J Willem M Nissink

ResearcherID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 19

Top Venues

Journal of medicinal chemistry

Communications biology

Nature chemical biology

The Journal of biological chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Thomas G Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L Braybrooke, Andrew Campbell, Rodrigo J Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R Diène, Charlene Fallan, David I Fisher, Frederick W Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J Morrow, Myria Nikolaou, J Willem M Nissink, Patrick O'Shea, Radoslaw Polanski, Markus Schade, James S Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC. Communications biology 7 (1) (2024)
Thomas G Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L Braybrooke, Andrew Campbell, Rodrigo J Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R Diène, Charlene Fallan, David I Fisher, Frederick W Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J Morrow, Myria Nikolaou, J Willem M Nissink, Patrick O'Shea, Radoslaw Polanski, Markus Schade, James S Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC. Communications biology 7 (1) (2024)
Thomas G Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L Braybrooke, Andrew Campbell, Rodrigo J Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R Diène, Charlene Fallan, David I Fisher, Frederick W Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J Morrow, Myria Nikolaou, J Willem M Nissink, Patrick O'Shea, Radoslaw Polanski, Markus Schade, James S Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter
Metabolism-driven in vitro/in vivo disconnect of an oral ERɑ VHL-PROTAC. Communications biology 7 (1) (2024)
João Morado, Paul N Mortenson, J Willem M Nissink, Jonathan W Essex, Chris-Kriton Skylaris
Does a Machine-Learned Potential Perform Better Than an Optimally Tuned Traditional Force Field? A Case Study on Fluorohydrins. Journal of chemical information and modeling (2023)
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R J Davey, David I Fisher, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J Hughes, Thomas A Hunt, Tony Johnson, Stefan L Kavanagh, Teresa C M Klinowska, Carrie J B Larner, Mandy Lawson, Andrew S Lister, David Longmire, Stacey Marden, Thomas M McGuire, Caroline McMillan, Lindsay McMurray, Christopher J Morrow, J Willem M Nissink, Thomas A Moss, Daniel H O' Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. Journal of medicinal chemistry 66 (4) (2023)
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R J Davey, David I Fisher, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J Hughes, Thomas A Hunt, Tony Johnson, Stefan L Kavanagh, Teresa C M Klinowska, Carrie J B Larner, Mandy Lawson, Andrew S Lister, David Longmire, Stacey Marden, Thomas M McGuire, Caroline McMillan, Lindsay McMurray, Christopher J Morrow, J Willem M Nissink, Thomas A Moss, Daniel H O' Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. Journal of medicinal chemistry 66 (4) (2023)
M Raymond V Finlay, Mark Anderton, Andrew Bailey, Scott Boyd, Joanna Brookfield, Ceri Cairnduff, Mark D Charles, Anne Cheasty, Susan E Critchlow, Janet Culshaw, Judit Debreczeni, Tennyson Ekwuru, Ian Hollingsworth, Neil Jones, Fred Leroux, Mairi Littleson, Hollie McCarron, Jennifer McKelvie, Lorraine Mooney, J Willem M Nissink, Joe Patel, David Perkins, Steve Powell, Mar Jimenez Quesada, Piotr Raubo, Verity Sabin, James Smith, Peter D Smith, Andrew Stark, Attilla K T Ting, Peng Wang, Zena Wilson, Jon J Winter-Holt, J Matthew Wood, Gail L Wrigley, Guoqing Yu, Peng Zhang
Correction to "Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models". Journal of medicinal chemistry (2023)
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R J Davey, David I Fisher, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J Hughes, Thomas A Hunt, Tony Johnson, Stefan L Kavanagh, Teresa C M Klinowska, Carrie J B Larner, Mandy Lawson, Andrew S Lister, David Longmire, Stacey Marden, Thomas M McGuire, Caroline McMillan, Lindsay McMurray, Christopher J Morrow, J Willem M Nissink, Thomas A Moss, Daniel H O' Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. Journal of medicinal chemistry 66 (4) (2023)
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Natalie Cureton, Paul R J Davey, David I Fisher, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Samantha J Hughes, Thomas A Hunt, Tony Johnson, Stefan L Kavanagh, Teresa C M Klinowska, Carrie J B Larner, Mandy Lawson, Andrew S Lister, David Longmire, Stacey Marden, Thomas M McGuire, Caroline McMillan, Lindsay McMurray, Christopher J Morrow, J Willem M Nissink, Thomas A Moss, Daniel H O' Donovan, Radoslaw Polanski, Stephen Stokes, Kumar Thakur, Dawn Trueman, Caroline Truman, Michael J Tucker, Haixia Wang, Nicky Whalley, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. Journal of medicinal chemistry (2023)
J Willem M Nissink, Sana Bazzaz, Carolyn Blackett, Matthew A Clark, Olga Collingwood, Jeremy S Disch, Diana Gikunju, Kristin Goldberg, John P Guilinger, Elizabeth Hardaker, Edward J Hennessy, Rachael Jetson, Anthony D Keefe, William McCoull, Lindsay McMurray, Allison Olszewski, Ross Overman, Alexander Pflug, Marian Preston, Philip B Rawlins, Emma Rivers, Marianne Schimpl, Paul Smith, Caroline Truman, Elizabeth Underwood, Juli Warwicker, Jon Winter-Holt, Simon Woodcock, Ying Zhang
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. Journal of medicinal chemistry 64 (6) (2021)
João Morado, Paul N Mortenson, J Willem M Nissink, Marcel L Verdonk, Richard A Ward, Jonathan W Essex, Chris-Kriton Skylaris
Generation of Quantum Configurational Ensembles Using Approximate Potentials. Journal of chemical theory and computation 17 (11) (2021)
William McCoull, Scott Boyd, Martin R Brown, Muireann Coen, Olga Collingwood, Nichola L Davies, Ann Doherty, Gary Fairley, Kristin Goldberg, Elizabeth Hardaker, Guang He, Edward J Hennessy, Philip Hopcroft, George Hodgson, Anne Jackson, Xiefeng Jiang, Ankur Karmokar, Anne-Laure Lainé, Nicola Lindsay, Yumeng Mao, Roshini Markandu, Lindsay McMurray, Neville McLean, Lorraine Mooney, Helen Musgrove, J Willem M Nissink, Alexander Pflug, Venkatesh Pilla Reddy, Philip B Rawlins, Emma Rivers, Marianne Schimpl, Graham F Smith, Sharon Tentarelli, Jon Travers, Robert I Troup, Josephine Walton, Cheng Wang, Stephen Wilkinson, Beth Williamson, Jon Winter-Holt, Dejian Yang, Yuting Zheng, Qianxiu Zhu, Paul D Smith
Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy. Journal of medicinal chemistry 64 (18) (2021)
Gabriele Fumagalli, Rodrigo J Carbajo, J Willem M Nissink, Jonathan Tart, Rongxuan Dou, Andrew P Thomas, David R Spring
Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides. Journal of medicinal chemistry 64 (23) (2021)
James S Scott, Thomas A Moss, Amber Balazs, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Elisabetta Chiarparin, Paul R J Davey, Oona Delpuech, Stephen Fawell, David I Fisher, Sladjana Gagrica, Eric T Gangl, Tyler Grebe, Ryan D Greenwood, Sudhir Hande, Holia Hatoum-Mokdad, Kara Herlihy, Samantha Hughes, Thomas A Hunt, Hoan Huynh, Sophie L M Janbon, Tony Johnson, Stefan Kavanagh, Teresa Klinowska, Mandy Lawson, Andrew S Lister, Stacey Marden, Dermot F McGinnity, Christopher J Morrow, J Willem M Nissink, Daniel H O' Donovan, Bo Peng, Radoslaw Polanski, Darren S Stead, Stephen Stokes, Kumar Thakur, Scott R Throner, Michael J Tucker, Jeffrey Varnes, Haixia Wang, David M Wilson, Dedong Wu, Ye Wu, Bin Yang, Wenzhan Yang
Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist. Journal of medicinal chemistry 63 (23) (2020)
M Raymond V Finlay, Mark Anderton, Andrew Bailey, Scott Boyd, Joanna Brookfield, Ceri Cairnduff, Mark Charles, Anne Cheasty, Susan E Critchlow, Janet Culshaw, Tennyson Ekwuru, Ian Hollingsworth, Neil Jones, Fred Leroux, Mairi Littleson, Hollie McCarron, Jennifer McKelvie, Lorraine Mooney, J Willem M Nissink, David Perkins, Steve Powell, Mar Jimenez Quesada, Piotr Raubo, Verity Sabin, James Smith, Peter D Smith, Andrew Stark, Attilla Ting, Peng Wang, Zena Wilson, Jon J Winter-Holt, J Matthew Wood, Gail L Wrigley, Guoqing Yu, Peng Zhang
Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models. Journal of medicinal chemistry 62 (14) (2019)
Pavel Macek, Matthew J Cliff, Kevin J Embrey, Geoffrey A Holdgate, J Willem M Nissink, Stanislava Panova, Jonathan P Waltho, Rick A Davies
Myc phosphorylation in its basic helix-loop-helix region destabilizes transient α-helical structures, disrupting Max and DNA binding. The Journal of biological chemistry 293 (24) (2018)
Kevin M Foote, J Willem M Nissink, Thomas McGuire, Paul Turner, Sylvie Guichard, James W T Yates, Alan Lau, Kevin Blades, Dan Heathcote, Rajesh Odedra, Gary Wilkinson, Zena Wilson, Christine M Wood, Philip J Jewsbury
Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. Journal of medicinal chemistry 61 (22) (2018)
Jonathan B Baell, J Willem M Nissink
Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations. ACS chemical biology 13 (1) (2017)
Jack C Exell, Mark J Thompson, L David Finger, Steven J Shaw, Judit Debreczeni, Thomas A Ward, Claire McWhirter, Catrine L B Siöberg, Daniel Martinez Molina, W Mark Abbott, Clifford D Jones, J Willem M Nissink, Stephen T Durant, Jane A Grasby
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nature chemical biology 12 (10) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

J Willem M Nissink