Lan Huang

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 49

Top Topics

Mass Spectrometry

Structural Basis

Endoplasmic Reticulum

Top Venues

Analytical chemistry

Proceedings of the National Academy of Sciences of the United States of America

Journal of proteome research

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Benjamin Velez, Richard M Walsh, Shaun Rawson, Aida Razi, Lea Adams, Erignacio Fermin Perez, Fenglong Jiao, Marie Blickling, Tamayanthi Rajakumar, Darlene Fung, Lan Huang, John Hanna
Mechanism of autocatalytic activation during proteasome assembly. Nature structural & molecular biology 31 (8) (2024)
Lihui Wang, Yue Xu, Tetsunari Fukushige, Layla Saidi, Xiaorong Wang, Clinton Yu, Jin-Gu Lee, Michael Krause, Lan Huang, Yihong Ye
Mono-UFMylation promotes misfolding-associated secretion of α-synuclein. Science advances 10 (11) (2024)
Linda Lauinger, Anna Andronicos, Karin Flick, Clinton Yu, Geetha Durairaj, Lan Huang, Peter Kaiser
Cadmium binding by the F-box domain induces p97-mediated SCF complex disassembly to activate stress response programs. Nature communications 15 (1) (2024)
Gianna M Fote, Vinay V Eapen, Ryan G Lim, Clinton Yu, Lisa Salazar, Nicolette R McClure, Jharrayne McKnight, Thai B Nguyen, Marie C Heath, Alice L Lau, Mark A Villamil, Ricardo Miramontes, Ian H Kratter, Steven Finkbeiner, Jack C Reidling, Joao A Paulo, Peter Kaiser, Lan Huang, David E Housman, Leslie M Thompson, Joan S Steffan
Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Linda Lauinger, Anna Andronicos, Karin Flick, Clinton Yu, Geetha Durairaj, Lan Huang, Peter Kaiser
Cadmium binding by the F-box domain induces p97-mediated SCF complex disassembly to activate stress response programs. Nature communications 15 (1) (2024)
Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang
DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Journal of proteome research (2024)
Lihui Wang, Yue Xu, Tetsunari Fukushige, Layla Saidi, Xiaorong Wang, Clinton Yu, Jin-Gu Lee, Michael Krause, Lan Huang, Yihong Ye
Mono-UFMylation promotes misfolding-associated secretion of α-synuclein. Science advances 10 (11) (2024)
Linda Lauinger, Anna Andronicos, Karin Flick, Clinton Yu, Geetha Durairaj, Lan Huang, Peter Kaiser
Cadmium binding by the F-box domain induces p97-mediated SCF complex disassembly to activate stress response programs. Nature communications 15 (1) (2024)
Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang
DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Journal of proteome research 23 (8) (2024)
Benjamin Velez, Richard M Walsh, Shaun Rawson, Aida Razi, Lea Adams, Erignacio Fermin Perez, Fenglong Jiao, Marie Blickling, Tamayanthi Rajakumar, Darlene Fung, Lan Huang, John Hanna
Mechanism of autocatalytic activation during proteasome assembly. Nature structural & molecular biology (2024)
Benjamin Velez, Richard M Walsh, Shaun Rawson, Aida Razi, Lea Adams, Erignacio Fermin Perez, Fenglong Jiao, Marie Blickling, Tamayanthi Rajakumar, Darlene Fung, Lan Huang, John Hanna
Mechanism of autocatalytic activation during proteasome assembly. Nature structural & molecular biology (2024)
Lihui Wang, Yue Xu, Tetsunari Fukushige, Layla Saidi, Xiaorong Wang, Clinton Yu, Jin-Gu Lee, Michael Krause, Lan Huang, Yihong Ye
Mono-UFMylation promotes misfolding-associated secretion of α-synuclein. Science advances 10 (11) (2024)
Gianna M Fote, Vinay V Eapen, Ryan G Lim, Clinton Yu, Lisa Salazar, Nicolette R McClure, Jharrayne McKnight, Thai B Nguyen, Marie C Heath, Alice L Lau, Mark A Villamil, Ricardo Miramontes, Ian H Kratter, Steven Finkbeiner, Jack C Reidling, Joao A Paulo, Peter Kaiser, Lan Huang, David E Housman, Leslie M Thompson, Joan S Steffan
Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Linda Lauinger, Anna Andronicos, Karin Flick, Clinton Yu, Geetha Durairaj, Lan Huang, Peter Kaiser
Cadmium binding by the F-box domain induces p97-mediated SCF complex disassembly to activate stress response programs. Nature communications 15 (1) (2024)
Lihui Wang, Yue Xu, Tetsunari Fukushige, Layla Saidi, Xiaorong Wang, Clinton Yu, Jin-Gu Lee, Michael Krause, Lan Huang, Yihong Ye
Mono-UFMylation promotes misfolding-associated secretion of α-synuclein. Science advances 10 (11) (2024)
Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang
DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Journal of proteome research 23 (8) (2024)
Gianna M Fote, Vinay V Eapen, Ryan G Lim, Clinton Yu, Lisa Salazar, Nicolette R McClure, Jharrayne McKnight, Thai B Nguyen, Marie C Heath, Alice L Lau, Mark A Villamil, Ricardo Miramontes, Ian H Kratter, Steven Finkbeiner, Jack C Reidling, Joao A Paulo, Peter Kaiser, Lan Huang, David E Housman, Leslie M Thompson, Joan S Steffan
Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang
DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Journal of proteome research 23 (8) (2024)
Fenglong Jiao, Clinton Yu, Andrew Wheat, Lijun Chen, Tung-Shing Mamie Lih, Hui Zhang, Lan Huang
DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Journal of proteome research (2024)
Gianna M Fote, Vinay V Eapen, Ryan G Lim, Clinton Yu, Lisa Salazar, Nicolette R McClure, Jharrayne McKnight, Thai B Nguyen, Marie C Heath, Alice L Lau, Mark A Villamil, Ricardo Miramontes, Ian H Kratter, Steven Finkbeiner, Jack C Reidling, Joao A Paulo, Peter Kaiser, Lan Huang, David E Housman, Leslie M Thompson, Joan S Steffan
Huntingtin contains an ubiquitin-binding domain and regulates lysosomal targeting of mitochondrial and RNA-binding proteins. Proceedings of the National Academy of Sciences of the United States of America 121 (32) (2024)
Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J Adams, Michael R Hoopmann, William C Temple, Adila Izgutdina, Bonell Patiño Escobar, Maryna Gorelik, Christian H Ihling, Matthew A Nix, Akul Naik, William H Xie, Juwita Hübner, Lisa A Rollins, Sandy M Reid, Emilio Ramos, Corynn Kasap, Veronica Steri, Juan Antonio Camara Serrano, Fernando Salangsang, Paul Phojanakong, Melanie McMillan, Victor Gavallos, Andrew D Leavitt, Aaron C Logan, Cliona M Rooney, Justin Eyquem, Andrea Sinz, Benjamin S Braun, Elliot Stieglitz, Catherine C Smith, Robert L Moritz, Sachdev S Sidhu, Lan Huang, Arun P Wiita
Structural surfaceomics reveals an AML-specific conformation of integrin β 2 as a CAR T cellular therapy target. Nature cancer (2023)
Fenglong Jiao, Leah J Salituro, Clinton Yu, Craig B Gutierrez, Scott D Rychnovsky, Lan Huang
Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry. Analytical chemistry 95 (4) (2023)
Fenglong Jiao, Leah J Salituro, Clinton Yu, Craig B Gutierrez, Scott D Rychnovsky, Lan Huang
Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry. Analytical chemistry (2023)
Shiheng Liu, Hong Wang, Xiaorun Li, Fan Zhang, Jane K J Lee, Zihang Li, Clinton Yu, Jason J Hu, Xiaojing Zhao, Takuma Suematsu, Ana L Alvarez-Cabrera, Qiushi Liu, Liye Zhang, Lan Huang, Inna Aphasizheva, Ruslan Aphasizhev, Z Hong Zhou
Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science (New York, N.Y.) 381 (6653) (2023)
Fenglong Jiao, Leah J Salituro, Clinton Yu, Craig B Gutierrez, Scott D Rychnovsky, Lan Huang
Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry. Analytical chemistry 95 (4) (2023)
Fenglong Jiao, Leah J Salituro, Clinton Yu, Craig B Gutierrez, Scott D Rychnovsky, Lan Huang
Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry. Analytical chemistry 95 (4) (2023)
Ruizhu Zhang, Shuxian Pan, Suya Zheng, Qingqing Liao, Zhao-Di Jiang, Di-Xian Wang, Xuemei Li, Ao Hu, Xinran Li, Ye-Zhang Zhu, Xiaoqi Shen, Jing Lei, Siming Zhong, Xiaomei Zhang, Lingyun Huang, Xiaorong Wang, Lan Huang, Li Shen, Bao- Liang Song, Jing-Wei Zhao, Zhiping Wang, Bing Yang, Xing Guo
Lipid-anchored proteasomes control membrane protein homeostasis. Science advances 9 (48) (2023)
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M Burke, Ilan E Chemmama, Robyn M Kaake, Peter Baker, Scott D Rychnovsky, Jing Yang, Lan Huang
Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 118 (32) (2022)
Clinton Yu, Xiaorong Wang, Lan Huang
Developing a Targeted Quantitative Strategy for Sulfoxide-Containing MS-Cleavable Cross-Linked Peptides to Probe Conformational Dynamics of Protein Complexes. Analytical chemistry 94 (10) (2022)
Fenglong Jiao, Clinton Yu, Andrew Wheat, Xiaorong Wang, Scott D Rychnovsky, Lan Huang
Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis. Analytical chemistry 94 (10) (2022)
Han Han, Hiroki J Nakaoka, Line Hofmann, Jeff Jiajing Zhou, Clinton Yu, Lisha Zeng, Junyu Nan, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Ruxi Qi, Lee Bardwell, Dmitry A Fishman, Ken W Y Cho, Lan Huang, Ray Luo, Rahul Warrior, Wenqi Wang
The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1. Nature cell biology 24 (1) (2022)
Shaun Rawson, Richard M Walsh, Benjamin Velez, Helena Maria Schnell, Fenglong Jiao, Marie Blickling, Jessie Ang, Meera K Bhanu, Lan Huang, John Hanna
Yeast PI31 inhibits the proteasome by a direct multisite mechanism. Nature structural & molecular biology 29 (8) (2022)
Clinton Yu, Xiaorong Wang, Wenxue Li, Yansheng Liu, Lan Huang
Developing a Bimolecular Affinity Purification Strategy to Isolate 26S Proteasome Holocomplexes for Complex-Centric Proteomic Analysis. Analytical chemistry 93 (39) (2021)
Yuefan Wang, Yingwei Hu, Naseruddin Höti, Lan Huang, Hui Zhang
Characterization of In Vivo Protein Complexes via Chemical Cross-Linking and Mass Spectrometry. Analytical chemistry 94 (3) (2021)
Peng Chen, Ji Zeng, Zheng Liu, Hatim Thaker, Siyu Wang, Songhai Tian, Jie Zhang, Liang Tao, Craig B Gutierrez, Li Xing, Ralf Gerhard, Lan Huang, Min Dong, Rongsheng Jin
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection. Nature communications 12 (1) (2021)
Lu Chen, Yanan Zhang, Xin Shu, Qiong Chen, Tiantian Wei, Heman Wang, Xiaorong Wang, Qirou Wu, Xiaomei Zhang, Xiaoyan Liu, Suya Zheng, Lan Huang, Junyu Xiao, Chao Jiang, Bing Yang, Zhiping Wang, Xing Guo
Proteasome regulation by reversible tyrosine phosphorylation at the membrane. Oncogene 40 (11) (2021)
Kenneth Wu, Khoi Q Huynh, Iris Lu, Moses Moustakim, Haibin Miao, Clinton Yu, Matthew J Haeusgen, Benjamin D Hopkins, Lan Huang, Ning Zheng, Roberto Sanchez, Robert J DeVita, Zhen-Qiang Pan
Inhibitors of cullin-RING E3 ubiquitin ligase 4 with antitumor potential. Proceedings of the National Academy of Sciences of the United States of America 118 (8) (2021)
Jing-Zi Zhang, Ruoyu Zhao, Clinton Yu, Christine L N Bryant, Kenneth Wu, Zhihong Liu, Yibing Ding, Yue Zhao, Bin Xue, Zhen-Qiang Pan, Chaojun Li, Lan Huang, Chaojun Li
IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5. Journal of proteome research 19 (3) (2020)
Craig Gutierrez, Ilan E Chemmama, Haibin Mao, Clinton Yu, Ignacia Echeverria, Sarah A Block, Scott D Rychnovsky, Ning Zheng, Andrej Sali, Lan Huang
Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling. Proceedings of the National Academy of Sciences of the United States of America 117 (8) (2020)
Jing-Zi Zhang, Neng Tang, Yinjuan Zhao, Ruoyu Zhao, Xiao Fu, Dandan Zhao, Yue Zhao, Lan Huang, Chaojun Li, Yudong Qiu, Bin Xue, Chaojun Li
Global Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice. Journal of proteome research 19 (4) (2020)
Clinton Yu, Eric J Novitsky, Nicholas W Cheng, Scott D Rychnovsky, Lan Huang
Exploring Spacer Arm Structures for Designs of Asymmetric Sulfoxide-Containing MS-Cleavable Cross-Linkers. Analytical chemistry 92 (8) (2020)
Xiao Gao, Qingwei Wang, Ying Wang, Jiang Liu, Shuang Liu, Jian Liu, Xingli Zhou, Li Zhou, Hui Chen, Linian Pan, Jiwei Chen, Da Wang, Qing Zhang, Shihui Shen, Yu Xiao, Zhipeng Wu, Yiyun Cheng, Geng Chen, Syeda Kubra, Jun Qin, Lan Huang, Pei Zhang, Chuangui Wang, Robb E Moses, David M Lonard, Bert W O' Malley, Fuad Fares, Bianhong Zhang, Xiaotao Li, Lei Li, Jianru Xiao
Author Correction: The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Nature communications 11 (1) (2020)
Selma S Alkafeef, Shelley Lane, Clinton Yu, Tingting Zhou, Norma V Solis, Scott G Filler, Lan Huang, Haoping Liu
Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes. PLoS genetics 16 (6) (2020)
Xiao Gao, Qingwei Wang, Ying Wang, Jiang Liu, Shuang Liu, Jian Liu, Xingli Zhou, Li Zhou, Hui Chen, Linian Pan, Jiwei Chen, Da Wang, Qing Zhang, Shihui Shen, Yu Xiao, Zhipeng Wu, Yiyun Cheng, Geng Chen, Syeda Kubra, Jun Qin, Lan Huang, Pei Zhang, Chuangui Wang, Robb E Moses, David M Lonard, Bert W O' Malley, Fuad Fares, Bianhong Zhang, Xiaotao Li, Lei Li, Jianru Xiao
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Nature communications 11 (1) (2020)
Peng Chen, Kwok-Ho Lam, Zheng Liu, Frank A Mindlin, Baohua Chen, Craig B Gutierrez, Lan Huang, Yongrong Zhang, Therwa Hamza, Hanping Feng, Tsutomu Matsui, Mark E Bowen, Kay Perry, Rongsheng Jin
Structure of the full-length Clostridium difficile toxin B. Nature structural & molecular biology 26 (8) (2019)
Xiaoyan Liu, Weidi Xiao, Yanan Zhang, Sandra E Wiley, Tao Zuo, Yingying Zheng, Natalie Chen, Lu Chen, Xiaorong Wang, Yawen Zheng, Lan Huang, Shixian Lin, Anne N Murphy, Jack E Dixon, Ping Xu, Xing Guo
Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function. Proceedings of the National Academy of Sciences of the United States of America 117 (1) (2019)
Claudio Iacobucci, Christine Piotrowski, Ruedi Aebersold, Bruno C Amaral, Philip Andrews, Katja Bernfur, Christoph H Borchers, Nicolas I Brodie, James E Bruce, Yong Cao, Stéphane Chaignepain, Juan D Chavez, Stéphane Claverol, Juergen Cox, Trisha Davis, Gianluca Degliesposti, Meng-Qiu Dong, Nufar Edinger, Cecilia Emanuelsson, Marina Gay, Michael Götze, Francisco Gomes-Neto, Fabio César Gozzo, Craig Gutierrez, Caroline Haupt, Albert J R Heck, Franz Herzog, Lan Huang, Michael R Hoopmann, Nir Kalisman, Oleg Klykov, Zdeněk Kukačka, Fan Liu, Michael J MacCoss, Karl Mechtler, Ravit Mesika, Robert L Moritz, Nagarjuna Nagaraj, Victor Nesati, Ana G C Neves-Ferreira, Robert Ninnis, Petr Novák, Francis J O'Reilly, Matthias Pelzing, Evgeniy Petrotchenko, Lolita Piersimoni, Manolo Plasencia, Tara Louise Pukala, Kasper Dyrberg Rand, Juri Rappsilber, Dana Reichmann, Carolin Sailer, Chris P Sarnowski, Richard A Scheltema, Carla Schmidt, David C Schriemer, Yi Shi, J Mark Skehel, Moriya Slavin, Frank Sobott, Victor Solis-Mezarino, Heike Stephanowitz, Florian Stengel, Christian E Stieger, Esben Trabjerg, Michael Trnka, Marta Vilaseca, Rosa Viner, Yufei Xiang, Sule Yilmaz, Alex Zelter, Daniel Ziemianowicz, Alexander Leitner, Andrea Sinz
First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study. Analytical chemistry 91 (11) (2019)
Craig B Gutierrez, Sarah A Block, Clinton Yu, Stephanie M Soohoo, Alexander S Huszagh, Scott D Rychnovsky, Lan Huang
Development of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein-Protein Interactions. Analytical chemistry 90 (12) (2018)
Clinton Yu, Lan Huang
Cross-Linking Mass Spectrometry: An Emerging Technology for Interactomics and Structural Biology. Analytical chemistry 90 (1) (2017)