacey Marden, Thomas M McGuire, Caroline McMillan, Lindsay McMurray, Christopher J Morrow, J Willem M Nissink, Thomas A Moss, Daniel H O' Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. Journal of medicinal chemistry 66 (4) (2023)
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R J Davey, David I Fisher, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J Hughes, Thomas A Hunt, Tony Johnson, Stefan L Kavanagh, Teresa C M Klinowska, Carrie J B Larner, Mandy Lawson, Andrew S Lister, David Longmire, Stacey Marden, Thomas M McGuire, Caroline McMillan, Lindsay McMurray, Christopher J Morrow, J Willem M Nissink, Thomas A Moss, Daniel H O' Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. Journal of medicinal chemistry 66 (4) (2023)
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R J Davey, David I Fisher, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J Hughes, Thomas A Hunt, Tony Johnson, Stefan L Kavanagh, Teresa C M Klinowska, Carrie J B Larner, Mandy Lawson, Andrew S Lister, David Longmire, Stacey Marden, Thomas M McGuire, Caroline McMillan, Lindsay McMurray, Christopher J Morrow, J Willem M Nissink, Thomas A Moss, Daniel H O' Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. Journal of medicinal chemistry 66 (4) (2023)
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R J Davey, David I Fisher, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J Hughes, Thomas A Hunt, Tony Johnson, Stefan L Kavanagh, Teresa C M Klinowska, Carrie J B Larner, Mandy Lawson, Andrew S Lister, David Longmire, Stacey Marden, Thomas M McGuire, Caroline McMillan, Lindsay McMurray, Christopher J Morrow, J Willem M Nissink, Thomas A Moss, Daniel H O' Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. Journal of medicinal chemistry (2023)
Mandy Lawson, Natalie Cureton, Susana Ros, Azadeh C Bashi, Jelena Urosevic, Sophie D'Arcy, Oona Delpuech, Michelle DuPont, David I Fisher, Eric T Gangl, Hilary J Lewis, Dawn Trueman, Neha Wali, Stuart Charles Williamson, Jennifer I Moss, Elodie Montaudon, Héloïse Derrien, Elisabetta Marangoni, Ricardo J Miragaia, Sladjana Gagrica, Pablo Morentin Gutierrez, Thomas Moss, Gareth A Maglennon, Daniel Sutton, Radoslaw Polanski, Alan Rosen, Jonathan Cairns, Pei Zhang, Mònica Sánchez-Guixé, Violeta Serra, Susan E Critchlow, James S Scott, Justin P O Lindemann, Simon T Barry, Teresa Klinowska, Christopher J Morrow, Larissa S Carnevalli
The next-generation oral selective estrogen receptor degrader camizestrant (AZD9833) suppresses ER+ breast cancer growth and overcomes endocrine and CDK4/6 inhibitor resistance. Cancer research (2023)
Dušan Petrović, James S Scott, Michael S Bodnarchuk, Olivier Lorthioir, Scott Boyd, George M Hughes, Jordan Lane, Allan Wu, David Hargreaves, James Robinson, Jens Sadowski
Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors. Journal of chemical information and modeling 62 (16) (2022)
Stephen J Atkinson, Laura Evans, James S Scott
A patent review of MAT2a inhibitors (2018-2021). Expert opinion on therapeutic patents 32 (10) (2022)
James S Scott, Bernard Barlaam
Selective estrogen receptor degraders (SERDs) and covalent antagonists (SERCAs): a patent review (2015-present). Expert opinion on therapeutic patents (2021)
Robert I Troup, Benjamin Jeffries, Raphael El-Bekri Saudain, Eleni Georgiou, Johanna Fish, James S Scott, Elisabetta Chiarparin, Charlene Fallan, Bruno Linclau
Skipped Fluorination Motifs: Synthesis of Building Blocks and Comparison of Lipophilicity Trends with Vicinal and Isolated Fluorination Motifs. The Journal of organic chemistry 86 (2) (2021)
Claudia De Fusco, Marianne Schimpl, Ulf Börjesson, Tony Cheung, Iain Collie, Laura Evans, Priyanka Narasimhan, Christopher Stubbs, Mercedes Vazquez-Chantada, David J Wagner, Michael Grondine, Matthew G Sanders, Sharon Tentarelli, Elizabeth Underwood, Argyrides Argyrou, James M Smith, James T Lynch, Elisabetta Chiarparin, Graeme R Robb, Sharan K Bagal, James S Scott
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model. Journal of medicinal chemistry 64 (10) (2021)
Benjamin Jeffries, Zhong Wang, Robert I Troup, Anaïs Goupille, Jean-Yves Le Questel, Charlene Fallan, James S Scott, Elisabetta Chiarparin, Jérôme Graton, Bruno Linclau
Lipophilicity trends upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl groups. Beilstein journal of organic chemistry 16 (2020)
Thomas G Hayhow, Rachel E A Borrows, Coura R Diène, Gary Fairley, Charlene Fallan, Shaun M Fillery, James S Scott, David W Watson
A Buchwald-Hartwig Protocol to Enable Rapid Linker Exploration of Cereblon E3-Ligase PROTACs*. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (70) (2020)
James S Scott, Thomas A Moss, Amber Balazs, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Paul R J Davey, Oona Delpuech, Stephen Fawell, David I Fisher, Sladjana Gagrica, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Kara Herlihy, Samantha Hughes, Thomas A Hunt, Hoan Huynh, Sophie L M Janbon, Tony Johnson, Stefan Kavanagh, Teresa Klinowska, Mandy Lawson, Andrew S Lister, Stacey Marden, Dermot F McGinnity, Christopher J Morrow, J Willem M Nissink, Daniel H O' Donovan, Bo Peng, Radoslaw Polanski, Darren S Stead, Stephen Stokes, Kumar Thakur, Scott R Throner, Michael J Tucker, Jeffrey Varnes, Haixia Wang, David M Wilson, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist. Journal of medicinal chemistry 63 (23) (2020)
Ryan T Howard, Paul Hemsley, Philip Petteruti, Charlie N Saunders, Javier A Molina Bermejo, James S Scott, Jeffrey W Johannes, Edward William Tate
Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS chemical biology 15 (2) (2020)
Benjamin Jeffries, Zhong Wang, Hannah R Felstead, Jean-Yves Le Questel, James S Scott, Elisabetta Chiarparin, Jérôme Graton, Bruno Linclau
Systematic Investigation of Lipophilicity Modulation by Aliphatic Fluorination Motifs. Journal of medicinal chemistry 63 (3) (2020)
James S Scott, Andrew Bailey, David Buttar, Rodrigo J Carbajo, Jon Curwen, Paul R J Davey, Robert D M Davies, Sébastien L Degorce, Craig Donald, Eric Gangl, Ryan Greenwood, Sam D Groombridge, Tony Johnson, Scott Lamont, Mandy Lawson, Andrew Lister, Christopher J Morrow, Thomas A Moss, Jennifer H Pink, Radoslaw Polanski
Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists. Journal of medicinal chemistry 62 (3) (2019)
Sébastien L Degorce, Rana Anjum, Andrew Bloecher, Rodrigo J Carbajo, Keith S Dillman, Lisa Drew, Christopher T Halsall, Eva M Lenz, Nicola A Lindsay, Michele F Mayo, Jennifer H Pink, Graeme R Robb, Alan Rosen, James S Scott, Yafeng Xue
Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88L265P Mutant Diffuse Large B Cell Lymphoma. Journal of medicinal chemistry 62 (21) (2019)
Benjamin Jeffries, Zhong Wang, Jérôme Graton, Simon D Holland, Thomasin Brind, Ryan D R Greenwood, Jean-Yves Le Questel, James S Scott, Elisabetta Chiarparin, Bruno Linclau
Reducing the Lipophilicity of Perfluoroalkyl Groups by CF2-F/CF2-Me or CF3/CH3 Exchange. Journal of medicinal chemistry 61 (23) (2018)
Sébastien L Degorce, Michael S Bodnarchuk, Iain A Cumming, James S Scott
Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines. Journal of medicinal chemistry 61 (19) (2018)
James S Scott, Sébastien L Degorce, Rana Anjum, Janet Culshaw, Robert D M Davies, Nichola L Davies, Keith S Dillman, James E Dowling, Lisa Drew, Andrew D Ferguson, Sam D Groombridge, Christopher T Halsall, Julian A Hudson, Scott Lamont, Nicola A Lindsay, Stacey K Marden, Michele F Mayo, J Elizabeth Pease, David R Perkins, Jennifer H Pink, Graeme R Robb, Alan Rosen, Minhui Shen, Claire McWhirter, Dedong Wu
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma. Journal of medicinal chemistry 60 (24) (2017)

James S Scott.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

James S Scott