Lei-Ke Zhang (Leike Zhang)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 47

Top Topics

Structural Basis

Top Venues

Signal transduction and targeted therapy

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Zhidong Jiang, Bo Feng, Lu Chen, Tianqing Nie, Shizhao Chen, Li Wang, Hui Liu, Ting Yu, Yumin Zhang, Miao Zheng, Yechun Xu, Hong Liu, Yi Zang, Haixia Su, Lei-Ke Zhang, Jia Li, Yu Zhou
Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CL pro Inhibitors as anti-SARS-CoV-2 Drug Candidate. Journal of medicinal chemistry (2024)
Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Geng-Fu Xiao, Zihe Rao, Lu Lu, Lei-Ke Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal transduction and targeted therapy 9 (1) (2024)
Zhidong Jiang, Bo Feng, Lu Chen, Tianqing Nie, Shizhao Chen, Li Wang, Hui Liu, Ting Yu, Yumin Zhang, Miao Zheng, Yechun Xu, Hong Liu, Yi Zang, Haixia Su, Lei-Ke Zhang, Jia Li, Yu Zhou
Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CL pro Inhibitors as anti-SARS-CoV-2 Drug Candidate. Journal of medicinal chemistry 67 (15) (2024)
Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Geng-Fu Xiao, Zihe Rao, Lu Lu, Lei-Ke Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal transduction and targeted therapy 9 (1) (2024)
Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Geng-Fu Xiao, Zihe Rao, Lu Lu, Lei-Ke Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal transduction and targeted therapy 9 (1) (2024)
Weilong Deng, Xiao Hu, Xiaoman Tian, Yuanyuan Zhang, Weijuan Shang, Lei-Ke Zhang, Lu-Qing Shang
Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L. Journal of medicinal chemistry (2024)
Zhidong Jiang, Bo Feng, Lu Chen, Tianqing Nie, Shizhao Chen, Li Wang, Hui Liu, Ting Yu, Yumin Zhang, Miao Zheng, Yechun Xu, Hong Liu, Yi Zang, Haixia Su, Lei-Ke Zhang, Jia Li, Yu Zhou
Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CL pro Inhibitors as anti-SARS-CoV-2 Drug Candidate. Journal of medicinal chemistry 67 (15) (2024)
Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Geng-Fu Xiao, Zihe Rao, Lu Lu, Lei-Ke Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal transduction and targeted therapy 9 (1) (2024)
Yi Wang, Xiaoyan Pan, Hongying Ji, Xiaoli Zuo, Geng-Fu Xiao, Jia Li, Lei-Ke Zhang, Bingqing Xia, Zhaobing Gao
Impact of SARS-CoV-2 envelope protein mutations on the pathogenicity of Omicron XBB. Cell discovery 9 (1) (2023)
Xiangrui Jiang, Haixia Su, Weijuan Shang, Feng Zhou, Yan Zhang, Wenfeng Zhao, Qiumeng Zhang, Hang Xie, Lei Jiang, Tianqing Nie, Feipu Yang, Muya Xiong, Xiaoxing Huang, Minjun Li, Ping Chen, Shaoping Peng, Geng-Fu Xiao, Hualiang Jiang, Renhong Tang, Lei-Ke Zhang, Jingshan Shen, Yechun Xu
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir. Nature communications 14 (1) (2023)
Mengwei Xu, Huan Xu, Weiwei Wan, Xiaoqin Jian, Runming Jin, Lin Wang, Jingshi Wang, Gengfu Xiao, Lei-Ke Zhang, Hongbo Chen, Yuxi Wen
PDIA4 Is a Host Factor Important for Lymphocytic Choriomeningitis Virus Infection. Viruses 15 (12) (2023)
Bingqing Xia, Xiaoyan Pan, Rong-Hua Luo, Xurui Shen, Shuangqu Li, Yi Wang, Xiaoli Zuo, Yan Wu, Yingqi Guo, Geng-Fu Xiao, Qiguang Li, Xin-Yan Long, Xiao-Yan He, Hong-Yi Zheng, Ying Lu, Wei Pang, Yong-Tang Zheng, Jia Li, Lei-Ke Zhang, Zhaobing Gao
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2. Cell discovery 9 (1) (2023)
Bingqing Xia, Xiaoyan Pan, Rong-Hua Luo, Xurui Shen, Shuangqu Li, Yi Wang, Xiaoli Zuo, Yan Wu, Yingqi Guo, Geng-Fu Xiao, Qiguang Li, Xin-Yan Long, Xiao-Yan He, Hong-Yi Zheng, Ying Lu, Wei Pang, Yong-Tang Zheng, Jia Li, Lei-Ke Zhang, Zhaobing Gao
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2. Cell discovery 9 (1) (2023)
Mengwei Xu, Huan Xu, Weiwei Wan, Xiaoqin Jian, Runming Jin, Lin Wang, Jingshi Wang, Gengfu Xiao, Lei-Ke Zhang, Hongbo Chen, Yuxi Wen
PDIA4 Is a Host Factor Important for Lymphocytic Choriomeningitis Virus Infection. Viruses 15 (12) (2023)
Mengwei Xu, Huan Xu, Weiwei Wan, Xiaoqin Jian, Runming Jin, Lin Wang, Jingshi Wang, Gengfu Xiao, Lei-Ke Zhang, Hongbo Chen, Yuxi Wen
PDIA4 Is a Host Factor Important for Lymphocytic Choriomeningitis Virus Infection. Viruses 15 (12) (2023)
Zhidong Jiang, Bo Feng, Yumin Zhang, Tianqing Nie, Hong Liu, Jia Li, Haixia Su, Lei-Ke Zhang, Yi Zang, Yu Zhou
Discovery of novel non-peptidic and non-covalent small-molecule 3CL pro inhibitors as potential candidate for COVID-19 treatment. Signal transduction and targeted therapy 8 (1) (2023)
Bingqing Xia, Xiaoyan Pan, Rong-Hua Luo, Xurui Shen, Shuangqu Li, Yi Wang, Xiaoli Zuo, Yan Wu, Yingqi Guo, Geng-Fu Xiao, Qiguang Li, Xin-Yan Long, Xiao-Yan He, Hong-Yi Zheng, Ying Lu, Wei Pang, Yong-Tang Zheng, Jia Li, Lei-Ke Zhang, Zhaobing Gao
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2. Cell discovery 9 (1) (2023)
Xia-Ming Jiang, Qi-Lin Xin, Kai Liu, Xue-Fang Peng, Shuo Han, Ling-Yu Zhang, Wei Liu, Geng-Fu Xiao, Hao Li, Lei-Ke Zhang
Regulation of the WNT-CTNNB1 signaling pathway by severe fever with thrombocytopenia syndrome virus in a cap-snatching manner. mBio (2023)
Haofeng Wang, Qi Yang, Xiaoce Liu, Zili Xu, Maolin Shao, Dongxu Li, Yinkai Duan, Jielin Tang, Xianqiang Yu, Yumin Zhang, Aihua Hao, Yajie Wang, Jie Chen, Chenghao Zhu, Luke W Guddat, Hongli Chen, Lei-Ke Zhang, Xinwen Chen, Biao Jiang, Lei Sun, Zihe Rao, Haitao Yang
Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry. Nature communications 14 (1) (2023)
Zhidong Jiang, Bo Feng, Yumin Zhang, Tianqing Nie, Hong Liu, Jia Li, Haixia Su, Lei-Ke Zhang, Yi Zang, Yu Zhou
Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CL pro inhibitors as potential candidate for COVID-19 treatment. Signal transduction and targeted therapy 8 (1) (2023)
Yumin Zhang, Yuan Sun, Yuanchao Xie, Weijuan Shang, Zhen Wang, Hualiang Jiang, Jingshan Shen, Geng-Fu Xiao, Lei-Ke Zhang
A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir. Signal transduction and targeted therapy 8 (1) (2023)
Mengwei Xu, Huan Xu, Weiwei Wan, Xiaoqin Jian, Runming Jin, Lin Wang, Jingshi Wang, Gengfu Xiao, Lei-Ke Zhang, Hongbo Chen, Yuxi Wen
PDIA4 Is a Host Factor Important for Lymphocytic Choriomeningitis Virus Infection. Viruses 15 (12) (2023)
Bingqing Xia, Xiaoyan Pan, Rong-Hua Luo, Xurui Shen, Shuangqu Li, Yi Wang, Xiaoli Zuo, Yan Wu, Yingqi Guo, Geng-Fu Xiao, Qiguang Li, Xin-Yan Long, Xiao-Yan He, Hong-Yi Zheng, Ying Lu, Wei Pang, Yong-Tang Zheng, Jia Li, Lei-Ke Zhang, Zhaobing Gao
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2. Cell discovery 9 (1) (2023)
Lei-Ke Zhang, Xue-Fang Peng, Qingxing Wang, Jin Li, Shouming Lv, Shuo Han, Lingyu Zhang, Heng Ding, Cong-Yi Wang, Gengfu Xiao, Xuguang Du, Ke Peng, Hao Li, Wei Liu
CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virus. Science advances 9 (31) (2023)
Pengxuan Ren, Hui Li, Tianqing Nie, Xiaoqin Jian, Changyue Yu, Jian Li, Haixia Su, Xianglei Zhang, Shiwei Li, Xin Yang, Chao Peng, Yue Yin, Lei-Ke Zhang, Yechun Xu, Hong Liu, Fang Bai
Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group. Journal of medicinal chemistry (2023)
Ruxue Zhang, Yumin Zhang, Wei Zheng, Weijuan Shang, Yan Wu, Ning Li, Jun Xiong, Hualiang Jiang, Jingshan Shen, Gengfu Xiao, Yuanchao Xie, Lei-Ke Zhang
Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model. Signal transduction and targeted therapy 7 (1) (2022)
Lin Zhu, Ting Gao, Yi Huang, Jing Jin, Di Wang, Lei-Ke Zhang, Yanwen Jin, Ping Li, Yong Hu, Yan Wu, Hainan Liu, Qincai Dong, Guangfei Wang, Tong Zheng, Caiwei Song, Yu Bai, Xun Zhang, Yaoning Liu, Weihong Yang, Ke Xu, Gang Zou, Lei Zhao, Ruiyuan Cao, Xinbo Zhou, Xianzhu Xia, Geng-Fu Xiao, Xuan Liu, Cheng Cao
Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and pathogenesis by AKIP1 association. Nature communications 13 (1) (2022)
Yiru Long, Jianhua Sun, Tian-Zhang Song, Tingting Liu, Feng Tang, Xinxin Zhang, Longfei Ding, Yunqiu Miao, Jianming Zhu, Xiaoyan Pan, Qi An, Mian Qin, Xiankun Tong, Xionghua Peng, Pan Yu, Peng Zhu, Jianqing Xu, Xiaoyan Zhang, Yachun Zhang, Datao Liu, Ben Chen, Huilin Chen, Lei-Ke Zhang, Gengfu Xiao, Jianping Zuo, Wei Tang, Ji Zhou, Heng Li, Zhijian Xu, Hong-Yi Zheng, Xin-Yan Long, Qiuping Qin, Yong Gan, Jin Ren, Wei Huang, Yong-Tang Zheng, Guangyi Jin, Likun Gong
CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity. Cell discovery 8 (1) (2022)
Yuanchao Xie, Wanchao Yin, Yumin Zhang, Weijuan Shang, Zhen Wang, Xiaodong Luan, Guanghui Tian, Haji A Aisa, Yechun Xu, Gengfu Xiao, Jia Li, Hualiang Jiang, Shu-Yang Zhang, Lei-Ke Zhang, H Eric Xu, Jingshan Shen
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2. Cell research 31 (11) (2021)
Qingxing Wang, Qin-Lin Xin, Weijuan Shang, Weiwei Wan, Gengfu Xiao, Lei-Ke Zhang
Activation of the STAT3 Signaling Pathway by the RNA-Dependent RNA Polymerase Protein of Arenavirus. Viruses 13 (6) (2021)
Wanchao Yin, Xiaodong Luan, Zhihai Li, Ziwei Zhou, Qingxing Wang, Minqi Gao, Xiaoxi Wang, Fulai Zhou, Jingjing Shi, Erli You, Mingliang Liu, Qingxia Wang, Yi Jiang, Hualiang Jiang, Gengfu Xiao, Lei-Ke Zhang, Xuekui Yu, Shu-Yang Zhang, H Eric Xu
Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. Nature structural & molecular biology 28 (3) (2021)
Hao Li, Xia-Ming Jiang, Ning Cui, Chun Yuan, Shao-Fei Zhang, Qing-Bin Lu, Zhen-Dong Yang, Qin-Lin Xin, Ya-Bin Song, Xiao-Ai Zhang, Hai-Zhou Liu, Juan Du, Xue-Juan Fan, Lan Yuan, Yi-Mei Yuan, Zhen Wang, Juan Wang, Lan Zhang, Dong-Na Zhang, Zhi-Bo Wang, Ke Dai, Jie-Ying Bai, Zhao-Nian Hao, Hang Fan, Li-Qun Fang, Gengfu Xiao, Yang Yang, Ke Peng, Hong-Quan Wang, Jian-Xiong Li, Lei-Ke Zhang, Wei Liu
Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome. Signal transduction and targeted therapy 6 (1) (2021)
Qian Wang, Lin Wang, Yumin Zhang, XiangLei Zhang, Lei-Ke Zhang, Weijuan Shang, Fang Bai
Probing the Allosteric Inhibition Mechanism of a Spike Protein Using Molecular Dynamics Simulations and Active Compound Identifications. Journal of medicinal chemistry (2021)
Wenhao Dai, Dirk Jochmans, Hang Xie, Hang Yang, Jian Li, Haixia Su, Di Chang, Jiang Wang, Jingjing Peng, Lili Zhu, Yong Nian, Rolf Hilgenfeld, Hualiang Jiang, Kaixian Chen, Lei-Ke Zhang, Yechun Xu, Johan Neyts, Hong Liu
Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. Journal of medicinal chemistry (2021)
Zhengyuan Wang, Yao Zhao, Qingxing Wang, Yangfei Xing, Lu Feng, Juan Kong, Chao Peng, Lei-Ke Zhang, Haitao Yang, Min Lu
Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro. Signal transduction and targeted therapy 6 (1) (2021)
Kangsa Amporndanai, Xiaoli Meng, Weijuan Shang, Zhenming Jin, Michael Rogers, Yao Zhao, Zihe Rao, Zhi-Jie Liu, Haitao Yang, Lei-Ke Zhang, Paul M O'Neill, S Samar Hasnain
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives. Nature communications 12 (1) (2021)
Yanbo Wang, Xiaoju Zhu, Xia-Ming Jiang, Jingwei Guo, Zheng Fu, Zhen Zhou, Ping Yang, Hongyuan Guo, Xu Guo, Gaoli Liang, Ping Zeng, Gengfu Xiao, Jizheng Ma, Xin Yin, Lei-Ke Zhang, Chao Yan, Chen-Yu Zhang
Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients. Signal transduction and targeted therapy 6 (1) (2021)
Yao Zhao, Chao Fang, Qi Zhang, Ruxue Zhang, Xiangbo Zhao, Yinkai Duan, Haofeng Wang, Yan Zhu, Lu Feng, Jinyi Zhao, Maolin Shao, Xiu-Na Yang, Lei-Ke Zhang, Chao Peng, Kailin Yang, Dawei Ma, Zihe Rao, Haitao Yang
Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332. Protein & cell (2021)
Bingqing Xia, Xurui Shen, Yang He, Xiaoyan Pan, Feng-Liang Liu, Yi Wang, Feipu Yang, Sui Fang, Yan Wu, Zilei Duan, Xiaoli Zuo, Zhuqing Xie, Xiangrui Jiang, Ling Xu, Hao Chi, Shuangqu Li, Qian Meng, Hu Zhou, Yubo Zhou, Xi Cheng, Xiaoming Xin, Lin Jin, Hai-Lin Zhang, Dan-Dan Yu, Ming-Hua Li, Xiao-Li Feng, Jie-Kai Chen, Hualiang Jiang, Gengfu Xiao, Yong-Tang Zheng, Lei-Ke Zhang, Jingshan Shen, Jia Li, Zhaobing Gao
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target. Cell research 31 (8) (2021)
Haixia Su, Sheng Yao, Wenfeng Zhao, Yumin Zhang, Jia Liu, Qiang Shao, Qingxing Wang, Minjun Li, Hang Xie, Weijuan Shang, Changqiang Ke, Lu Feng, Xiangrui Jiang, Jingshan Shen, Gengfu Xiao, Hualiang Jiang, Lei-Ke Zhang, Yang Ye, Yechun Xu
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. Nature communications 12 (1) (2021)
Lei-Ke Zhang, Yuan Sun, Haolong Zeng, Qingxing Wang, Xiaming Jiang, Wei-Juan Shang, Yan Wu, Shufen Li, Yu-Lan Zhang, Zhao-Nian Hao, Hongbo Chen, Runming Jin, Wei Liu, Hao Li, Ke Peng, Gengfu Xiao
Author Correction: Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension. Cell discovery 7 (1) (2021)
Zhen Zhou, Yu Zhou, Xia-Ming Jiang, Yanbo Wang, Xi Chen, Gengfu Xiao, Chen-Yu Zhang, Yongxiang Yi, Lei-Ke Zhang, Liang Li
Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication. Cell discovery 6 (2020)
Weiwei Wan, Shenglin Zhu, Shufen Li, Weijuan Shang, Ruxue Zhang, Hao Li, Wei Liu, Gengfu Xiao, Ke Peng, Lei-Ke Zhang
High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2. ACS infectious diseases 7 (6) (2020)
Lei-Ke Zhang, Yuan Sun, Haolong Zeng, Qingxing Wang, Xiaming Jiang, Wei-Juan Shang, Yan Wu, Shufen Li, Yu-Lan Zhang, Zhao-Nian Hao, Hongbo Chen, Runming Jin, Wei Liu, Hao Li, Ke Peng, Gengfu Xiao
Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension. Cell discovery 6 (1) (2020)
Zhen Zhou, Yu Zhou, Xia-Ming Jiang, Yanbo Wang, Xi Chen, Gengfu Xiao, Chen-Yu Zhang, Yongxiang Yi, Lei-Ke Zhang, Liang Li
Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication. Cell discovery 6 (1) (2020)
Zhenming Jin, Yao Zhao, Yuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, Tianyu Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, Luke W Guddat, Gengfu Xiao, Lei-Ke Zhang, Haitao Yang, Zihe Rao
Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nature structural & molecular biology 27 (6) (2020)
Dianhai Hou, Xi Chen, Lei-Ke Zhang
Proteomic Analysis of Mamestra Brassicae Nucleopolyhedrovirus Progeny Virions from Two Different Hosts. PloS one 11 (4) (2016)