Sibylle Neuhoff

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 31

Top Topics

Emergency Department

Electronic Health Record

Roux En Y Gastric Bypass

Mycobacterium Tuberculosis

Top Venues

Clinical pharmacology and therapeutics

CPT: pharmacometrics & systems pharmacology

Hepatology communications

Drug metabolism and disposition: the biological fate of chemicals

This page only lists publications with an associated author ORCID identifier.

Publications

Mattie Hartauer, William A Murphy, Kim L R Brouwer, Roz Southall, Sibylle Neuhoff
Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework. CPT: pharmacometrics & systems pharmacology (2024)
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Manal F Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L R Brouwer
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD. Hepatology communications 8 (3) (2024)
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Manal F Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L R Brouwer
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD. Hepatology communications 8 (3) (2024)
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Manal F Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L R Brouwer
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD. Hepatology communications 8 (3) (2024)
Liam Curry, Sarah Alrubia, Frederic Y Bois, Ruth Clayton, Eman El-Khateeb, Trevor N Johnson, Muhammad Faisal, Sibylle Neuhoff, Kris Wragg, Amin Rostami-Hodjegan
A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator. CPT: pharmacometrics & systems pharmacology (2024)
William A Murphy, Anna Mae Diehl, Matthew Shane Loop, Dong Fu, Cynthia D Guy, Manal F Abdelmalek, Georgia Sofia Karachaliou, Noora Sjöstedt, Sibylle Neuhoff, Paavo Honkakoski, Kim L R Brouwer
Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD. Hepatology communications 8 (3) (2024)
Olha Shuklinova, Sibylle Neuhoff, Sebastian Polak
How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study. Clinical pharmacology and therapeutics 116 (1) (2024)
Mattie Hartauer, William A Murphy, Kim L R Brouwer, Roz Southall, Sibylle Neuhoff
Hepatic OATP1B zonal distribution: Implications for rifampicin-mediated drug-drug interactions explored within a PBPK framework. CPT: pharmacometrics & systems pharmacology (2024)
Olha Shuklinova, Sibylle Neuhoff, Sebastian Polak
How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study. Clinical pharmacology and therapeutics (2024)
Grace Chen, Kefeng Sun, Ingrid Michon, Zoe Barter, Sibylle Neuhoff, Lipika Ghosh, Katarina Ilic, Ivy H Song
Physiologically-based pharmacokinetic modeling for maribavir to inform dosing in drug-drug interaction scenarios with cyp3a4 Inducers and Inhibitors. Journal of clinical pharmacology (2023)
Matthew D Harwood, Katharina Zettl, Manuel Weinheimer, Venkatesh Pilla-Reddy, Hong Shen, Frank Jacobs, Xiaoyan Chu, Felix Huth, Masanori Nakakariya, Paresh P Chothe, Sibylle Neuhoff, Jacek R Wiśniewski
Interlaboratory Variability in the Madin-Darby Canine Kidney Cell Proteome. Molecular pharmaceutics (2023)
Iain Gardner, Mandy Xu, Chunyan Han, Yi Wang, Xingjin Jiao, Masoud Jamei, Hiba Khalidi, Peter J Kilford, Sibylle Neuhoff, Roz Southall, David B Turner, Helen Musther, Barry Jones, Simon J Taylor
Non-specific binding of compounds in in vitro metabolism assays: A comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models. Xenobiotica; the fate of foreign compounds in biological systems (2022)
Valerio Taggi, Mario Riera Romo, Micheline Piquette-Miller, Henriette E Meyer Zu Schwabedissen, Sibylle Neuhoff
Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta. Pharmaceutics 14 (7) (2022)
Yukiko Murata, Sibylle Neuhoff, Amin Rostami-Hodjegan, Hiroyuki Takita, Zubida M Al-Majdoub, Kayode Ogungbenro
In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition. The AAPS journal 24 (1) (2022)
Peter J Kilford, Kuan-Fu Chen, Kim Crewe, Iain Gardner, Oliver Hatley, Alice Ban Ke, Sibylle Neuhoff, Mian Zhang, Karen Rowland Yeo
Prediction of CYP-mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator. CPT: pharmacometrics & systems pharmacology 11 (7) (2022)
Kunal S Taskar, Xinning Yang, Sibylle Neuhoff, Mitesh Patel, Kenta Yoshida, Mary F Paine, Kim L R Brouwer, Xiaoyan Chu, Yuichi Sugiyama, Jack Cook, Joseph W Polli, Imad Hanna, Yurong Lai, Maciej Zamek-Gliszczynski, null null
Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective. Clinical pharmacology and therapeutics 112 (3) (2022)
William A Murphy, Jeffry Adiwidjaja, Noora Sjöstedt, Kyunghee Yang, James J Beaudoin, Jessica Spires, Scott Q Siler, Sibylle Neuhoff, Kim L R Brouwer
Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH). Clinical pharmacology and therapeutics (2022)
Kim L R Brouwer, Raymond Evers, Elizabeth Hayden, Shuiying Hu, Cindy Yanfei Li, Henriette E Meyer Zu Schwabedissen, Sibylle Neuhoff, Stefan Oswald, Micheline Piquette-Miller, Chitra Saran, Noora Sjöstedt, Jason A Sprowl, Simone H Stahl, Wei Yue
Regulation of Drug Transport Proteins-From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium. Clinical pharmacology and therapeutics 112 (3) (2022)
Xiaoyan Chu, Bhagwat Prasad, Sibylle Neuhoff, Kenta Yoshida, James Steven Leeder, Dwaipayan Mukherjee, Kunal S Taskar, Manthena V S Varma, Xinyuan Zhang, Xinning Yang, Aleksandra Galetin
Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective. Clinical pharmacology and therapeutics 112 (3) (2022)
Udoamaka Ezuruike, Mian Zhang, Amita Pansari, Mailys De Sousa Mendes, Xian Pan, Sibylle Neuhoff, Iain Gardner
Guide to development of compound files for PBPK modeling in the Simcyp population-based simulator. CPT: pharmacometrics & systems pharmacology 11 (7) (2022)
Caroline Sychterz, Iain Gardner, Manting Chiang, Ramakrishna Rachumallu, Sibylle Neuhoff, Vidya Perera, Samira Merali, Brian J Schmidt, Lu Gaohua
Performance Verification of CYP2C19 Enzyme Abundance Polymorphism Settings within the Simcyp Simulator v21. Metabolites 12 (10) (2022)
Marilyn N Martinez, Jonathan P Mochel, Sibylle Neuhoff, Devendra Pade
Comparison of Canine and Human Physiological Factors: Understanding Interspecies Differences that Impact Drug Pharmacokinetics. The AAPS journal 23 (3) (2021)
Xian Pan, Shinji Yamazaki, Sibylle Neuhoff, Mian Zhang, Venkatesh Pilla Reddy
Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P-glycoprotein-cytochrome P450 3A4 dual substrates. CPT: pharmacometrics & systems pharmacology (2021)
Venkatesh Pilla Reddy, Heeseung Jo, Sibylle Neuhoff
Food constituent- and herb-drug interactions in oncology: Influence of quantitative modelling on Drug labelling. British journal of clinical pharmacology 87 (10) (2021)
Zubida M Al-Majdoub, Brahim Achour, Narciso Couto, Martyn Howard, Yasmine Elmorsi, Daniel Scotcher, Sarah Alrubia, Eman El-Khateeb, Areti-Maria Vasilogianni, Noura Alohali, Sibylle Neuhoff, Lutz Schmitt, Amin Rostami-Hodjegan, Jill Barber
Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin. FEBS letters 594 (23) (2020)
Mailys De Sousa Mendes, Alexandra L Orton, Helen E Humphries, Barry Jones, Iain Gardner, Sibylle Neuhoff, Venkatesh Pilla Reddy
A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates. Drug metabolism and disposition: the biological fate of chemicals 48 (11) (2020)
Noora Sjöstedt, Sibylle Neuhoff, Kim L R Brouwer
Physiologically-Based Pharmacokinetic Model of Morphine and Morphine-3-Glucuronide in Nonalcoholic Steatohepatitis. Clinical pharmacology and therapeutics 109 (3) (2020)
Matthew D Harwood, Mian Zhang, Shriram M Pathak, Sibylle Neuhoff
The Regional-Specific Relative and Absolute Expression of Gut Transporters in Adult Caucasians: A Meta-Analysis. Drug metabolism and disposition: the biological fate of chemicals 47 (8) (2019)
Irina E Antonescu, Karina F Rasmussen, Sibylle Neuhoff, Xavier Fretté, Maria Karlgren, Christel A S Bergstrom, Carsten Uhd Nielsen, Bente Steffansen
The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach. Molecular pharmaceutics 16 (11) (2019)
Udoamaka Ezuruike, Helen Humphries, Maurice Dickins, Sibylle Neuhoff, Iain Gardner, Karen Rowland Yeo
Risk-Benefit Assessment of Ethinylestradiol Using a Physiologically Based Pharmacokinetic Modeling Approach. Clinical pharmacology and therapeutics 104 (6) (2018)
Sibylle Neuhoff, Geoffrey T Tucker
Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity? British journal of clinical pharmacology 84 (7) (2018)