Marianne Schimpl

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 20

Top Venues

Journal of medicinal chemistry

ACS medicinal chemistry letters

Journal of the American Chemical Society

International journal of molecular sciences

AstraZeneca PLC

University of Dundee (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

AstraZeneca PLC

United Kingdom

Associate Principal Scientist :: R & D

Education History

University of Dundee Sep 11 2006 - Nov 01 2010

United Kingdom

PHD :: Collegoe of Life Sciences

Publications

Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T Collie, Ian L Dale, Claudia De Fusco, Keith Dillman, Laura Evans, Lyman J Feron, Alison J Foster, Michael Grondine, Vasudev Kantae, Gillian M Lamont, Scott Lamont, James T Lynch, Sten Nilsson Lill, Graeme R Robb, Jamal Saeh, Marianne Schimpl, James S Scott, James M Smith, Bharath Srinivasan, Sharon Tentarelli, Mercedes Vazquez-Chantada, David J Wagner, Jarrod J Walsh, David Watson, Beth Williamson
Development of a Series of Pyrrolopyridone MAT2A Inhibitors. Journal of medicinal chemistry 67 (6) (2024)
Adelphe M Mfuh, Jeffrey A Boerth, Gayathri Bommakanti, Christina Chan, Alex J Chinn, Erin Code, Patrick J Fricke, Kathryn A Giblin, Andrea Gohlke, Catherine Hansel, Niresh Hariparsad, Samantha J Hughes, Meizhong Jin, Vasudev Kantae, Stefan L Kavanagh, Michelle L Lamb, Jordan Lane, Rachel Moore, Taranee Puri, Taylor R Quinn, Iswarya Reddy, Graeme R Robb, Kevin J Robbins, Miguel Gancedo Rodrigo, Marianne Schimpl, Baljinder Singh, Meha Singh, Haoran Tang, Clare Thomson, Jarrod J Walsh, Jamie Ware, Iain D G Watson, Min-Wei Ye, Gail L Wrigley, Andrew X Zhang, Yun Zhang, Neil P Grimster
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. Journal of medicinal chemistry 67 (2) (2024)
Taylor R Quinn, Kathryn A Giblin, Clare Thomson, Jeffrey A Boerth, Gayathri Bommakanti, Erin Braybrooke, Christina Chan, Alex J Chinn, Erin Code, Caifeng Cui, Yukai Fan, Neil P Grimster, Keishi Kohara, Michelle L Lamb, Lina Ma, Adelphe M Mfuh, Graeme R Robb, Kevin J Robbins, Marianne Schimpl, Haoran Tang, Jamie Ware, Gail L Wrigley, Lin Xue, Yun Zhang, Huimin Zhu, Samantha J Hughes
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design. Journal of medicinal chemistry 67 (16) (2024)
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T Collie, Ian L Dale, Claudia De Fusco, Keith Dillman, Laura Evans, Lyman J Feron, Alison J Foster, Michael Grondine, Vasudev Kantae, Gillian M Lamont, Scott Lamont, James T Lynch, Sten Nilsson Lill, Graeme R Robb, Jamal Saeh, Marianne Schimpl, James S Scott, James M Smith, Bharath Srinivasan, Sharon Tentarelli, Mercedes Vazquez-Chantada, David J Wagner, Jarrod J Walsh, David Watson, Beth Williamson
Development of a Series of Pyrrolopyridone MAT2A Inhibitors. Journal of medicinal chemistry 67 (6) (2024)
Adelphe M Mfuh, Jeffrey A Boerth, Gayathri Bommakanti, Christina Chan, Alex J Chinn, Erin Code, Patrick J Fricke, Kathryn A Giblin, Andrea Gohlke, Catherine Hansel, Niresh Hariparsad, Samantha J Hughes, Meizhong Jin, Vasudev Kantae, Stefan L Kavanagh, Michelle L Lamb, Jordan Lane, Rachel Moore, Taranee Puri, Taylor R Quinn, Iswarya Reddy, Graeme R Robb, Kevin J Robbins, Miguel Gancedo Rodrigo, Marianne Schimpl, Baljinder Singh, Meha Singh, Haoran Tang, Clare Thomson, Jarrod J Walsh, Jamie Ware, Iain D G Watson, Min-Wei Ye, Gail L Wrigley, Andrew X Zhang, Yun Zhang, Neil P Grimster
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. Journal of medicinal chemistry (2024)
Taylor R Quinn, Kathryn A Giblin, Clare Thomson, Jeffrey A Boerth, Gayathri Bommakanti, Erin Braybrooke, Christina Chan, Alex J Chinn, Erin Code, Caifeng Cui, Yukai Fan, Neil P Grimster, Keishi Kohara, Michelle L Lamb, Lina Ma, Adelphe M Mfuh, Graeme R Robb, Kevin J Robbins, Marianne Schimpl, Haoran Tang, Jamie Ware, Gail L Wrigley, Lin Xue, Yun Zhang, Huimin Zhu, Samantha J Hughes
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design. Journal of medicinal chemistry (2024)
Taylor R Quinn, Kathryn A Giblin, Clare Thomson, Jeffrey A Boerth, Gayathri Bommakanti, Erin Braybrooke, Christina Chan, Alex J Chinn, Erin Code, Caifeng Cui, Yukai Fan, Neil P Grimster, Keishi Kohara, Michelle L Lamb, Lina Ma, Adelphe M Mfuh, Graeme R Robb, Kevin J Robbins, Marianne Schimpl, Haoran Tang, Jamie Ware, Gail L Wrigley, Lin Xue, Yun Zhang, Huimin Zhu, Samantha J Hughes
Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design. Journal of medicinal chemistry 67 (16) (2024)
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T Collie, Ian L Dale, Claudia De Fusco, Keith Dillman, Laura Evans, Lyman J Feron, Alison J Foster, Michael Grondine, Vasudev Kantae, Gillian M Lamont, Scott Lamont, James T Lynch, Sten Nilsson Lill, Graeme R Robb, Jamal Saeh, Marianne Schimpl, James S Scott, James M Smith, Bharath Srinivasan, Sharon Tentarelli, Mercedes Vazquez-Chantada, David J Wagner, Jarrod J Walsh, David Watson, Beth Williamson
Development of a Series of Pyrrolopyridone MAT2A Inhibitors. Journal of medicinal chemistry (2024)
Stephen J Atkinson, Sharan K Bagal, Argyrides Argyrou, Sean Askin, Tony Cheung, Elisabetta Chiarparin, Muireann Coen, Iain T Collie, Ian L Dale, Claudia De Fusco, Keith Dillman, Laura Evans, Lyman J Feron, Alison J Foster, Michael Grondine, Vasudev Kantae, Gillian M Lamont, Scott Lamont, James T Lynch, Sten Nilsson Lill, Graeme R Robb, Jamal Saeh, Marianne Schimpl, James S Scott, James M Smith, Bharath Srinivasan, Sharon Tentarelli, Mercedes Vazquez-Chantada, David J Wagner, Jarrod J Walsh, David Watson, Beth Williamson
Development of a Series of Pyrrolopyridone MAT2A Inhibitors. Journal of medicinal chemistry (2024)
Adelphe M Mfuh, Jeffrey A Boerth, Gayathri Bommakanti, Christina Chan, Alex J Chinn, Erin Code, Patrick J Fricke, Kathryn A Giblin, Andrea Gohlke, Catherine Hansel, Niresh Hariparsad, Samantha J Hughes, Meizhong Jin, Vasudev Kantae, Stefan L Kavanagh, Michelle L Lamb, Jordan Lane, Rachel Moore, Taranee Puri, Taylor R Quinn, Iswarya Reddy, Graeme R Robb, Kevin J Robbins, Miguel Gancedo Rodrigo, Marianne Schimpl, Baljinder Singh, Meha Singh, Haoran Tang, Clare Thomson, Jarrod J Walsh, Jamie Ware, Iain D G Watson, Min-Wei Ye, Gail L Wrigley, Andrew X Zhang, Yun Zhang, Neil P Grimster
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors. Journal of medicinal chemistry 67 (2) (2024)
Jeffrey A Boerth, Alex J Chinn, Marianne Schimpl, Gayathri Bommakanti, Christina Chan, Erin L Code, Kathryn A Giblin, Andrea Gohlke, Catherine S Hansel, Meizhong Jin, Stefan L Kavanagh, Michelle L Lamb, Jordan S Lane, Carrie J B Larner, Adelphe M Mfuh, Rachel K Moore, Taranee Puri, Taylor R Quinn, Minwei Ye, Kevin J Robbins, Miguel Gancedo Rodrigo, Haoran Tang, Jarrod Walsh, Jamie Ware, Gail L Wrigley, Iswarya Karapa Reddy, Yun Zhang, Neil P Grimster
Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity. ACS medicinal chemistry letters 14 (12) (2023)
Jeffrey A Boerth, Alex J Chinn, Marianne Schimpl, Gayathri Bommakanti, Christina Chan, Erin L Code, Kathryn A Giblin, Andrea Gohlke, Catherine S Hansel, Meizhong Jin, Stefan L Kavanagh, Michelle L Lamb, Jordan S Lane, Carrie J B Larner, Adelphe M Mfuh, Rachel K Moore, Taranee Puri, Taylor R Quinn, Minwei Ye, Kevin J Robbins, Miguel Gancedo Rodrigo, Haoran Tang, Jarrod Walsh, Jamie Ware, Gail L Wrigley, Iswarya Karapa Reddy, Yun Zhang, Neil P Grimster
Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity. ACS medicinal chemistry letters 14 (12) (2023)
Frederick W Goldberg, Attilla K T Ting, David Beattie, Gillian M Lamont, Charlene Fallan, M Raymond V Finlay, Beth Williamson, Marianne Schimpl, Alexander R Harmer, Oladipupo B Adeyemi, Pär Nordell, Anna S Cronin, Mercedes Vazquez-Chantada, Derek Barratt, Antonio Ramos-Montoya, Elaine B Cadogan, Barry R Davies
Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8 H -purin-8-one Inhibitors of DNA-PK. ACS medicinal chemistry letters 13 (8) (2022)
Jon J Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin, Ian L Dale, Paul R J Davey, Nichola L Davies, Christopher Denz, Shaun M Fillery, Carine M Guérot, Fujin Han, Samantha J Hughes, Meghana Kulkarni, Zhaoqun Liu, Alexander Milbradt, Thomas A Moss, Huijun Niu, Joe Patel, Alfred A Rabow, Marianne Schimpl, Junjie Shi, Dongqing Sun, Dejian Yang, Sylvie Guichard
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models. Journal of medicinal chemistry 65 (4) (2022)
Lotte van Beek, Éilís McClay, Saleha Patel, Marianne Schimpl, Laura Spagnolo, Taiana Maia de Oliveira
PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling. International journal of molecular sciences 22 (10) (2021)
J Willem M Nissink, Sana Bazzaz, Carolyn Blackett, Matthew A Clark, Olga Collingwood, Jeremy S Disch, Diana Gikunju, Kristin Goldberg, John P Guilinger, Elizabeth Hardaker, Edward J Hennessy, Rachael Jetson, Anthony D Keefe, William McCoull, Lindsay McMurray, Allison Olszewski, Ross Overman, Alexander Pflug, Marian Preston, Philip B Rawlins, Emma Rivers, Marianne Schimpl, Paul Smith, Caroline Truman, Elizabeth Underwood, Juli Warwicker, Jon Winter-Holt, Simon Woodcock, Ying Zhang
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. Journal of medicinal chemistry 64 (6) (2021)
Jeffrey W Johannes, Amber Balazs, Derek Barratt, Michal Bista, Matthew D Chuba, Sabina Cosulich, Susan E Critchlow, Sébastien L Degorce, Paolo Di Fruscia, Scott D Edmondson, Kevin Embrey, Stephen Fawell, Avipsa Ghosh, Sonja J Gill, Anders Gunnarsson, Sudhir M Hande, Tom D Heightman, Paul Hemsley, Giuditta Illuzzi, Jordan Lane, Carrie Larner, Elisabetta Leo, Lina Liu, Andrew Madin, Scott Martin, Lisa McWilliams, Mark J O'Connor, Jonathan P Orme, Fiona Pachl, Martin J Packer, Xiaohui Pei, Andrew Pike, Marianne Schimpl, Hongyao She, Anna D Staniszewska, Verity Talbot, Elizabeth Underwood, Jeffrey G Varnes, Lin Xue, Tieguang Yao, Ke Zhang, Andrew X Zhang, Xiaolan Zheng
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs. Journal of medicinal chemistry 64 (19) (2021)
William McCoull, Scott Boyd, Martin R Brown, Muireann Coen, Olga Collingwood, Nichola L Davies, Ann Doherty, Gary Fairley, Kristin Goldberg, Elizabeth Hardaker, Guang He, Edward J Hennessy, Philip Hopcroft, George Hodgson, Anne Jackson, Xiefeng Jiang, Ankur Karmokar, Anne-Laure Lainé, Nicola Lindsay, Yumeng Mao, Roshini Markandu, Lindsay McMurray, Neville McLean, Lorraine Mooney, Helen Musgrove, J Willem M Nissink, Alexander Pflug, Venkatesh Pilla Reddy, Philip B Rawlins, Emma Rivers, Marianne Schimpl, Graham F Smith, Sharon Tentarelli, Jon Travers, Robert I Troup, Josephine Walton, Cheng Wang, Stephen Wilkinson, Beth Williamson, Jon Winter-Holt, Dejian Yang, Yuting Zheng, Qianxiu Zhu, Paul D Smith
Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy. Journal of medicinal chemistry 64 (18) (2021)
Claudia De Fusco, Marianne Schimpl, Ulf Börjesson, Tony Cheung, Iain Collie, Laura Evans, Priyanka Narasimhan, Christopher Stubbs, Mercedes Vazquez-Chantada, David J Wagner, Michael Grondine, Matthew G Sanders, Sharon Tentarelli, Elizabeth Underwood, Argyrides Argyrou, James M Smith, James T Lynch, Elisabetta Chiarparin, Graeme R Robb, Sharan K Bagal, James S Scott
Fragment-Based Design of a Potent MAT2a Inhibitor and in Vivo Evaluation in an MTAP Null Xenograft Model. Journal of medicinal chemistry 64 (10) (2021)
Kirsten McAulay, Emily A Hoyt, Morgan Thomas, Marianne Schimpl, Michael S Bodnarchuk, Hilary J Lewis, Derek Barratt, Deepa Bhavsar, David M Robinson, Michael J Deery, Derek J Ogg, Gonçalo J L Bernardes, Richard A Ward, Michael J Waring, Jason G Kettle
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors. Journal of the American Chemical Society 142 (23) (2020)

Marianne Schimpl.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Marianne Schimpl